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Equity (Details Textual) - USD ($) |  |  |  | 1 Months Ended | 12 Months Ended
--- | --- | --- | --- | --- | ---
Jun. 09, 2015 | Feb. 11, 2015 | Jul. 10, 2014 | Dec. 31, 2014 | Jun. 30, 2014 | Mar. 24, 2014 | Jan. 31, 2014 | Dec. 27, 2013 | Sep. 30, 2013 | Dec. 31, 2015 | Dec. 31, 2014 | Dec. 31, 2013
Equity (Textual) |  |  |  |  |  |  |  |  |  |  |  |  |
Fair value assumptions, risk free interest rate | [1] |  |  |  |  |  |  |  |  |  | 1.06% | 1.10% |
Fair value assumptions, expected volatility rate | [2] |  |  |  |  |  |  |  |  |  | 87.00% | 71.00% |
Fair value assumptions, expected term |  |  |  |  |  |  |  |  |  |  | 2 years | 3 years |
Fair value assumptions, expected dividend rate | [3] |  |  |  |  |  |  |  |  |  |  |  |
Proceeds from the exercise of options |  |  |  |  |  |  |  |  |  |  | $ 15,680 | $ 275,153 | $ 13,053
Expense related to common stock granted |  |  |  |  |  |  |  |  |  |  | 3,400,000 | 2,400,000 | 300,000
Unrecognized compensation expense |  |  |  |  | $ 10,200,000 |  |  |  |  |  | 7,200,000 | $ 10,200,000 |
Gross proceeds from public offering |  |  |  |  |  | $ 12,500,000 |  |  |  |  | 15,100,000 |  |
Net proceeds from public offering |  |  |  |  |  |  |  |  |  |  | $ 14,700,000 |  |
Price per share |  |  |  |  |  | $ 7.50 |  |  |  |  | $ 2.52 |  |
Common stock, par value |  |  |  |  | $ 0.001 | $ 0.001 |  |  |  |  | $ 0.001 | $ 0.001 |
Common stock issued, shares |  |  |  |  |  | 1,670,000 |  |  |  |  | 5,626,119 |  |
Proceeds from common stock issued |  |  |  |  |  |  |  |  |  |  | $ 37,637,959 | $ 15,435,305 | 2,883,257
Underwriting discount |  |  |  |  |  |  |  |  | $ 2,900,000 |  |  |  |
Underwriting agreement description |  |  |  |  |  |  |  |  | Investors agreed to purchase (i) an aggregate of 554,310 shares (the “Shares”) of common stock at $6.00 per share and (ii) five-year warrants to purchase an aggregate of 138,577 shares of common stock at an exercise price of $9.00 per share. The Company received $3.3 million in gross proceeds from the sale of securities. |  |  |  |
Registration statement description |  |  |  |  |  |  | This Registration Statement contained two prospectuses: (i) a base prospectus which covers the offering, issuance and sale by the Company of up to $200 million of its common stock, preferred stock, warrants and/or units; and (ii) a sales agreement prospectus covering the offering, issuance and sale by us of up to a maximum aggregate offering price of $75,000,000 of its common stock that may be issued and sold under a sales agreement (the “ Sales Agreement ” ) with MLV & Co. LLC ( “ MLV ” ) dated March 24, 2014. |  |  |  |  |  |
Maximum offering price |  |  |  |  |  |  | 75,000,000 |  |  |  |  |  |
Aggregate offering amount of securities sold to investors |  |  |  |  |  |  | The Company will pay MLV in cash, upon the sale of common stock pursuant to the Sales Agreement, an amount equal to 3.0% of the gross proceeds from the sale of common stock. On April 28, 2014, the Company issued 500 shares and received net proceeds of $6,000 under the Sales Agreement with MLV. |  |  |  |  |  |
Proceeds from the sale of common stock, net of offering costs |  |  |  |  |  |  |  |  |  |  | $ 37,637,959 | 15,435,305 | $ 2,883,257
Fair value of warrants |  |  |  |  |  |  |  |  |  |  |  | $ 2,100,000 |
Investor [Member] |  |  |  |  |  |  |  |  |  |  |  |  |
Equity (Textual) |  |  |  |  |  |  |  |  |  |  |  |  |
Warrants issued to purchase common stock, shares |  |  |  |  |  |  |  |  |  |  |  | 137,952 | 138,577
Price per share |  | $ 2.60 |  |  |  |  |  |  |  |  |  |  |
Proceeds from common stock issued |  | $ 5,000,000 |  |  |  |  |  |  |  |  |  |  |
Proceeds from the sale of common stock, net of offering costs |  | 5,000,000 |  |  |  |  |  |  |  |  |  |  |
