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Related Party Transactions - Additional Information (Details) - USD ($) | 12 Months Ended
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Dec. 31, 2019 | Dec. 31, 2018 | Dec. 31, 2017
Novartis International Pharmaceutical Ltd. |  |  |
Related Party Transaction [Line Items] |  |  |
Payments to related parties | $ 2,500,000 | $ 0 | $ 900,000
Silverstein Foundation | Funding Agreement |  |  |
Related Party Transaction [Line Items] |  |  |
Fund received from related parties | $ 0 | $ 500,000 | $ 0
Common Stock |  |  |
Related Party Transaction [Line Items] |  |  |
Issuance of common shares to PureTech, shares |  |  | 1,886,363

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