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Equity (Details Textual) - USD ($) |  |  |  |  |  |  |  | 1 Months Ended | 12 Months Ended
--- | --- | --- | --- | --- | --- | --- | --- | --- | ---
Oct. 04, 2016 | Jun. 09, 2015 | Feb. 11, 2015 | Jul. 10, 2014 | Jun. 30, 2014 | Mar. 24, 2014 | Sep. 30, 2013 | Jan. 31, 2014 | Dec. 31, 2016 | Dec. 31, 2015 | Dec. 31, 2014 | Dec. 31, 2013
Equity (Textual) |  |  |  |  |  |  |  |  |  |  |  |  |
Common stock, par value |  |  |  |  |  |  |  |  |  | $ 0.001 | $ 0.001 |  |
Fair value assumptions, expected volatility rate | [1] |  |  |  |  |  |  |  |  |  | 87.00% |  |
Fair value assumptions, expected term |  |  |  |  |  |  |  |  |  | 2 years | 2 years |  |
Fair value assumptions, expected dividend rate | [2] |  |  |  |  |  |  |  |  |  |  |  |
Fair value assumptions, expected risk free interest rate | [3] |  |  |  |  |  |  |  |  | 0.85% | 1.06% |  |
Stock-based compensation |  |  |  |  |  |  |  |  |  | $ 4,297,778 | $ 7,061,622 | $ 6,280,629 |
Price per share |  |  |  |  |  |  |  |  |  | $ 1.96 | $ 2.52 |  |
Registration statement description |  |  |  |  |  |  | This Registration Statement contained two prospectuses: (i) a base prospectus which covers the offering, issuance and sale by the Company of up to $200 million of its common stock, preferred stock, warrants and/or units; and (ii) a sales agreement prospectus covering the offering, issuance and sale by us of up to a maximum aggregate offering price of $75,000,000 of its common stock that may be issued and sold under a sales agreement (the " Sales Agreement " ) with MLV & Co. LLC ( " MLV " ) dated March 24, 2014. |  |  |  |  |  |
Aggregate offering amount of securities sold to investors |  |  |  |  |  |  | The Company will pay MLV in cash, upon the sale of common stock pursuant to the Sales Agreement, an amount equal to 3.0% of the gross proceeds from the sale of common stock. On April 28, 2014, the Company issued 500 shares and received net proceeds of $6,000 under the Sales Agreement with MLV. |  |  |  |  |  |
Gross proceeds from public offering |  |  |  |  |  |  |  |  |  | $ 7,000,000 | $ 15,100,000 |  |
Maximum offering price |  |  |  |  |  |  | $ 75,000,000 |  |  |  |  |  |
Net proceeds from public offering |  |  |  |  |  |  |  |  |  | $ 6,800,000 | $ 14,700,000 |  |
Number of common shares issued |  |  |  |  |  |  |  |  |  | 3,504,427 | 5,626,119 |  |
Proceeds from the exercise of options |  |  |  |  |  |  |  |  |  | $ 18,105 | $ 15,680 | $ 275,153 |
2013 Stock Plan [Member] |  |  |  |  |  |  |  |  |  |  |  |  |
Equity (Textual) |  |  |  |  |  |  |  |  |  |  |  |  |
Number of additional shares authorized |  |  |  |  |  |  |  |  |  | 12,750,000 | 9,250,000 |  |
2013 Equity Incentive Plan [Member] |  |  |  |  |  |  |  |  |  |  |  |  |
Equity (Textual) |  |  |  |  |  |  |  |  |  |  |  |  |
Number of additional shares authorized |  |  |  |  |  |  |  |  |  |  |  |  | 1,000,000
Placement agent [Member] |  |  |  |  |  |  |  |  |  |  |  |  |
Equity (Textual) |  |  |  |  |  |  |  |  |  |  |  |  |