Net proceeds from sale of stock |  | $ 4,480,000 |  |  |  |  |  |  |  |  |  |  |
Shares purchased by investors |  | 1,923,078 |  |  |  |  |  |  |  |  |  |  |
Consultant [Member] |  |  |  |  |  |  |  |  |  |  |  |  |
Equity (Textual) |  |  |  |  |  |  |  |  |  |  |  |  |
Fair value assumptions, expected term |  |  |  |  |  |  |  |  |  |  |  | 10 years |
Warrants issued to purchase common stock, shares |  |  |  |  |  |  |  |  |  |  |  | 285,000 |
Consultant [Member] | Minimum [Member] |  |  |  |  |  |  |  |  |  |  |  |  |
Equity (Textual) |  |  |  |  |  |  |  |  |  |  |  |  |
Exercise price of warrants |  |  |  |  | 5.55 |  |  |  |  |  |  | $ 5.55 |
Consultant [Member] | Maximum [Member] |  |  |  |  |  |  |  |  |  |  |  |  |
Equity (Textual) |  |  |  |  |  |  |  |  |  |  |  |  |
Exercise price of warrants |  |  |  |  | 11.66 |  |  |  |  |  |  | 11.66 |
2013 Stock Plan [Member] |  |  |  |  |  |  |  |  |  |  |  |  |
Equity (Textual) |  |  |  |  |  |  |  |  |  |  |  |  |
Number of additional shares authorized |  |  |  |  |  |  |  |  |  |  | 10,750,000 |  |
2013 Stock Plan [Member] | Employees, directors and consultants [Member] |  |  |  |  |  |  |  |  |  |  |  |  |
Equity (Textual) |  |  |  |  |  |  |  |  |  |  |  |  |
Number of stock option granted |  |  |  |  |  |  |  |  |  | 2,750,000 |  |  |
Award expiration date |  |  |  |  |  |  |  |  |  | Sep. 09, 2023 |  |  |
2013 Equity Incentive Plan [Member] |  |  |  |  |  |  |  |  |  |  |  |  |
Equity (Textual) |  |  |  |  |  |  |  |  |  |  |  |  |
Number of additional shares authorized |  |  |  |  |  |  |  |  |  |  |  |  | 1,000,000
2013 Equity Incentive Plan [Member] | Employees, directors and consultants [Member] |  |  |  |  |  |  |  |  |  |  |  |  |
Equity (Textual) |  |  |  |  |  |  |  |  |  |  |  |  |
Number of stock option granted |  |  |  |  |  |  |  |  |  | 450,000 |  |  |
Award expiration date |  |  |  |  |  |  |  |  |  | Sep. 09, 2023 |  |  |
Placement agent [Member] |  |  |  |  |  |  |  |  |  |  |  |  |
Equity (Textual) |  |  |  |  |  |  |  |  |  |  |  |  |
Exercise price of warrants |  |  |  |  |  |  |  |  |  |  | $ 9 |  |
Common stock issued, shares |  |  |  |  |  |  |  |  |  |  |  |  | 69,289
Placement agent cash fees |  |  |  |  |  |  |  | $ 400,000 |  |  |  |  |
Placement agent attorney fees |  |  |  |  |  |  |  | 40,000 |  |  |  |  |
Net proceeds from sale of stock |  |  |  |  |  |  |  | 3,300,000 |  |  |  |  |
Net proceeds from issuance of services |  |  |  |  |  |  |  | 2,900,000 |  |  |  |  |
Warrant [Member] |  |  |  |  |  |  |  |  |  |  |  |  |
Equity (Textual) |  |  |  |  |  |  |  |  |  |  |  |  |
Fair value of warrants determined utilizing the Black-Scholes option pricing model |  |  |  |  |  |  |  | $ 600,000 |  |  |  |  |
Exercise price of warrants |  |  |  |  | $ 9.00 |  |  |  |  |  |  | $ 9.00 |
Fair value assumptions, risk free interest rate |  |  |  |  |  |  |  | 1.64% |  |  |  |  |
Fair value assumptions, expected volatility rate |  |  |  |  |  |  |  | 88.00% |  |  |  |  | 91.56%
Fair value assumptions, expected term |  |  |  |  |  |  |  | 5 years |  |  |  | 5 years | 5 years
Fair value assumptions, expected dividend rate |  |  |  |  |  |  |  | 0.00% |  |  |  | 0.00% | 0.00%
Expense related to common stock granted |  |  |  |  |  |  |  |  |  |  | $ 200,000 | $ 100,000 | $ 200,000
Unrecognized compensation expense |  |  |  |  | $ 1,500,000 |  |  |  |  |  |  | $ 1,500,000 | $ 200,000
Price per share |  |  |  |  | $ 6.00 |  |  |  |  |  |  | $ 6.00 |
Common stock issued, shares |  |  |  |  | 551,810 |  |  |  |  |  |  |  | 122,000
Warrants/ Common stock granted |  |  |  |  | 137,952 |  |  |  |  |  |  |  |
Warrants exercised by warrant holders |  |  |  |  |  |  |  |  |  |  | 2,013,360 | 2,501,993 | 2,403,429
Warrants to purchase common stock vested, shares |  |  |  |  |  |  |  |  |  |  |  |  | 72,000
