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Note 11 - Benefit Plans (Tables)

9 Months Ended

Sep. 30, 2024

Notes Tables

Share-Based Payment Arrangement, Cost by Plan [Table Text Block]

		Three Months Ended September 30,								Nine Months Ended September 30,
(in thousands)		2024				2023				2024				2023
General and administrative		$	1,126			$	1,311			$	3,310			$	3,888
Research and development			1,062				1,085				2,842				3,182
Total stock-based compensation expense		$	2,188			$	2,396			$	6,152			$	7,070

		Three Months Ended September 30,								Nine Months Ended September 30,
(in thousands)		2024				2023				2024				2023
Stock options		$	2,194			$	2,384			$	6,147			$	7,044
Stock awards			(6	)			12				5				26
Total stock-based compensation expense		$	2,188			$	2,396			$	6,152			$	7,070

Share-Based Payment Arrangement, Option, Activity [Table Text Block]

(in thousands, except share, per share, and term data)		Number of Options				Weighted Average Exercise Price Per Share				Weighted Average Remaining Term (Years)				Intrinsic Value
Outstanding – December 31, 2023			1,092,343			$	45.20				7.28			$	302
Granted			918,849				7.04				9.72				—
Exercised			(41,090	)			3.00				—				65
Forfeited			(12,288	)			88.26				—				—
Expired			(61,770	)			—				—				—
Outstanding – September 30, 2024			1,896,044			$	28.76				8.43			$	—
Vested and exercisable – September 30, 2024			728,239			$	51.48				7.05			$	—
Vested, exercisable or expected to vest – September 30, 2024			1,896,044			$	28.76				8.43			$	—

Schedule of Share-Based Payment Award, Stock Options, Valuation Assumptions [Table Text Block]

		Nine Months Ended September 30,
		2024				2023
Expected stock price volatility			97.78% –111.49	%			96.22% –103.24	%
Risk-free interest rate			3.62% –4.58	%			3.26% –4.41	%
Expected dividend yield			0.00	%			0.00	%
Expected term of options (in years)			5.00 –10.00				5.00 –6.43

Share-Based Payment Arrangement, Restricted Stock and Restricted Stock Unit, Activity [Table Text Block]

		Number of Stock Awards				Weighted Average Grant Date Fair Value
Unvested balance – December 31, 2023			38,943			$	194.41
Converted to shares of Common Stock upon vesting			(543	)			23.00
Forfeited			(959	)			196.84
Unvested balance – September 30, 2024			37,441			$	196.84

X

- Definition

Tabular disclosure of cost recognized for award under share-based payment arrangement by plan. Includes, but is not limited to, related tax benefit.

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-SubTopic 10
-Section 50
-Paragraph 2
-Subparagraph (h)(1)
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