Exercise price |  |  |  |  |  |  |  |  |  |  |  | $ 9 |
Placement agent cash fees |  |  |  |  |  |  |  |  | $ 400,000 |  |  |  |
Placement agent attorney fees |  |  |  |  |  |  |  |  | 40,000 |  |  |  |
Net proceeds from sale of stock |  |  |  |  |  |  |  |  | 3,300,000 |  |  |  |
Net proceeds from issuance of services |  |  |  |  |  |  |  |  | $ 2,900,000 |  |  |  |
Minimum [Member] |  |  |  |  |  |  |  |  |  |  |  |  |
Equity (Textual) |  |  |  |  |  |  |  |  |  |  |  |  |
Fair value assumptions, expected volatility rate | [1] |  |  |  |  |  |  |  |  | 61.00% |  |  |
Maximum [Member] |  |  |  |  |  |  |  |  |  |  |  |  |
Equity (Textual) |  |  |  |  |  |  |  |  |  |  |  |  |
Fair value assumptions, expected volatility rate | [1] |  |  |  |  |  |  |  |  | 69.00% |  |  |
Investor [Member] |  |  |  |  |  |  |  |  |  |  |  |  |
Equity (Textual) |  |  |  |  |  |  |  |  |  |  |  |  |
Proceeds from common stock issued |  |  | $ 5,000,000 |  |  |  |  |  |  |  |  |  |
Net proceeds from sale of stock |  |  | $ 4,480,000 |  |  |  |  |  |  |  |  |  |
Price per share |  |  | $ 2.60 |  |  |  |  |  |  |  |  |  |
Number of common shares issued |  |  | 1,923,078 |  |  |  |  |  |  |  |  |  |
Employees, directors and consultants [Member] | 2013 Stock Plan [Member] |  |  |  |  |  |  |  |  |  |  |  |  |
Equity (Textual) |  |  |  |  |  |  |  |  |  |  |  |  |
Number of stock option granted |  |  |  |  |  |  |  | 2,750,000 |  |  |  |  |
Award expiration date |  |  |  |  |  |  |  | Sep. 09, 2023 |  |  |  |  |
Employees, directors and consultants [Member] | 2013 Equity Incentive Plan [Member] |  |  |  |  |  |  |  |  |  |  |  |  |
Equity (Textual) |  |  |  |  |  |  |  |  |  |  |  |  |
Number of stock option granted |  |  |  |  |  |  |  | 450,000 |  |  |  |  |
Award expiration date |  |  |  |  |  |  |  | Sep. 09, 2023 |  |  |  |  |
Stock Options [Member] |  |  |  |  |  |  |  |  |  |  |  |  |
Equity (Textual) |  |  |  |  |  |  |  |  |  |  |  |  |
Stock based compensation expense |  |  |  |  |  |  |  |  |  | $ 3,600,000 | $ 3,400,000 | $ 2,400,000 |
Number of stock option granted |  |  |  |  |  |  |  |  |  | 2,225,000 | 1,554,499 | 1,338,100 |
Stock option exercise prices |  |  |  |  |  |  |  |  |  | $ 0.78 | $ 0.78 | $ 0.95 |
Unrecognized compensation expense |  |  |  |  |  |  |  |  |  | $ 6,700,000 | $ 7,200,000 |  |
Proceeds from the exercise of options |  |  |  |  |  |  |  |  |  | $ 18,105,000 | $ 15,680,000 | $ 300,000 |
Number of stock option cancelled |  |  |  |  |  |  |  |  |  | 266,485 | 576,000 |  |
Number of stock exercised |  |  |  |  |  |  |  |  |  | 23,212 | 20,000 | 310,400 |
Stock Options [Member] | Employees, directors and consultants [Member] |  |  |  |  |  |  |  |  |  |  |  |  |
Equity (Textual) |  |  |  |  |  |  |  |  |  |  |  |  |
Number of stock option granted |  |  |  |  |  |  |  |  |  | 2,225,000 | 1,554,499 |  |
Share-based compensation term |  |  |  |  |  |  |  |  |  | 10 years | 10 years | 10 years |
Share-based compensation vesting period |  |  |  |  |  |  |  |  |  | 4 years |  | 4 years |
