<SEC-DOCUMENT>0001213900-18-002272.txt : 20180226
<SEC-HEADER>0001213900-18-002272.hdr.sgml : 20180226
<ACCEPTANCE-DATETIME>20180226091652
ACCESSION NUMBER:		0001213900-18-002272
CONFORMED SUBMISSION TYPE:	424B5
PUBLIC DOCUMENT COUNT:		2
FILED AS OF DATE:		20180226
DATE AS OF CHANGE:		20180226

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Actinium Pharmaceuticals, Inc.
		CENTRAL INDEX KEY:			0001388320
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				880378336
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		424B5
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	333-216748
		FILM NUMBER:		18638820

	BUSINESS ADDRESS:	
		STREET 1:		275 MADISON AVENUE, 7TH FLOOR
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10016
		BUSINESS PHONE:		646-677-3875

	MAIL ADDRESS:	
		STREET 1:		275 MADISON AVENUE, 7TH FLOOR
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10016

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	Cactus Ventures, Inc.
		DATE OF NAME CHANGE:	20070130
</SEC-HEADER>
<DOCUMENT>
<TYPE>424B5
<SEQUENCE>1
<FILENAME>f424b5022318_actinium.htm
<DESCRIPTION>PROSPECTUS SUPPLEMENT NO. 1
<TEXT>
<HTML>
<HEAD>


<TITLE></TITLE>
</HEAD>
<BODY LANG="EN-US" STYLE=
"text-justify-trim: punctuation; margin: 0; padding: 10pt;">

<DIV CLASS="WordSection1" STYLE=
"width: 600px; margin: 0 auto; page: WordSection1;">
<TABLE CLASS="MsoNormalTable" BORDER="0" CELLSPACING="0"
CELLPADDING="0" WIDTH="100%" STYLE=
"width: 100.0%; border-collapse: collapse; border: 0px solid #000; border-width: 0px; margin: 0;">
<TR>
<TD WIDTH="49%" VALIGN="bottom" STYLE=
"width: 49.24%; padding: 0in 0in 0in 0in;">
<P CLASS="Texttable" STYLE=
"line-height: normal; mso-style-name: Texttable; margin: 0in; margin-bottom: .0001pt; text-autospace: none; font-size: 10.0pt; font-family: TimesNewRomanPSStd-Regular; color: black;"> <FONT STYLE="font-size: 7.5pt">Amendment
No. 1 Dated February 26, 2017 to<BR>
Prospectus Supplement Dated February 15, 2017</FONT> <BR>
<FONT STYLE="font-size: 7.5pt">(To Prospectus Dated October 24, 2017)</FONT></P>
</TD>
<TD WIDTH="1%" VALIGN="bottom" STYLE=
"width: 1.5%; padding: 0in 0in 0in 0in;">
<P CLASS="NoParagraphStyle" STYLE=
'line-height: normal; mso-style-name: "\[No Paragraph Style\]"; margin: 0in; margin-bottom: .0001pt; text-autospace: none; font-size: 12.0pt; font-family: "MinionPro-Regular","serif"; color: black;'>
<FONT STYLE=
"font-family: TimesNewRomanPSStd-Regular; color: windowtext;">&nbsp;</FONT></P>
</TD>
<TD WIDTH="49%" VALIGN="top" STYLE=
"width: 49.24%; padding: 0in 0in 0in 0in;">
<P CLASS="Texttable" ALIGN="right" STYLE=
"text-align: right; line-height: normal; mso-style-name: Texttable; margin: 0in; margin-bottom: .0001pt; text-autospace: none; font-size: 10.0pt; font-family: TimesNewRomanPSStd-Regular; color: black;">
<FONT CLASS="Bold" STYLE=
"mso-style-name: Bold; font-weight: bold;"><FONT LANG="EN-GB"
STYLE="font-size: 7.5pt;">Filed Pursuant to Rule 424(b)(5)<BR>
Registration No. 333-216748</FONT></FONT></P>
</TD>
</TR>
</TABLE>
<P CLASS="Textflush" ALIGN="center" STYLE=
"margin-top: 10.0pt; text-align: center; mso-style-name: Text_flush; margin-right: 0in; margin-bottom: .0001pt; margin-left: 0in; line-height: 12.0pt; text-autospace: none; font-size: 10.0pt; font-family: TimesNewRomanPSStd-Regular; color: black;">
<IMG WIDTH="356" HEIGHT="96" SRC="image001.jpg" alt=""></P>
<P CLASS="H1" STYLE=
"margin-top: 1.0pt; mso-style-name: H1; margin-right: 0in; margin-bottom: .0001pt; margin-left: 0in; text-align: center; line-height: 14.0pt; page-break-after: avoid; text-autospace: none; font-size: 12.0pt; font-family: TimesNewRomanPSStd-Bold; color: black; font-weight: bold;">
<FONT CLASS="Bold" STYLE=
"mso-style-name: Bold; font-weight: bold;">Subscription Rights to
Purchase Up to 50,000,000 Units</FONT></P>
<P CLASS="Textflush" STYLE=
"margin-top: 2.5pt; mso-style-name: Text_flush; margin-right: 0in; margin-bottom: .0001pt; margin-left: 0in; line-height: 12.0pt; text-autospace: none; font-size: 10.0pt; font-family: TimesNewRomanPSStd-Regular; color: black;"> <FONT STYLE="font-size: 7pt; letter-spacing: -0.05pt">This
amendment amends and supplements the prospectus supplement dated February 15, 2018, which we refer to as the prospectus supplement,
and which forms a part of our Registration Statement on Form S-3 (Registration No. 333-216748). This amendment is being filed
to amend and supplement certain information included in the prospectus supplement with the information contained in this amendment.
