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CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS (Unaudited) - USD ($) $ in Thousands | 3 Months Ended
--- | ---
Mar. 31, 2022 | Mar. 31, 2021
Cash flows from operating activities: |  |
Net loss | $ (28,168) | $ (18,689)
Adjustments to reconcile net loss to net cash used in operating activities: |  |
Depreciation and amortization | 1,968 | 2,176
Share-based compensation | 4,390 | 3,632
Loss on disposal of assets | 11 | 23
Non-cash interest expense | 17 |
Amortization of right-of-use assets | 288 | 290
Loss from equity method investments | 952 |
Amortization of discount on note receivable | (87) |
Changes in operating assets and liabilities: |  |
Prepaid expenses | 374 | (619)
Accounts receivable |  | (9,263)
Other assets and other current assets | 171 | (6)
Accounts payable | (374) | 221
Other liabilities and other current liabilities | (5,150) | (2,146)
Deferred revenue | (2,830) | 92,914
Lease liabilities and right-of-use assets | (434) | (461)
Net cash provided by (used in) operating activities | (28,872) | 68,072
Cash flows from investing activities: |  |
Purchases of property, equipment and software | (818) | (1,125)
Net cash used in investing activities | (818) | (1,125)
Cash flows from financing activities: |  |
Proceeds from stock option exercises | 340 | 1,297
Proceeds from employee stock purchase plan | 282 | 418
Proceeds from issuance of common stock to collaboration partners |  | 35,000
Proceeds from offering of common stock, net of issuance costs | 1,627 |
Net cash provided by financing activities | 2,249 | 36,715
Net increase (decrease) in cash and cash equivalents | (27,441) | 103,662
Cash and cash equivalents—beginning of period | 143,663 | 89,798
Cash and cash equivalents —end of period | 116,222 | 193,460
Supplemental disclosures of noncash activities: |  |
Property, equipment and software additions included in accounts payable and other current liabilities | 74 | $ 637
Unsettled at-the-market issuances of common stock included in other current assets | $ 217 |

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