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Income Taxes, Valuation Allowance, Operating Loss Carryforwards and Tax Credit Carry-forwards (Details) - USD ($) $ in Thousands | 12 Months Ended |  |
--- | --- | --- | ---
Dec. 31, 2018 | Dec. 31, 2017 | Dec. 31, 2016
Income Taxes [Abstract] |  |  |
Net change in valuation allowance | $ 2,271 |  |
Income Taxes [Abstract] |  |  |
Net operating loss carryforwards | 25,000 | $ 17,000 | $ 28,000
Federal [Member] |  |  |
Income Taxes [Abstract] |  |  |
Net operating loss carryforwards | $ 112,709 |  |
Operating loss carryforwards, expiration dates | Dec. 31, 2027 |  |
Federal [Member] | Research and Development [Member] |  |  |
Tax credit carryforwards [Abstract] |  |  |
Tax credit carryforwards | $ 1,635 |  |
Federal tax credit carryforward, expiration dates | Dec. 31, 2031 |  |
State [Member] |  |  |
Income Taxes [Abstract] |  |  |
Net operating loss carryforwards | $ 107,948 |  |
Operating loss carryforwards, expiration dates | Dec. 31, 2028 |  |

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