This amendment should be read in conjunction with the prospectus supplement and the prospectus dated October 24, 2017. This amendment
amends only those sections of the prospectus supplement listed in this amendment; all other sections of the prospectus supplement
remain as is.</FONT> </P>
<P CLASS="Textflush" STYLE=
"margin-top: 2.5pt; mso-style-name: Text_flush; margin-right: 0in; margin-bottom: .0001pt; margin-left: 0in; line-height: 12.0pt; text-autospace: none; font-size: 10.0pt; font-family: TimesNewRomanPSStd-Regular; color: black;"> <FONT STYLE="font-size: 7pt">The
prospectus supplement and this amendment relate to our distribution to holders of our common stock and to holders of certain of
our outstanding warrants who are entitled to participate in this offering, at no charge, non-transferable subscription rights
to purchase up to an aggregate of $25.0 million of units, subject to increase as described in the prospectus supplement. Each
unit, which we refer to as a Unit, consists of one share of common stock, 0.25 series A warrants and 0.75 series B warrants, which
we refer to as the Common Stock, Series A Warrants, and Series B Warrants, respectively. We refer to the Series A Warrants and
the Series B Warrants collectively as the Warrants. Each whole Series A Warrant and whole Series B Warrant will be exercisable
for one share of our common stock. We refer to the offering that is the subject of the prospectus supplement, as amended by this
amendment, as the Rights Offering. In the Rights Offering, you have received one subscription right for every share of common
stock owned at 5:00 p.m., Eastern Time, on February 14, 2018, the record date of the Rights Offering, or the Record Date. The
Common Stock, Series A Warrants and Series B Warrants comprising the Units will separate upon the closing of the Rights Offering
and will be issued separately but may only be purchased as a Unit, and the Units will not trade as a separate security. The subscription
rights will not be tradable.</FONT> </P>
<P CLASS="Textflush" STYLE=
"margin-top: 2.5pt; mso-style-name: Text_flush; margin-right: 0in; margin-bottom: .0001pt; margin-left: 0in; line-height: 12.0pt; text-autospace: none; font-size: 10.0pt; font-family: TimesNewRomanPSStd-Regular; color: black;"> <FONT STYLE="font-size: 7pt">On
February 23, 2018, our board of directors determined that the subscription price per Unit should be reduced to $0.50 per Unit,
that the Series A Warrant exercise price should be reduced to $0.60 per share, and that the Series B Warrant exercise price should
be reduced to $0.70 per share. Our board of directors also determined that the redemption price threshold of $1.80 per share of
common stock, for the Series A Warrants, should be reduced to $1.20 per share, and that the redemption price threshold of $3.30
per share of common stock, for the Series B Warrants, should be reduced to $2.10 per share.</FONT> </P>
<P CLASS="Textflush" STYLE=
"margin-top: 2.5pt; mso-style-name: Text_flush; margin-right: 0in; margin-bottom: .0001pt; margin-left: 0in; line-height: 12.0pt; text-autospace: none; font-size: 10.0pt; font-family: TimesNewRomanPSStd-Regular; color: black;"> <FONT STYLE="font-size: 7pt">Accordingly,
after giving effect to the foregoing revisions to the pricing terms, each subscription right will entitle you to purchase one
Unit, which we refer to as the Basic Subscription Right, at a subscription price per Unit of $0.50, which we refer to as the Subscription
Price. Each whole Series A Warrant entitles the holder to purchase one share of common stock at an exercise price of $0.60 per
share from the date of issuance through its expiration 12 months from the date of issuance, and each whole Series B Warrant entitles
the holder to purchase one share of common stock at an exercise price of $0.70 per share from the date of issuance through its
expiration 30 months from the date of issuance. Any rights certificates previously distributed to holders of our common stock
or participating warrants are hereby deemed to be amended to reflect the foregoing revisions to the pricing terms.</FONT> </P>
<P CLASS="Textflush" STYLE=
"margin-top: 2.5pt; mso-style-name: Text_flush; margin-right: 0in; margin-bottom: .0001pt; margin-left: 0in; line-height: 12.0pt; text-autospace: none; font-size: 10.0pt; font-family: TimesNewRomanPSStd-Regular; color: black;"> <FONT STYLE="font-size: 7pt">The
