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Share-based compensation - Schedule of exercise price and weighted average contractual term of share options outstanding and exercisable (Details) - Stock options
 12 Months Ended
Dec. 31, 2021
Share
$ / shares
Dec. 31, 2020
Share
$ / shares
Dec. 31, 2019
Share
$ / shares
Dec. 31, 2018
Share
$ / shares
Disclosure of terms and conditions of share-based payment arrangement [line items]        
Exercise price of options outstanding | $ / shares $ 2.75 $ 6.11 $ 21.96 $ 74.53
Number of share options outstanding in share-based payment arrangement | Share 3,224,859 1,693,063 1,454,943 485,159
Weighted average remaining contractual life of outstanding share options 2 years 6 months 3 years 10 months 17 days 4 years 7 months 2 days  
Exercise price of exercisable Share options | $ / shares $ 2.72 $ 6.13 $ 21.24  
Number of share options exercisable in share-based payment arrangement | Share 3,197,601 1,528,186 1,200,242  
1.70        
Disclosure of terms and conditions of share-based payment arrangement [line items]        
Exercise price of options outstanding | $ / shares $ 1.70      
Number of share options outstanding in share-based payment arrangement | Share 154,953      
Weighted average remaining contractual life of outstanding share options 3 years 5 months 15 days      
Exercise price of exercisable Share options | $ / shares $ 1.70      
Number of share options exercisable in share-based payment arrangement | Share 154,953      
2.91        
Disclosure of terms and conditions of share-based payment arrangement [line items]        
Exercise price of options outstanding | $ / shares $ 2.91      
Number of share options outstanding in share-based payment arrangement | Share 5,150      
Weighted average remaining contractual life of outstanding share options 4 years      
Exercise price of exercisable Share options | $ / shares $ 2.91      
Number of share options exercisable in share-based payment arrangement | Share 5,150      
2.25        
Disclosure of terms and conditions of share-based payment arrangement [line items]        
Exercise price of options outstanding | $ / shares $ 2.25      
Number of share options outstanding in share-based payment arrangement | Share 2,559,995      
Weighted average remaining contractual life of outstanding share options 2 years 5 months 1 day      
Exercise price of exercisable Share options | $ / shares $ 2.25      
Number of share options exercisable in share-based payment arrangement | Share 2,559,995      
2.61        
Disclosure of terms and conditions of share-based payment arrangement [line items]        
Exercise price of options outstanding | $ / shares $ 2.61 $ 2.61 $ 2.61  
Number of share options outstanding in share-based payment arrangement | Share 12,684 12,683 35,065  
Weighted average remaining contractual life of outstanding share options 1 year 5 months 26 days 2 years 5 months 26 days 3 years 5 months 26 days  
Exercise price of exercisable Share options | $ / shares $ 2.61 $ 2.61 $ 2.61  
Number of share options exercisable in share-based payment arrangement | Share 12,683 12,683 35,065  
3.75        
Disclosure of terms and conditions of share-based payment arrangement [line items]        
Exercise price of options outstanding | $ / shares $ 3.75 $ 3.75    
Number of share options outstanding in share-based payment arrangement | Share 10,500 5,500    
Weighted average remaining contractual life of outstanding share options 3 years 11 months 1 day 6 years 5 months 19 days    
Exercise price of exercisable Share options | $ / shares $ 3.75 $ 3.75    
Number of share options exercisable in share-based payment arrangement | Share 6,500 500    
3.86        
Disclosure of terms and conditions of share-based payment arrangement [line items]        
Exercise price of options outstanding | $ / shares $ 3.86 $ 3.86    
Number of share options outstanding in share-based payment arrangement | Share 256,245 872,139    
Weighted average remaining contractual life of outstanding share options 3 years 2 months 15 days 4 years 29 days    
Exercise price of exercisable Share options | $ / shares $ 3.86 $ 3.86    
Number of share options exercisable in share-based payment arrangement | Share 252,993 864,139    