Warrant to purchase common stock vested, value |  |  |  |  |  |  |  |  |  |  |  |  | $ 200,000
Warrants to purchase common stock expected to vest, shares |  |  |  |  |  |  |  |  |  |  |  |  | 50,000
Warrants to purchase common stock expected to vest, value |  |  |  |  |  |  |  |  |  |  |  |  | $ 200,000
Term of warrants |  |  |  |  |  |  |  | 5 years |  |  |  |  |
Warrant [Member] | Minimum [Member] |  |  |  |  |  |  |  |  |  |  |  |  |
Equity (Textual) |  |  |  |  |  |  |  |  |  |  |  |  |
Exercise price of warrants |  |  |  |  |  |  |  |  |  |  |  |  | $ 3.60
Fair value assumptions, expected volatility rate |  |  |  |  |  |  |  |  |  |  |  | 82.47% |
Fair value assumptions, expected discount rate |  |  |  |  |  |  |  |  |  |  | 1.56% | 1.56% | 1.36%
Term of warrants |  |  |  |  |  |  |  |  |  |  |  |  | 7 years
Warrant [Member] | Maximum [Member] |  |  |  |  |  |  |  |  |  |  |  |  |
Equity (Textual) |  |  |  |  |  |  |  |  |  |  |  |  |
Exercise price of warrants |  |  |  |  |  |  |  |  |  |  |  |  | $ 6.70
Fair value assumptions, expected volatility rate |  |  |  |  |  |  |  |  |  |  |  | 87.76% |
Fair value assumptions, expected discount rate |  |  |  |  |  |  |  |  |  |  | 1.91% | 1.66% | 1.55%
Term of warrants |  |  |  |  |  |  |  |  |  |  |  |  | 10 years
Common Stock [Member] |  |  |  |  |  |  |  |  |  |  |  |  |
Equity (Textual) |  |  |  |  |  |  |  |  |  |  |  |  |
Common stock issued, shares |  |  |  |  |  |  |  |  |  |  | 1,736,277 | 2,336,658 | 2,336,988
Proceeds from common stock issued |  |  |  |  |  |  |  |  |  |  | $ 200,000 | $ 200,000 | $ 3,500,000
Common Stock [Member] | Placement agent [Member] |  |  |  |  |  |  |  |  |  |  |  |  |
Equity (Textual) |  |  |  |  |  |  |  |  |  |  |  |  |
Fair value of warrants determined utilizing the Black-Scholes option pricing model |  |  |  |  |  |  |  | $ 300,000 | $ 400,000 |  |  |  |
Exercise price of warrants |  |  |  |  |  |  |  | $ 9.00 |  |  |  |  |
Fair value assumptions, risk free interest rate |  |  |  |  |  |  |  | 1.64% | 0.07% |  |  |  |
Fair value assumptions, expected volatility rate |  |  |  |  |  |  |  | 88.00% | 84.06% |  |  |  |
Fair value assumptions, expected term |  |  |  |  |  |  |  | 5 years | 5 years |  |  |  |
Fair value assumptions, expected dividend rate |  |  |  |  |  |  |  | 0.00% | 0.00% |  |  |  |
Common stock issued, shares |  |  |  |  |  |  |  | 68,976 |  |  |  |  |
Restricted Stock [Member] |  |  |  |  |  |  |  |  |  |  |  |  |
Equity (Textual) |  |  |  |  |  |  |  |  |  |  |  |  |
Number of shares of restricted stock, granted |  |  |  |  |  |  |  |  |  |  | 344,784 |  |
Expense related to common stock granted |  |  |  |  |  |  |  |  |  |  | $ 3,400,000 | $ 3,700,000 | $ 200,000
Restricted Stock [Member] | Employees, directors and consultants [Member] |  |  |  |  |  |  |  |  |  |  |  |  |
Equity (Textual) |  |  |  |  |  |  |  |  |  |  |  |  |
Number of shares of restricted stock, granted |  |  |  |  |  |  |  |  |  |  | 152,499 | 633,041 | 312,500
Restricted stock granted value |  |  |  |  |  |  |  |  |  |  | $ 800,000 | $ 4,900,000 | $ 700,000
Restricted stock granted not been issued |  |  |  |  |  |  |  |  |  |  |  | 202,497 |
Number of stock option cancelled |  |  |  |  |  |  |  |  |  |  | 126,265 | 50,000 |
Description restricted stock |  |  |  |  |  |  |  |  |  |  |  | Of the total shares of restricted stock granted, 20,000 shares vest 3 months from the grant date, 30,374 shares vest 1 year from the grant date, 30,000 shares have a vesting period of 2 years, 202,497 shares have a vesting period of 4 years and 350,000 shares vest at the date of grant. | 80,000 shares of restricted stock vest 1 year from the grant date, 100,000 shares have a vesting period of 24 months. The remaining restricted shares granted are performance based and vest over time.