over-subscription privilege and allocation mechanics in the Rights Offering remain unchanged from before. Accordingly, if you
exercise your Basic Subscription Rights in full, and any portion of the Units remain available under the Rights Offering, you
will be entitled to an over-subscription privilege to purchase a portion of the unsubscribed Units at the Subscription Price,
subject to proration and ownership limitations, which we refer to as the Over-Subscription Privilege. Each subscription right
consists of a Basic Subscription Right and an Over-Subscription Privilege, which we refer to as the Subscription Right.</FONT> </P>
<P CLASS="Textflush" STYLE=
"margin-top: 2.5pt; mso-style-name: Text_flush; margin-right: 0in; margin-bottom: .0001pt; margin-left: 0in; line-height: 12.0pt; text-autospace: none; font-size: 10.0pt; font-family: TimesNewRomanPSStd-Regular; color: black;"> <FONT STYLE="font-size: 7pt">The
Subscription Rights will expire if they are not exercised by 5:00 p.m., Eastern Time, on March 2, 2018, unless the Rights Offering
is extended or earlier terminated by us. If we elect to extend the Rights Offering, we will issue a press release announcing the
extension no later than 9:00 a.m., Eastern Time, on the next business day after the most recently announced expiration date of
the Rights Offering. We may extend the Rights Offering for additional periods in our sole discretion. Once made, all exercises
of Subscription Rights are irrevocable.</FONT> </P>
<P CLASS="Textflush" STYLE=
"margin-top: 2.5pt; mso-style-name: Text_flush; margin-right: 0in; margin-bottom: .0001pt; margin-left: 0in; line-height: 12.0pt; text-autospace: none; font-size: 10.0pt; font-family: TimesNewRomanPSStd-Regular; color: black;"> <FONT STYLE="font-size: 7pt"><B>As
a result of the foregoing revisions to the pricing terms of the Rights Offering, any holders of subscription rights who have already
exercised their subscription rights at the original subscription price of $0.70 per Unit, or who submit election forms referencing
the original subscription price of $0.70 per Unit, will be considered to have exercised their subscription rights at the revised
Subscription Price of $0.50 per Unit and will receive the appropriate number of shares of Common Stock, Series A Warrants and
Series B Warrants as if such holder had subscribed at the revised Subscription Price of $0.50 per Unit.</B></FONT> </P>
<P CLASS="Textflush" STYLE=
"margin-top: 2.5pt; mso-style-name: Text_flush; margin-right: 0in; margin-bottom: .0001pt; margin-left: 0in; line-height: 12.0pt; text-autospace: none; font-size: 10.0pt; font-family: TimesNewRomanPSStd-Regular; color: black;">
<FONT STYLE="font-size: 7.0pt;">We have not entered into any
standby purchase agreement or other similar arrangement in
connection with the Rights Offering. The Rights Offering is being
conducted on a best-efforts basis and there is no minimum amount of
proceeds necessary to be received in order for us to close the
Rights Offering.</FONT></P>
<P CLASS="Textflush" STYLE=
"margin-top: 2.5pt; mso-style-name: Text_flush; margin-right: 0in; margin-bottom: .0001pt; margin-left: 0in; line-height: 12.0pt; text-autospace: none; font-size: 10.0pt; font-family: TimesNewRomanPSStd-Regular; color: black;">
<FONT STYLE="font-size: 7.0pt;">We have engaged Maxim Group LLC to
act as dealer-manager in the Rights Offering.</FONT></P>
<P CLASS="Textflush" STYLE=
"margin-top: 2.5pt; mso-style-name: Text_flush; margin-right: 0in; margin-bottom: .0001pt; margin-left: 0in; line-height: 12.0pt; text-autospace: none; font-size: 10.0pt; font-family: TimesNewRomanPSStd-Regular; color: black;"> <FONT STYLE="font-size: 7pt"><B>Investing
in our securities involves a high degree of risk. See the section entitled &ldquo;Risk Factors&rdquo; beginning on page S-21 of
the prospectus supplement. You should carefully consider these risk factors, as well as the information contained in the prospectus
supplement, as amended by this amendment, and the prospectus, before you invest.</B></FONT> </P>
<P CLASS="Textflush" STYLE=
"margin-top: 2.5pt; mso-style-name: Text_flush; margin-right: 0in; margin-bottom: .0001pt; margin-left: 0in; line-height: 12.0pt; text-autospace: none; font-size: 10.0pt; font-family: TimesNewRomanPSStd-Regular; color: black;"> <FONT STYLE="font-size: 7pt">Broadridge
Corporate Issuer Solutions, Inc. will serve as the Subscription Agent and Information Agent for the Rights Offering. The Subscription
