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Statements of Cash Flows - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2021 | Dec. 31, 2020
Cash flows from operating activities |  |
Net loss | $ (43,159) | $ (31,350)
Adjustments to reconcile net loss to net cash, cash equivalents, and restricted cash used in operating activities |  |
Depreciation and amortization | 3,178 | 2,903
Amortization of convertible notes debt discount |  | 4,389
Gain on debt extinguishments, net | (2,298) |
Stock‑based compensation expense | 4,944 | 3,709
Change in fair value of warrant liability |  | 1,252
Change in contingent consideration | 1,622 | 818
Provision for doubtful accounts | 193 | 296
Accrued interest, amortization of debt issuance costs and other | 2,706 | 1,418
Changes in operating assets and liabilities: |  |
Accounts receivable | 11,454 | (10,308)
Other current assets | 1,369 | (6,588)
Other long-term assets and liabilities | 875 | (1,808)
Accounts payable and other accrued liabilities | (7,425) | 11,654
Deferred revenue | (1,682) | 2,249
Net cash and cash equivalents and restricted cash used in operating activities | (28,223) | (21,366)
Cash flows from investing activities |  |
Purchase of property and equipment | (2,241) | (1,945)
Patent costs and intangible asset acquisition, net | (306) | (232)
Payments to acquire Oncimmune assets |  | (750)
Net cash and cash equivalents and restricted cash used in investing activities | (2,547) | (2,927)
Cash flows from financing activities |  |
Proceeds from initial public offering |  | 72,000
Proceeds from the issuance of common stock | 16,343 |
Proceeds from issuance of common stock under employee stock purchase plan | 328 |
Proceeds from exercise of stock options | 769 | 1,340
Proceeds from issuances of convertible notes payable |  | 12,955
Proceeds from term loan and notes payable | 30,078 | 3,085
Repayment of term loan and notes payable | (45,428) |
Payment of debt issuance costs | (164) |
Equity financing costs | (664) | (8,243)
Other |  | (6)
Net cash and cash equivalents and restricted cash provided by financing activities | 1,262 | 81,131
Net increase (decrease) in cash and cash equivalents and restricted cash | (29,508) | 56,838
Cash, cash equivalents, and restricted cash ‑ beginning of period | 62,306 | 5,468
Cash, cash equivalents, and restricted cash ‑ end of period | 32,798 | 62,306
Supplemental cash flow information |  |
Conversion of preferred stock into common stock |  | 193,959
Conversion of convertible notes and accrued interest into common stock |  | 26,616
Reclassification of put option liability to additional paid-in capital |  | 6,650
Value of put option recorded at issuance of convertible debt payable |  | 3,389
Cash paid for interest | 1,676 | 1,844
Reclassification of warrant liability to additional paid-in capital |  | $ 1,624
Non-cash debt issuance costs included in Accrued liabilities | $ 15 |

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