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Shareholders' Equity (Tables) | 12 Months Ended
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Dec. 31, 2022
Stockholders' Equity Note [Abstract] |
Schedule of ordinary share capital |
|  | December 31, 2022 |  |  | December 31, 2021 |
|  | Authorized |  |  | Issued and outstanding |  |  | Authorized |  |  | Issued and outstanding |
|  | Number of shares |
Ordinary shares with no par value |  |  | 47,800,000 |  |  |  | 19,851,833 |  |  |  | 47,800,000 |  |  |  | 18,756,570 |
Schedule of status of options to employees |
|  | Number of options |  |  | Weighted average exercise price |  |  | Aggregate intrinsic value |  |  | Weighted average remaining contractual life (years) |
Outstanding at beginning of year |  |  | 2,726,911 |  |  | $ | 6.25 |  |  | $ | 2,323 |  |  |  | 6.44 |
Granted |  |  | 1,124,520 |  |  | $ | 5.51 |  |  |  |  |  |  |  |  |
Exercised |  |  | (30,206 | ) |  | $ | 3.60 |  |  | $ | 21 |  |  |  |  |
Forfeited and expired |  |  | (517,879 | ) |  | $ | 6.57 |  |  |  |  |  |  |  |  |
Outstanding at end of year |  |  | 3,303,346 |  |  | $ | 5.97 |  |  | $ | 115 |  |  |  | 6.14 |
Exercisable options |  |  | 2,016,737 |  |  | $ | 5.81 |  |  | $ | 115 |  |  |  | 4.34 |
Vested and expected to vest |  |  | 3,303,346 |  |  | $ | 5.97 |  |  | $ | 115 |  |  |  | 6.14 |
Schedule of relative fair value of the warrants to purchase Ordinary shares issued |
|  | 2022 |  |  | 2021 |  |  | 2020 |
Dividend yield (%) |  |  | 0 |  |  |  | 0 |  |  |  | 0 |
Expected volatility (%) |  |  | 70.45-92.67 |  |  |  | 72.97-78.69 |  |  |  | 74.35-84.77 |
Risk-free interest rate (%) |  |  | 1.81-4.30 |  |  |  | 0.62-1.32 |  |  |  | 0.23-1.38 |
Expected term (in years) |  |  | 1.2-6 |  |  |  | 5-6 |  |  |  | 5-6 |
Schedule of share-based compensation expense recognized |
|  | Year Ended December 31, |
|  | 2022 |  |  | 2021 |  |  | 2020 |
Research and development |  | $ | 2,081 |  |  | $ | 2,203 |  |  | $ | 1,806 |
Marketing and business development |  |  | 383 |  |  |  | 317 |  |  |  | 140 |
General and administrative |  |  | 1,843 |  |  |  | 2,230 |  |  |  | 2,631 |
Total share-based compensation expense |  | $ | 4,307 |  |  | $ | 4,750 |  |  | $ | 4,577 |
Schedule of outstanding options granted |
Grant date |  | Options outstanding as of December 31, 2022 |  |  | Average Exercise price per share ($) |  |  | Options exercisable as of December 31, 2022 |  |  | Exercisable through
October 2013 |  |  | 5,719 |  |  | $ | 5.06 |  |  |  | 5,719 |  |  | October 2023
September 2014 |  |  | 5,719 |  |  | $ | 5.06 |  |  |  | 5,719 |  |  | September 2024
April 2016 |  |  | 5,975 |  |  | $ | 3.10 |  |  |  | 5,975 |  |  | April 2026
December 2016 |  |  | 7,170 |  |  | $ | 3.93 |  |  |  | 7,170 |  |  | December 2026
June 2017 |  |  | 197,722 |  |  | $ | 4.10 |  |  |  | 197,722 |  |  | June 2027
November 2017 |  |  | 17,925 |  |  | $ | 7.70 |  |  |  | 17,925 |  |  | November 2027
August 2019 |  |  | 71,700 |  |  | $ | 8.18 |  |  |  | 71,700 |  |  | August 2029
June 2020 |  |  | 64,530 |  |  | $ | 6.62 |  |  |  | 53,724 |  |  | June 2030
April 2021 |  |  | 62,741 |  |  | $ | 9.57 |  |  |  | 62,741 |  |  | April 2031
August 2021 |  |  | 15,000 |  |  | $ | 8.13 |  |  |  | 6,206 |  |  | August 2031
December 2021 |  |  | 10,000 |  |  | $ | 6.80 |  |  |  | 3,300 |  |  | December 2031
May 2022 |  |  | 65,625 |  |  | $ | 5.00 |  |  |  | 32,809 |  |  | May 2032
November 2022 |  |  | 5,000 |  |  | $ | 1.05 |  |  |  | - |  |  | November 2032
|  |  | 534,826 |  |  |  |  |  |  |  | 470,710 |  |  |
Grant date |  | Warrants outstanding as of December 31, 2022 |  |  | Average Exercise price per share ($) |  |  | Warrants exercisable as of December 31, 2022 |  |  | Exercisable through
August 2019 |  |  | 200,596 |  |  | $ | 15.95 |  |  |  | 200,596 |  |  | August 2023
September 2020 |  |  | 17,925 |  |  | $ | 16.00 |  |  |  | 17,925 |  |  | September 2024
April 2022 |  |  | 155,794 |  |  | $ | 5.14 |  |  |  | 155,794 |  |  | April 2029
July 2022 |  |  | 38,948 |  |  | $ | 5.14 |  |  |  | 38,948 |  |  | April 2029
|  |  | 413,263 |  |  |  |  |  |  |  | 413,263 |  |  |
Schedule of relative fair value of the warrants to purchase Ordinary shares issued |
|  | July 19, |  |  | April 26, |
|  | 2022 |  |  | 2022 |
Share price ($) |  |  | 5.12 |  |  |  | 4.96 |
Exercise price ($) |  |  | 5.14 |  |  |  | 5.14 |
Expected volatility (%) |  |  | 60.57 |  |  |  | 60.81 |
Adjustment to risk-free interest rate (%) |  |  | 3.07 |  |  |  | 2.84 |
Dividend yield (%) |  |  | - |  |  |  | - |
Risk-free interest rate (%) |  |  | 3.11 |  |  |  | 2.88 |
Expected life (in years) |  |  | 6.72 |  |  |  | 6.94 |

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