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Condensed Consolidated Statements of Cash Flows (Unaudited) - USD ($)
$ in Thousands
 9 Months Ended
Sep. 30, 2019
Sep. 30, 2018
Operating activities:    
Net loss $ (53,849) $ (31,857)
Adjustments to reconcile net loss to net cash used in operating activities:    
Accretion on marketable securities (901) (305)
Depreciation and amortization expense 90 55
Loss on disposal of property and equipment 35  
Stock-based compensation expense 2,808 2,212
Changes in operating assets and liabilities:    
Restricted cash (161) (84)
Prepaid expenses and other current assets (2,513) (769)
Accounts payable 6,975 2,807
Accrued liabilities (507) (386)
Funding advance   500
Other liabilities (13) 22
Net cash used in operating activities (48,036) (27,805)
Investing activities:    
Purchases of property and equipment (241) (333)
Maturities of marketable securities 105,500  
Purchases of marketable securities (97,104) (92,293)
Net cash provided by (used in) investing activities 8,155 (92,626)
Financing activities:    
Proceeds from public offering, net of issuance costs 49,748 89,938
Proceeds from at-the-market offering, net of issuance costs 6,726  
Taxes paid related to net share settlement of restricted stock units (20)  
Proceeds from exercising stock options 6  
Net cash provided by financing activities 56,460 89,938
Net increase (decrease) in cash and cash equivalents 16,579 (30,493)
Cash and cash equivalents at beginning of period 7,042 53,349
Cash and cash equivalents at end of period 23,621 22,856
Supplemental disclosure of non-cash investing and financing activities:    
Purchases of property and equipment included in accounts payable   2
Conversion of redeemable convertible preferred stock into common stock   $ 81,620
Issuance costs associated with at-the-market offering included in accounts payable $ 9