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Schedule of Estimated Values of Stock Option Grants Valuation Assumptions (Details) | 12 Months Ended
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Dec. 31, 2021 | Dec. 31, 2020
April 30, 2015 Grant [Member] |  |
Share-based Compensation Arrangement by Share-based Payment Award [Line Items] |  |
Risk-free interest rate | 1.43% | 1.43%
Weighted average expected term | 5 years | 5 years
Expected volatility | 143.10% | 143.10%
Expected dividend yield | 0.00% | 0.00%
January 1, 2016 Grant [Member] |  |
Share-based Compensation Arrangement by Share-based Payment Award [Line Items] |  |
Risk-free interest rate | 1.76% | 1.76%
Weighted average expected term | 5 years | 5 years
Expected volatility | 134.18% | 134.18%
Expected dividend yield | 0.00% | 0.00%
February 10, 2016 Grant [Member] |  |
Share-based Compensation Arrangement by Share-based Payment Award [Line Items] |  |
Risk-free interest rate | 1.15% | 1.15%
Weighted average expected term | 5 years | 5 years
Expected volatility | 132.97% | 132.97%
Expected dividend yield | 0.00% | 0.00%
December 6, 2016 Grant [Member] |  |
Share-based Compensation Arrangement by Share-based Payment Award [Line Items] |  |
Risk-free interest rate | 1.84% | 1.84%
Weighted average expected term | 5 years | 5 years
Expected volatility | 123.82% | 123.82%
Expected dividend yield | 0.00% | 0.00%
September 25, 2017 Grant [Member] |  |
Share-based Compensation Arrangement by Share-based Payment Award [Line Items] |  |
Risk-free interest rate | 1.85% | 1.85%
Weighted average expected term | 5 years | 5 years
Expected volatility | 130.79% | 130.79%
Expected dividend yield | 0.00% | 0.00%
January 30, 2019 Grant [Member] |  |
Share-based Compensation Arrangement by Share-based Payment Award [Line Items] |  |
Risk-free interest rate | 2.54% | 2.54%
Weighted average expected term | 5 years | 5 years
Expected volatility | 115.80% | 115.80%
Expected dividend yield | 0.00% | 0.00%
March 11, 2019 Grant [Member] |  |
Share-based Compensation Arrangement by Share-based Payment Award [Line Items] |  |
Risk-free interest rate | 2.44% | 2.44%
Weighted average expected term | 5 years | 5 years
Expected volatility | 116.46% | 116.46%
Expected dividend yield | 0.00% | 0.00%
September 2, 2020 Grant [Member] |  |
Share-based Compensation Arrangement by Share-based Payment Award [Line Items] |  |
Risk-free interest rate | 0.26% | 0.26%
Weighted average expected term | 5 years | 5 years
Expected volatility | 121.33% | 121.33%
Expected dividend yield | 0.00% | 0.00%

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- Definition The estimated dividend rate (a percentage of the share price) to be paid (expected dividends) to holders of the underlying shares over the option's term. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (f)(2)(iii) -URI http://asc.fasb.org/extlink&oid=120381028&loc=d3e5070-113901 + Details
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- Definition The estimated measure of the percentage by which a share price is expected to fluctuate during a period. Volatility also may be defined as a probability-weighted measure of the dispersion of returns about the mean. The volatility of a share price is the standard deviation of the continuously compounded rates of return on the share over a specified period. That is the same as the standard deviation of the differences in the natural logarithms of the stock prices plus dividends, if any, over the period. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (f)(2)(ii) -URI http://asc.fasb.org/extlink&oid=120381028&loc=d3e5070-113901 + Details
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- Definition The risk-free interest rate assumption that is used in valuing an option on its own shares. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (f)(2)(iv) -URI http://asc.fasb.org/extlink&oid=120381028&loc=d3e5070-113901 + Details
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- Definition Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table. + References No definition available. + Details
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- Definition Expected term of award under share-based payment arrangement, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents reported fact of one year, five months, and thirteen days. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (f)(2)(i) -URI http://asc.fasb.org/extlink&oid=120381028&loc=d3e5070-113901 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SAB Topic 14.D.2) -URI http://asc.fasb.org/extlink&oid=122041274&loc=d3e301413-122809 + Details
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