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Note 2 - Summary of Significant Accounting Policies (Details Textual) - USD ($)	3 Months Ended
	Mar. 31, 2024	Mar. 31, 2023	Dec. 31, 2023
Inventory, Raw Materials, Gross	$ 23,000		$ 23,000
Inventory, Finished Goods, Gross	14,000		$ 14,000
Research and Development Expense	5,869,000	$ 7,395,000
Grant Funding on Conditional Grants [Member]
Research and Development Expense	$ 300,000	$ 0
Reverse Recapitalization [Member] | Clene Nanomedicine Contingent Earn-out [Member]
Business Combination, Contingent Earnout Shares, Milestone One (in shares)	3,338,483
Business Combination, Contingent Earnout, Milestone One, Minimum Price (in dollars per share)	$ 15
Business Combination, Contingent Earnout, Milestone One, Consecutive Trading Days (Day)	20 days
Business Combination, Contingent Earnout, Milestone One, Trading Day Period (Day)	30 days
Business Combination, Contingent Earnout, Milestone One, Period (Year)	3 years
Business Combination, Contingent Earnout Shares, Milestone Two (in shares)	2,503,851
Business Combination, Contingent Earnout, Milestone Two, Minimum Price (in dollars per share)	$ 20
Business Combination, Contingent Earnout, Milestone Two, Consecutive Trading Days (Day)	20 days
Business Combination, Contingent Earnout, Milestone Two, Trading Day Period (Day)	30 days
Business Combination, Contingent Earnout, Milestone Two, Period (Year)	5 years
Business Combination, Contingent Earnout, Milestone Two, Change of Control Period (Year)	5 years
Reverse Recapitalization [Member] | Initial Stockholders Contingent Earn-out [Member]
Business Combination, Contingent Earnout Shares, Milestone One (in shares)	375,000
Business Combination, Contingent Earnout Shares, Milestone Two (in shares)	375,000
Equipment [Member] | Minimum [Member]
Property, Plant and Equipment, Useful Life (Year)	3 years
Equipment [Member] | Maximum [Member]
Property, Plant and Equipment, Useful Life (Year)	5 years
Furniture and Fixtures [Member] | Minimum [Member]
Property, Plant and Equipment, Useful Life (Year)	3 years
Furniture and Fixtures [Member] | Maximum [Member]
Property, Plant and Equipment, Useful Life (Year)	7 years
Computer Equipment [Member] | Minimum [Member]
Property, Plant and Equipment, Useful Life (Year)	2 years
Computer Equipment [Member] | Maximum [Member]
Property, Plant and Equipment, Useful Life (Year)	5 years

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