Stock option exercise prices |  |  |  |  |  |  |  |  |  |  |  | $ 0.78 |
Fair value assumptions, expected term |  |  |  |  |  |  |  |  |  | 6 years | 6 years | 6 years |
Fair value assumptions, expected dividend rate |  |  |  |  |  |  |  |  |  | 0.00% | 0.00% | 0.00% |
Fair value of warrants determined utilizing the Black-Scholes option pricing model |  |  |  |  |  |  |  |  |  | $ 3,100,000 | $ 3,200,000 | $ 8,700,000 |
Stock Options [Member] | Employees, directors and consultants [Member] | Minimum [Member] |  |  |  |  |  |  |  |  |  |  |  |  |
Equity (Textual) |  |  |  |  |  |  |  |  |  |  |  |  |
Exercise price |  |  |  |  |  |  |  |  |  | $ 1.79 | $ 1.79 | $ 0.78 |
Share-based compensation vesting period |  |  |  |  |  |  |  |  |  |  | 1 year |  |
Fair value assumptions, expected discount rate |  |  |  |  |  |  |  |  |  | 1.28% | 1.56% | 1.77% |
Fair value assumptions, expected volatility rate |  |  |  |  |  |  |  |  |  | 81.45% | 85.01% | 82.47% |
Stock Options [Member] | Employees, directors and consultants [Member] | Maximum [Member] |  |  |  |  |  |  |  |  |  |  |  |  |
Equity (Textual) |  |  |  |  |  |  |  |  |  |  |  |  |
Exercise price |  |  |  |  |  |  |  |  |  | $ 3.58 | $ 3.58 | $ 11.95 |
Share-based compensation vesting period |  |  |  |  |  |  |  |  |  |  | 4 years 2 months 1 day |  |
Fair value assumptions, expected discount rate |  |  |  |  |  |  |  |  |  | 1.97% | 1.91% | 2.07% |
Fair value assumptions, expected volatility rate |  |  |  |  |  |  |  |  |  | 87.95% | 94.89% | 87.76% |
Common Stock [Member] |  |  |  |  |  |  |  |  |  |  |  |  |
Equity (Textual) |  |  |  |  |  |  |  |  |  |  |  |  |
Common stock issued, shares |  |  |  |  |  |  |  |  |  | 3,504,493 |  |  |
Proceeds from common stock issued |  |  |  |  |  |  |  |  |  | $ 6,800,000 |  |  |
Common Stock [Member] | Placement agent [Member] |  |  |  |  |  |  |  |  |  |  |  |  |
Equity (Textual) |  |  |  |  |  |  |  |  |  |  |  |  |
Common stock issued, shares |  |  |  |  |  |  |  |  | 68,976 |  |  |  |
Exercise price |  |  |  |  |  |  |  |  | $ 9.00 |  |  |  |
Fair value assumptions, expected volatility rate |  |  |  |  |  |  |  |  | 88.00% |  |  |  |
Fair value assumptions, expected term |  |  |  |  |  |  |  |  | 5 years |  |  |  |
Fair value assumptions, expected dividend rate |  |  |  |  |  |  |  |  | 0.00% |  |  |  |
Fair value assumptions, expected risk free interest rate |  |  |  |  |  |  |  |  | 1.64% |  |  |  |
Fair value of warrants determined utilizing the Black-Scholes option pricing model |  |  |  |  |  |  |  |  | $ 300,000 |  |  |  |
Warrant [Member] |  |  |  |  |  |  |  |  |  |  |  |  |
Equity (Textual) |  |  |  |  |  |  |  |  |  |  |  |  |
Common stock issued, shares |  |  |  |  |  |  |  |  |  | 125,862 |  | 551,810 |
Proceeds from common stock issued |  |  |  | $ 200,000 |  |  |  |  |  |  |  | $ 200,000 |
Stock based compensation expense |  |  |  |  |  |  |  |  |  | $ 100,000 | $ 200,000 | $ 100,000 |
Number of stock option granted |  |  |  |  |  |  |  |  |  | 45,000 |  |  |
