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Stock-Based Compensation (Details Textual) (USD $) | 3 Months Ended | 9 Months Ended |  | 3 Months Ended | 9 Months Ended | 3 Months Ended | 9 Months Ended | 0 Months Ended | 9 Months Ended | 0 Months Ended | 9 Months Ended | 0 Months Ended | 3 Months Ended | 9 Months Ended
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Sep. 30, 2013 | Sep. 30, 2012 | Sep. 30, 2013 Plans | Sep. 30, 2012 | Dec. 31, 2012 | Sep. 30, 2012 Board Member [Member] | Sep. 30, 2012 Board Member [Member] | Sep. 30, 2012 Employees [Member] | Sep. 30, 2012 Employees [Member] | May 06, 2013 Stock Options [Member] | Sep. 30, 2013 Stock Options [Member] | Apr. 04, 2013 Warrant [Member] | Dec. 03, 2010 Warrant [Member] | Sep. 30, 2013 Warrant [Member] | Sep. 30, 2013 1998 Non-Officer Stock Option Plan [Member] | Sep. 30, 2013 1998 Non-Officer Stock Option Plan [Member] Minimum [Member] | Sep. 30, 2013 1998 Non-Officer Stock Option Plan [Member] Maximum [Member] | Sep. 30, 2013 2006 Equity Incentive Plan [Member] | Sep. 30, 2013 2006 Equity Incentive Plan [Member] Minimum [Member] | Sep. 30, 2013 2006 Equity Incentive Plan [Member] Maximum [Member] | Sep. 30, 2013 2001 Non-Employee Director Stock Option Plan [Member] | Sep. 30, 2013 2001 Non-Employee Director Stock Option Plan [Member] Minimum [Member] | Sep. 30, 2013 2001 Non-Employee Director Stock Option Plan [Member] Maximum [Member] | Sep. 12, 2011 Three Year Stock Purchase Warrants [Member] | Sep. 30, 2013 Three Year Stock Purchase Warrants [Member] | Sep. 30, 2012 Three Year Stock Purchase Warrants [Member] | Sep. 30, 2013 Three Year Stock Purchase Warrants [Member] | Sep. 30, 2012 Three Year Stock Purchase Warrants [Member]
Stock-Based Compensation (Textual) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Stock option expiration date |  |  |  |  |  |  |  |  |  |  |  |  |  |  | June 2008 |  |  |  |  |  | March 2011 |  |  |  |  |  |  |
Options outstanding, vested and expected to vest, outstanding, number |  |  |  |  |  |  |  |  |  |  | 1,644,583 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Options outstanding, vested and expected to vest, aggregate intrinsic value | $ 524,000 |  | $ 524,000 |  |  |  |  |  |  |  | $ 3,200,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Additional common stock authorized for issuance as incentive stock options |  |  |  |  |  |  |  |  |  | 2,000,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Common stock issued upon exercise of warrants, value |  |  |  |  |  |  |  |  |  |  | 409,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Common stock issued upon exercise of warrants, Shares |  |  |  |  |  |  |  |  |  |  | (182,361) |  |  | (3,871,063) |  |  |  |  |  |  |  |  |  |  |  |  |  |
Stock option vesting period |  |  | 7 years | 7 years |  |  |  |  |  |  |  |  |  |  |  | 1 year | 4 years |  | 1 year | 4 years |  | 1 year | 4 years |  |  |  |  |
Stock option expiration period |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 10 years |  |  | 10 years |  |  |  | 5 years | 7 years |  |  |  |  |
Warrant issued in period |  |  |  |  |  |  |  |  |  |  |  |  | 120,000 |  |  |  |  |  |  |  |  |  |  | 20,000 |  |  |  |
Exercise price of warrants per share |  |  |  |  |  |  |  |  |  |  |  |  | $ 1.63 |  |  |  |  |  |  |  |  |  |  | $ 3.90 |  |  |  |
Fair value of warrants |  |  |  |  |  |  |  |  |  |  |  |  | 198,000 | 166,000 |  |  |  |  |  |  |  |  |  | 75,000 |  |  |  |
Amortized period of warrants |  |  |  |  |  |  |  |  |  |  |  |  | 24 months |  |  |  |  |  |  |  |  |  |  | 24 months |  |  |  |
Compensation expense related to the vesting of stock options | 700,000 | 690,000 | 1,900,000 | 2,900,000 |  |  |  |  |  |  |  |  |  | 25,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Fair value of warrants granted included in product research and development expenses |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 6,000 | 9,000 | 25,000 | 28,000
Additional cash exercise price per share |  |  |  |  |  |  |  |  |  |  |  | $ 1.00 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Proceeds from exercise of warrants |  |  | 699,000 | 155,000 |  |  |  |  |  |  |  | 40,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Warrants exercised to purchase common stock |  |  |  |  |  |  |  |  |  |  |  | 40,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Subscription receivable | 286,000 |  | 286,000 |  |  |  |  |  |  |  | 286,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Stock options vesting period description |  |  | The options have a 7-year life and 1/3 of the options are vested on the one year anniversary date of grant with the remaining to vest monthly over the remaining 24-months | The options have a 7-year life and 1/3 of the options are vested on the one year anniversary date of grant with the remaining to vest monthly over the remaining 24-months |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Number of equity incentive plans |  |  | 2 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Number of non-employee director stock option plan |  |  | 1 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Options granted to purchase of common stock to employee |  |  | 130,000 |  |  | 0 | 360,000 | 45,000 | 1,145,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Stock options, grant date fair value |  |  | $ 682,500 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Recognition period of unamortized expense related to stock options and warrants |  |  | 1 year 7 months 6 days |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Stock options exercise | 62,350 |  | 62,350 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |

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