<?xml version="1.0" encoding="us-ascii"?>
<!-- DFIN ActiveDisclosure(SM) XBRL Schema Document - http://www.dfinsolutions.com/ -->
<!-- Creation Date      : 2019-12-16T22:42:58.6907028+00:00 -->
<!-- Version            : 5.0.1.294 -->
<!-- Package ID         : 651bf0c6b3da4ff2a7e8ccc710908918 -->
<!-- Copyright (c) 2019 Donnelley Financial Solutions, Inc. All Rights Reserved. -->
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  <xsd:element id="mesa_TwoThousandElevenAndTwoThousandSeventeenEquityIncentivePlanMember" name="TwoThousandElevenAndTwoThousandSeventeenEquityIncentivePlanMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mesa_EmployeesMember" name="EmployeesMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mesa_AmericanAirlinesIncMember" name="AmericanAirlinesIncMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mesa_CRJ900AircraftMember" name="CRJ900AircraftMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mesa_CRJ700AircraftMember" name="CRJ700AircraftMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mesa_E175AircraftMember" name="E175AircraftMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mesa_UnitedAirlinesIncMember" name="UnitedAirlinesIncMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mesa_E175LLAircraftMember" name="E175LLAircraftMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mesa_StockWithheldToCoverTaxWithholdingRequirementsUponVestingToRestrictedStockUnitsShares" name="StockWithheldToCoverTaxWithholdingRequirementsUponVestingToRestrictedStockUnitsShares" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mesa_IssuanceOfStockUponCancellationOfExistingUnvestedRestrictedPhantomStockUnitsAndRestrictedStockUnits" name="IssuanceOfStockUponCancellationOfExistingUnvestedRestrictedPhantomStockUnitsAndRestrictedStockUnits" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mesa_IssuanceOfStockUponCancellationOfExistingUnvestedRestrictedPhantomStockUnits" name="IssuanceOfStockUponCancellationOfExistingUnvestedRestrictedPhantomStockUnits" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mesa_IssuanceOfStockUponCancellationOfExistingUnvestedRestrictedStock" name="IssuanceOfStockUponCancellationOfExistingUnvestedRestrictedStock" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mesa_MaximumNumberOfAircraftToPermanentlyWithdrawInTheEventCompanyFailsToMeetNewOrRevisePerformanceMetrics" name="MaximumNumberOfAircraftToPermanentlyWithdrawInTheEventCompanyFailsToMeetNewOrRevisePerformanceMetrics" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mesa_NumberOfAircraftConvertedToBeUtilizedAsOperationalSpares" name="NumberOfAircraftConvertedToBeUtilizedAsOperationalSpares" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" />
  <xsd:element id="mesa_NumberOfAircraftPermanentlyWithdrawDueToFailureToMeetNewRevisedPerformanceMetrics" name="NumberOfAircraftPermanentlyWithdrawDueToFailureToMeetNewRevisedPerformanceMetrics" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mesa_NumberOfAdditionalAircraftPermanentlyWithdrawnDueToCompanyFailureToMeetCertainPerformanceMetrics" name="NumberOfAdditionalAircraftPermanentlyWithdrawnDueToCompanyFailureToMeetCertainPerformanceMetrics" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mesa_NumberOfAircraftsPurchased" name="NumberOfAircraftsPurchased" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mesa_NumberOfAdditionalAircraft" name="NumberOfAdditionalAircraft" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" />
  <xsd:element id="mesa_NumberOfYearsInOperation" name="NumberOfYearsInOperation" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mesa_LeaseExtensionPeriod" name="LeaseExtensionPeriod" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mesa_AircraftLeasePeriod" name="AircraftLeasePeriod" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mesa_LeaseExpirationYear" name="LeaseExpirationYear" type="xbrli:gYearItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mesa_NumberOfLeasedAircraft" name="NumberOfLeasedAircraft" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" />
