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Commitments and Contingencies - Additional Information (Details)
$ in Thousands
12 Months Ended
Jun. 14, 2022
USD ($)
ft²
Sep. 03, 2021
USD ($)
ft²
Dec. 31, 2025
USD ($)
Dec. 31, 2024
USD ($)
Other Commitments [Line Items]        
Right-of-use asset     $ 1,638 $ 4,384
Operating lease right-of-use asset impairment charge     400 2,600
Transaction-related fees     2,800 $ 0
Oxfordshire        
Other Commitments [Line Items]        
Size of space under lease agreement (in square feet) | ft²   31,000    
Refundable security deposit   $ 700    
Right-of-use asset     $ 0  
Maryland        
Other Commitments [Line Items]        
Size of space under lease agreement (in square feet) | ft² 19,700      
Refundable security deposit $ 200      
Additional lease term 5 years      
Leasehold improvement expense $ 3,500      
In-License Agreements | Minimum        
Other Commitments [Line Items]        
Percentage of future royalties for direct sales of a covered product     1.00%  
Net payments received for allowable sublicenses of technology developed     3.00%  
In-License Agreements | Maximum        
Other Commitments [Line Items]        
Percentage of future royalties for direct sales of a covered product     5.00%  
Net payments received for allowable sublicenses of technology developed     7.00%