<SEC-DOCUMENT>0001837741-26-000003-index.html : 20260303
<SEC-HEADER>0001837741-26-000003.hdr.sgml : 20260303
<ACCEPTANCE-DATETIME>20260303162839
ACCESSION NUMBER:		0001837741-26-000003
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20260302
FILED AS OF DATE:		20260303
DATE AS OF CHANGE:		20260303

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Mano Michael
		CENTRAL INDEX KEY:			0001837741
		ORGANIZATION NAME:           	

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-36167
		FILM NUMBER:		26714849

	MAIL ADDRESS:	
		STREET 1:		85 WELLS AVENUE
		STREET 2:		SUITE 210
		CITY:			NEWTON
		STATE:			MA
		ZIP:			02459

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Karyopharm Therapeutics Inc.
		CENTRAL INDEX KEY:			0001503802
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		ORGANIZATION NAME:           	03 Life Sciences
		EIN:				263931704
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		85 WELLS AVENUE
		STREET 2:		SECOND FLOOR
		CITY:			NEWTON
		STATE:			MA
		ZIP:			02459
		BUSINESS PHONE:		617-658-0600

	MAIL ADDRESS:	
		STREET 1:		85 WELLS AVENUE
		STREET 2:		SECOND FLOOR
		CITY:			NEWTON
		STATE:			MA
		ZIP:			02459
</SEC-HEADER>
<DOCUMENT>
<TYPE>4
<SEQUENCE>1
<FILENAME>ownership.xml
<DESCRIPTION>4
<TEXT>
Document 1 - file: ownership.html

Document 1 - RAW XML: ownership.xml

</DOCUMENT>
</SEC-DOCUMENT>