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Note 8 - Income Taxes - Reconciliation of Income Tax Expenses (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019
Loss before income tax	$ 64,638	$ 63,821	$ 40,333
Expected income tax benefit	13,574	13,403	8,470
Tax rate difference	(3,796)	(4,653)	(3,425)
Non-deductible expenses	(788)	(688)	(5,228)
Research tax credits	1,096	641	2,360
Non-taxable income	21	120	0
Tax preference	3,755	0	0
Others	(262)	68	(99)
Change in valuation allowance	(17,170)	(8,891)	(2,078)
Total income tax expenses	$ (3,570)	$ 0	$ 0

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Amount of the difference between reported income tax expense (benefit) and expected income tax expense (benefit) computed by applying the domestic federal statutory income tax rates to pretax income (loss) from continuing operations attributable to tax preference.

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