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Segment Reporting - Summary of Significant Research and Development and General and Administrative Expense to CODM (Details) - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2024
Dec. 31, 2023
Revenue $ 68,696 $ 48,727
Platform development and early-stage research expenses [Abstract]    
Share based compensation 12,604 14,040
Depreciation and amortization 3,404 6,817
Total research and development expenses 59,559 53,375
General and administrative expense    
Total general and administrative expenses 35,299 39,088
Total operating expenses 94,858 92,463
Operating loss (26,162) (43,736)
Total other income 33,329 1,209
Income (loss) from continuing operations 7,167 (42,527)
Loss from discontinued operations 0 (18,792)
Net income (loss) 7,167 (61,319)
Operating Segments    
Revenue 68,696 48,727
Platform development and early-stage research expenses [Abstract]    
Employee-related costs (other than share based compensation) 18,753 19,788
Share based compensation 2,560 3,642
Laboratory supplies and services 3,016 5,741
CMOs and outsourced research and development 1,083 4,753
Facility-related costs, laboratory equipment, and maintenance 3,082 3,308
Depreciation and amortization 2,718 4,022
Licensing fees and other research and development costs 2,428 2,508
Total research and development expenses 59,559 53,375
General and administrative expense    
Employee-related costs (including share-based compensation) 21,861 22,517
Consulting and professional services 6,327 7,445
Other operating expenses and all other costs 7,111 9,126
Total general and administrative expenses 35,299 39,088
Total operating expenses 94,858 92,463
Operating loss (26,162) (43,736)
Total other income 33,329 1,209
Income (loss) from continuing operations 7,167 (42,527)
Loss from discontinued operations (18,792)
Net income (loss) 7,167 (61,319)
Operating Segments | PBGENE-HBV    
Direct research and development expenses by product candidate:    
External development costs 16,111 9,261
Operating Segments | PBGENE-3243    
Direct research and development expenses by product candidate:    
External development costs $ 9,808 $ 352