Agent will hold the funds we receive from subscribers until we complete, abandon or terminate the Rights Offering. If you want
to participate in this Rights Offering and you are the record holder of your shares or participating warrants, we recommend that
you submit your subscription documents to the Subscription Agent well before the deadline. If you want to participate in this
Rights Offering and you hold shares through your broker, dealer, bank or other nominee, you should promptly contact your broker,
dealer, bank or other nominee and submit your subscription documents in accordance with the instructions and within the time period
provided by your broker, dealer, bank or other nominee. For a detailed discussion, see &ldquo;The Rights Offering &mdash; The
Subscription Rights&rdquo; In the prospectus supplement, as amended by this amendment.</FONT> </P>
<P CLASS="Textflush" STYLE=
"margin-top: 2.5pt; mso-style-name: Text_flush; margin-right: 0in; margin-bottom: .0001pt; margin-left: 0in; line-height: 12.0pt; text-autospace: none; font-size: 10.0pt; font-family: TimesNewRomanPSStd-Regular; color: black;">
<FONT STYLE="font-size: 7.0pt; letter-spacing: -.1pt;">Our board of
directors reserves the right to terminate the Rights Offering for
any reason any time before the closing of the Rights Offering. If
we terminate the Rights Offering, all subscription payments
received will be returned within 10 business days, without interest
or deduction. We expect the Rights Offering to expire on or about
March 2, 2018, subject to our right to extend the Rights Offering
as described above, and that we would close on subscriptions within
five business days of such date.</FONT></P>
<P CLASS="Textflush" STYLE=
"margin-top: 2.5pt; margin-right: 0in; margin-bottom: 10.0pt; margin-left: 0in; mso-style-name: Text_flush; line-height: 12.0pt; text-autospace: none; font-size: 10.0pt; font-family: TimesNewRomanPSStd-Regular; color: black;">
<FONT STYLE="font-size: 7.0pt; letter-spacing: -.1pt;">Our common
stock is listed on NYSE American under the symbol
&ldquo;ATNM.&rdquo; On February 23, 2018, the last reported sale
price of our common stock was $0.54 per share. There is no
established public trading market for the Series A Warrants or the
Series B Warrants. We do not intend to apply for listing of the
Series A Warrants and Series B Warrants on any securities exchange
or recognized trading system. The Subscription Rights are
non-transferrable and will not be listed for trading on NYSE
American or any other securities exchange or market. You are urged
to obtain a current price quote for our common stock before
exercising your Subscription Rights.</FONT></P>
<TABLE CLASS="MsoNormalTable" BORDER="0" CELLSPACING="0"
CELLPADDING="0" WIDTH="100%" STYLE=
"width: 100.0%; border-collapse: collapse; border: 0px solid #000; border-width: 0px; margin: 0;">
<TR>
<TD WIDTH="70%" VALIGN="bottom" STYLE=
"width: 70.26%; background: white; padding: 0in 0in 0in 0in;">
<P CLASS="NoParagraphStyle" STYLE=
'line-height: normal; mso-style-name: "\[No Paragraph Style\]"; margin: 0in; margin-bottom: .0001pt; text-autospace: none; font-size: 12.0pt; font-family: "MinionPro-Regular","serif"; color: black;'>
<FONT STYLE=
"font-family: TimesNewRomanPSStd-Regular; color: windowtext;">&nbsp;</FONT></P>
</TD>
<TD WIDTH="1%" VALIGN="bottom" STYLE=
"width: 1.48%; background: white; padding: 0in 0in 0in 0in;">
<P CLASS="NoParagraphStyle" STYLE=
'line-height: normal; mso-style-name: "\[No Paragraph Style\]"; margin: 0in; margin-bottom: .0001pt; text-autospace: none; font-size: 12.0pt; font-family: "MinionPro-Regular","serif"; color: black;'>
<FONT STYLE=
"font-family: TimesNewRomanPSStd-Regular; color: windowtext;">&nbsp;</FONT></P>
</TD>
<TD WIDTH="13%" COLSPAN="2" VALIGN="bottom" STYLE=
"width: 13.38%; background: white; padding: 0in 0in 0in 0in;">
<DIV STYLE=
"border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 0in 0in 0in;">
<P CLASS="TCH" STYLE=
"margin-right: 0in; line-height: normal; border: none; padding: 0in; padding-bottom: 0pt !important; mso-style-name: TCH; margin-top: 0in; margin-bottom: .0001pt; margin-left: 0in; text-align: center; text-autospace: none; font-size: 8.0pt; font-family: TimesNewRomanPSStd-Bold; color: black; font-weight: bold;">
Per Unit</P>
</DIV>
</TD>
<TD WIDTH="1%" VALIGN="bottom" STYLE=
"width: 1.48%; background: white; padding: 0in 0in 0in 0in;">
