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Equity (Details Textual) - USD ($) |  |  |  |  |  |  |  | 1 Months Ended | 12 Months Ended
--- | --- | --- | --- | --- | --- | --- | --- | --- | ---
Aug. 02, 2017 | Jun. 06, 2017 | Mar. 14, 2017 | Oct. 04, 2016 | Jun. 09, 2015 | Feb. 11, 2015 | Jan. 31, 2012 | Dec. 21, 2015 | Feb. 11, 2015 | Dec. 31, 2013 | Sep. 30, 2013 | Dec. 31, 2017 | Dec. 31, 2016 | Dec. 31, 2015
Equity (Textual) |  |  |  |  |  |  |  |  |  |  |  |  |  |
Net proceeds from issuance of shares |  |  |  |  |  |  |  |  |  |  |  | $ 3,800,000 |  |
Total unrecognized compensation expense |  |  |  |  |  |  |  |  |  |  |  | $ 3,300,000 |  |
Mr. Traversa [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Equity (Textual) |  |  |  |  |  |  |  |  |  |  |  |  |  |
Stock based compensation expense, Travesa options |  | Pursuant to the agreement, all the outstanding vested options (which originally were to expire 90 days from termination date) as well as 68,200 unvested options granted prior to December 31, 2016, shall be exercisable until the end of the term of each option grant agreement. |  |  |  |  |  |  |  |  |  |  |  |
Fair value assumptions, expected dividend rate |  |  |  |  |  |  |  |  |  |  |  | 0.00% |  |
Total option expense |  |  |  |  |  |  |  |  |  |  |  | $ 174,000 |  |
Executive Chairman [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Equity (Textual) |  |  |  |  |  |  |  |  |  |  |  |  |  |
Warrant to purchase of common stock |  |  |  |  |  |  | 64,746 |  |  |  |  |  |  |
CEO [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Equity (Textual) |  |  |  |  |  |  |  |  |  |  |  |  |  |
Warrant to purchase of common stock |  |  |  |  |  |  | 99,617 |  |  |  |  |  |  |
Public offering [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Equity (Textual) |  |  |  |  |  |  |  |  |  |  |  |  |  |
Issuance of common stock, shares | 21,500,000 |  |  |  |  | 4,444,444 |  |  |  |  |  |  |  |
Proceeds from common stock issued | $ 16,100,000 |  |  | $ 8,000,000 |  |  |  |  |  |  |  |  |  |
Exercise price | $ 1.05 |  |  |  |  | $ 6.50 |  |  | $ 6.50 |  |  |  |  |
Warrants, vesting period | 5 years |  |  |  |  |  |  |  |  |  |  |  |  |
Fair value assumptions, expected discount rate |  |  |  |  |  | 1.26% |  |  |  |  |  |  |  |
Fair value assumptions, expected term |  |  |  |  |  | 4 years |  |  |  |  |  |  |  |
Fair value assumptions, expected volatility rate |  |  |  |  |  | 72.00% |  |  |  |  |  |  |  |
Fair value assumptions, expected dividend rate |  |  |  |  |  | 0.00% |  |  |  |  |  |  |  |
Warrant to purchase of common stock | 18,275,000 |  |  |  |  | 3,333,333 |  |  |  |  |  |  |  |
Offering price | $ 0.75 |  |  | $ 1.25 |  | $ 4.50 |  |  | $ 4.50 |  |  |  |  |
Net proceeds from public offering | $ 15,000,000 |  |  |  |  | $ 18,500,000 |  |  |  |  |  |  |  |
Fair value of warrants |  |  |  |  |  | $ 3,540,659 |  |  | $ 3,500,000 |  |  |  |  |
Warrants exercisable term |  |  |  |  |  |  |  |  | 4 years |  |  |  |  |
Underwritten offering common stock |  |  |  |  |  |  |  |  | 4,444,444 |  |  |  |  |
Warrant [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Equity (Textual) |  |  |  |  |  |  |  |  |  |  |  |  |  |
Stock-based compensation expense |  |  |  |  |  |  |  |  |  |  |  | $ 50,000 | $ 100,000 | $ 2,000,000
Exercise price | $ 1.05 |  |  |  |  |  |  |  |  |  |  |  |  |
