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Note 9 - Share-based Compensation (Tables) | 12 Months Ended
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Dec. 31, 2023
Notes Tables |
Share-Based Payment Arrangement, Restricted Stock and Restricted Stock Unit, Activity [Table Text Block] |
|  | Number of shares |  |  | Weighted average grant date fair value |
|  |  |  |  |  | $ |
Outstanding at December 31, 2020 |  |  | 130,946 |  |  |  | 17.30 |
Granted |  |  | 15,164 |  |  |  | 14.64 |
Vested |  |  | (22,683 | ) |  |  | 14.78 |
Forfeited |  |  | (40,679 | ) |  |  | 14.00 |
Outstanding at December 31, 2021 |  |  | 82,748 |  |  |  | 19.12 |
Granted |  |  | 1,359 |  |  |  | 2.85 |
Vested |  |  | (6,216 | ) |  |  | 11.10 |
Forfeited |  |  | (907 | ) |  |  | 11.03 |
Outstanding at December 31, 2022 |  |  | 76,984 |  |  |  | 19.57 |
Granted |  |  | 101,098 |  |  |  | 1.18 |
Vested |  |  | (102,118 | ) |  |  | 1.28 |
Forfeited |  |  | (75,964 | ) |  |  | 19.69 |
Outstanding at December 31, 2023 |  |  | - |  |  |  | - |
Expected to vest at December 31, 2023 |  |  | - |  |  |  | - |
Share-Based Payment Arrangement, Option, Activity [Table Text Block] |
|  | Number of options |  |  | Weighted average exercise price |  |  | Weighted average grant date fair value |  |  | Weighted average remaining contractual term |  |  | Aggregate intrinsic value |
|  |  |  |  |  | $ |  |  | $ |  |  | Years |  |  | $ |
Outstanding at December 31, 2020 |  |  | 1,939,049 |  |  |  | 14.12 |  |  |  |  |  |  |  | 9.38 |  |  |  |  |
Granted |  |  | 1,134,672 |  |  |  | 11.24 |  |  |  | 8.19 |  |  |  |  |  |  |  |  |
Exercised |  |  | (98,500 | ) |  |  | 16.13 |  |  |  | 9.66 |  |  |  |  |  |  |  | 473 |
Forfeited |  |  | (307,883 | ) |  |  | 14.52 |  |  |  | 9.06 |  |  |  |  |  |  |  |  |
Outstanding at December 31, 2021 |  |  | 2,667,338 |  |  |  | 12.77 |  |  |  |  |  |  |  | 8.82 |  |  |  | - |
Granted |  |  | 615,407 |  |  |  | 3.94 |  |  |  | 2.98 |  |  |  |  |  |  |  |  |
Exercised |  |  | (60,000 | ) |  |  | 10.81 |  |  |  | 7.81 |  |  |  |  |  |  |  |  |
Forfeited |  |  | (1,212,306 | ) |  |  | 12.93 |  |  |  | 8.54 |  |  |  |  |  |  |  |  |
Outstanding at December 31, 2022 |  |  | 2,010,439 |  |  |  | 10.03 |  |  |  |  |  |  |  | 7.84 |  |  |  | 15 |
Granted |  |  | 760,723 |  |  |  | 1.14 |  |  |  | 0.88 |  |  |  |  |  |  |  |  |
Forfeited |  |  | (905,936 | ) |  |  | 9.91 |  |  |  | 6.65 |  |  |  |  |  |  |  |  |
Outstanding at December 31, 2023 |  |  | 1,865,226 |  |  |  | 6.46 |  |  |  |  |  |  |  | 7.66 |  |  |  | - |
Exercisable as of December 31, 2023 |  |  | 752,240 |  |  |  | 8.06 |  |  |  |  |  |  |  | 6.77 |  |  |  | - |
Vested and expected to vest at December 31, 2023 |  |  | 1,501,346 |  |  |  | 5.40 |  |  |  |  |  |  |  | 7.87 |  |  |  | - |
|  | Number of options |  |  | Weighted average exercise price |  |  | Weighted |  |  | Weighted average remaining |  |  | Aggregate intrinsic value |
|  |  |  |  |  | $ |  |  | $ |  |  | Years |  |  | $ |
Outstanding at December 31, 2021 |  |  | - |  |  |  | - |  |  |  |  |  |  |  | - |  |  |  | - |
Granted |  |  | 1,281,000 |  |  |  | 0.50 |  |  |  | 0.38 |  |  |  |  |  |  |  |  |
Forfeited |  |  | (93,000 | ) |  |  | 0.50 |  |  |  | 0.36 |  |  |  |  |  |  |  |  |
Outstanding at December 31, 2022 |  |  | 1,188,000 |  |  |  | 0.50 |  |  |  |  |  |  |  | 9.69 |  |  |  | - |
Granted |  |  | 172,000 |  |  |  | 0.50 |  |  |  | 0.32 |  |  |  |  |  |  |  |  |
Exercised |  |  | (8,000 | ) |  |  | 0.50 |  |  |  | 0.40 |  |  |  |  |  |  |  | - |
Forfeited |  |  | (95,000 | ) |  |  | 0.50 |  |  |  | 0.36 |  |  |  |  |  |  |  |  |
Outstanding at December 31, 2023 |  |  | 1,257,000 |  |  |  | 0.50 |  |  |  |  |  |  |  | 8.82 |  |  |  | - |
Exercisable as of December 31, 2023 |  |  | 436,500 |  |  |  | 0.50 |  |  |  |  |  |  |  | 8.84 |  |  |  | - |
Vested and expected to vest at December 31, 2023 |  |  | 1,257,000 |  |  |  | 0.50 |  |  |  |  |  |  |  | 8.82 |  |  |  | - |
