    <SEC-DOCUMENT>0001104659-26-050437-index.html : 20260428
    <SEC-HEADER>0001104659-26-050437.hdr.sgml : 20260428
    <ACCEPTANCE-DATETIME>20260428164927
    ACCESSION NUMBER:		0001104659-26-050437
    CONFORMED SUBMISSION TYPE:	ARS
    PUBLIC DOCUMENT COUNT:		1
    CONFORMED PERIOD OF REPORT:	20251231
    FILED AS OF DATE:		20260428
    DATE AS OF CHANGE:		20260428
    EFFECTIVENESS DATE:		20260428

    FILER:

    	COMPANY DATA:
    		COMPANY CONFORMED NAME:			Gain Therapeutics, Inc.
    		CENTRAL INDEX KEY:			0001819411
    		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
    		ORGANIZATION NAME:           	03 Life Sciences
    		EIN:				851726310
    		STATE OF INCORPORATION:			DE
    		FISCAL YEAR END:			1231

    	FILING VALUES:
    		FORM TYPE:		ARS
    		SEC ACT:		1934 Act
    		SEC FILE NUMBER:	001-40237
    		FILM NUMBER:		26908794

    	BUSINESS ADDRESS:
    		STREET 1:		4800 HAMPDEN LANE
    		STREET 2:		SUITE 200
    		CITY:			BETHESDA
    		STATE:			MD
    		ZIP:			20814
    		BUSINESS PHONE:		(301) 500-1556

    	MAIL ADDRESS:
    		STREET 1:		4800 HAMPDEN LANE
    		STREET 2:		SUITE 200
    		CITY:			BETHESDA
    		STATE:			MD
    		ZIP:			20814
    </SEC-HEADER>
    <DOCUMENT>
    <TYPE>ARS
    <SEQUENCE>1
    <FILENAME>ganx-20251231xars.pdf
    <DESCRIPTION>ARS
    <TEXT>
    Document 1 - file: ganx-20251231xars.pdf

    </DOCUMENT>
    </SEC-DOCUMENT>