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Income Taxes (Details) - USD ($) | Dec. 31, 2017 | Dec. 31, 2016
--- | --- | ---
Deferred tax assets: |  |
Net operating losses carry forward | $ 30,826,534 | $ 38,874,255
Share-based compensation | 3,731,413 | 8,081,711
Research & Development/Orphan Drug Credits | 6,324,998 | 830,085
Others | 11,369 | 16,329
Less: valuation allowance | (40,894,314) | (47,802,380)
Deferred tax assets, net | $ 0 | $ 0

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