REVENUE AND SEGMENT INFORMATION - Significant expense categories (Details) - USD ($)	3 Months Ended
Mar. 31, 2025	Mar. 31, 2024
SEGMENT INFORMATION
Total research and development	$ 1,662,925	$ 2,246,911
Selling, general and administrative
Stock-based compensation	818,426	959,465
Selling, general and administrative	8,431,880	9,283,067
Capital expenditures of the segment	47,242	127,018
Single reportable segment
SEGMENT INFORMATION
Clinical expenses	979,113	1,627,449
Other research and development expenses	683,812	619,462
Total research and development	1,662,925	2,246,911
Selling, general and administrative
Royalty expense	257,883	712,385
Stock-based compensation	626,641	959,465
Legal, financial and other consulting	637,981	680,706
Other general and administrative	6,909,375	6,930,511
Selling, general and administrative	$ 8,431,880	$ 9,283,067

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Amount of expense for research and development. The amount is net of grant income and grant income-related expenses.

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Amount of expense for award under share-based payment arrangement. Excludes amount capitalized.

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Amount of general and administrative expense classified as other.

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A fee charged for services from professionals such as doctors, lawyers and accountants. The term is often expanded to include other professions, for example, pharmacists charging to maintain a medicinal profile of a client or customer.

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Amount of expense for research and development. Excludes cost for computer software product to be sold, leased, or otherwise marketed, writeoff of research and development assets acquired in transaction other than business combination or joint venture formation or both, and write-down of intangible asset acquired in business combination or from joint venture formation or both, used in research and development activity.

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Amount of expense related to royalty payments under a contractual arrangement such as payment for mineral and drilling rights and use of technology or intellectual property.

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Amount of expenditure for addition to long-lived assets included in determination of segment assets by chief operating decision maker (CODM) or otherwise regularly provided to CODM. Excludes expenditure for addition to financial instrument, long-term customer relationship of financial institution, mortgage and other servicing rights, deferred policy acquisition cost, and deferred tax assets.

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Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.

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The aggregate total costs related to selling a firm's product and services, as well as all other general and administrative expenses. Direct selling expenses (for example, credit, warranty, and advertising) are expenses that can be directly linked to the sale of specific products. Indirect selling expenses are expenses that cannot be directly linked to the sale of specific products, for example telephone expenses, Internet, and postal charges. General and administrative expenses include salaries of non-sales personnel, rent, utilities, communication, etc.

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