<DOCUMENT>
<TYPE>EX-32.1
<SEQUENCE>4
<FILENAME>globalwiseex321.txt
<DESCRIPTION>SECTION 1350 CERTIFICATION
<TEXT>

Exhibit 32.1


                   Globalwise Investments, Inc.

                 CERTIFICATION OF PERIODIC REPORT
    Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002
                      18 U.S.C. Section 1350

The undersigned executive officer of Globalwise Investments, Inc. (the
"Company") certifies pursuant to Section 906 of the Sarbanes-Oxley Act of 2002
that:

.     the quarterly report on Form 10-QSB of the Company for the quarter ended
      March 31, 2006, fully complies with the requirements of Section 13(a) or
      15(d) of the Securities Exchange Act of 1934; and

.     the information contained in the Form 10-QSB fairly presents, in all
      material respects, the financial condition and results of operations of
      the Company.


                                      /s/ Donald R. Mayer
Date: May 10, 2006                    ________________________________
                                      Donald R. Mayer
                                      Principal Executive Officer
                                      Principal Financial Officer


</TEXT>
</DOCUMENT>
