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Note 6 - Property, Plant and Equipment, Net - Schedule of Property, Plant and Equipment, Net (Details) - USD ($) | Dec. 31, 2025 | Dec. 31, 2024
--- | --- | ---
Property, Plant and Equipment, Gross |  | $ 39,912,318 | $ 46,390,570
Property, Plant and Equipment, Gross |  | 39,912,318 | 46,390,570
Accumulated depreciation |  | (18,837,624) | (21,041,551)
Property, plant and equipment, net(2) | [1] | 21,074,694 | 25,349,019
Laboratory and Manufacturing Equipment [Member] |  |  |
Property, Plant and Equipment, Gross |  |  | 21,234,259
Property, Plant and Equipment, Gross |  |  | 21,234,259
Laboratory and Manufacturing Equipment [Member] | Minimum [Member] |  |  |
Property, Plant and Equipment, Gross |  | 17,255,585 |
Property, Plant and Equipment, Gross |  | 17,255,585 |
Building and Building Improvements [Member] |  |  |
Property, Plant and Equipment, Gross |  |  | 20,889,395
Property, Plant and Equipment, Gross |  |  | 20,889,395
Building and Building Improvements [Member] | Minimum [Member] |  |  |
Property, Plant and Equipment, Gross |  | 20,902,758 |
Property, Plant and Equipment, Gross |  | 20,902,758 |
Office Furniture and Equipment [Member] |  |  |
Property, Plant and Equipment, Gross |  |  | 1,056,145
Property, Plant and Equipment, Gross |  |  | 1,056,145
Office Furniture and Equipment [Member] | Minimum [Member] |  |  |
Property, Plant and Equipment, Gross |  | 702,838 |
Property, Plant and Equipment, Gross |  | 702,838 |
Construction in Progress [Member] |  |  |
Property, Plant and Equipment, Gross | [2] | 534,270 | 2,693,904
Property, Plant and Equipment, Gross | [2] | 534,270 | 2,693,904
Land [Member] |  |  |
Property, Plant and Equipment, Gross |  | 516,867 | 516,867
Property, Plant and Equipment, Gross |  | $ 516,867 | $ 516,867
[1] | As of December 31, 2025, property, plant and equipment, net includes approximately $12,300,000 of idle assets, which primarily related to one of the Company's manufacturing facilities that was previously utilized for Re-Tain® that we now plan to refit for use in producing First Defense® products. We are monitoring these assets for impairment. No impairment was recognized on these assets during the years ended December 31, 2025 or 2024.
[2] | We recognized $2,667,100 in non-cash impairment charges during the year ended December 31, 2025, related to the write down of machinery that we determined had no related future undiscounted cash flows other than the current estimated proceeds from its sale. This determination was made after further delays in FDA regulatory approval of the Company's Re-Tain® product in development. As a result, we decided to focus on First Defense® and pause further investment in Re-Tain® manufacturing, leading to the Company no longer having a use for the machinery. This impairment charge is included in other expense, net, in the accompanying statement of operations for the year ended December 31, 2025. No similar impairment was recognized during the year ended December 31, 2024.

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