<P CLASS="NoParagraphStyle" STYLE=
'line-height: normal; mso-style-name: "\[No Paragraph Style\]"; margin: 0in; margin-bottom: .0001pt; text-autospace: none; font-size: 12.0pt; font-family: "MinionPro-Regular","serif"; color: black;'>
<FONT STYLE=
"font-family: TimesNewRomanPSStd-Regular; color: windowtext;">&nbsp;</FONT></P>
</TD>
<TD WIDTH="13%" COLSPAN="2" VALIGN="bottom" STYLE=
"width: 13.38%; background: white; padding: 0in 0in 0in 0in;">
<DIV STYLE=
"border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 0in 0in 0in;">
<P CLASS="TCH" STYLE=
"margin-right: 0in; line-height: normal; border: none; padding: 0in; padding-bottom: 0pt !important; mso-style-name: TCH; margin-top: 0in; margin-bottom: .0001pt; margin-left: 0in; text-align: center; text-autospace: none; font-size: 8.0pt; font-family: TimesNewRomanPSStd-Bold; color: black; font-weight: bold;">
<FONT LANG="EN-GB">Total<FONT CLASS="superscript" STYLE=
"font-size: 6pt !important; mso-style-name: superscript; vertical-align: super;">(2)</FONT></FONT></P>
</DIV>
</TD>
</TR>
<TR>
<TD WIDTH="70%" VALIGN="bottom" STYLE=
"width: 70.26%; background: #CCEEFF; padding: 0in 0in 0in 0in;"><P CLASS="Tbody" STYLE=
"line-height: normal; padding-bottom: 3px !important; mso-style-name: Tbody; margin-top: 0in; margin-right: 0in; margin-bottom: .0001pt; margin-left: 10.0pt; text-indent: -10.0pt; text-autospace: none; font-size: 10.0pt; font-family: TimesNewRomanPSStd-Regular; color: black;"><FONT STYLE="font-size: 8pt">Subscription
                                         price</FONT></P>
</TD>
<TD WIDTH="1%" VALIGN="bottom" STYLE=
"width: 1.48%; background: #CCEEFF; padding: 0in 0in 0in 0in;"><P CLASS="NoParagraphStyle" STYLE=
'line-height: normal; mso-style-name: "\[No Paragraph Style\]"; margin: 0in; margin-bottom: .0001pt; text-autospace: none; font-size: 12.0pt; font-family: "MinionPro-Regular","serif"; color: black;'><FONT STYLE="font-family: TimesNewRomanPSStd-Regular; font-size: 8pt; color: windowtext">&nbsp;</FONT></P>
</TD>
<TD WIDTH="1%" VALIGN="bottom" STYLE=
"width: 1.12%; background: #CCEEFF; padding: 0in 0in 0in 0in;"><P CLASS="Tbodyrightalign" ALIGN="left" STYLE=
"margin-right: 0in; text-align: left; line-height: normal; padding-bottom: 3px !important; mso-style-name: Tbody_rightalign; margin-top: 0in; margin-bottom: .0001pt; margin-left: 0in; text-autospace: none; font-size: 10.0pt; font-family: TimesNewRomanPSStd-Regular; color: black;"><FONT STYLE="font-size: 8pt">$</FONT></P>
</TD>
<TD WIDTH="12%" VALIGN="bottom" STYLE=
"width: 12.26%; background: #CCEEFF; padding: 0in 0in 0in 0in;"><P CLASS="Tbodyrightalign" STYLE=
"margin-right: 0in; line-height: normal; padding-bottom: 3px !important; mso-style-name: Tbody_rightalign; margin-top: 0in; margin-bottom: .0001pt; margin-left: 0in; text-align: right; text-autospace: none; font-size: 10.0pt; font-family: TimesNewRomanPSStd-Regular; color: black;"><FONT STYLE="font-size: 8pt">0.500</FONT></P>
</TD>
<TD WIDTH="1%" VALIGN="bottom" STYLE=
"width: 1.48%; background: #CCEEFF; padding: 0in 0in 0in 0in;"><P CLASS="NoParagraphStyle" STYLE=
'line-height: normal; mso-style-name: "\[No Paragraph Style\]"; margin: 0in; margin-bottom: .0001pt; text-autospace: none; font-size: 12.0pt; font-family: "MinionPro-Regular","serif"; color: black;'><FONT STYLE="font-family: TimesNewRomanPSStd-Regular; font-size: 8pt; color: windowtext">&nbsp;</FONT></P>
</TD>
<TD WIDTH="1%" VALIGN="bottom" STYLE=
"width: 1.12%; background: #CCEEFF; padding: 0in 0in 0in 0in;"><P CLASS="Tbodyrightalign" ALIGN="left" STYLE=
"margin-right: 0in; text-align: left; line-height: normal; padding-bottom: 3px !important; mso-style-name: Tbody_rightalign; margin-top: 0in; margin-bottom: .0001pt; margin-left: 0in; text-autospace: none; font-size: 10.0pt; font-family: TimesNewRomanPSStd-Regular; color: black;"><FONT STYLE="font-size: 8pt">$</FONT></P>
</TD>
<TD WIDTH="12%" VALIGN="bottom" STYLE=
"width: 12.26%; background: #CCEEFF; padding: 0in 0in 0in 0in;"><P CLASS="Tbodyrightalign" STYLE=
"margin-right: 0in; line-height: normal; padding-bottom: 3px !important; mso-style-name: Tbody_rightalign; margin-top: 0in; margin-bottom: .0001pt; margin-left: 0in; text-align: right; text-autospace: none; font-size: 10.0pt; font-family: TimesNewRomanPSStd-Regular; color: black;"><FONT STYLE="font-size: 8pt">25,000,000</FONT></P>
</TD>
</TR>
<TR>
<TD WIDTH="70%" VALIGN="bottom" STYLE=
