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Income Taxes - Reconciliation of Federal Statutory Income Tax Rate and Income Tax Benefit (Details) - USD ($) $ in Thousands | 12 Months Ended
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Dec. 31, 2024 | Dec. 31, 2023
Reconciliation of income taxes amount, Amount |  |
Income tax expense at statutory rate, Amount | $ 1,501 | $ (12,877)
State income taxes, net of federal tax benefit, Amount | 46 | (1,774)
Non-deductible expenses, Amount | 97 | 81
Stock compensation - nondeductible, Amount | 1,032 | 681
Stock compensation - forfeitures, Amount | 1,136 | 3,176
Change in fair value, Amount | (6,507) | 4
Change in state impact on IRC section 174, Amount | (553) |
R&D and orphan drug credits, Amount | (2,944) | (6,078)
Other, Amount | (11) | 657
Change in state tax rate | 8,464 | (1,632)
Change in valuation allowance, Amount | $ (2,261) | $ 17,762
Reconciliation of income taxes rate, Percentage |  |
Income tax expense at statutory rate, Percentage | 21.00% | 21.00%
State income taxes, net of federal tax benefit, Percentage | 0.60% | 2.90%
Non-deductible expenses, Percentage | 1.40% | 0.00%
Stock compensation - nondeductible, Percentage | 14.40% | (1.20%)
Stock compensation - forfeitures, Percentage | 15.90% | (5.20%)
Change in fair value, Percent | (91.10%) | 0.00%
Change in state impact on IRC section 174, Percent | (7.70%) |
R&D and orphan drug credits, Percentage | (41.20%) | 9.90%
Other, Percentage | (0.10%) | (1.10%)
Change in state tax rate | 118.40% | 2.70%
Change in valuation allowance, Percentage | (31.60%) | (29.00%)
Total effective tax rate | 0.00% | 0.00%

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- Definition Amount of the difference between reported income tax expense (benefit) and expected income tax expense (benefit) computed by applying the domestic federal statutory income tax rates to pretax income (loss) from continuing operations attributable to state and local income tax expense (benefit). + References Reference 1: http://www.xbrl.org/2003/role/exampleRef -Topic 740 -SubTopic 10 -Name Accounting Standards Codification -Section 55 -Paragraph 231 -Publisher FASB -URI https://asc.fasb.org/1943274/2147482663/740-10-55-231 Reference 2: http://www.xbrl.org/2003/role/disclosureRef -Topic 740 -SubTopic 10 -Name Accounting Standards Codification -Section 50 -Paragraph 12A -Subparagraph (a)(1) -Publisher FASB -URI https://asc.fasb.org/1943274/2147482685/740-10-50-12A Reference 3: http://www.xbrl.org/2009/role/commonPracticeRef -Topic 740 -SubTopic 10 -Name Accounting Standards Codification -Section 50 -Paragraph 12 -Publisher FASB -URI https://asc.fasb.org/1943274/2147482685/740-10-50-12 + Details
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