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Share capital (Tables)

12 Months Ended

Dec. 31, 2021

Disclosure of reserves within equity [abstract]

Schedule of changes in share capital

	Class A shares					Class B shares						Warrants
	#		$		#		$			#			$
Balance, December 31, 2018	72		151,588			6,843,780			51,093,434			546,212			3,341,826
Shares issued [a] [b] [c] [d]	-		-			408,651			8,681,103			-			-
of Prismic Pharmaceuticals, Inc. [e]	-		-			510,940			12,361,657			67,598			1,420,407
Stock options exercised	-		-			-			-			-			-
Share-based payments	-		-			130,189			1,340,929			-			-
Warrants exercised	-		-			12,167			109,214			(12,167	)		(37,753	)
Warrants expired	-		-			-			-			(134,192	)		(402,491	)
Balance, December 31, 2019	72		151,588			7,905,727			73,586,337			467,451			4,321,989
Shares issued [g] [j] [k] [l] [n] [o]	-		-			8,925,942			22,242,975			6,335,758			1,110,904
Share-based payments [f] [h] [i] [m]	-		-			2,307,569			6,663,479			-			-
Share options exercised	-		-			22,382			563,747			-			-
Warrants expired	-		-			-			-			(54,100	)		(463,935	)
Balance, December 31, 2020	72		151,588			19,161,620			103,056,538			6,749,109			4,968,958
Shares issued [p]	-		-			15,480,462			38,341,407			-			-
Share-based payments [q] [r] [s]	-		-			1,462,558			3,751,412			100,000			98,513
Share cancellation [q]	-		-			(156,278	)		-			-			-
Lucid acquisition [t]	-		-			4,502,392			7,023,732			112,162			70,563
Warrants expired	-		-			-			-			(4,476	)		(617	)
Balance, December 31, 2021	72		151,588			40,450,754			152,173,089			6,956,795			5,137,417

Schedule of changes in warrants outstanding and weighted average exercise price

					Weighted average
		Number of warrants			exercise price
		#			C$
Outstanding as at December 31, 2018		546,212			9.47
Issued		67,598			10.45
Exercised		(12,167	)		7.81
Expired		(134,192	)		7.64
Outstanding as at December 31, 2019		467,451			10.20
Issued		6,335,758			5.27
Expired		(54,100	)		4.97
Outstanding as at December 31, 2020		6,749,109			5.62
Issued		212,162			1.93
Expired		(4,476	)		5.43
Outstanding as at December 31, 2021		6,956,795			5.50

Schedule of fair value assumptions of warrants outstanding

		2021			2020			2019
Grant date share price		C$2.00 - C$2.04			C$2.58 - C$4.00			C$32.16
Exercise price		C$1.53 - C$2.50			C$3.46 - C$5.80			C$2.61 - C$26.73
Expected dividend yield		-			-			-
Risk free interest rate		0.43% - 0.46%			0.32% 0.36%			1.41% - 1.52%
Expected life		1.19 - 2 years			5 years			1.39 - 6.55 years
Expected volatility		88% - 129%			118% - 121%			100%

Schedule of number of warrants outstanding and exercise price

Warrants Outstanding
		Exercise price			Number outstanding
Expiry Date		C$			#
May 24, 2022		18.09			163,535
September 15, 2022		4.42			199,005
November 30, 2022		1.21			46,242
December 31, 2022		2.43			65,920
May 20, 2023		16.08			7,311
June 23, 2023		2.50			100,000
July 24, 2023		13.07			3,357
September 11, 2023		5.43			22,382
May 4, 2025		26.73			3,730
May 10, 2025		26.73			1,865
May 17, 2025		26.73			3,730
May 31, 2025		26.73			1,865
June 8, 2025		9.65			1,500,000
August 6, 2025 (i)		5.40			1,381,215
October 20, 2025 (ii)		3.30			3,454,543
January 16, 2026		26.73			1,722
January 20, 2026		26.73			373
		5.50			6,956,795

Warrants Outstanding
		Exercise price			Number outstanding
Expiry Date		C$			#
August 1, 2021		5.43			4,476
May 24, 2022		18.09			163,535
September 15, 2022		4.42			199,005
May 20, 2023		16.08			7,311
July 24, 2023		13.07			3,357
September 11, 2023		5.43			22,382
May 4, 2025		26.73			3,730
May 10, 2025		26.73			1,865
May 17, 2025		26.73			3,730
May 31, 2025		26.73			1,865
June 8, 2025		9.65			1,500,000
August 6, 2025 (i)		5.42			1,381,215
October 20, 2025 (ii)		3.31			3,454,543
January 16, 2026		26.73			1,722
January 20, 2026		26.73			373
		5.62			6,749,109

Warrants Outstanding
		Exercise price			Number outstanding
Expiry Date		C$			#
January 5, 2020		6.03			37,313
November 30, 2020		2.61			16,787
August 1, 2021		5.43			4,476
May 24, 2022		18.09			163,535
September 15, 2022		4.42			199,005
May 20, 2023		16.08			7,311
July 24, 2023		13.07			3,357
September 11, 2023		5.43			22,382
May 4, 2025		26.73			3,730
May 10, 2025		26.73			1,865
May 17, 2025		26.73			3,730
May 31, 2025		26.73			1,865
January 16, 2026		26.73			1,722
January 20, 2026		26.73			373
		10.20			467,451

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