  <xsd:element id="mesa_NoticePeriodForTerminationOfAgreement" name="NoticePeriodForTerminationOfAgreement" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mesa_RegulatoryAssetsAbstract" name="RegulatoryAssetsAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mesa_SummaryOfSignificantAccountingPoliciesLineItems" name="SummaryOfSignificantAccountingPoliciesLineItems" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mesa_SummaryOfSignificantAccountingPoliciesTable" name="SummaryOfSignificantAccountingPoliciesTable" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mesa_AircraftMember" name="AircraftMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mesa_AircraftAndRotableSparePartsMember" name="AircraftAndRotableSparePartsMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mesa_RotableSparePartsMember" name="RotableSparePartsMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mesa_ReductionOfUnfavorableLeaseLiability" name="ReductionOfUnfavorableLeaseLiability" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mesa_EngineOverhaulExpense" name="EngineOverhaulExpense" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mesa_EngineOverhaulPassThroughExpense" name="EngineOverhaulPassThroughExpense" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mesa_AirframeCheckExpense" name="AirframeCheckExpense" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mesa_AirframeCheckPassThroughExpense" name="AirframeCheckPassThroughExpense" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mesa_PercentageLeased" name="PercentageLeased" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mesa_ChangeInAccountingPolicyEffectOfIncreaseDecreaseInSarsAndPhantomStockLiability" name="ChangeInAccountingPolicyEffectOfIncreaseDecreaseInSarsAndPhantomStockLiability" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mesa_NumberOfNominalOperatingLeasedAircraft" name="NumberOfNominalOperatingLeasedAircraft" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" />
  <xsd:element id="mesa_NumberOfAircraft" name="NumberOfAircraft" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" />
  <xsd:element id="mesa_LeaseObligationAggregateExposureAmount" name="LeaseObligationAggregateExposureAmount" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mesa_UnutilizedManufacturerCredits" name="UnutilizedManufacturerCredits" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mesa_AircraftAndOtherFlightEquipmentSubstantiallyPledgedMember" name="AircraftAndOtherFlightEquipmentSubstantiallyPledgedMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mesa_AmortizationOfUnfavorableLeaseLiability" name="AmortizationOfUnfavorableLeaseLiability" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mesa_WriteOffOfUnfavorableLeaseLiability" name="WriteOffOfUnfavorableLeaseLiability" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mesa_NotesPayableToFinancialInstitutionCollateralizedByUnderlyingAircraftDueTwoThousandNineteenMember" name="NotesPayableToFinancialInstitutionCollateralizedByUnderlyingAircraftDueTwoThousandNineteenMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mesa_NotesPayableToFinancialInstitutionCollateralizedByUnderlyingAircraftDueTwoThousandTwentyTwoMember" name="NotesPayableToFinancialInstitutionCollateralizedByUnderlyingAircraftDueTwoThousandTwentyTwoMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mesa_NotesPayableToFinancialInstitutionCollateralizedByUnderlyingAircraftDueTwoThousandTwentyFourMember" name="NotesPayableToFinancialInstitutionCollateralizedByUnderlyingAircraftDueTwoThousandTwentyFourMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mesa_SeniorAndSubordinatedNotesPayableToSecuredPartiesCollateralizedByUnderlyingAircraftDueTwoThousandTwentySevenMember" name="SeniorAndSubordinatedNotesPayableToSecuredPartiesCollateralizedByUnderlyingAircraftDueTwoThousandTwentySevenMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mesa_NotesPayableToSecuredPartiesCollateralizedByUnderlyingAircraftDueTwoThousandTwentyEightMember" name="NotesPayableToSecuredPartiesCollateralizedByUnderlyingAircraftDueTwoThousandTwentyEightMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mesa_SeniorAndSubordinatedNotesPayableToSecuredPartiesCollateralizedByUnderlyingAircraftDueTwoThousandTwentyEightMember" name="SeniorAndSubordinatedNotesPayableToSecuredPartiesCollateralizedByUnderlyingAircraftDueTwoThousandTwentyEightMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mesa_SeniorAndSubordinatedNotesPayableToSecuredPartiesCollateralizedByUnderlyingAircraftDueTwoThousandTwentyTwoMember" name="SeniorAndSubordinatedNotesPayableToSecuredPartiesCollateralizedByUnderlyingAircraftDueTwoThousandTwentyTwoMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mesa_NotesPayableToFinancialInstitutionCollateralizedByUnderlyingEquipmentDueTwoThousandTwentyTwoMember" name="NotesPayableToFinancialInstitutionCollateralizedByUnderlyingEquipmentDueTwoThousandTwentyTwoMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mesa_NotesPayableToFinancialInstitutionCollateralizedByUnderlyingEquipmentDueTwoThousandTwentyMember" name="NotesPayableToFinancialInstitutionCollateralizedByUnderlyingEquipmentDueTwoThousandTwentyMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mesa_NotesPayableToFinancialInstitutionDueTwoThousandTwentyMember" name="NotesPayableToFinancialInstitutionDueTwoThousandTwentyMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mesa_NotesPayableToFinancialInstitutionDueTwoThousandNineteenMember" name="NotesPayableToFinancialInstitutionDueTwoThousandNineteenMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mesa_OtherObligationsDueToFinancialInstitutionCollateralizedByUnderlyingEquipmentDueTwoThousandTwentyThreeMember" name="OtherObligationsDueToFinancialInstitutionCollateralizedByUnderlyingEquipmentDueTwoThousandTwentyThreeMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mesa_NotesPayableToFinancialInstitutionCollateralizedByTheUnderlyingEquipmentDueTwoThousandTwentyFourMember" name="NotesPayableToFinancialInstitutionCollateralizedByTheUnderlyingEquipmentDueTwoThousandTwentyFourMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mesa_NotesPayableToFinancialInstitutionCollateralizedByUnderlyingAircraftDueTwoThousandTwentyThreeMember" name="NotesPayableToFinancialInstitutionCollateralizedByUnderlyingAircraftDueTwoThousandTwentyThreeMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mesa_NotesPayableToFinancialInstitutionDueTwoThousandTwentyThreeMember" name="NotesPayableToFinancialInstitutionDueTwoThousandTwentyThreeMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mesa_FlightEquipmentMaintenanceMember" name="FlightEquipmentMaintenanceMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mesa_DebtInstrumentMaturityYear" name="DebtInstrumentMaturityYear" type="xbrli:gYearItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mesa_FiveCRJ700AndNineCRJ900Member" name="FiveCRJ700AndNineCRJ900Member" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mesa_ThreeCRJ900AndThreeCRJ700Member" name="ThreeCRJ900AndThreeCRJ700Member" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mesa_TenCRJ900AircraftMember" name="TenCRJ900AircraftMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mesa_EightCRJ900AircraftMember" name="EightCRJ900AircraftMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mesa_SeniorNotesDueTwoThousandTwentySevenMember" name="SeniorNotesDueTwoThousandTwentySevenMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mesa_SubordinatedNotesDueTwoThousandTwentySevenMember" name="SubordinatedNotesDueTwoThousandTwentySevenMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mesa_TenE175AircraftMember" name="TenE175AircraftMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mesa_EightE175AircraftMember" name="EightE175AircraftMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mesa_SeniorNotesDueTwoThousandTwentyEightMember" name="SeniorNotesDueTwoThousandTwentyEightMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mesa_SubordinatedNotesDueTwoThousandTwentyEightMember" name="SubordinatedNotesDueTwoThousandTwentyEightMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mesa_SeniorNotesDueTwoThousandTwentyTwoMember" name="SeniorNotesDueTwoThousandTwentyTwoMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mesa_SubordinatedNotesDuetwothousandtwentytwoMember" name="SubordinatedNotesDuetwothousandtwentytwoMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mesa_SeniorNotesDueTwoThousandTwentyMember" name="SeniorNotesDueTwoThousandTwentyMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mesa_SubordinatedNotesDueTwoThousandTwentyMember" name="SubordinatedNotesDueTwoThousandTwentyMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mesa_NumberOfAircraftRefinanced" name="NumberOfAircraftRefinanced" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" />
  <xsd:element id="mesa_NumberOfAircraftFinanced" name="NumberOfAircraftFinanced" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" />
  <xsd:element id="mesa_DebtInstrumentImputedInterestRate" name="DebtInstrumentImputedInterestRate" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" />
