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Nature of the Business (Details) - USD ($)
 1 Months Ended 3 Months Ended 9 Months Ended
May 21, 2021
Feb. 16, 2021
Jul. 22, 2021
Sep. 30, 2021
Sep. 30, 2020
Sep. 30, 2021
Sep. 30, 2020
Dec. 31, 2020
Nature of the Business [Line Items]                
Warrants outstanding (in Shares)       4,815,000   4,815,000    
Aggregate proceeds if warrants exercised   $ 30,700,000 $ 3,000,000          
Offering Cost       $ 0   $ 27,000    
Aggregate proceeds received       10,000   $ 10,000    
Offering price per share (in Dollars per share)           $ 0.01    
Warrants outstanding (in Shares)     1,140,731          
Common stock underlying warrant outstanding (in Shares) 115,851   1,024,880          
Net income loss       28,944,000 $ (10,295,000) $ (14,163,000) $ (20,055,000)  
Cash       60,552,000 $ 36,781,000 60,552,000 36,781,000 $ 59,275,000
Accumulated deficit       $ (167,724,000)   (167,724,000)   $ (153,561,000)
Net cash (used in) operating activities           $ (25,018,000) $ (13,121,000)  
Tottenham [Member]                
Nature of the Business [Line Items]                
Warrants outstanding (in Shares)   2,517,500            
Clene Nanomedicine [Member]                
Nature of the Business [Line Items]                
Warrants outstanding (in Shares)   904,231            
PIPE [Member]                
Nature of the Business [Line Items]                
Warrants outstanding (in Shares)               2,239,500
Warrant [Member] | Clene Inc [Member]                
Nature of the Business [Line Items]                
Warrants outstanding (in Shares)   4,541,481            
Warrant [Member] | PIPE [Member]                
Nature of the Business [Line Items]                
Warrants outstanding (in Shares)               2,004,500
Private Placement [Member]                
Nature of the Business [Line Items]                
Common Stock, issued in a private placement (in Shares) 960,540