"width: 70.26%; background: white; padding: 0in 0in 0in 0in;"><P CLASS="Tbody" STYLE=
"line-height: normal; padding-bottom: 3px !important; mso-style-name: Tbody; margin-top: 0in; margin-right: 0in; margin-bottom: .0001pt; margin-left: 10.0pt; text-indent: -10.0pt; text-autospace: none; font-size: 10.0pt; font-family: TimesNewRomanPSStd-Regular; color: black;"><FONT STYLE="font-size: 8pt">Dealer-Manager
                                         fees and expenses<SUP><FONT STYLE="font-size: 6pt">(1)</FONT></SUP></FONT></P>
</TD>
<TD WIDTH="1%" VALIGN="bottom" STYLE=
"width: 1.48%; background: white; padding: 0in 0in 0in 0in;"><P CLASS="NoParagraphStyle" STYLE=
'line-height: normal; mso-style-name: "\[No Paragraph Style\]"; margin: 0in; margin-bottom: .0001pt; text-autospace: none; font-size: 12.0pt; font-family: "MinionPro-Regular","serif"; color: black;'><FONT STYLE="font-family: TimesNewRomanPSStd-Regular; font-size: 8pt; color: windowtext">&nbsp;</FONT></P>
</TD>
<TD WIDTH="1%" VALIGN="bottom" STYLE=
"width: 1.12%; background: white; padding: 0in 0in 0in 0in;"><P CLASS="Tbodyrightalign" ALIGN="left" STYLE=
"margin-right: 0in; text-align: left; line-height: normal; padding-bottom: 3px !important; mso-style-name: Tbody_rightalign; margin-top: 0in; margin-bottom: .0001pt; margin-left: 0in; text-autospace: none; font-size: 10.0pt; font-family: TimesNewRomanPSStd-Regular; color: black;"><FONT STYLE="font-size: 8pt">$</FONT></P>
</TD>
<TD WIDTH="12%" VALIGN="bottom" STYLE=
"width: 12.26%; background: white; padding: 0in 0in 0in 0in;"><P CLASS="Tbodyrightalign" STYLE=
"margin-right: 0in; line-height: normal; padding-bottom: 3px !important; mso-style-name: Tbody_rightalign; margin-top: 0in; margin-bottom: .0001pt; margin-left: 0in; text-align: right; text-autospace: none; font-size: 10.0pt; font-family: TimesNewRomanPSStd-Regular; color: black;"><FONT STYLE="font-size: 8pt">&nbsp;0.037</FONT></P>
</TD>
<TD WIDTH="1%" VALIGN="bottom" STYLE=
"width: 1.48%; background: white; padding: 0in 0in 0in 0in;"><P CLASS="NoParagraphStyle" STYLE=
'line-height: normal; mso-style-name: "\[No Paragraph Style\]"; margin: 0in; margin-bottom: .0001pt; text-autospace: none; font-size: 12.0pt; font-family: "MinionPro-Regular","serif"; color: black;'><FONT STYLE="font-family: TimesNewRomanPSStd-Regular; font-size: 8pt; color: windowtext">&nbsp;</FONT></P>
</TD>
<TD WIDTH="1%" VALIGN="bottom" STYLE=
"width: 1.12%; background: white; padding: 0in 0in 0in 0in;"><P CLASS="Tbodyrightalign" ALIGN="left" STYLE=
"margin-right: 0in; text-align: left; line-height: normal; padding-bottom: 3px !important; mso-style-name: Tbody_rightalign; margin-top: 0in; margin-bottom: .0001pt; margin-left: 0in; text-autospace: none; font-size: 10.0pt; font-family: TimesNewRomanPSStd-Regular; color: black;"><FONT STYLE="font-size: 8pt">$</FONT></P>
</TD>
<TD WIDTH="12%" VALIGN="bottom" STYLE=
"width: 12.26%; background: white; padding: 0in 0in 0in 0in;"><P CLASS="Tbodyrightalign" STYLE=
"margin-right: 0in; line-height: normal; padding-bottom: 3px !important; mso-style-name: Tbody_rightalign; margin-top: 0in; margin-bottom: .0001pt; margin-left: 0in; text-align: right; text-autospace: none; font-size: 10.0pt; font-family: TimesNewRomanPSStd-Regular; color: black;"><FONT STYLE="font-size: 8pt">1,835,000</FONT></P>
</TD>
</TR>
<TR>
<TD WIDTH="70%" VALIGN="bottom" STYLE=
"width: 70.26%; background: #CCEEFF; padding: 0in 0in 0in 0in;"><P CLASS="Tbody" STYLE=
"line-height: normal; padding-bottom: 3px !important; mso-style-name: Tbody; margin-top: 0in; margin-right: 0in; margin-bottom: .0001pt; margin-left: 10.0pt; text-indent: -10.0pt; text-autospace: none; font-size: 10.0pt; font-family: TimesNewRomanPSStd-Regular; color: black;"><FONT STYLE="font-size: 8pt">Proceeds
                                         to us, before expenses</FONT></P>
</TD>
<TD WIDTH="1%" VALIGN="bottom" STYLE=
"width: 1.48%; background: #CCEEFF; padding: 0in 0in 0in 0in;"><P CLASS="NoParagraphStyle" STYLE=
'line-height: normal; mso-style-name: "\[No Paragraph Style\]"; margin: 0in; margin-bottom: .0001pt; text-autospace: none; font-size: 12.0pt; font-family: "MinionPro-Regular","serif"; color: black;'><FONT STYLE="font-family: TimesNewRomanPSStd-Regular; font-size: 8pt; color: windowtext">&nbsp;</FONT></P>
</TD>
<TD WIDTH="1%" VALIGN="bottom" STYLE=
"width: 1.12%; background: #CCEEFF; padding: 0in 0in 0in 0in;"><P CLASS="Tbodyrightalign" ALIGN="left" STYLE=
