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Segment Reporting (Tables) | 12 Months Ended
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Dec. 31, 2024
Segment Reporting [Abstract] |
Summary of Significant Research and Development and General and Administrative Expense to CODM | The table below summarizes the significant research and development and general and administrative expense categories regularly provided to the CODM:
|  | Years Ended December 31, |
(in thousands) |  | 2024 |  |  | 2023 |
Revenue |  | $ | 68,696 |  |  | $ | 48,727 |
Operating expenses |  |  |  |  |  |
Research and development |  |  |  |  |  |
Direct research and development expenses by product candidate: |  |  |  |  |  |
PBGENE-HBV external development costs |  |  | 16,111 |  |  |  | 9,261 |
PBGENE-3243 external development costs |  |  | 9,808 |  |  |  | 352 |
Platform development and early-stage research expenses: |  |  |  |  |  |
Employee-related costs (other than share-based compensation) |  |  | 18,753 |  |  |  | 19,788 |
Share-based compensation |  |  | 2,560 |  |  |  | 3,642 |
Laboratory supplies and services |  |  | 3,016 |  |  |  | 5,741 |
CMOs and outsourced research and development |  |  | 1,083 |  |  |  | 4,753 |
Facility-related costs, laboratory equipment, and maintenance |  |  | 3,082 |  |  |  | 3,308 |
Depreciation and amortization |  |  | 2,718 |  |  |  | 4,022 |
Licensing fees and other research and development costs |  |  | 2,428 |  |  |  | 2,508 |
Total research and development expenses |  | $ | 59,559 |  |  | $ | 53,375 |
General and administrative expense |  |  |  |  |  |
Employee-related costs (including share-based compensation) |  |  | 21,861 |  |  |  | 22,517 |
Consulting and professional services |  |  | 6,327 |  |  |  | 7,445 |
Other operating expenses and all other costs |  |  | 7,111 |  |  |  | 9,126 |
Total general and administrative expenses |  | $ | 35,299 |  |  | $ | 39,088 |
Total operating expenses |  | $ | 94,858 |  |  | $ | 92,463 |
Operating loss |  |  | (26,162 | ) |  |  | (43,736 | )
Total other income (expense) |  |  | 33,329 |  |  |  | 1,209 |
Income (loss) from continuing operations |  | $ | 7,167 |  |  | $ | (42,527 | )
Loss from discontinued operations |  |  | — |  |  |  | (18,792 | )
Net income (loss) |  | $ | 7,167 |  |  | $ | (61,319 | )

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- Definition Tabular disclosure of the profit or loss and total assets for each reportable segment. An entity discloses certain information on each reportable segment if the amounts (a) are included in the measure of segment profit or loss reviewed by the chief operating decision maker or (b) are otherwise regularly provided to the chief operating decision maker, even if not included in that measure of segment profit or loss. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Name Accounting Standards Codification -Topic 280 -SubTopic 10 -Section 50 -Paragraph 25 -Publisher FASB -URI https://asc.fasb.org/1943274/2147482810/280-10-50-25 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Name Accounting Standards Codification -Topic 280 -SubTopic 10 -Section 50 -Paragraph 22 -Publisher FASB -URI https://asc.fasb.org/1943274/2147482810/280-10-50-22 Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef -Name Accounting Standards Codification -Topic 280 -SubTopic 10 -Section 50 -Paragraph 30 -Publisher FASB -URI https://asc.fasb.org/1943274/2147482810/280-10-50-30 + Details
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