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CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS (Unaudited) - USD ($)
$ in Thousands
 9 Months Ended
Sep. 30, 2022
Sep. 30, 2021
Cash flows from operating activities:    
Net loss $ (83,149) $ (8,312)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation and amortization 5,838 6,806
Share-based compensation 14,661 12,079
Loss on disposal of assets 58 23
Non-cash interest expense 210 42
Amortization of right-of-use assets 891 897
Non-cash consideration received from collaboration partners   (17,894)
Change in fair value of equity investments   (274)
Loss from equity method investment 4,183  
Amortization of discount on note receivable (264)  
Changes in operating assets and liabilities:    
Prepaid expenses 5,142 (323)
Accounts receivable (227) 9,512
Other assets and other current assets (4,689) 47
Accounts payable (187) 240
Other liabilities and other current liabilities (2,237) (976)
Deferred revenue 37,209 2,391
Lease liabilities and right-of-use assets (1,349) (1,430)
Contract liabilities   10,000
Net cash (used in) provided by operating activities (23,910) 12,828
Cash flows from investing activities:    
Purchases of property, equipment and software (2,687) (3,548)
Purchases of intangible assets   (750)
Net cash used in investing activities (2,687) (4,298)
Cash flows from financing activities:    
Proceeds from stock option exercises 387 5,757
Proceeds from employee stock purchase plan 443 804
Proceeds from offering of common stock, net of issuance costs 49,345 18,130
Proceeds from issuance of common stock to collaboration partners 25,000 35,000
Borrowings from revolving credit facility, net of issuance costs 19,810  
Proceeds from issuance of term loan, net of issuance costs paid to lender   2,465
Payments of debt issuance costs   (13)
Net cash provided by financing activities 94,985 62,143
Net increase in cash and cash equivalents 68,388 70,673
Cash and cash equivalents—beginning of period 143,663 89,798
Cash and cash equivalents —end of period 212,051 160,471
Supplemental disclosures of noncash activities:    
Property, equipment and software additions included in accounts payable and accrued expenses other current liabilities 232 695
Cash paid for interest $ 422 36
Unsettled at-the-market issuances of common stock included in other current assets   549
Contract liability accrual related to Servier Program Purchase Agreement milestones   10,000
Non-cash consideration received from collaboration partners   $ 17,894