"margin-right: 0in; text-align: left; line-height: normal; padding-bottom: 3px !important; mso-style-name: Tbody_rightalign; margin-top: 0in; margin-bottom: .0001pt; margin-left: 0in; text-autospace: none; font-size: 10.0pt; font-family: TimesNewRomanPSStd-Regular; color: black;"><FONT STYLE="font-size: 8pt">$</FONT></P>
</TD>
<TD WIDTH="12%" VALIGN="bottom" STYLE=
"width: 12.26%; background: #CCEEFF; padding: 0in 0in 0in 0in;"><P CLASS="Tbodyrightalign" STYLE=
"margin-right: 0in; line-height: normal; padding-bottom: 3px !important; mso-style-name: Tbody_rightalign; margin-top: 0in; margin-bottom: .0001pt; margin-left: 0in; text-align: right; text-autospace: none; font-size: 10.0pt; font-family: TimesNewRomanPSStd-Regular; color: black;"><FONT STYLE="font-size: 8pt">&nbsp;0.463</FONT></P>
</TD>
<TD WIDTH="1%" VALIGN="bottom" STYLE=
"width: 1.48%; background: #CCEEFF; padding: 0in 0in 0in 0in;"><P CLASS="NoParagraphStyle" STYLE=
'line-height: normal; mso-style-name: "\[No Paragraph Style\]"; margin: 0in; margin-bottom: .0001pt; text-autospace: none; font-size: 12.0pt; font-family: "MinionPro-Regular","serif"; color: black;'><FONT STYLE="font-family: TimesNewRomanPSStd-Regular; font-size: 8pt; color: windowtext">&nbsp;</FONT></P>
</TD>
<TD WIDTH="1%" VALIGN="bottom" STYLE=
"width: 1.12%; background: #CCEEFF; padding: 0in 0in 0in 0in;"><P CLASS="Tbodyrightalign" ALIGN="left" STYLE=
"margin-right: 0in; text-align: left; line-height: normal; padding-bottom: 3px !important; mso-style-name: Tbody_rightalign; margin-top: 0in; margin-bottom: .0001pt; margin-left: 0in; text-autospace: none; font-size: 10.0pt; font-family: TimesNewRomanPSStd-Regular; color: black;"><FONT STYLE="font-size: 8pt">$</FONT></P>
</TD>
<TD WIDTH="12%" VALIGN="bottom" STYLE=
"width: 12.26%; background: #CCEEFF; padding: 0in 0in 0in 0in;"><P CLASS="Tbodyrightalign" STYLE=
"margin-right: 0in; line-height: normal; padding-bottom: 3px !important; mso-style-name: Tbody_rightalign; margin-top: 0in; margin-bottom: .0001pt; margin-left: 0in; text-align: right; text-autospace: none; font-size: 10.0pt; font-family: TimesNewRomanPSStd-Regular; color: black;"><FONT STYLE="font-size: 8pt">23,165,000</FONT></P>
</TD>
</TR>
</TABLE>
<P CLASS="Tablefootnotef" STYLE=
"margin-top: 0in; line-height: normal; border: none; mso-style-name: Tablefootnote_f; margin-right: 0in; margin-bottom: .0001pt; margin-left: .25in; text-indent: -.25in; text-autospace: none; padding: 0in; font-size: 8.0pt; font-family: TimesNewRomanPSStd-Regular; color: black;">
<FONT STYLE="font-size: 7.0pt;">____________</FONT></P>
<P CLASS="Tablefootnotef" STYLE=
"margin-top: 0in; line-height: normal; border: none; mso-style-name: Tablefootnote_f; margin-right: 0in; margin-bottom: .0001pt; margin-left: .25in; text-indent: -.25in; text-autospace: none; padding: 0in; font-size: 8.0pt; font-family: TimesNewRomanPSStd-Regular; color: black;"> <FONT STYLE="font-size: 7pt">(1)</FONT><FONT STYLE="font-size: 8.5pt">&nbsp;&nbsp;&nbsp;
</FONT><FONT STYLE="font-size: 7pt">In connection with this Rights Offering, we have agreed to pay to Maxim Group LLC as the dealer-manager
a cash fee equal to 7% of the gross proceeds received by us directly from exercises of the Subscription Rights. We have also agreed
to reimburse the dealer-manager for its expenses up to $85,000. See &ldquo;Plan of Distribution&rdquo; in the prospectus supplement.</FONT> </P>
<P CLASS="Tablefootnotem" STYLE=
"margin-left: .25in; text-indent: -.25in; mso-style-name: Tablefootnote_m; margin-top: 0in; margin-right: 0in; margin-bottom: .0001pt; line-height: 11.0pt; text-autospace: none; font-size: 9.0pt; font-family: TimesNewRomanPSStd-Regular; color: black;">
<FONT STYLE="font-size: 7.0pt;">(2)</FONT><FONT STYLE=
"font-size: 8.5pt;">&nbsp;&nbsp;&nbsp;</FONT> <FONT STYLE=
"font-size: 7.0pt;">Assumes the Rights Offering is fully
subscribed, but excludes proceeds from the exercise of Warrants
included within the Units.</FONT></P>
<P CLASS="Textflush" STYLE=
"margin-top: 2.5pt; mso-style-name: Text_flush; margin-right: 0in; margin-bottom: .0001pt; margin-left: 0in; line-height: 12.0pt; text-autospace: none; font-size: 10.0pt; font-family: TimesNewRomanPSStd-Regular; color: black;">
<FONT CLASS="Bold" STYLE=
"mso-style-name: Bold; font-weight: bold;"><FONT STYLE=
"font-size: 7.0pt;">Our board of directors is making no
recommendation regarding your exercise of the Subscription Rights.