Common shares issued for cashless exercise of warrants |  |  |  |  |  |  |  |  |  |  |  | 1,736,277 |  | 1,532,124
Additional common stock issued for exercise of options and warrants |  |  |  |  |  |  |  |  |  |  |  |  | 23,212 | 224,153
Proceeds from stock options and warrants exercised |  |  |  |  |  |  |  |  |  |  |  |  | $ 18,105 | $ 173,620
Number of stock option/restricted shares canceled |  |  |  |  |  |  |  |  |  |  |  | 1,789,623 |  |
Number of stock option/warrants granted |  |  |  |  |  |  |  |  |  |  |  | 18,496,575 | 130,000 | 3,333,333
Fair value of stock options and warrants |  |  |  |  |  |  |  |  |  |  |  | $ 64,091 |  |
Fair value assumptions, expected discount rate | 1.83% |  |  |  |  |  |  |  |  |  |  |  |  |
Fair value assumptions, expected term | 5 years |  |  |  |  |  |  |  |  |  |  |  |  |
Fair value assumptions, expected volatility rate | 82.00% |  |  |  |  |  |  |  |  |  |  |  |  |
Fair value assumptions, expected dividend rate |  |  |  |  |  |  |  |  |  |  |  |  | 0.00% |
Warrant to purchase of common stock | 18,275,000 |  | 57,212 |  |  |  |  |  |  |  |  | 9,364 | 183,718 | 2,013,360
Share Price | $ 0.75 |  |  |  |  |  |  |  |  |  |  |  |  |
Fair value of warrants | $ 4,900,000 |  |  |  |  |  |  |  |  |  |  |  |  |
Warrants exercisable term | 5 years |  |  |  |  |  |  |  |  |  |  |  |  |
Underwritten offering common stock | 21,500,000 |  |  |  |  |  |  |  |  |  |  |  |  |
Common Stock [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Equity (Textual) |  |  |  |  |  |  |  |  |  |  |  |  |  |
Issuance of common stock, shares |  |  |  |  |  |  |  |  |  |  |  | 2,672,973 |  |
Offering costs |  |  |  |  |  |  |  |  |  |  |  | $ 200,000 |  |
Common shares issued for cashless exercise of warrants |  |  |  |  |  |  |  |  |  |  |  | 4,234 | 125,892 | 1,736,277
Investor [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Equity (Textual) |  |  |  |  |  |  |  |  |  |  |  |  |  |
Proceeds from common stock issued |  |  |  |  | $ 5,000,000 |  |  |  |  |  |  |  |  |
Sale of stock, shares |  |  |  |  | 1,923,078 |  |  |  |  |  |  |  |  |
Net proceeds from sale of stock |  |  |  |  | $ 4,480,000 |  |  |  |  |  |  |  |  |
Offering price |  |  |  |  | $ 2.60 |  |  |  |  |  |  |  |  |
Memorial Sloan Kettering Cancer Center [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Equity (Textual) |  |  |  |  |  |  |  |  |  |  |  |  |  |
Sale of stock, shares |  |  |  |  |  |  |  | 5,700,000 |  |  |  | 1,230.954 |  |
Consultants [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Equity (Textual) |  |  |  |  |  |  |  |  |  |  |  |  |  |
Common shares for consulting services, value |  |  |  |  |  |  |  |  |  |  |  | $ 99,056 |  |
Common shares for consulting services, shares |  |  |  |  |  |  |  |  |  |  |  | 67,385 |  |
Share Price |  |  |  |  |  |  |  |  |  |  |  | $ 1.47 |  |
Consultants [Member] | Warrant [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Equity (Textual) |  |  |  |  |  |  |  |  |  |  |  |  |  |
Fair value of warrants |  |  |  |  |  |  |  |  |  |  |  |  | $ 116,000 |
Maximum [Member] | Mr. Traversa [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Equity (Textual) |  |  |  |  |  |  |  |  |  |  |  |  |  |
Fair value assumptions, expected discount rate |  |  |  |  |  |  |  |  |  |  |  | 1.39% |  |
Fair value assumptions, expected term |  |  |  |  |  |  |  |  |  |  |  | 8 years 10 months 25 days |  |
