<SEC-DOCUMENT>9999999997-16-026106.txt : 20160926
<SEC-HEADER>9999999997-16-026106.hdr.sgml : 20160926
<ACCEPTANCE-DATETIME>20160926133327
ACCESSION NUMBER:		9999999997-16-026106
CONFORMED SUBMISSION TYPE:	CT ORDER
PUBLIC DOCUMENT COUNT:		1
FILED AS OF DATE:		20160926
DATE AS OF CHANGE:		20160926
<ACTION-DATE>20160926
<RECEIVED-DATE>20160926

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Karyopharm Therapeutics Inc.
		CENTRAL INDEX KEY:			0001503802
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				263931704
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		CT ORDER
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-36167
		FILM NUMBER:		161901798

	BUSINESS ADDRESS:	
		STREET 1:		85 WELLS AVENUE
		STREET 2:		SECOND FLOOR
		CITY:			NEWTON
		STATE:			MA
		ZIP:			02459
		BUSINESS PHONE:		617-658-0600

	MAIL ADDRESS:	
		STREET 1:		85 WELLS AVENUE
		STREET 2:		SECOND FLOOR
		CITY:			NEWTON
		STATE:			MA
		ZIP:			02459
</SEC-HEADER>
<DOCUMENT>
<TYPE>CT ORDER
<SEQUENCE>1
<FILENAME>filename1.pdf
<TEXT>
<PDF>
begin 644 filename1.pdf
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M8FH-"CD@,"!O8FH-"CP\+T%U=&AO<BAU<RD@+T-R96%T;W(H_O\ 30!I &,
M<@!O ', ;P!F '0 K@ @ %< ;P!R &0 (  R #  ,0 P*2 O0W)E871I;VY$
M871E*$0Z,C Q-C Y,C8Q,S,Q,34M,#0G,# G*2 O36]D1&%T92A$.C(P,38P
M.3(V,3,S,3$U+3 T)S P)RD@+U!R;V1U8V5R*/[_ $T :0!C '( ;P!S &\
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&"B4E14]&

end
</PDF>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