Schedule of Share-Based Payment Award, Stock Options, Valuation Assumptions [Table Text Block] |
| For the year ended December 31,
| 2021 |  | 2022 |  | 2023
Fair value of ordinary share | 9.48 | ~ | 31.31 |  | 1.14 | ~ | 3.48 |  | 0.77 | ~ | 1.75
Risk-free interest rate | 0.37% | ~ | 1.47% |  | 1.23% | ~ | 3.16% |  | 3.47% | ~ | 4.29%
Expected term (years) | 5.0 | ~ | 7.49 |  | 3.05 | ~ | 6.00 |  | 5.07 | ~ | 6.00
Expected volatility | 75% | ~ | 90% |  | 100% | ~ | 115% |  |  |  | 105%
Expected dividend yield |  |  | 0% |  |  |  | 0% |  |  |  | 0%
Contractual life (years) |  |  | 10 |  | 5 | ~ | 10 |  |  |  | 10
|  | For the year ended December 31, 2021 |
Exercise price |  |  | 10.18 |
Fair value of ordinary share |  |  | 10.71 |
Risk-free interest rate |  |  | 1.63 | %
Contractual term (years) |  |  | 10 |
Expected volatility |  |  | 75 | %
Expected dividend yield |  |  | 0 | %
|  | For the year ended December 31,
|  | 2022 |  | 2023
Fair value of ordinary share |  | 0.44 | ~ | 0.50 |  | 0.19 | ~ | 0.44
Risk-free interest rate |  | 2.54% | ~ | 3.75% |  | 3.47% | ~ | 4.73%
Expected term (years) |  | 5.25 | ~ | 6.50 |  | 5.04 | ~ | 6.50
Expected volatility |  | 99.34% | ~ | 106.73% |  | 105.97% | ~ | 141.40%
Expected dividend yield |  |  |  | 0% |  |  |  | 0%
Contractual life (years) |  |  |  | 10 |  |  |  | 10
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Table Text Block] |
|  | Year ended December 31, |
|  | 2021 |  |  | 2022 |  |  | 2023 |
|  | $ |  |  | $ |  |  | $ |
Research and development |  |  | 901 |  |  |  | 859 |  |  |  | (181 | )
General and administrative |  |  | 2,251 |  |  |  | 725 |  |  |  | 735 |
Total |  |  | 3,152 |  |  |  | 1,584 |  |  |  | 554 |
|  | Year ended December 31, |
|  | 2022 |  |  | 2023 |
|  | $ |  |  | $ |
Research and development |  |  | 71 |  |  |  | 89 |
General and administrative |  |  | 10 |  |  |  | 127 |
Total |  |  | 81 |  |  |  | 216 |

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- Definition Tabular disclosure of allocation of amount expensed and capitalized for award under share-based payment arrangement to statement of income or comprehensive income and statement of financial position. Includes, but is not limited to, corresponding line item in financial statement. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (h)(1) -Publisher FASB -URI https://asc.fasb.org/1943274/2147480429/718-10-50-2 + Details
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- Definition Tabular disclosure for stock option plans. Includes, but is not limited to, outstanding awards at beginning and end of year, grants, exercises, forfeitures, and weighted-average grant date fair value. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Topic 718 -SubTopic 10 -Name Accounting Standards Codification -Section 50 -Paragraph 2 -Subparagraph (c)(1) -Publisher FASB -URI https://asc.fasb.org/1943274/2147480429/718-10-50-2 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Name Accounting Standards Codification -Section 50 -Paragraph 2 -Subparagraph (d) -SubTopic 10 -Topic 718 -Publisher FASB -URI https://asc.fasb.org/1943274/2147480429/718-10-50-2 Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef -Name Accounting Standards Codification -Section 50 -Paragraph 2 -Subparagraph (e) -SubTopic 10 -Topic 718 -Publisher FASB -URI https://asc.fasb.org/1943274/2147480429/718-10-50-2 + Details
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- Definition Disclosure of the number and weighted-average grant date fair value for restricted stock and restricted stock units that were outstanding at the beginning and end of the year, and the number of restricted stock and restricted stock units that were granted, vested, or forfeited during the year. + References No definition available. + Details
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