<?xml version="1.0" encoding="us-ascii"?>
<!-- DFIN ActiveDisclosure(SM) XBRL Schema Document - http://www.dfinsolutions.com/ -->
<!-- Creation Date      : 2019-05-15T10:34:16.4257653+00:00 -->
<!-- Version            : 3.4.7044.22220 -->
<!-- Package ID         : cb736b326cc14e2e82af83e33f15c701 -->
<!-- Copyright (c) 2019 Donnelley Financial Solutions, Inc. All Rights Reserved. -->
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  <xsd:element id="mesa_ThreeCRJ900AndThreeCRJ700Member" name="ThreeCRJ900AndThreeCRJ700Member" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mesa_TenCRJ900AircraftMember" name="TenCRJ900AircraftMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mesa_EightCRJ900AircraftMember" name="EightCRJ900AircraftMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mesa_SeniorNotesDueTwoThousandTwentySevenMember" name="SeniorNotesDueTwoThousandTwentySevenMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mesa_SubordinatedNotesDueTwoThousandTwentySevenMember" name="SubordinatedNotesDueTwoThousandTwentySevenMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mesa_TenE175AircraftMember" name="TenE175AircraftMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mesa_EightE175AircraftMember" name="EightE175AircraftMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mesa_SeniorNotesDueTwoThousandTwentyEightMember" name="SeniorNotesDueTwoThousandTwentyEightMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mesa_SubordinatedNotesDueTwoThousandTwentyEightMember" name="SubordinatedNotesDueTwoThousandTwentyEightMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mesa_SeniorNotesDueTwoThousandTwentyTwoMember" name="SeniorNotesDueTwoThousandTwentyTwoMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mesa_SubordinatedNotesDuetwothousandtwentytwoMember" name="SubordinatedNotesDuetwothousandtwentytwoMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mesa_SeniorNotesDueTwoThousandTwentyMember" name="SeniorNotesDueTwoThousandTwentyMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mesa_SubordinatedNotesDueTwoThousandTwentyMember" name="SubordinatedNotesDueTwoThousandTwentyMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mesa_NumberOfAircraftRefinanced" name="NumberOfAircraftRefinanced" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" />
  <xsd:element id="mesa_NumberOfAircraftFinanced" name="NumberOfAircraftFinanced" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" />
  <xsd:element id="mesa_DebtInstrumentImputedInterestRate" name="DebtInstrumentImputedInterestRate" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" />
  <xsd:element id="mesa_NumberOfSpareEnginesLeased" name="NumberOfSpareEnginesLeased" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mesa_PledgedAsCollateralMember" name="PledgedAsCollateralMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mesa_EquipmentNotesMember" name="EquipmentNotesMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mesa_TermLoanMember" name="TermLoanMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mesa_SpareEngineFacilityMember" name="SpareEngineFacilityMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mesa_NumberOfAircraftPurchased" name="NumberOfAircraftPurchased" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mesa_GoodsAndServicesCredit" name="GoodsAndServicesCredit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mesa_EarningsPerShareAndEquityAbstract" name="EarningsPerShareAndEquityAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mesa_EarningsPerShareLineItems" name="EarningsPerShareLineItems" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mesa_EarningsPerShareTable" name="EarningsPerShareTable" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mesa_MaximumPercentageOfStockPertainingToRestrictions" name="MaximumPercentageOfStockPertainingToRestrictions" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mesa_ExtendedTermOfOutstandingWarrantsExpirationPeriod" name="ExtendedTermOfOutstandingWarrantsExpirationPeriod" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mesa_IncomeTaxesLineItems" name="IncomeTaxesLineItems" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mesa_IncomeTaxesTable" name="IncomeTaxesTable" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mesa_PeriodOneMember" name="PeriodOneMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mesa_PeriodTwoMember" name="PeriodTwoMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mesa_OperatingLossCarryforwardsExpirationYear" name="OperatingLossCarryforwardsExpirationYear" type="xbrli:gYearItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mesa_RestrictedStockAwardMember" name="RestrictedStockAwardMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mesa_NumberOfLeasedAircraft" name="NumberOfLeasedAircraft" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" />
  <xsd:element id="mesa_AircraftMember" name="AircraftMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mesa_HeadquartersAndOtherFacilityMember" name="HeadquartersAndOtherFacilityMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mesa_Other1Member" name="Other1Member" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
</xsd:schema>