Exercise price |  |  |  | $ 6.50 |  |  |  |  |  | $ 1.77 |  | $ 9.00 |
Share-based compensation term |  |  |  | 4 years |  |  |  |  |  |  |  |  |
Fair value of stock option |  |  |  | $ 3,500,000 |  |  |  |  |  |  |  |  |
Fair value assumptions, expected discount rate |  |  |  | 1.26% |  |  |  |  |  |  |  |  |
Fair value assumptions, expected volatility rate |  |  |  | 72.00% |  |  |  |  | 88.00% |  |  |  |
Fair value assumptions, expected term |  |  |  | 4 years |  |  |  |  | 5 years |  |  |  |
Fair value assumptions, expected dividend rate |  |  |  | 0.00% |  |  |  |  | 0.00% |  |  |  |
Fair value assumptions, expected risk free interest rate |  |  |  |  |  |  |  |  | 1.64% |  |  |  |
Stock-based compensation |  |  |  |  |  |  |  |  |  | $ 100,000 | $ 200,000 | $ 100,000 |
Price per share |  |  |  | $ 4.50 |  |  |  |  |  |  |  | $ 6.00 |
Warrants/ Common stock granted |  |  |  |  |  |  |  |  |  |  |  | 137,952 |
Fair value of warrants determined utilizing the Black-Scholes option pricing model |  |  |  |  |  |  |  |  | $ 600,000 |  |  |  |
Number of common shares issued |  |  |  | 1,736,277 |  |  |  |  |  | 125,862 |  | 2,336,658 |
Warrants issued to purchase common stock, shares |  |  |  | 3,333,333 |  |  |  |  |  |  |  |  |
Common shares issued for cashless exercise of warrants |  |  |  |  |  |  |  |  |  | 125,862 | 1,532,124 | 2,162,181 |
Additional common stock issued for exercise of options and warrants |  |  |  |  |  |  |  |  |  | 23,212 | 224,153 | 484,877 |
Proceeds from stock options and warrants exercised |  |  |  |  |  |  |  |  |  | $ 18,105 | $ 173,620 | $ 435,147 |
Number of stock exercised |  |  |  | 2,013,360 |  |  |  |  |  | 183,718 |  | 2,501,993 |
Underwritten offering shares of common stock |  |  |  | 4,444,444 |  |  |  |  |  |  |  |  |
Warrant [Member] | Placement agent [Member] |  |  |  |  |  |  |  |  |  |  |  |  |
Equity (Textual) |  |  |  |  |  |  |  |  |  |  |  |  |
Fair value assumptions, expected volatility rate |  |  |  |  |  |  |  |  |  |  |  | 88.00% |
Fair value assumptions, expected term |  |  |  |  |  |  |  |  |  |  |  | 5 years |
Fair value assumptions, expected dividend rate |  |  |  |  |  |  |  |  |  |  |  | 0.00% |
Fair value assumptions, expected risk free interest rate |  |  |  |  |  |  |  |  |  |  |  | 1.64% |
Warrants issued to purchase common stock, shares |  |  |  |  |  |  |  |  |  |  |  | 68,976 |
Warrant [Member] | Minimum [Member] |  |  |  |  |  |  |  |  |  |  |  |  |
Equity (Textual) |  |  |  |  |  |  |  |  |  |  |  |  |
Exercise price |  |  |  |  |  |  |  |  |  | $ 1.35 |  |  |
Warrant [Member] | Maximum [Member] |  |  |  |  |  |  |  |  |  |  |  |  |
Equity (Textual) |  |  |  |  |  |  |  |  |  |  |  |  |
Exercise price |  |  |  |  |  |  |  |  |  | $ 1.77 |  |  |
Warrant [Member] | Consultant [Member] |  |  |  |  |  |  |  |  |  |  |  |  |
Equity (Textual) |  |  |  |  |  |  |  |  |  |  |  |  |
Share-based compensation term |  |  |  |  |  |  |  |  |  |  |  | 10 years |
Fair value assumptions, expected term |  |  |  |  |  |  |  |  |  |  |  | 5 years |
