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CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS - USD ($) | 9 Months Ended | 11 Months Ended | 12 Months Ended
--- | --- | --- | ---
Sep. 30, 2022 | Sep. 30, 2021 | Dec. 31, 2021 | Dec. 31, 2021 | Dec. 31, 2020
Revenue: |  |  |  |  |
Revenue from contracts with customers | $ 21,932,000 | $ 13,317,000 |  | $ 18,871,000 | $ 12,987,000
Revenue from collaborative arrangements | 1,733,000 | 2,662,000 |  | 3,337,000 | 1,163,000
Revenue from related party transactions | 2,116,000 | 2,348,000 |  | 3,253,000 | 4,203,000
Revenues | 25,781,000 | 18,327,000 |  | 25,461,000 | 18,353,000
Cost and operating expenses: |  |  |  |  |
Cost of revenues from contracts with customers (exclusive of depreciation shown below) | (18,162,000) | (8,480,000) |  | (13,167,000) | (8,185,000)
Research and development expense | (39,858,000) | (29,223,000) |  | (44,229,000) | (34,454,000)
Depreciation expense | 3,433,000 | 2,763,000 |  | 3,806,000 | 2,979,000
Selling, general and administrative expense | (19,482,000) | (11,595,000) |  | (13,216,000) | (9,029,000)
Total cost and operating expenses | (82,004,000) | (53,571,000) |  | (76,480,000) | (58,054,000)
Loss from operations | (56,223,000) | (35,244,000) |  | (51,019,000) | (39,701,000)
Other (expense) income: |  |  |  |  |
Interest income (expense), net | 3,000 | (5,000) |  | (7,000) | (351,000)
Gain on extinguishment of debt | 0 | 3,065,000 |  | 3,065,000 | 0
Other (expense) income, net | (1,100,000) | (778,000) |  | (673,000) | 172,000
Total other (expense) income, net | (1,097,000) | 2,282,000 |  | 2,385,000 | (179,000)
Loss before income taxes | (57,320,000) | (32,962,000) |  | (48,634,000) | (39,880,000)
Income tax expense | 0 | 0 | $ 0 | 0 | 0
Gain from equity method investees, net | 2,346,000 | 2,371,000 |  | 1,945,000 | 2,167,000
Net income (loss) | (54,974,000) | (30,591,000) |  | (46,689,000) | (37,713,000)
Unpaid cumulative dividends on preferred stock | (28,925,000) | (27,068,000) |  | (36,758,000) | (31,291,000)
Net loss allocated to common shareholders | (83,899,000) | (57,659,000) |  | (83,447,000) | (69,004,000)
Other comprehensive loss: |  |  |  |  |
Foreign currency translation adjustments | (767,000) | (29,000) |  | 95,000 | 625,000
Comprehensive loss | $ (55,741,000) | $ (30,620,000) |  | $ (46,594,000) | $ (37,088,000)
Net loss per common share - basic (usd per share) | $ (39,790) | $ (30,190) |  | $ (42.59) | $ (42.34)
Net loss per common share - diluted (usd per share) | $ (39,790) | $ (30,190) |  | $ (42.59) | $ (42.34)
Weighted-average number of common shares outstanding - basic (in shares) | 2,108,472,000 | 1,909,635,000 |  | 1,959,165,000 | 1,629,821,000
Weighted-average shares used in calculating net loss per share, diluted (in shares) | 2,108,472,000 | 1,909,635,000 |  | 1,959,165,000 | 1,629,821,000
Collaborative Arrangement, Transaction with Party to Collaborative Arrangement |  |  |  |  |
Cost and operating expenses: |  |  |  |  |
Cost of revenues from contracts with customers (exclusive of depreciation shown below) | $ (727,000) | $ (935,000) |  | $ (1,254,000) | $ (743,000)
Related Party |  |  |  |  |
Cost and operating expenses: |  |  |  |  |
Cost of revenues from contracts with customers (exclusive of depreciation shown below) | $ (342,000) | $ (575,000) |  | $ (808,000) | $ (2,664,000)

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