<DOCUMENT>
<TYPE>EX-32.1
<SEQUENCE>4
<FILENAME>globalex321.txt
<DESCRIPTION>SECTION 1350 CERTIFICATION
<TEXT>


Exhibit 32.1

                   Globalwise Investments, Inc.

                 CERTIFICATION OF PERIODIC REPORT
    Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002
                      18 U.S.C. Section 1350

The undersigned officer of Globalwise Investments, Inc. certifies pursuant to
Section 906 of the Sarbanes-Oxley Act of 2002, that:

.      the annual report on Form 10-KSB of the Company for the year ended
       December 31, 2005, fully complies with the requirements of Section
       13(a) or 15(d) of the Securities Exchange Act of 1934; and

.      the information contained in the Form 10-KSB fairly presents, in all
       material respects, the financial condition and results of operations of
       the Company.



Date:  March 24, 2006
                                   /s/ Donald R. Mayer
                                   ____________________________________
                                   Donald R. Mayer
                                   Principal Executive Officer
                                   Principal Financial Officer
</TEXT>
</DOCUMENT>
