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Pay vs Performance Disclosure - USD ($)
 12 Months Ended
Dec. 31, 2025
Dec. 31, 2024
Dec. 31, 2023
Pay vs Performance Disclosure      
Pay vs Performance Disclosure, Table

Pay Versus Performance

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Year

 

 

Summary
Compensation
Table Total
for PEO
(1)($)

 

 

Compensation
Actually
Paid to PEO
(2)($)

 

 

Average
Summary
Compensation
Table Total
for Non-PEO
Named
Executive
Officers
(1)($)

 

 

Average
Compensation
Actually Paid
to Non-PEO
Named
Executive
Officers
(2)($)

 

 

Value of
Initial Fixed
$100
Investment
Based on Total
Shareholder
Return
($)

 

 

Net
Income (Loss)
($)

 

 

2025

 

 

 

2,320,902

 

 

 

2,124,337

 

 

 

1,707,857

 

 

 

1,616,881

 

 

 

14.43

 

 

 

(196,038,779

)

 

2024

 

 

 

2,069,341

 

 

 

1,651,223

 

 

 

1,109,637

 

 

 

948,263

 

 

 

19.89

 

 

 

(76,422,196

)

 

2023

 

 

 

2,626,288

 

 

 

35,742

 

 

 

1,167,408

 

 

 

477,452

 

 

 

25.44

 

 

 

(143,098,583

)
(1)
For 2025, 2024 and 2023, our PEO was Mr. Paulson, who was appointed as our President and Chief Executive Officer effective May 3, 2021. Our Other NEOs were Mr. Poulton and Dr. Rangwala for 2025, Sohanya Cheng, our current Chief Commercial Officer and Dr. Rangwala for 2024, and Michael Mason, our former Chief Financial Officer, Ms. Cheng, Mr. Poulton and Dr. Rangwala for 2023.
(2)
The following table describes the adjustments, each of which is prescribed by SEC rules, to calculate the CAP Amounts from the SCT Amounts. The SCT Amounts and the CAP Amounts do not reflect the actual amount of compensation earned by or paid to our NEOs during 2025, but rather are amounts determined in accordance with Item 402 of Regulation S-K under the Exchange Act. No awards vested in the year they were granted.

 

 

 

2025

 

Adjustments

 

PEO

 

 

Other NEOs *

 

Total Compensation from SCT

 

 

2,320,902

 

 

 

1,707,857

 

Adjustments for stock and option awards:

 

 

 

 

 

 

(Subtract): Aggregate value for stock awards and option awards included in SCT for the covered fiscal year

 

 

(1,080,540

)

 

 

(314,144

)

Add: Fair value at year end of awards granted during the covered fiscal year that were outstanding and unvested at the covered fiscal year end

 

 

1,202,552

 

 

 

322,981

 

Add (Subtract): Change as of the end of the covered fiscal year (from the end of the prior fiscal year) in fair value of awards granted in any prior fiscal year that were outstanding and unvested at the covered fiscal year end

 

 

(187,282

)

 

 

(68,170

)

Add (Subtract): Change as of the vesting date (from the end of the prior fiscal year) in fair value of awards granted in any prior fiscal year for which vesting conditions were satisfied during the covered fiscal year

 

 

(131,295

)

 

 

(31,643

)

CAP Amounts (as calculated)

 

 

2,124,337

 

 

 

1,616,881

 

 

* Amounts presented are averages for Mr. Poulton and Dr. Rangwala in 2025.

Valuation assumptions used to calculate fair values did not materially differ from those used to calculate fair values at the time of grant as reflected in the SCT Amounts for all NEOs.

    
Named Executive Officers, Footnote For 2025, 2024 and 2023, our PEO was Mr. Paulson, who was appointed as our President and Chief Executive Officer effective May 3, 2021. Our Other NEOs were Mr. Poulton and Dr. Rangwala for 2025, Sohanya Cheng, our current Chief Commercial Officer and Dr. Rangwala for 2024, and Michael Mason, our former Chief Financial Officer, Ms. Cheng, Mr. Poulton and Dr. Rangwala for 2023.    
PEO Total Compensation Amount $ 2,320,902 $ 2,069,341 $ 2,626,288
PEO Actually Paid Compensation Amount $ 2,124,337 1,651,223 35,742
Adjustment To PEO Compensation, Footnote
(2)
The following table describes the adjustments, each of which is prescribed by SEC rules, to calculate the CAP Amounts from the SCT Amounts. The SCT Amounts and the CAP Amounts do not reflect the actual amount of compensation earned by or paid to our NEOs during 2025, but rather are amounts determined in accordance with Item 402 of Regulation S-K under the Exchange Act. No awards vested in the year they were granted.