Fair value assumptions, expected dividend rate |  |  |  |  |  |  |  |  |  | 0.00% |  | 0.00% |
Unrecognized compensation expense |  |  |  |  |  |  |  |  |  |  |  | $ 1,500,000 |
Warrants/ Common stock granted |  |  |  |  |  |  |  |  |  | 130,000 |  |  |
Warrants issued to purchase common stock, shares |  |  |  |  |  |  |  |  |  |  |  | 285,000 |
Fair value of warrants |  |  |  |  |  |  |  |  |  |  |  | $ 2,100,000 |
Warrant [Member] | Consultant [Member] | Minimum [Member] |  |  |  |  |  |  |  |  |  |  |  |  |
Equity (Textual) |  |  |  |  |  |  |  |  |  |  |  |  |
Exercise price |  |  |  |  |  |  |  |  |  | $ 0.98 |  |  |
Share-based compensation term |  |  |  |  |  |  |  |  |  | 5 years |  |  |
Fair value of stock option |  |  |  |  |  |  |  |  |  | $ 116,000 |  |  |
Fair value assumptions, expected discount rate |  |  |  |  |  |  |  |  |  | 1.13% |  | 1.56% |
Fair value assumptions, expected volatility rate |  |  |  |  |  |  |  |  |  | 79.79% |  | 82.47% |
Fair value assumptions, expected term |  |  |  |  |  |  |  |  |  | 5 years |  |  |
Warrant [Member] | Consultant [Member] | Maximum [Member] |  |  |  |  |  |  |  |  |  |  |  |  |
Equity (Textual) |  |  |  |  |  |  |  |  |  |  |  |  |
Exercise price |  |  |  |  |  |  |  |  |  | $ 1.77 |  |  |
Share-based compensation term |  |  |  |  |  |  |  |  |  | 10 years |  |  |
Fair value assumptions, expected discount rate |  |  |  |  |  |  |  |  |  | 1.20% |  | 1.66% |
Fair value assumptions, expected volatility rate |  |  |  |  |  |  |  |  |  | 84.84% |  | 87.76% |
Fair value assumptions, expected term |  |  |  |  |  |  |  |  |  | 10 years |  |  |
Warrant [Member] | Investor [Member] |  |  |  |  |  |  |  |  |  |  |  |  |
Equity (Textual) |  |  |  |  |  |  |  |  |  |  |  |  |
Warrants issued to purchase common stock, shares |  |  |  |  |  |  |  |  |  |  |  | 137,952 |
Restricted Stock [Member] |  |  |  |  |  |  |  |  |  |  |  |  |
Equity (Textual) |  |  |  |  |  |  |  |  |  |  |  |  |
Number of shares of restricted stock, granted |  |  |  |  |  |  |  |  |  | 60,700 |  |  |
Stock based compensation expense |  |  |  |  |  |  |  |  |  | $ 600,000 | $ 3,400,000 | $ 3,700,000 |
Number of shares of restricted stock for prior years, granted |  |  |  |  |  |  |  |  |  | 21,000 |  |  |
Restricted Stock [Member] | Consultant [Member] |  |  |  |  |  |  |  |  |  |  |  |  |
Equity (Textual) |  |  |  |  |  |  |  |  |  |  |  |  |
Number of shares of restricted stock, granted |  |  |  |  |  |  |  |  |  | 250,700 | 479,651 |  |
Restricted stock granted value |  |  |  |  |  |  |  |  |  | $ 400,000 | $ 2,300,000 |  |
Restricted stock granted not been issued |  |  |  |  |  |  |  |  |  | 60,700 | 329,651 |  |
Description restricted stock |  |  |  |  |  |  |  |  |  | Of the 250,700 restricted share awards granted in 2016, 60,700 shares vested at the date of grant, 150,000 shares vest over a six-month period and 40,000 shares vest over 2 years. | Of the 479,651 restricted share awards granted in 2015, 329,651 shares vested at the date of grant and 150,000 shares vest over a six-month period. |  |