4.42        
Disclosure of terms and conditions of share-based payment arrangement [line items]        
Exercise price of options outstanding | $ / shares $ 4.42 $ 4.42 $ 4.42  
Number of share options outstanding in share-based payment arrangement | Share 99,503 99,502 99,502  
Weighted average remaining contractual life of outstanding share options 8 months 15 days 1 year 8 months 15 days 2 years 8 months 15 days  
Exercise price of exercisable Share options | $ / shares $ 4.42 $ 4.42 $ 4.42  
Number of share options exercisable in share-based payment arrangement | Share 99,502 99,502 99,502  
4.75        
Disclosure of terms and conditions of share-based payment arrangement [line items]        
Exercise price of options outstanding | $ / shares $ 4.75 $ 4.75    
Number of share options outstanding in share-based payment arrangement | Share 15,000 110,000    
Weighted average remaining contractual life of outstanding share options 3 years 3 months 14 days 4 years 3 months 14 days    
Exercise price of exercisable Share options | $ / shares $ 4.75 $ 4.75    
Number of share options exercisable in share-based payment arrangement | Share 15,000 77,500    
5.03        
Disclosure of terms and conditions of share-based payment arrangement [line items]        
Exercise price of options outstanding | $ / shares $ 5.43 $ 5.03    
Number of share options outstanding in share-based payment arrangement | Share 16,265 60,000    
Weighted average remaining contractual life of outstanding share options 1 year 5 months 26 days 4 years 8 months 12 days    
Exercise price of exercisable Share options | $ / shares $ 5.43 $ 5.03    
Number of share options exercisable in share-based payment arrangement | Share 16,264 7,498    
5.43        
Disclosure of terms and conditions of share-based payment arrangement [line items]        
Exercise price of options outstanding | $ / shares   $ 5.43 $ 5.43  
Number of share options outstanding in share-based payment arrangement | Share   16,264 16,264  
Weighted average remaining contractual life of outstanding share options   2 years 5 months 26 days 3 years 5 months 26 days  
Exercise price of exercisable Share options | $ / shares   $ 5.43 $ 5.43  
Number of share options exercisable in share-based payment arrangement | Share   16,264 16,264  
6.16        
Disclosure of terms and conditions of share-based payment arrangement [line items]        
Exercise price of options outstanding | $ / shares   $ 6.16    
Number of share options outstanding in share-based payment arrangement | Share   20,000    
Weighted average remaining contractual life of outstanding share options   3 years 2 months 4 days    
Exercise price of exercisable Share options | $ / shares   $ 6.16    
Number of share options exercisable in share-based payment arrangement | Share   20,000    
7.17        
Disclosure of terms and conditions of share-based payment arrangement [line items]        
Exercise price of options outstanding | $ / shares   $ 7.17 $ 7.17  
Number of share options outstanding in share-based payment arrangement | Share   199,005 199,005  
Weighted average remaining contractual life of outstanding share options   3 years 9 months 29 days 4 years 9 months 29 days  
Exercise price of exercisable Share options | $ / shares   $ 7.17 $ 7.17  
Number of share options exercisable in share-based payment arrangement | Share   199,005 199,005  
7.63        
Disclosure of terms and conditions of share-based payment arrangement [line items]        
Exercise price of options outstanding | $ / shares $ 7.63 $ 7.63 $ 7.63  
Number of share options outstanding in share-based payment arrangement | Share 50,000 203,750 203,750  
Weighted average remaining contractual life of outstanding share options 4 years 4 years 4 months 2 days 5 years 4 months 2 days  
Exercise price of exercisable Share options | $ / shares $ 7.63 $ 7.63 $ 7.63  
Number of share options exercisable in share-based payment arrangement | Share 30,000 138,750 58,750  
9.54        
Disclosure of terms and conditions of share-based payment arrangement [line items]        
Exercise price of options outstanding | $ / shares   $ 9.54    
Number of share options outstanding in share-based payment arrangement | Share   15,000    