 

 

 

2025

 

Adjustments

 

PEO

 

 

Other NEOs *

 

Total Compensation from SCT

 

 

2,320,902

 

 

 

1,707,857

 

Adjustments for stock and option awards:

 

 

 

 

 

 

(Subtract): Aggregate value for stock awards and option awards included in SCT for the covered fiscal year

 

 

(1,080,540

)

 

 

(314,144

)

Add: Fair value at year end of awards granted during the covered fiscal year that were outstanding and unvested at the covered fiscal year end

 

 

1,202,552

 

 

 

322,981

 

Add (Subtract): Change as of the end of the covered fiscal year (from the end of the prior fiscal year) in fair value of awards granted in any prior fiscal year that were outstanding and unvested at the covered fiscal year end

 

 

(187,282

)

 

 

(68,170

)

Add (Subtract): Change as of the vesting date (from the end of the prior fiscal year) in fair value of awards granted in any prior fiscal year for which vesting conditions were satisfied during the covered fiscal year

 

 

(131,295

)

 

 

(31,643

)

CAP Amounts (as calculated)

 

 

2,124,337

 

 

 

1,616,881

 

 

* Amounts presented are averages for Mr. Poulton and Dr. Rangwala in 2025.

Valuation assumptions used to calculate fair values did not materially differ from those used to calculate fair values at the time of grant as reflected in the SCT Amounts for all NEOs.

    
Non-PEO NEO Average Total Compensation Amount $ 1,707,857 1,109,637 1,167,408
Non-PEO NEO Average Compensation Actually Paid Amount $ 1,616,881 948,263 477,452
Compensation Actually Paid vs. Total Shareholder Return

img118964590_4.gif

    
Compensation Actually Paid vs. Net Income

img118964590_3.gif

    
Total Shareholder Return Amount $ 14.43 19.89 25.44
Net Income (Loss) $ (196,038,779) $ (76,422,196) $ (143,098,583)
PEO Name Mr. Paulson Mr. Paulson Mr. Paulson
PEO | Aggregate Grant Date Fair Value of Equity Award Amounts Reported in Summary Compensation Table      
Pay vs Performance Disclosure      
Adjustment to Compensation, Amount $ (1,080,540)    
PEO | Year-end Fair Value of Equity Awards Granted in Covered Year that are Outstanding and Unvested      
Pay vs Performance Disclosure      
Adjustment to Compensation, Amount 1,202,552    
PEO | Year-over-Year Change in Fair Value of Equity Awards Granted in Prior Years That are Outstanding and Unvested      
Pay vs Performance Disclosure      
Adjustment to Compensation, Amount (187,282)    
PEO | Change in Fair Value as of Vesting Date of Prior Year Equity Awards Vested in Covered Year      
Pay vs Performance Disclosure      
Adjustment to Compensation, Amount (131,295)    
Non-PEO NEO | Aggregate Grant Date Fair Value of Equity Award Amounts Reported in Summary Compensation Table      
Pay vs Performance Disclosure      
Adjustment to Compensation, Amount (314,144)    
Non-PEO NEO | Year-end Fair Value of Equity Awards Granted in Covered Year that are Outstanding and Unvested      
Pay vs Performance Disclosure      
Adjustment to Compensation, Amount 322,981    
Non-PEO NEO | Year-over-Year Change in Fair Value of Equity Awards Granted in Prior Years That are Outstanding and Unvested      
Pay vs Performance Disclosure      
Adjustment to Compensation, Amount (68,170)    
Non-PEO NEO | Change in Fair Value as of Vesting Date of Prior Year Equity Awards Vested in Covered Year      
Pay vs Performance Disclosure      
Adjustment to Compensation, Amount $ (31,643)