Restricted Stock [Member] | Employees, directors and consultants [Member] |  |  |  |  |  |  |  |  |  |  |  |  |
Equity (Textual) |  |  |  |  |  |  |  |  |  |  |  |  |
Number of shares of restricted stock, granted |  |  |  |  |  |  |  |  |  |  | 152,499 | 633,041 |
Restricted stock granted value |  |  |  |  |  |  |  |  |  |  | $ 800,000 | $ 4,900,000 |
Restricted stock granted not been issued |  |  |  |  |  |  |  |  |  |  |  | 202,497 |
Number of stock option cancelled |  |  |  |  |  |  |  |  |  |  | 126,265 | 50,000 |
Description restricted stock |  |  |  |  |  |  |  |  |  |  |  | Of the total shares of restricted stock granted, 20,000 shares vest 3 months from the grant date, 30,374 shares vest 1 year from the grant date, 30,000 shares have a vesting period of 2 years, 202,497 shares have a vesting period of 4 years and 350,000 shares vest at the date of grant. |
Public offering [Member] |  |  |  |  |  |  |  |  |  |  |  |  |
Equity (Textual) |  |  |  |  |  |  |  |  |  |  |  |  |
Common stock issued, shares |  |  |  | 4,444,444 | 1,827,123 | 1,670,000 |  |  |  |  |  |  |
Common stock, par value |  |  |  |  |  | $ 0.001 |  |  |  |  |  |  |
Exercise price |  |  |  | $ 6.50 |  |  |  |  |  |  |  |  |
Fair value assumptions, expected term |  |  |  | 4 years |  |  |  |  |  |  |  |  |
Price per share |  | $ 1.25 |  | $ 4.50 | $ 7.50 | $ 7.50 |  |  |  |  |  |  |
Gross proceeds from public offering |  |  |  | $ 20,000,000 | $ 13,700,000 | $ 12,500,000 |  |  |  |  |  |  |
Net proceeds from public offering |  |  |  | $ 18,500,000 | 12,600,000 | 11,500,000 |  |  |  |  |  |  |
Number of common shares issued |  | 8,000,000 |  |  |  |  |  |  |  |  |  |  |
Underwriting discount |  |  |  |  |  | $ 900,000 |  |  |  |  |  |  |
Underwriting agreement description |  |  |  |  |  | Under the terms of the underwriting agreement, the Company also granted the underwriters a 30-day option to purchase up to an additional 250,000 shares of common stock to cover over-allotments, if any, at the offering price. |  |  |  |  |  |  |
Other offering expenses |  |  |  |  |  | $ 100,000 |  |  |  |  |  |  |
Auditor fees |  |  |  |  |  | $ 100,000 |  |  |  |  |  |  |
Proceeds from the exercise of options |  |  |  |  | $ 1,200,000 |  |  |  |  |  |  |  |
Number of additional stock option granted |  |  |  |  | 157,123 |  |  |  |  |  |  |  |
Warrants issued to purchase common stock, shares |  |  |  | 3,333,333 |  |  |  |  |  |  |  |  |
Fair value of warrants |  |  |  | $ 3,540,659 |  |  |  |  |  |  |  |  |
[1] | The volatility was estimated using the historical volatilities of the Company's common stock traded in NYSE MKT market.
[2] | Management determined the dividend yield to be 0% based upon its expectation that it will not pay dividends for the foreseeable future.
[3] | The risk-free interest rate was determined by management using the Treasury Bill rate as of the respective measurement date.

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