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Income Taxes (Tables)

12 Months Ended

Dec. 31, 2017

Income Tax Disclosure [Abstract]

Schedule of components of deferred tax assets and liabilities

		2017				2016
Deferred tax assets:
Net operating losses carry forward		$	30,826,534			$	38,874,255
Share-based compensation			3,731,413				8,081,711
Research & Development/Orphan Drug Credits			6,324,998				830,085
Others			11,369				16,329
Less: valuation allowance			(40,894,314	)			(47,802,380	)
Deferred tax assets, net		$	-			$	-

Schedule of difference between income tax provision and U.S federal statutory rate

		For the year ended
		December 31, 2017								December 31, 2016								December 31, 2015
Federal income taxes at 34%		$	(9,044,420	)			(34.0	)%		$	(8,269,386	)			(34.0	)%		$	(7,148,607	)			(34.0	)%
State income taxes			(1,940,945	)			(7.3	)%			973,547				4.0	%
Change in Federal statutory rate			17,939,714				67.4	%			-				-	%			-				-	%
Deferred true-up			3,090,815				11.8	%			(10,511,380	)			(43.3	)%			1,104,763				5.2	%
Research and Development/Orphan Drug Tax Credit			(3,029,074	)			(11.4	)%			(141,769	)			(0.6	)%			-				-	%
Unrealized derivative gain/loss			(120,870	)			(0.5	)%			(956,840	)			(3.9	)%
Other			12,845				0.0	%			13,632				0.1	%			-				-	%
Change in valuation allowance			(6,908,065	)			(26.0	)%			18,892,196				77.7	%			6,043,844				28.8	%
Provision for income tax		$	-				-			$	-				-			$	-				-

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- References

No definition available.

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- Definition

Tabular disclosure of the components of income tax expense attributable to continuing operations for each year presented including, but not limited to: current tax expense (benefit), deferred tax expense (benefit), investment tax credits, government grants, the benefits of operating loss carryforwards, tax expense that results from allocating certain tax benefits either directly to contributed capital or to reduce goodwill or other noncurrent intangible assets of an acquired entity, adjustments of a deferred tax liability or asset for enacted changes in tax laws or rates or a change in the tax status of the entity, and adjustments of the beginning-of-the-year balances of a valuation allowance because of a change in circumstances that causes a change in judgment about the realizability of the related deferred tax asset in future years.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 740
-SubTopic 10
-Section 50
-Paragraph 9
-URI http://asc.fasb.org/extlink&oid=84230637&loc=d3e32639-109319

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- Definition

Tabular disclosure of the components of net deferred tax asset or liability recognized in an entity's statement of financial position, including the following: the total of all deferred tax liabilities, the total of all deferred tax assets, the total valuation allowance recognized for deferred tax assets.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 740
-SubTopic 10
-Section 50
-Paragraph 2
-URI http://asc.fasb.org/extlink&oid=84230637&loc=d3e32537-109319

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