Fair value assumptions, expected volatility rate |  |  |  |  |  |  |  |  |  |  |  | 79.81% |  |
Maximum [Member] | Warrant [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Equity (Textual) |  |  |  |  |  |  |  |  |  |  |  |  |  |
Exercise price |  |  |  |  |  |  |  |  |  |  |  |  | $ 1.77 |
Fair value assumptions, expected discount rate |  |  |  |  |  |  |  |  |  |  |  |  | 1.20% |
Fair value assumptions, expected term |  |  |  |  |  |  |  |  |  |  |  |  | 10 years |
Fair value assumptions, expected volatility rate |  |  |  |  |  |  |  |  |  |  |  |  | 84.84% |
Warrants exercisable term |  |  |  |  |  |  |  |  |  |  |  |  | 10 years |
Minimum [Member] | Mr. Traversa [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Equity (Textual) |  |  |  |  |  |  |  |  |  |  |  |  |  |
Fair value assumptions, expected discount rate |  |  |  |  |  |  |  |  |  |  |  | 0.97% |  |
Fair value assumptions, expected term |  |  |  |  |  |  |  |  |  |  |  | 3 months |  |
Fair value assumptions, expected volatility rate |  |  |  |  |  |  |  |  |  |  |  | 45.72% |  |
Minimum [Member] | Warrant [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Equity (Textual) |  |  |  |  |  |  |  |  |  |  |  |  |  |
Exercise price |  |  |  |  |  |  |  |  |  |  |  |  | $ 0.98 |
Fair value assumptions, expected discount rate |  |  |  |  |  |  |  |  |  |  |  |  | 1.13% |
Fair value assumptions, expected term |  |  |  |  |  |  |  |  |  |  |  |  | 5 years |
Fair value assumptions, expected volatility rate |  |  |  |  |  |  |  |  |  |  |  |  | 79.79% |
Warrants exercisable term |  |  |  |  |  |  |  |  |  |  |  |  | 5 years |
2013 Equity Incentive Plan [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Equity (Textual) |  |  |  |  |  |  |  |  |  |  |  |  |  |
Number of additional shares authorized |  |  |  |  |  |  |  |  |  | 1,000,000 |  |  |  |
2013 Equity Incentive Plan [Member] | Employees, directors and consultants [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Equity (Textual) |  |  |  |  |  |  |  |  |  |  |  |  |  |
Number of stock option/warrants granted |  |  |  |  |  |  |  |  |  |  | 450,000 |  |  |
Plan expiration date |  |  |  |  |  |  |  |  |  |  | Sep. 09, 2023 |  |  |
2013 Stock Plan [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Equity (Textual) |  |  |  |  |  |  |  |  |  |  |  |  |  |
Number of additional shares authorized |  |  |  |  |  |  |  |  |  |  |  | 17,750,000 | 12,750,000 | 9,250,000
2013 Stock Plan [Member] | Employees, directors and consultants [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Equity (Textual) |  |  |  |  |  |  |  |  |  |  |  |  |  |
Number of stock option/warrants granted |  |  |  |  |  |  |  |  |  |  | 2,750,000 |  |  |
Plan expiration date |  |  |  |  |  |  |  |  |  |  | Sep. 09, 2023 |  |  |
Stock Options [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Equity (Textual) |  |  |  |  |  |  |  |  |  |  |  |  |  |
Number of stock option/restricted shares canceled |  |  |  |  |  |  |  |  |  |  |  | 3,329,794 | 266,485 | 576,000
Number of stock option/warrants granted |  |  |  |  |  |  |  |  |  |  |  | 2,597,500 | 2,225,000 | 1,554,499
Stock options, term |  |  |  |  |  |  |  |  |  |  |  | 10 years | 10 years | 10 years
Fair value of stock options and warrants |  |  |  |  |  |  |  |  |  |  |  | $ 2,400,000 | $ 3,100,000 | $ 3,200,000
Fair value assumptions, expected term |  |  |  |  |  |  |  |  |  |  |  | 6 years | 6 years | 6 years