Weighted average remaining contractual life of outstanding share options   4 years 21 days    
Exercise price of exercisable Share options | $ / shares   $ 9.54    
Number of share options exercisable in share-based payment arrangement | Share   13,125    
10.65        
Disclosure of terms and conditions of share-based payment arrangement [line items]        
Exercise price of options outstanding | $ / shares $ 10.65 $ 10.65 $ 10.65  
Number of share options outstanding in share-based payment arrangement | Share 3,731 3,730 3,730  
Weighted average remaining contractual life of outstanding share options 1 year 5 months 26 days 2 years 5 months 26 days 3 years 5 months 26 days  
Exercise price of exercisable Share options | $ / shares $ 10.65 $ 10.65 $ 10.65  
Number of share options exercisable in share-based payment arrangement | Share 3,730 3,730 3,730  
13.07        
Disclosure of terms and conditions of share-based payment arrangement [line items]        
Exercise price of options outstanding | $ / shares $ 13.07 $ 13.07 $ 13.07  
Number of share options outstanding in share-based payment arrangement | Share 10,856 10,855 10,855  
Weighted average remaining contractual life of outstanding share options 1 year 5 months 26 days 2 years 5 months 26 days 3 years 5 months 26 days  
Exercise price of exercisable Share options | $ / shares $ 13.07 $ 13.07 $ 13.07  
Number of share options exercisable in share-based payment arrangement | Share 10,855 10,855 10,855  
13.47        
Disclosure of terms and conditions of share-based payment arrangement [line items]        
Exercise price of options outstanding | $ / shares $ 13.47 $ 13.47 $ 13.47  
Number of share options outstanding in share-based payment arrangement | Share 1,418 1,418 1,418  
Weighted average remaining contractual life of outstanding share options 1 year 5 months 26 days 2 years 5 months 26 days 3 years 5 months 26 days  
Exercise price of exercisable Share options | $ / shares $ 13.47 $ 13.47 $ 13.47  
Number of share options exercisable in share-based payment arrangement | Share 1,418 1,418 1,418  
16.08        
Disclosure of terms and conditions of share-based payment arrangement [line items]        
Exercise price of options outstanding | $ / shares $ 16.08 $ 16.08 $ 16.08  
Number of share options outstanding in share-based payment arrangement | Share 18,410 18,409 18,409  
Weighted average remaining contractual life of outstanding share options 1 year 5 months 26 days 2 years 5 months 26 days 3 years 5 months 26 days  
Exercise price of exercisable Share options | $ / shares $ 16.08 $ 16.08 $ 16.08  
Number of share options exercisable in share-based payment arrangement | Share 18,409 18,409 18,409  
17.89        
Disclosure of terms and conditions of share-based payment arrangement [line items]        
Exercise price of options outstanding | $ / shares $ 17.89 $ 17.89 $ 17.89  
Number of share options outstanding in share-based payment arrangement | Share 4,178 4,178 4,178  
Weighted average remaining contractual life of outstanding share options 1 year 5 months 26 days 2 years 5 months 26 days 3 years 5 months 26 days  
Exercise price of exercisable Share options | $ / shares $ 17.89 $ 17.89 $ 17.89  
Number of share options exercisable in share-based payment arrangement | Share 4,178 4,178 4,178  
18.09        
Disclosure of terms and conditions of share-based payment arrangement [line items]        
Exercise price of options outstanding | $ / shares $ 18.09 $ 18.09 $ 18.09  
Number of share options outstanding in share-based payment arrangement | Share 2,488 17,413 37,313  
Weighted average remaining contractual life of outstanding share options 1 year 2 months 26 days 2 years 2 months 15 days 3 years 4 months 2 days  
Exercise price of exercisable Share options | $ / shares $ 18.09 $ 18.09 $ 18.09  
Number of share options exercisable in share-based payment arrangement | Share 2,488 17,413 37,313  
20.10        
Disclosure of terms and conditions of share-based payment arrangement [line items]        
Exercise price of options outstanding | $ / shares   $ 20.10 $ 20.10  
Number of share options outstanding in share-based payment arrangement | Share   8,289 493,363  