Restricted Stock [Member] | Consultant [Member] |  |  |  |  |  |  |  |  |  |  |  |  |
Equity (Textual) |  |  |  |  |  |  |  |  |  |  |  |  |
Number of shares of restricted stock, granted |  |  |  |  |  |  |  |  |  |  | 479,651 |  |
Restricted stock granted value |  |  |  |  |  |  |  |  |  |  | $ 2,300,000 |  |
Restricted stock granted not been issued |  |  |  |  |  |  |  |  |  |  | 329,651 |  |
Description restricted stock |  |  |  |  |  |  |  |  |  |  | Of the 479,651 restricted share awards granted in 2015, 329,651 shares vested at the date of grant and 150,000 shares vest over a six-month period. |  |
Public Offering [Member] |  |  |  |  |  |  |  |  |  |  |  |  |
Equity (Textual) |  |  |  |  |  |  |  |  |  |  |  |  |
Exercise price of warrants |  |  | $ 6.50 |  |  |  |  |  |  |  |  |  |
Fair value assumptions, expected volatility rate |  |  | 72.00% |  |  |  |  |  |  |  |  |  |
Fair value assumptions, expected term |  |  | 4 years |  |  |  |  |  |  |  |  |  |
Fair value assumptions, expected dividend rate |  |  | 0.00% |  |  |  |  |  |  |  |  |  |
Fair value assumptions, expected discount rate |  |  | 1.26% |  |  |  |  |  |  |  |  |  |
Warrants issued to purchase common stock, shares |  |  | 3,333,333 |  |  |  |  |  |  |  |  |  |
Number of additional stock option granted |  |  |  | 157,123 |  |  |  |  |  |  |  |  |
Proceeds from the exercise of options |  |  |  | $ 1,200,000 |  |  |  |  |  |  |  |  |
Gross proceeds from public offering |  |  | $ 20,000,000 | 13,700,000 |  |  |  |  |  |  |  |  |
Net proceeds from public offering |  |  | $ 18,500,000 | $ 12,600,000 |  | $ 11,500,000 |  |  |  |  |  |  |
Price per share |  | $ 2.60 | $ 4.50 | $ 7.50 |  |  |  |  |  |  |  |  |
Common stock issued, shares |  |  | 4,444,444 | 1,827,123 |  |  |  |  |  |  |  |  |
Underwriting discount |  |  |  | $ 12,600,000 |  | $ 900,000 |  |  |  |  |  |  |
Underwriting agreement description |  |  | In addition, the Company granted the underwriters a 30-day option to purchase up to an additional 666,666 shares of common stock and warrants to purchase 499,999 shares of common stock solely to cover over-allotments, if any. The underwriter did not exercise the over-allotment option. |  |  | Under the terms of the underwriting agreement, the Company also granted the underwriters a 30-day option to purchase up to an additional 250,000 shares of common stock to cover over-allotments, if any, at the offering price. |  |  |  |  |  |  |
Warrants/ Common stock granted |  |  | 666,666 |  |  |  |  |  |  |  |  |  |
Other offering expenses |  |  |  |  |  | $ 100,000 |  |  |  |  |  |  |
Auditor fees |  |  |  |  |  | $ 100,000 |  |  |  |  |  |  |
Fair value of warrants |  |  | $ 3,500,000 |  |  |  |  |  |  |  |  |  |
Warrant One [Member] |  |  |  |  |  |  |  |  |  |  |  |  |
Equity (Textual) |  |  |  |  |  |  |  |  |  |  |  |  |
Common shares issued for cashless exercise of warrants |  |  |  |  |  |  |  |  |  |  | 1,532,124 | 2,162,181 | 235,158
Additional common stock issued for exercise of options and warrants |  |  |  |  |  |  |  |  |  |  | 224,153 | 484,877 | 2,118,480
