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Income Taxes - Additional Information (Details) - USD ($)
 12 Months Ended
Jan. 01, 2025
Dec. 31, 2030
Dec. 31, 2029
Dec. 31, 2028
Dec. 31, 2027
Dec. 31, 2026
Dec. 31, 2024
Dec. 31, 2023
Dec. 31, 2022
Income Tax Disclosure [Line Items]                  
Increase (decrease) in valuation allowance of net deferred tax assets             $ (2,300,000)    
Net Operating loss carry forwards expiration year             2027    
Ownership percentage change in outstanding common stock period             3 years    
Ownership Percentage Change Of Outstanding Common Stock             50.00%    
Uncertain tax position             $ 0    
Unrecognized tax benefits             0 $ 0  
Unrecognized tax benefits, income tax penalties and interest accrued             $ 0 0  
Percentage of decrease in corporate income tax rate             2.50%    
GILTI tax expense             $ 0 0  
2021 Appropriations Act                  
Income Tax Disclosure [Line Items]                  
Increase (decrease) in valuation allowance of net deferred tax assets             (8,500,000)    
Forecast                  
Income Tax Disclosure [Line Items]                  
Percentage of decrease in corporate income tax rate 2.25% 0.00% 1.00% 1.00% 2.00% 2.00%      
Federal                  
Income Tax Disclosure [Line Items]                  
Net operating loss carryforwards             235,500,000 195,000,000  
Federal contribution carryforwards             $ 100,000 $ 200,000  
Federal contribution expiration beginning year             2026 2026  
Federal | Research and Development                  
Income Tax Disclosure [Line Items]                  
Tax credit carryforwards             $ 20,200,000 $ 17,200,000  
Tax credit carry forwards expiration beginning year             2029    
Federal | Orphan Drug Tax Credit Carry forward                  
Income Tax Disclosure [Line Items]                  
Tax credit carryforwards             $ 13,500,000    
Tax credit carry forwards expiration beginning year             2038   2038
State                  
Income Tax Disclosure [Line Items]                  
Net operating loss carryforwards             $ 212,000,000 166,800,000  
State | Research and Development                  
Income Tax Disclosure [Line Items]                  
Tax credit carry forwards expiration beginning year             2030    
Maximum [Member] | State | Research and Development                  
Income Tax Disclosure [Line Items]                  
Tax credit carryforwards             $ 100,000 $ 100,000