  <xsd:element id="mesa_NumberOfSpareEnginesLeased" name="NumberOfSpareEnginesLeased" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mesa_PledgedAsCollateralMember" name="PledgedAsCollateralMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mesa_EquipmentNotesMember" name="EquipmentNotesMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mesa_TermLoanMember" name="TermLoanMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mesa_SpareEngineFacilityMember" name="SpareEngineFacilityMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mesa_WorkingCapitalDrawLoanMember" name="WorkingCapitalDrawLoanMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mesa_RefinancedDebtDueDate" name="RefinancedDebtDueDate" type="xbrli:gYearItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mesa_NumberOfAircraftPurchased" name="NumberOfAircraftPurchased" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mesa_GoodsAndServicesCredit" name="GoodsAndServicesCredit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mesa_EarningsPerShareAndEquityAbstract" name="EarningsPerShareAndEquityAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mesa_EarningsPerShareLineItems" name="EarningsPerShareLineItems" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mesa_EarningsPerShareTable" name="EarningsPerShareTable" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mesa_MaximumPercentageOfStockPertainingToRestrictions" name="MaximumPercentageOfStockPertainingToRestrictions" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mesa_ExtendedTermOfOutstandingWarrantsExpirationPeriod" name="ExtendedTermOfOutstandingWarrantsExpirationPeriod" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mesa_ProceedsFromIssuanceInitialPublicOfferingNetOfIssuanceCosts" name="ProceedsFromIssuanceInitialPublicOfferingNetOfIssuanceCosts" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mesa_UnderwritingDiscountsAndCommissions" name="UnderwritingDiscountsAndCommissions" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mesa_OfferingCosts" name="OfferingCosts" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mesa_IncomeTaxReconciliationIncreasesReductionsInTaxResultingFromAbstract" name="IncomeTaxReconciliationIncreasesReductionsInTaxResultingFromAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mesa_DeferredTaxAssetsPrepaidAndOther" name="DeferredTaxAssetsPrepaidAndOther" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mesa_DeferredTaxAssetsOperatingLease" name="DeferredTaxAssetsOperatingLease" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mesa_OperatingLossCarryforwardsExpirationYear" name="OperatingLossCarryforwardsExpirationYear" type="xbrli:gYearItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mesa_IncomeTaxesLineItems" name="IncomeTaxesLineItems" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mesa_IncomeTaxesTable" name="IncomeTaxesTable" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mesa_PeriodOneMember" name="PeriodOneMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mesa_PeriodTwoMember" name="PeriodTwoMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mesa_AMTCreditCarryoverMember" name="AMTCreditCarryoverMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mesa_TaxCutsAndJobsActOf2017ChangeInTaxRateDiscreteNetTaxBenefit" name="TaxCutsAndJobsActOf2017ChangeInTaxRateDiscreteNetTaxBenefit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mesa_TaxCutsAndJobsActOf2017ChangeInTaxRateDeferredTaxLiabilityExcludesValuationAllowance" name="TaxCutsAndJobsActOf2017ChangeInTaxRateDeferredTaxLiabilityExcludesValuationAllowance" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mesa_TaxCutsAndJobsActOf2017ChangeInTaxRateIncreaseToValuationAllowance" name="TaxCutsAndJobsActOf2017ChangeInTaxRateIncreaseToValuationAllowance" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mesa_TaxCutsAndJobsActOf2017ChangeInTaxRateDeferredTaxExpenseBenefit" name="TaxCutsAndJobsActOf2017ChangeInTaxRateDeferredTaxExpenseBenefit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mesa_AlternativeMinimumTaxNoncurrent" name="AlternativeMinimumTaxNoncurrent" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mesa_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsCancelledInPeriod" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsCancelledInPeriod" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mesa_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsIssuedInPeriod" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsIssuedInPeriod" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mesa_TwoThousandElevenPlanMember" name="TwoThousandElevenPlanMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mesa_TwoThousandSeventeenPlanMember" name="TwoThousandSeventeenPlanMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mesa_RestrictedStockAwardMember" name="RestrictedStockAwardMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mesa_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsExchangedInPeriodRestrictedShares" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsExchangedInPeriodRestrictedShares" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mesa_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsExchangedInPeriodPhantomStock" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsExchangedInPeriodPhantomStock" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mesa_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsExchangedInPeriodStockAppreciationRights" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsExchangedInPeriodStockAppreciationRights" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mesa_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsExchangedStockAppreciationRightsVestedPriorToExchangeInPeriod" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsExchangedStockAppreciationRightsVestedPriorToExchangeInPeriod" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mesa_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsExchangedInPeriod" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsExchangedInPeriod" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mesa_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsCancelledWeightedAverageGrantDateFairValue" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsCancelledWeightedAverageGrantDateFairValue" type="num:perShareItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mesa_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsExchangedRestrictedSharesInPeriodWeightedAverageGrantDateFairValue" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsExchangedRestrictedSharesInPeriodWeightedAverageGrantDateFairValue" type="num:perShareItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mesa_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsExchangedPhantomStockInPeriodWeightedAverageGrantDateFairValue" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsExchangedPhantomStockInPeriodWeightedAverageGrantDateFairValue" type="num:perShareItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mesa_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsExchangedStockAppreciationRightsInPeriodWeightedAverageGrantDateFairValue" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsExchangedStockAppreciationRightsInPeriodWeightedAverageGrantDateFairValue" type="num:perShareItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mesa_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsExchangedStockAppreciationRightsVestedPriorToExchangeInPeriodWeightedAverageGrantDateFairValue" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsExchangedStockAppreciationRightsVestedPriorToExchangeInPeriodWeightedAverageGrantDateFairValue" type="num:perShareItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mesa_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsExercisedInPeriod" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsExercisedInPeriod" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mesa_DefinedContributionPlanSemiAnnualContributionOfEligibleEmployeesCompensationPercent" name="DefinedContributionPlanSemiAnnualContributionOfEligibleEmployeesCompensationPercent" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mesa_HeadquartersAndOtherFacilityMember" name="HeadquartersAndOtherFacilityMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mesa_Other1Member" name="Other1Member" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mesa_QuarterlyFinancialInformationDisclosureLineItems" name="QuarterlyFinancialInformationDisclosureLineItems" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mesa_QuarterlyFinancialInformationDisclosureTable" name="QuarterlyFinancialInformationDisclosureTable" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mesa_TerminationOfAircraftOperationDescription" name="TerminationOfAircraftOperationDescription" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mesa_CF348C5EngineMember" name="CF348C5EngineMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mesa_NumberOfAircraftRightToPurchase" name="NumberOfAircraftRightToPurchase" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mesa_NumberOfDeferredAircraftElectedToRemove" name="NumberOfDeferredAircraftElectedToRemove" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mesa_NumberOfNewSpareEnginesToBeAcquired" name="NumberOfNewSpareEnginesToBeAcquired" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mesa_NewSpareEnginesDeliveryMonthAndYearDescription" name="NewSpareEnginesDeliveryMonthAndYearDescription" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
</xsd:schema>