Weighted average remaining contractual life of outstanding share options   2 years 3 months 7 days 4 years 8 months 19 days  
Exercise price of exercisable Share options | $ / shares   $ 20.10 $ 20.10  
Number of share options exercisable in share-based payment arrangement | Share   8,289 493,363  
21.11        
Disclosure of terms and conditions of share-based payment arrangement [line items]        
Exercise price of options outstanding | $ / shares     $ 21.11  
Number of share options outstanding in share-based payment arrangement | Share     12,438  
Weighted average remaining contractual life of outstanding share options     4 years 8 months 1 day  
Exercise price of exercisable Share options | $ / shares     $ 21.11  
Number of share options exercisable in share-based payment arrangement | Share     12,438  
24.12        
Disclosure of terms and conditions of share-based payment arrangement [line items]        
Exercise price of options outstanding | $ / shares     $ 24.12  
Number of share options outstanding in share-based payment arrangement | Share     9,950  
Weighted average remaining contractual life of outstanding share options     4 years 7 months 2 days  
Exercise price of exercisable Share options | $ / shares     $ 24.12  
Number of share options exercisable in share-based payment arrangement | Share     6,219  
26.13        
Disclosure of terms and conditions of share-based payment arrangement [line items]        
Exercise price of options outstanding | $ / shares     $ 26.13  
Number of share options outstanding in share-based payment arrangement | Share     14,925  
Weighted average remaining contractual life of outstanding share options     3 years 7 months 13 days  
Exercise price of exercisable Share options | $ / shares     $ 26.13  
Number of share options exercisable in share-based payment arrangement | Share     14,925  
40.20        
Disclosure of terms and conditions of share-based payment arrangement [line items]        
Exercise price of options outstanding | $ / shares     $ 40.20  
Number of share options outstanding in share-based payment arrangement | Share     29,851  
Weighted average remaining contractual life of outstanding share options     4 years 5 months 12 days  
Exercise price of exercisable Share options | $ / shares     $ 40.20  
Number of share options exercisable in share-based payment arrangement | Share     22,388  
44.22        
Disclosure of terms and conditions of share-based payment arrangement [line items]        
Exercise price of options outstanding | $ / shares     $ 44.22  
Number of share options outstanding in share-based payment arrangement | Share     2,488  
Weighted average remaining contractual life of outstanding share options     3 years 4 months 28 days  
Exercise price of exercisable Share options | $ / shares     $ 44.22  
Number of share options exercisable in share-based payment arrangement | Share     2,488  
47.24        
Disclosure of terms and conditions of share-based payment arrangement [line items]        
Exercise price of options outstanding | $ / shares   $ 47.24 $ 47.24  
Number of share options outstanding in share-based payment arrangement | Share   1,493 1,493  
Weighted average remaining contractual life of outstanding share options   3 years 4 months 13 days 4 years 4 months 13 days  
Exercise price of exercisable Share options | $ / shares   $ 47.24 $ 47.24  
Number of share options exercisable in share-based payment arrangement | Share   1,493 1,493  
50.25        
Disclosure of terms and conditions of share-based payment arrangement [line items]        
Exercise price of options outstanding | $ / shares $ 50.25 $ 50.25 $ 50.25  
Number of share options outstanding in share-based payment arrangement | Share 3,483 5,224 227,861  
Weighted average remaining contractual life of outstanding share options 2 years 3 months 10 days 3 years 3 months 21 days 5 years 1 month 2 days  
Exercise price of exercisable Share options | $ / shares $ 50.25 $ 50.25 $ 50.25  
Number of share options exercisable in share-based payment arrangement | Share 3,483 5,224 129,353  
52.26        
Disclosure of terms and conditions of share-based payment arrangement [line items]        
Exercise price of options outstanding | $ / shares   $ 52.26 $ 52.26  
