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Stockholders' Equity (Details) - $ / shares | 12 Months Ended
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Dec. 31, 2017 | Dec. 31, 2016 | Dec. 31, 2015 | Dec. 31, 2014
Summary of all stock option plans |  |  |  |
Weighted Average Exercise Price, Options outstanding and exercisable, Ending Balance |  | $ 0.67 | $ 1.24 |
Warrants [Member] |  |  |  |
Summary of all stock option plans |  |  |  |
Number of Shares/Warrants, Options outstanding, Beginning Balance | 7,913,676 | 464,073 | 3,335,073 |
Warrants, Issued (Prefunded) |  | 4,313,676 |  |
Warrants, Issued (Purchase) | 3,250,001 | 3,600,000 |  |
Warrants, Expired/forfeited |  | (384,073) | (2,591,000) |
Number of Shares, Options exercised |  | (80,000) | (280,000) |
Number of Shares/Warrants, Options outstanding, Ending Balance | 11,163,677 | 7,913,676 | 464,073 | 3,335,073
Number of Shares/Warrants, Options outstanding, Ending Balance and exercisable | 7,913,676 |  |  |
Weighted Average Exercise Price, Options outstanding, Beginning Balance | $ 0.62 | $ 3.02 | $ 4.45 |
Weighted Average Exercise Price, Issued (Prefunded) |  | 0.01 |  |
Weighted Average Exercise Price, Issued (Purchase) | 2.00 | 1.12 |  |
Weighted Average Exercise Price, Options cancelled or expired |  | 3.13 | 5.06 |
Weighted Average Exercise Price, Options exercised |  | 2.00 | 1.30 |
Weighted Average Exercise Price, Options outstanding, Ending Balance | 1.02 | $ 0.62 | $ 3.02 | $ 4.45
Weighted Average Exercise Price, Options outstanding and exercisable, Ending Balance | $ 0.62 |  |  |
Weighted Average Remaining Contractual Life, Outstanding | 3 years 8 months 5 days | 5 years 1 month 17 days | 2 months 8 days | 11 months 4 days
Weighted Average Remaining Contractual Life, Outstanding and exercisable | 4 years 1 month 16 days |  |  |

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- Definition For presentations that combine terminations, the number of shares under options that were cancelled during the reporting period as a result of occurrence of a terminating event specified in contractual agreements pertaining to the stock option plan or that expired. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (c)(1)(iv)(3)-(4) -URI http://asc.fasb.org/extlink&oid=96867065&loc=d3e5070-113901 + Details
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