Proceeds from stock options and warrants exercised |  |  |  |  |  |  |  |  |  |  | $ 173,620 | $ 435,147 | $ 3,480,448
Stock Option Plan [Member] |  |  |  |  |  |  |  |  |  |  |  |  |
Equity (Textual) |  |  |  |  |  |  |  |  |  |  |  |  |
Fair value of warrants determined utilizing the Black-Scholes option pricing model |  |  |  |  |  |  |  |  |  |  |  |  |
Fair value assumptions, expected term |  |  |  |  |  |  |  |  |  |  | 6 years | 6 years | 6 years
Fair value assumptions, expected dividend rate |  |  |  |  |  |  |  |  |  |  | 0.00% | 0.00% | 0.00%
Number of stock option granted |  |  |  |  |  |  |  |  |  |  | 1,554,499 | 1,338,100 | 787,450
Number of stock option cancelled |  |  |  |  |  |  |  |  |  |  | 576,000 |  | 1,115,550
Share-based compensation term |  |  |  |  |  |  |  |  |  |  | 10 years | 10 years | 10 years
Share-based Compensation vesting period |  |  |  |  |  |  |  |  |  |  |  | 4 years | 4 years
Fair value of stock option |  |  |  |  |  |  |  |  |  |  | $ 3,200,000 | $ 8,700,000 | $ 3,700,000
Stock option exercise prices |  |  |  |  |  |  |  |  |  |  | $ 0.78 | $ 0.95 | $ 0.78
Proceeds from the exercise of options |  |  |  |  |  |  |  |  |  |  | $ 15,680 | $ 275,153 | $ 13,053
Number of option exercised |  |  |  |  |  |  |  |  |  |  | 20,000 | 310,400 | 16,650
Warrants/ Common stock granted |  |  |  |  |  |  |  |  |  |  |  |  | 787,450
Stock Option Plan [Member] | Minimum [Member] |  |  |  |  |  |  |  |  |  |  |  |  |
Equity (Textual) |  |  |  |  |  |  |  |  |  |  |  |  |
Exercise price of warrants |  |  |  |  |  |  |  |  |  |  |  |  | $ 3.60
Fair value assumptions, expected volatility rate |  |  |  |  |  |  |  |  |  |  | 85.01% | 82.47% | 83.32%
Fair value assumptions, expected discount rate |  |  |  |  |  |  |  |  |  |  | 1.69% | 1.77% | 1.36%
Share-based Compensation vesting period |  |  |  |  |  |  |  |  |  |  | 1 year |  |
Stock option exercise prices |  |  |  |  |  |  |  |  |  |  | $ 1.79 | $ 0.78 |
Stock Option Plan [Member] | Maximum [Member] |  |  |  |  |  |  |  |  |  |  |  |  |
Equity (Textual) |  |  |  |  |  |  |  |  |  |  |  |  |
Exercise price of warrants |  |  |  |  |  |  |  |  |  |  |  |  | $ 6.70
Fair value assumptions, expected volatility rate |  |  |  |  |  |  |  |  |  |  | 94.89% | 87.76% | 98.45%
Fair value assumptions, expected discount rate |  |  |  |  |  |  |  |  |  |  | 1.91% | 2.07% | 1.55%
Share-based Compensation vesting period |  |  |  |  |  |  |  |  |  |  | 4 years 2 months 1 day |  |
Stock option exercise prices |  |  |  |  |  |  |  |  |  |  | $ 3.58 | $ 11.95 |
[1] | The risk-free interest rate was determined by management using the Treasury Bill rate as of the respective measurement date.
[2] | As of December 31, 2015, the volatility was estimated using the historical volatilities of the Company's common stock traded in NYSE MKT market. As of December 31, 2014, the volatility was estimated using the historical volatilities of comparable companies in the same industry and region.
[3] | Management determined the dividend yield to be 0% based upon its expectation that it will not pay dividends for the foreseeable future.

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