Number of share options outstanding in share-based payment arrangement | Share   498 498  
Weighted average remaining contractual life of outstanding share options   3 years 2 months 15 days 4 years 2 months 15 days  
Exercise price of exercisable Share options | $ / shares   $ 52.26 $ 52.26  
Number of share options exercisable in share-based payment arrangement | Share   498 498  
55.28        
Disclosure of terms and conditions of share-based payment arrangement [line items]        
Exercise price of options outstanding | $ / shares   $ 55.28 $ 55.28  
Number of share options outstanding in share-based payment arrangement | Share   498 498  
Weighted average remaining contractual life of outstanding share options   3 years 1 month 13 days 4 years 1 month 13 days  
Exercise price of exercisable Share options | $ / shares   $ 55.28 $ 55.28  
Number of share options exercisable in share-based payment arrangement | Share   498 498  
59.30        
Disclosure of terms and conditions of share-based payment arrangement [line items]        
Exercise price of options outstanding | $ / shares   $ 59.30 $ 59.30  
Number of share options outstanding in share-based payment arrangement | Share   498 498  
Weighted average remaining contractual life of outstanding share options   2 years 11 months 15 days 3 years 11 months 15 days  
Exercise price of exercisable Share options | $ / shares   $ 59.30 $ 59.30  
Number of share options exercisable in share-based payment arrangement | Share   498 498  
75.38        
Disclosure of terms and conditions of share-based payment arrangement [line items]        
Exercise price of options outstanding | $ / shares   $ 75.38 $ 75.38  
Number of share options outstanding in share-based payment arrangement | Share   498 498  
Weighted average remaining contractual life of outstanding share options   3 years 14 days 4 years 14 days  
Exercise price of exercisable Share options | $ / shares   $ 75.38 $ 75.38  
Number of share options exercisable in share-based payment arrangement | Share   498 498  
86.43        
Disclosure of terms and conditions of share-based payment arrangement [line items]        
Exercise price of options outstanding | $ / shares   $ 86.43 $ 86.43  
Number of share options outstanding in share-based payment arrangement | Share   1,244 1,244  
Weighted average remaining contractual life of outstanding share options   2 years 10 months 13 days 3 years 10 months 17 days  
Exercise price of exercisable Share options | $ / shares   $ 86.43 $ 86.43  
Number of share options exercisable in share-based payment arrangement | Share   1,244 1,244  
88.44        
Disclosure of terms and conditions of share-based payment arrangement [line items]        
Exercise price of options outstanding | $ / shares     $ 88.44  
Number of share options outstanding in share-based payment arrangement | Share     14,925  
Weighted average remaining contractual life of outstanding share options     3 years 10 months 13 days  
Exercise price of exercisable Share options | $ / shares     $ 88.44  
Number of share options exercisable in share-based payment arrangement | Share     14,925  
120.60        
Disclosure of terms and conditions of share-based payment arrangement [line items]        
Exercise price of options outstanding | $ / shares     $ 120.60  
Number of share options outstanding in share-based payment arrangement | Share     9,950  
Weighted average remaining contractual life of outstanding share options     3 years 8 months 15 days  
Exercise price of exercisable Share options | $ / shares     $ 120.60  
Number of share options exercisable in share-based payment arrangement | Share     9,950  
142.71        
Disclosure of terms and conditions of share-based payment arrangement [line items]        
Exercise price of options outstanding | $ / shares   $ 142.71 $ 142.71  
Number of share options outstanding in share-based payment arrangement | Share   4,975 4,974  
Weighted average remaining contractual life of outstanding share options   2 years 8 months 26 days 3 years 8 months 26 days  
Exercise price of exercisable Share options | $ / shares   $ 142.71 $ 142.71  
Number of share options exercisable in share-based payment arrangement | Share   4,975 4,975