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Consolidated Statement of Changes in Stockholders' Equity (Deficit) - USD ($) | Total | Common Stock | Additional Paid-In Capital | Accumulated Deficit
--- | --- | --- | --- | ---
Beginning Balance at Dec. 31, 2013 | $ (1,559,545) | $ 24,565 | $ 64,933,145 | $ (66,517,255)
Beginning Balance, Shares at Dec. 31, 2013 |  | 24,565,447 |  |
Stock-based compensation | 6,280,629 | $ 381 | 6,280,248 |
Stock-based compensation, Shares |  | 379,901 |  |
Proceeds from the sale of common stock, net of offering costs | 15,435,305 | $ 2,380 | 15,432,925 |
Proceeds from the sale of common stock, net of offering costs, Shares |  | 2,379,433 |  |
Proceeds from the sale of common stock and warrants, net of offering costs |  |  |  |
Issuance of common stock from exercise of options | 275,153 | $ 310 | 274,843 |
Issuance of common stock from exercise of options, Shares |  | 310,400 |  |
Issuance of common stock from exercise of warrants | 159,994 | $ 2,336 | 157,658 |
Issuance of common stock from exercise of warrants, Shares |  | 2,336,658 |  |
Direct costs incurred before shares are issued | (30,000) |  | (30,000) |
Transfer of warrant derivatives from liability to equity classification | 2,203,443 |  | 2,203,443 |
Net loss | (24,687,509) |  |  | (24,687,509)
Ending Balance at Dec. 31, 2014 | (1,922,530) | $ 29,972 | 89,252,262 | (91,204,764)
Ending Balance, Shares at Dec. 31, 2014 |  | 29,971,839 |  |
Stock-based compensation | 7,061,622 | $ 345 | 7,061,277 |
Stock-based compensation, Shares |  | 344,784 |  |
Proceeds from the sale of common stock, net of offering costs |  |  |  |
Proceeds from the sale of common stock and warrants, net of offering costs | 37,637,959 | $ 11,994 | 37,625,965 |
Proceeds from the sale of common stock and warrants, net of offering costs, Shares |  | 11,993,641 |  |
Issuance of common stock from exercise of options | 15,680 | $ 20 | 15,660 |
Issuance of common stock from exercise of options, Shares |  | 20,000 |  |
Issuance of common stock from exercise of warrants | 157,940 | $ 1,736 | 156,204 |
Issuance of common stock from exercise of warrants, Shares |  | 1,736,277 |  |
Direct costs incurred before shares are issued |  |  |  |
Transfer of warrant derivatives from liability to equity classification | 48,691 |  | 48,691 |
Net loss | (21,025,314) |  |  | (21,025,314)
Ending Balance at Dec. 31, 2015 | 21,974,048 | $ 44,067 | 134,160,059 | (112,230,078)
Ending Balance, Shares at Dec. 31, 2015 |  | 44,066,541 |  |
Stock-based compensation | 4,297,778 | $ 82 | 4,297,696 |
Stock-based compensation, Shares |  | 81,700 |  |
Proceeds from the sale of common stock, net of offering costs |  |  |  |
Proceeds from the sale of common stock and warrants, net of offering costs | 16,022,667 | $ 11,504 | 16,011,163 |
Proceeds from the sale of common stock and warrants, net of offering costs, Shares |  | 11,504,427 |  |
Issuance of common stock from exercise of options | 18,105 | $ 23 | 18,082 |
Issuance of common stock from exercise of options, Shares |  | 23,212 |  |
Issuance of common stock from exercise of warrants |  | $ 126 | (126) |
Issuance of common stock from exercise of warrants, Shares |  | 125,862 |  |
Direct costs incurred before shares are issued |  |  |  |
Transfer of warrant derivatives from liability to equity classification | 17,455 |  | 17,455 |
Net loss | (24,321,724) |  |  | (24,321,724)
Ending Balance at Dec. 31, 2016 | $ 18,008,329 | $ 55,802 | $ 154,504,329 | $ (136,551,802)
Ending Balance, Shares at Dec. 31, 2016 |  | 55,801,742 |  |

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