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Consolidated Statement of Changes in Stockholders' Equity (Deficit) - USD ($) | Total | Common Stock | Additional Paid-In Capital | Accumulated Deficit
--- | --- | --- | --- | ---
Beginning Balance at Dec. 31, 2012 | $ 1,145,635 | $ 21,392 | $ 56,867,706 | $ (55,743,463)
Beginning Balance, Shares at Dec. 31, 2012 |  | 21,391,665 |  |
Stock-based compensation | 657,812 | $ 265 | 657,547 |
Stock-based compensation, Shares |  | 265,834 |  |
Proceeds from the sale of common stock, net of offering costs | 2,883,257 | $ 554 | 2,882,703 |
Proceeds from the sale of common stock, net of offering costs, Shares |  | 554,310 |  |
Issuance of common stock from exercise of options | 13,053 | $ 17 | 13,036 |
Issuance of common stock from exercise of options, Shares |  | 16,650 |  |
Issuance of common stock from exercise of warrants | 3,467,395 | $ 2,337 | 3,465,058 |
Issuance of common stock from exercise of warrants, Shares |  | 2,336,988 |  |
Transfer of warrant derivatives from liability to equity classification | 1,047,095 |  | $ 1,047,095 |
Net loss | (10,773,792) |  |  | $ (10,773,792)
Ending Balance at Dec. 31, 2013 | (1,559,545) | $ 24,565 | $ 64,933,145 | $ (66,517,255)
Ending Balance, Shares at Dec. 31, 2013 |  | 24,565,447 |  |
Stock-based compensation | 6,280,629 | $ 381 | 6,280,248 |
Stock-based compensation, Shares |  | 379,901 |  |
Proceeds from the sale of common stock, net of offering costs | 15,435,305 | $ 2,380 | 15,432,925 |
Proceeds from the sale of common stock, net of offering costs, Shares |  | 2,379,433 |  |
Issuance of common stock from exercise of options | 275,153 | $ 310 | 274,843 |
Issuance of common stock from exercise of options, Shares |  | 310,400 |  |
Issuance of common stock from exercise of warrants | 159,994 | $ 2,336 | 157,658 |
Issuance of common stock from exercise of warrants, Shares |  | 2,336,658 |  |
Direct costs incurred before shares are issued | (30,000) |  | (30,000) |
Transfer of warrant derivatives from liability to equity classification | 2,203,443 |  | 2,203,443 |
Net loss | (24,687,509) |  |  | $ (24,687,509)
Ending Balance at Dec. 31, 2014 | (1,922,530) | $ 29,972 | 89,252,262 | $ (91,204,764)
Ending Balance, Shares at Dec. 31, 2014 |  | 29,971,839 |  |
Stock-based compensation | 7,061,622 | $ 345 | 7,061,277 |
Stock-based compensation, Shares |  | 344,784 |  |
Proceeds from the sale of common stock, net of offering costs | 37,637,959 | $ 11,994 | 37,625,965 |
Proceeds from the sale of common stock, net of offering costs, Shares |  | 11,993,641 |  |
Issuance of common stock from exercise of options | 15,680 | $ 20 | 15,660 |
Issuance of common stock from exercise of options, Shares |  | 20,000 |  |
Issuance of common stock from exercise of warrants | 157,940 | $ 1,736 | 156,204 |
Issuance of common stock from exercise of warrants, Shares |  | 1,736,277 |  |
Transfer of warrant derivatives from liability to equity classification | 48,691 |  | 48,691 |
Net loss | (21,025,314) |  |  | $ (21,025,314)
Ending Balance at Dec. 31, 2015 | $ 21,974,048 | $ 44,067 | $ 134,160,059 | $ (112,230,078)
Ending Balance, Shares at Dec. 31, 2015 |  | 44,066,541 |  |

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