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Note 9 - Share-based Compensation (Tables)

12 Months Ended

Dec. 31, 2023

Notes Tables

Share-Based Payment Arrangement, Restricted Stock and Restricted Stock Unit, Activity [Table Text Block]

		Number of shares				Weighted average grant date fair value
						$
Outstanding at December 31, 2020			130,946				17.30
Granted			15,164				14.64
Vested			(22,683	)			14.78
Forfeited			(40,679	)			14.00
Outstanding at December 31, 2021			82,748				19.12
Granted			1,359				2.85
Vested			(6,216	)			11.10
Forfeited			(907	)			11.03
Outstanding at December 31, 2022			76,984				19.57
Granted			101,098				1.18
Vested			(102,118	)			1.28
Forfeited			(75,964	)			19.69
Outstanding at December 31, 2023			-				-
Expected to vest at December 31, 2023			-				-

Share-Based Payment Arrangement, Option, Activity [Table Text Block]

		Number  of options				Weighted  average exercise  price				Weighted average grant  date fair value				Weighted average  remaining contractual  term				Aggregate intrinsic  value
						$				$				Years				$
Outstanding at December 31, 2020			1,939,049				14.12								9.38
Granted			1,134,672				11.24				8.19
Exercised			(98,500	)			16.13				9.66								473
Forfeited			(307,883	)			14.52				9.06
Outstanding at December 31, 2021			2,667,338				12.77								8.82				-
Granted			615,407				3.94				2.98
Exercised			(60,000	)			10.81				7.81
Forfeited			(1,212,306	)			12.93				8.54
Outstanding at December 31, 2022			2,010,439				10.03								7.84				15
Granted			760,723				1.14				0.88
Forfeited			(905,936	)			9.91				6.65
Outstanding at December 31, 2023			1,865,226				6.46								7.66				-
Exercisable as of December 31, 2023			752,240				8.06								6.77				-
Vested and expected to vest at December 31, 2023			1,501,346				5.40								7.87				-

		Number  of options				Weighted average exercise  price				Weighted				Weighted average remaining				Aggregate intrinsic  value
						$				$				Years				$
Outstanding at December 31, 2021			-				-								-				-
Granted			1,281,000				0.50				0.38
Forfeited			(93,000	)			0.50				0.36
Outstanding at December 31, 2022			1,188,000				0.50								9.69				-
Granted			172,000				0.50				0.32
Exercised			(8,000	)			0.50				0.40								-
Forfeited			(95,000	)			0.50				0.36
Outstanding at December 31, 2023			1,257,000				0.50								8.82				-
Exercisable as of December 31, 2023			436,500				0.50								8.84				-
Vested and expected to vest at December 31, 2023			1,257,000				0.50								8.82				-

Schedule of Share-Based Payment Award, Stock Options, Valuation Assumptions [Table Text Block]

	For the year ended December 31,
	2021				2022				2023
Fair value of ordinary share	9.48	~	31.31		1.14	~	3.48		0.77	~	1.75
Risk-free interest rate	0.37%	~	1.47%		1.23%	~	3.16%		3.47%	~	4.29%
Expected term (years)	5.0	~	7.49		3.05	~	6.00		5.07	~	6.00
Expected volatility	75%	~	90%		100%	~	115%				105%
Expected dividend yield			0%				0%				0%
Contractual life (years)			10		5	~	10				10

		For the year ended December 31, 2021
Exercise price			10.18
Fair value of ordinary share			10.71
Risk-free interest rate			1.63	%
Contractual term (years)			10
Expected volatility			75	%
Expected dividend yield			0	%

		For the year ended December 31,
		2022				2023
Fair value of ordinary share		0.44	~	0.50		0.19	~	0.44
Risk-free interest rate		2.54%	~	3.75%		3.47%	~	4.73%
Expected term (years)		5.25	~	6.50		5.04	~	6.50
Expected volatility		99.34%	~	106.73%		105.97%	~	141.40%
Expected dividend yield				0%				0%
Contractual life (years)				10				10

Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Table Text Block]

		Year ended December 31,
		2021				2022				2023
		$				$				$
Research and development			901				859				(181	)
General and administrative			2,251				725				735
Total			3,152				1,584				554

		Year ended December 31,
		2022				2023
		$				$
Research and development			71				89
General and administrative			10				127
Total			81				216

X

- Definition

Tabular disclosure of allocation of amount expensed and capitalized for award under share-based payment arrangement to statement of income or comprehensive income and statement of financial position. Includes, but is not limited to, corresponding line item in financial statement.

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