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PROPERTY, PLANT AND EQUIPMENT (Details) (USD $) | Dec. 31, 2012 | Dec. 31, 2011
--- | --- | ---
Laboratory and manufacturing equipment | $ 3,029,559 | $ 2,978,716
Building and improvements | 2,785,698 | 2,667,220
Office furniture and equipment | 312,979 | 252,737
Construction in progress | 0 | 1,331
Land | 50,000 | 50,000
Property, plant and equipment, gross | 6,178,236 | 5,950,004
Less: accumulated depreciation | 3,820,627 | 3,434,673
Property, plant and equipment, net | $ 2,357,609 | $ 2,515,331

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- Definition Amount before accumulated depreciation of building structures held for productive use including addition, improvement, or renovation to the structure, including, but not limited to, interior masonry, interior flooring, electrical, and plumbing. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher AICPA -Name Accounting Principles Board Opinion (APB) -Number 12 -Paragraph 5 -LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy. Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 360 -SubTopic 10 -Section 50 -Paragraph 1 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=6391035&loc=d3e2868-110229 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 210 -SubTopic 10 -Section 45 -Paragraph 4 -Subparagraph (f) -URI http://asc.fasb.org/extlink&oid=6361293&loc=d3e6812-107765 + Details
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