<SEC-DOCUMENT>0001306923-21-000018-index.html : 20210216
<SEC-HEADER>0001306923-21-000018.hdr.sgml : 20210216
<ACCEPTANCE-DATETIME>20210216164121
ACCESSION NUMBER:		0001306923-21-000018
CONFORMED SUBMISSION TYPE:	SC 13G/A
PUBLIC DOCUMENT COUNT:		2
FILED AS OF DATE:		20210216
DATE AS OF CHANGE:		20210216

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Karyopharm Therapeutics Inc.
		CENTRAL INDEX KEY:			0001503802
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				263931704
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13G/A
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	005-87705
		FILM NUMBER:		21639765

	BUSINESS ADDRESS:	
		STREET 1:		85 WELLS AVENUE
		STREET 2:		SECOND FLOOR
		CITY:			NEWTON
		STATE:			MA
		ZIP:			02459
		BUSINESS PHONE:		617-658-0600

	MAIL ADDRESS:	
		STREET 1:		85 WELLS AVENUE
		STREET 2:		SECOND FLOOR
		CITY:			NEWTON
		STATE:			MA
		ZIP:			02459

FILED BY:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Palo Alto Investors LP
		CENTRAL INDEX KEY:			0001306923
		IRS NUMBER:				770558164
		STATE OF INCORPORATION:			CA
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13G/A

	BUSINESS ADDRESS:	
		STREET 1:		470 UNIVERSITY AVE
		CITY:			PALO ALTO
		STATE:			CA
		ZIP:			94301
		BUSINESS PHONE:		650-325-0772

	MAIL ADDRESS:	
		STREET 1:		470 UNIVERSITY AVE
		CITY:			PALO ALTO
		STATE:			CA
		ZIP:			94301

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	Palo Alto Investors, LLC
		DATE OF NAME CHANGE:	20041025
</SEC-HEADER>
<DOCUMENT>
<TYPE>SC 13G/A
<SEQUENCE>1
<FILENAME>Karyopharm_13G_A5.txt
<TEXT>
Document 1 - file: Karyopharm_13G_A5.txt

</DOCUMENT>
<DOCUMENT>
<TYPE>SC 13G/A
<SEQUENCE>2
<FILENAME>Karyopharm_13G_A5.pdf
<TEXT>
Document 2 - file: Karyopharm_13G_A5.pdf

</DOCUMENT>
</SEC-DOCUMENT>