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Property, Plant and Equipment, Net | 12 Months Ended
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Dec. 31, 2021
Property, Plant and Equipment [Abstract] |
PROPERTY, PLANT AND EQUIPMENT, net | 7. PROPERTY, PLANT AND EQUIPMENT, net Property, plant and equipment consisted of the following:
|  | Estimated Useful Lives (in years) |  |  | As of December 31, 2021 |  |  | As of December 31, 2020 |
Laboratory and manufacturing equipment |  |  | 3-10 |  |  | $ | 17,388,757 |  |  | $ | 15,786,620 |
Buildings and improvements |  |  | 10-39 |  |  |  | 19,119,698 |  |  |  | 18,999,500 |
Office furniture and equipment |  |  | 3-10 |  |  |  | 869,191 |  |  |  | 779,720 |
Construction in progress |  |  | n/a |  |  |  | 2,992,359 |  |  |  | 2,337,620 |
Land |  |  | n/a |  |  |  | 516,867 |  |  |  | 516,867 |
Property, plant and equipment, gross |  |  |  |  |  |  | 40,886,872 |  |  |  | 38,420,327 |
Accumulated depreciation |  |  |  |  |  |  | (13,993,273 | ) |  |  | (11,665,352 | )
Property, plant and equipment, net |  |  |  |  |  | $ | 26,893,599 |  |  | $ | 26,754,975 |
As of December 31, 2021 and 2020, construction in progress consisted principally of payments toward the First Defense® production capacity expansion project and equipment needed to bring the formulation and aseptic filling for Re-Tain® in-house. Property, plant and equipment disposals were $160,366 and $358,924 during the years ended December 31, 2021 and 2020, respectively. Depreciation expense was $2,442,036 and $2,328,179 during the years ended December 30, 2021 and 2020, respectively.

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- Definition The entire disclosure for long-lived, physical asset used in normal conduct of business and not intended for resale. Includes, but is not limited to, work of art, historical treasure, and similar asset classified as collections. + References Reference 1: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 958 -SubTopic 360 -Section 50 -Paragraph 6 -URI http://asc.fasb.org/extlink&oid=120429125&loc=d3e99893-112916 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 360 -URI http://asc.fasb.org/topic&trid=2155823 Reference 3: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 958 -SubTopic 360 -Section 50 -Paragraph 7 -URI http://asc.fasb.org/extlink&oid=120429125&loc=SL120174063-112916 Reference 4: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 958 -SubTopic 360 -Section 50 -Paragraph 1 -Subparagraph (d) -URI http://asc.fasb.org/extlink&oid=120429125&loc=d3e99779-112916 + Details
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