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Note 11 - Benefit Plans (Tables) | 9 Months Ended
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Sep. 30, 2024
Notes Tables |
Share-Based Payment Arrangement, Cost by Plan [Table Text Block] |
|  | Three Months Ended September 30, |  |  | Nine Months Ended September 30, |
(in thousands) |  | 2024 |  |  | 2023 |  |  | 2024 |  |  | 2023 |
General and administrative |  | $ | 1,126 |  |  | $ | 1,311 |  |  | $ | 3,310 |  |  | $ | 3,888 |
Research and development |  |  | 1,062 |  |  |  | 1,085 |  |  |  | 2,842 |  |  |  | 3,182 |
Total stock-based compensation expense |  | $ | 2,188 |  |  | $ | 2,396 |  |  | $ | 6,152 |  |  | $ | 7,070 |
|  | Three Months Ended September 30, |  |  | Nine Months Ended September 30, |
(in thousands) |  | 2024 |  |  | 2023 |  |  | 2024 |  |  | 2023 |
Stock options |  | $ | 2,194 |  |  | $ | 2,384 |  |  | $ | 6,147 |  |  | $ | 7,044 |
Stock awards |  |  | (6 | ) |  |  | 12 |  |  |  | 5 |  |  |  | 26 |
Total stock-based compensation expense |  | $ | 2,188 |  |  | $ | 2,396 |  |  | $ | 6,152 |  |  | $ | 7,070 |
Share-Based Payment Arrangement, Option, Activity [Table Text Block] |
(in thousands, except share, per share, and term data) |  | Number of Options |  |  | Weighted Average Exercise Price Per Share |  |  | Weighted Average Remaining Term (Years) |  |  | Intrinsic Value |
Outstanding – December 31, 2023 |  |  | 1,092,343 |  |  | $ | 45.20 |  |  |  | 7.28 |  |  | $ | 302 |
Granted |  |  | 918,849 |  |  |  | 7.04 |  |  |  | 9.72 |  |  |  | — |
Exercised |  |  | (41,090 | ) |  |  | 3.00 |  |  |  | — |  |  |  | 65 |
Forfeited |  |  | (12,288 | ) |  |  | 88.26 |  |  |  | — |  |  |  | — |
Expired |  |  | (61,770 | ) |  |  | — |  |  |  | — |  |  |  | — |
Outstanding – September 30, 2024 |  |  | 1,896,044 |  |  | $ | 28.76 |  |  |  | 8.43 |  |  | $ | — |
Vested and exercisable – September 30, 2024 |  |  | 728,239 |  |  | $ | 51.48 |  |  |  | 7.05 |  |  | $ | — |
Vested, exercisable or expected to vest – September 30, 2024 |  |  | 1,896,044 |  |  | $ | 28.76 |  |  |  | 8.43 |  |  | $ | — |
Schedule of Share-Based Payment Award, Stock Options, Valuation Assumptions [Table Text Block] |
|  | Nine Months Ended September 30, |
|  | 2024 |  |  | 2023 |
Expected stock price volatility |  |  | 97.78% –111.49 | % |  |  | 96.22% –103.24 | %
Risk-free interest rate |  |  | 3.62% –4.58 | % |  |  | 3.26% –4.41 | %
Expected dividend yield |  |  | 0.00 | % |  |  | 0.00 | %
Expected term of options (in years) |  |  | 5.00 –10.00 |  |  |  | 5.00 –6.43 |
Share-Based Payment Arrangement, Restricted Stock and Restricted Stock Unit, Activity [Table Text Block] |
|  | Number of Stock Awards |  |  | Weighted Average Grant Date Fair Value |
Unvested balance – December 31, 2023 |  |  | 38,943 |  |  | $ | 194.41 |
Converted to shares of Common Stock upon vesting |  |  | (543 | ) |  |  | 23.00 |
Forfeited |  |  | (959 | ) |  |  | 196.84 |
Unvested balance – September 30, 2024 |  |  | 37,441 |  |  | $ | 196.84 |

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- Definition Tabular disclosure of cost recognized for award under share-based payment arrangement by plan. Includes, but is not limited to, related tax benefit. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (h)(1) -Publisher FASB -URI https://asc.fasb.org/1943274/2147480429/718-10-50-2 + Details
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- Definition Tabular disclosure for stock option plans. Includes, but is not limited to, outstanding awards at beginning and end of year, grants, exercises, forfeitures, and weighted-average grant date fair value. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Topic 718 -SubTopic 10 -Name Accounting Standards Codification -Section 50 -Paragraph 2 -Subparagraph (c)(1) -Publisher FASB -URI https://asc.fasb.org/1943274/2147480429/718-10-50-2 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Name Accounting Standards Codification -Section 50 -Paragraph 2 -Subparagraph (d) -SubTopic 10 -Topic 718 -Publisher FASB -URI https://asc.fasb.org/1943274/2147480429/718-10-50-2 Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef -Name Accounting Standards Codification -Section 50 -Paragraph 2 -Subparagraph (e) -SubTopic 10 -Topic 718 -Publisher FASB -URI https://asc.fasb.org/1943274/2147480429/718-10-50-2 + Details
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- Definition Tabular disclosure of the significant assumptions used during the year to estimate the fair value of stock options, including, but not limited to: (a) expected term of share options and similar instruments, (b) expected volatility of the entity's shares, (c) expected dividends, (d) risk-free rate(s), and (e) discount for post-vesting restrictions. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Topic 718 -SubTopic 10 -Subparagraph (f)(2) -Name Accounting Standards Codification -Paragraph 2 -Section 50 -Publisher FASB -URI https://asc.fasb.org/1943274/2147480429/718-10-50-2 + Details
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- Definition Disclosure of the number and weighted-average grant date fair value for restricted stock and restricted stock units that were outstanding at the beginning and end of the year, and the number of restricted stock and restricted stock units that were granted, vested, or forfeited during the year. + References No definition available. + Details
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