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<!-- DFS ActiveDisclosure(SM) XBRL Schema Document - http://www.dfsco.com/financial-services/ -->
<!-- Creation Date      : 2019-02-13T19:31:56.5137632+00:00 -->
<!-- Version            : 3.3.6957.35136 -->
<!-- Package ID         : 3fd2e7437f554b6980504ee9b449d6b1 -->
<!-- Copyright (c) 2019 Donnelley Financial, LLC. All Rights Reserved. -->
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  <element id="mesa_SeniorNotesDueTwoThousandTwentyTwoMember" name="SeniorNotesDueTwoThousandTwentyTwoMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
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  <element id="mesa_SubordinatedNotesDueTwoThousandTwentyMember" name="SubordinatedNotesDueTwoThousandTwentyMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
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  <element id="mesa_NumberOfAircraftFinanced" name="NumberOfAircraftFinanced" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" />
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  <element id="mesa_NumberOfSpareEnginesLeased" name="NumberOfSpareEnginesLeased" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <element id="mesa_PledgedAsCollateralMember" name="PledgedAsCollateralMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <element id="mesa_EquipmentNotesMember" name="EquipmentNotesMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
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  <element id="mesa_NumberOfAircraftPurchased" name="NumberOfAircraftPurchased" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
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  <element id="mesa_EarningsPerShareLineItems" name="EarningsPerShareLineItems" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
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  <element id="mesa_PeriodTwoMember" name="PeriodTwoMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
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  <element id="mesa_TaxCutsAndJobsActOf2017ChangeInTaxRateIncreaseToValuationAllowance" name="TaxCutsAndJobsActOf2017ChangeInTaxRateIncreaseToValuationAllowance" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
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  <element id="mesa_HeadquartersAndOtherFacilityMember" name="HeadquartersAndOtherFacilityMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
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  <element id="mesa_NumberOfAircraftToPermanentlyWithdrawIfOperationalPerformanceMetricsIsNotComplied" name="NumberOfAircraftToPermanentlyWithdrawIfOperationalPerformanceMetricsIsNotComplied" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" />
  <element id="mesa_MaximumNumberOfAircraftToWithdrawInAnyCalendarMonthIfOperationalPerformanceMetricsIsNotComplied" name="MaximumNumberOfAircraftToWithdrawInAnyCalendarMonthIfOperationalPerformanceMetricsIsNotComplied" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <element id="mesa_MaximumNumberOfAircraftToWithdrawIfOperationalPerformanceMetricsIsNotComplied" name="MaximumNumberOfAircraftToWithdrawIfOperationalPerformanceMetricsIsNotComplied" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
</schema>
