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Collaboration and License Agreements - Additional Information (Details) - USD ($) |  |  | 3 Months Ended |  |
--- | --- | --- | --- | --- | ---
Apr. 09, 2021 | Jan. 06, 2021 | Mar. 31, 2022 | Mar. 31, 2021 | Dec. 31, 2021 | Aug. 31, 2021
Collaboration and License Agreements [Line items] |  |  |  |  |  |
Common stock, shares issued |  |  | 62,585,043 |  | 61,712,577 |
Proceeds from offering of common stock, net of issuance costs |  |  | $ 1,627,000 |  |  |
Revenue |  |  | 3,317,000 | $ 16,349,000 |  |
Deferred revenue |  |  | 19,686,000 |  | $ 21,244,000 |
Prepaid expenses |  |  | 17,060,000 |  | 17,434,000 |
Research and development |  |  | 19,972,000 | 25,593,000 |  |
Revenue recorded included in deferred revenue |  |  | 3,300,000 |  |  |
Servier | Program Purchase Agreement |  |  |  |  |  |
Collaboration and License Agreements [Line items] |  |  |  |  |  |
Research and development | $ 1,250,000 |  |  |  |  |
Waiver of milestone payment | $ 18,750,000 |  |  |  |  |
Development and License Agreement | Eli Lilly and Company |  |  |  |  |  |
Collaboration and License Agreements [Line items] |  |  |  |  |  |
Upfront cash payment |  | $ 100,000,000.0 |  |  |  |
Milestone payments to be received for additional targets |  | 420,000,000.0 |  |  |  |
Transaction price from the Stock Purchase Agreement |  | $ 7,300,000 |  |  |  |
Revenue |  |  | 3,300,000 | 5,400,000 |  |
Deferred revenue related to agreement |  |  | 85,400,000 |  | 88,300,000 |
Development and License Agreement | Eli Lilly and Company | Current Liabilities |  |  |  |  |  |
Collaboration and License Agreements [Line items] |  |  |  |  |  |
Deferred revenue |  |  | 19,700,000 |  | 21,200,000 |
Development and License Agreement | Eli Lilly and Company | Stock Purchase Agreement |  |  |  |  |  |
Collaboration and License Agreements [Line items] |  |  |  |  |  |
Common stock, shares issued |  | 3,762,190 |  |  |  |
Proceeds from offering of common stock, net of issuance costs |  | $ 35,000,000.0 |  |  |  |
Upfront Compensation |  | 135,000,000.0 |  |  |  |
Equity upon the issuance of the shares |  | 27,700,000 |  |  |  |
Transaction price allocated to the revenue arrangement |  | $ 107,300,000 |  |  |  |
Development and License Agreement | iECURE |  |  |  |  |  |
Collaboration and License Agreements [Line items] |  |  |  |  |  |
Investment in equity securities |  |  | 0 |  |  | $ 500,000
Prepaid Expense and Other Assets |  |  | 12,200,000 |  |  | 17,400,000
Prepaid expenses |  |  | 9,800,000 |  |  | 15,100,000
Other Assets |  |  | 2,400,000 |  |  | $ 2,300,000
Research and development |  |  | 700,000 |  |  |
Development And Commercial License Agreement | Servier |  |  |  |  |  |
Collaboration and License Agreements [Line items] |  |  |  |  |  |
Deferred revenue related to agreement |  |  | 0 |  | $ 0 |
Revenue recorded included in deferred revenue |  |  | $ 0 | $ 10,300,000 |  |

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