Fair value assumptions, expected dividend rate |  |  |  |  |  |  |  |  |  |  |  | 0.00% | 0.00% | 0.00%
Total option expense |  |  |  |  |  |  |  |  |  |  |  | $ 3,100,000 | $ 3,600,000 | $ 3,400,000
Gross proceeds |  |  |  |  |  |  |  |  |  |  |  |  | $ 18,105 | $ 15,680
Warrants exercised, shares |  |  |  |  |  |  |  |  |  |  |  |  | 23,212 | 20,000
Stock Options [Member] | Maximum [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Equity (Textual) |  |  |  |  |  |  |  |  |  |  |  |  |  |
Exercise price |  |  |  |  |  |  |  |  |  |  |  | $ 1.58 | $ 2.25 | $ 3.58
Stock options, vesting period |  |  |  |  |  |  |  |  |  |  |  | 4 years | 10 years | 4 years 2 months 1 day
Fair value assumptions, expected discount rate |  |  |  |  |  |  |  |  |  |  |  | 2.28% | 1.97% | 1.91%
Fair value assumptions, expected volatility rate |  |  |  |  |  |  |  |  |  |  |  | 82.37% | 87.95% | 94.89%
Stock Options [Member] | Minimum [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Equity (Textual) |  |  |  |  |  |  |  |  |  |  |  |  |  |
Exercise price |  |  |  |  |  |  |  |  |  |  |  | $ 0.57 | $ 0.95 | $ 1.79
Stock options, vesting period |  |  |  |  |  |  |  |  |  |  |  | 1 year | 4 years | 4 years
Fair value assumptions, expected discount rate |  |  |  |  |  |  |  |  |  |  |  | 1.84% | 1.28% | 1.56%
Fair value assumptions, expected volatility rate |  |  |  |  |  |  |  |  |  |  |  | 80.83% | 81.45% | 85.01%
Restricted Stock [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Equity (Textual) |  |  |  |  |  |  |  |  |  |  |  |  |  |
Issuance of common stock, shares |  |  |  |  |  |  |  |  |  |  |  |  | 21,000 |
Stock-based compensation expense |  |  |  |  |  |  |  |  |  |  |  | $ 200,000 | $ 600,000 | $ 3,400,000
Number of shares yet to issue of restricted stock, vested |  |  |  |  |  |  |  |  |  |  |  | 281,301 |  |
Restricted stock granted, shares |  |  |  |  |  |  |  |  |  |  |  |  | 60,700 |
Restricted Stock [Member] | Consultants [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Equity (Textual) |  |  |  |  |  |  |  |  |  |  |  |  |  |
Number of shares of restricted stock, vested |  |  |  |  |  |  |  |  |  |  |  | 26,000 |  |
Common shares for consulting services, value |  |  |  |  |  |  |  |  |  |  |  | $ 65,813 |  |
Common shares for consulting services, shares |  |  |  |  |  |  |  |  |  |  |  | 59,393 | 250,700 | 479,651
Restricted stock granted value |  |  |  |  |  |  |  |  |  |  |  |  | $ 400,000 | $ 2,300,000
Restricted stock granted, shares |  |  |  |  |  |  |  |  |  |  |  |  | 60,700 | 329,651
Description of restricted stock |  |  |  |  |  |  |  |  |  |  |  |  | Of the 250,700 restricted share awards granted in 2016, 60,700 shares vested at the date of grant, 150,000 shares vest over a six-month period and 40,000 shares vest over 2 years. | Of the 479,651 restricted share awards granted in 2015, 329,651 shares vested at the date of grant and 150,000 shares vest over a six-month period.
Restricted Stock [Member] | Employees [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Equity (Textual) |  |  |  |  |  |  |  |  |  |  |  |  |  |
Number of stock option/restricted shares canceled |  |  |  |  |  |  |  |  |  |  |  |  |  | 126,265
Number of common stock options, granted |  |  |  |  |  |  |  |  |  |  |  |  |  | 152,499
Restricted stock granted value |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 800,000

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