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Segment information - Significant Segment Expenses (Details) - USD ($) $ in Thousands | 3 Months Ended | 6 Months Ended
--- | --- | ---
Jun. 30, 2025 | Jun. 30, 2024 | Jun. 30, 2025 | Jun. 30, 2024
Indirect research and development expenses: |  |  |  |
Total research and development expenses | $ 7,953 | $ 11,662 | $ 16,243 | $ 22,787
Research and Development of Immunotherapies and Vaccines |  |  |  |
Direct research and development expenses: |  |  |  |
Total direct research and development expenses | 4,710 | 6,438 | 8,202 | 12,277
Change in direct research and development expenses | (1,728) |  | (4,075) |
Indirect research and development expenses: |  |  |  |
Total indirect research and development expenses | 3,243 | 5,224 | 8,041 | 10,510
Change In indirect research and development expenses | (1,981) |  | (2,469) |
Total research and development expenses | 7,953 | 11,662 | 16,243 | 22,787
Change in research and development expenses | (3,709) |  | (6,544) |
Research and Development of Immunotherapies and Vaccines | Personnel-related (including share-based compensation) |  |  |  |
Indirect research and development expenses: |  |  |  |
Total indirect research and development expenses | 2,450 | 4,763 | 6,394 | 9,097
Change In indirect research and development expenses | (2,313) |  | (2,703) |
Research and Development of Immunotherapies and Vaccines | Facility related |  |  |  |
Indirect research and development expenses: |  |  |  |
Total indirect research and development expenses | 350 | 342 | 685 | 732
Change In indirect research and development expenses | 8 |  | (47) |
Research and Development of Immunotherapies and Vaccines | Other indirect costs |  |  |  |
Indirect research and development expenses: |  |  |  |
Total indirect research and development expenses | 443 | 119 | 962 | 681
Change In indirect research and development expenses | 324 |  | 281 |
Research and Development of Immunotherapies and Vaccines | VTP-1000 Celiac |  |  |  |
Direct research and development expenses: |  |  |  |
Total direct research and development expenses | 1,782 | 1,371 | 2,764 | 2,744
Change in direct research and development expenses | 411 |  | 20 |
Research and Development of Immunotherapies and Vaccines | VTP-300 HBV |  |  |  |
Direct research and development expenses: |  |  |  |
Total direct research and development expenses | 1,837 | 3,034 | 3,187 | 4,947
Change in direct research and development expenses | (1,197) |  | (1,760) |
Research and Development of Immunotherapies and Vaccines | Other clinical programs |  |  |  |
Direct research and development expenses: |  |  |  |
Total direct research and development expenses | 642 | 1,125 | 1,383 | 2,893
Change in direct research and development expenses | (483) |  | (1,510) |
Research and Development of Immunotherapies and Vaccines | Other pre-clinical programs |  |  |  |
Direct research and development expenses: |  |  |  |
Total direct research and development expenses | 449 | 908 | 868 | 1,693
Change in direct research and development expenses | (459) |  | (825) |
Research and Development of Immunotherapies and Vaccines | VTP-500 MERS | Personnel-related (including share-based compensation) |  |  |  |
Indirect research and development expenses: |  |  |  |
Total indirect research and development expenses | $ 100 | $ 200 | $ 100 | $ 300

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