You should carefully consider whether to exercise your Subscription
Rights before the expiration date. You may not revoke or revise any
exercises of Subscription Rights once made.</FONT></FONT></P>
<P CLASS="Textflush" STYLE=
"margin-top: 2.5pt; mso-style-name: Text_flush; margin-right: 0in; margin-bottom: .0001pt; margin-left: 0in; line-height: 12.0pt; text-autospace: none; font-size: 10.0pt; font-family: TimesNewRomanPSStd-Regular; color: black;"> <FONT STYLE="font-size: 7pt"><B>Neither
the Securities and Exchange Commission nor any state securities commission has approved or disapproved of these securities or
passed upon the adequacy or accuracy of the prospectus supplement, as amended by this amendment, or the prospectus. Any representation
to the contrary is a criminal offense.</B></FONT> </P>
<P CLASS="H1" STYLE=
"margin-top: 4.0pt; mso-style-name: H1; margin-right: 0in; margin-bottom: .0001pt; margin-left: 0in; text-align: center; line-height: 14.0pt; page-break-after: avoid; text-autospace: none; font-size: 12.0pt; font-family: TimesNewRomanPSStd-Bold; color: black; font-weight: bold;">
<FONT CLASS="Italic" STYLE=
"mso-style-name: Italic; font-style: italic;"><FONT STYLE=
"font-size: 8.0pt; font-weight: normal;">Dealer-Manager</FONT></FONT></P>
<P CLASS="H1" STYLE=
"margin-top: 0in; mso-style-name: H1; margin-right: 0in; margin-bottom: .0001pt; margin-left: 0in; text-align: center; line-height: 14.0pt; page-break-after: avoid; text-autospace: none; font-size: 12.0pt; font-family: TimesNewRomanPSStd-Bold; color: black; font-weight: bold;">
<FONT CLASS="Bold" STYLE=
"mso-style-name: Bold; font-weight: bold;">Maxim Group
LLC</FONT></P>
<P CLASS="Textflush" ALIGN="center" STYLE=
"margin-top: 0in; text-align: center; mso-style-name: Text_flush; margin-right: 0in; margin-bottom: .0001pt; margin-left: 0in; line-height: 12.0pt; text-autospace: none; font-size: 10.0pt; font-family: TimesNewRomanPSStd-Regular; color: black;">
<FONT STYLE="font-size: 7.0pt;">The date of this prospectus
supplement is February 26, 2018</FONT></P>
<P CLASS="RRH" STYLE=
"margin: 0in; margin-bottom: .0001pt; page-break-after: always; border-bottom: 1px solid; mso-style-name: RRH; margin-top: 10.0pt; margin-right: 0in; margin-left: 0in; text-align: center; text-autospace: none; font-size: 10.0pt; font-family: TimesNewRomanPSStd-Regular; color: black;">
&nbsp;</P>
<P CLASS="Textflush" STYLE=
"mso-style-name: Text_flush; margin-top: 12.0pt; margin-right: 0in; margin-bottom: .0001pt; margin-left: 0in; line-height: 12.0pt; text-autospace: none; font-size: 10.0pt; font-family: TimesNewRomanPSStd-Regular; color: black;"> This
amendment amends and supplements the prospectus supplement to reflect the reduction of the Subscription Price per Unit to $0.50,
the reduction of the Series A Warrant exercise price to $0.60 per share, the reduction of the Series B Warrant exercise price
to $0.70 per share, the reduction of the Series A Warrant redemption price threshold to $1.20 per share, the reduction of the
Series B Warrant redemption price threshold to $2.10 per share and to make related changes. All references in the prospectus supplement
to the Unit Subscription Price of $0.70 per share are hereby amended to $0.50 per Unit. All references to the Series A Warrants
exercise price of $0.90 per share are hereby amended to reflect an exercise price of $0.60 per share. All references to the Series
B Warrant exercise price of $1.05 per share are hereby amended to reflect an exercise price of $0.70 per share. All references
to the redemption price threshold of $1.80 per share, for the Series A Warrants, are hereby amended to $1.20 per share. All references
to the redemption price threshold of $3.30 per share, for the Series B Warrants, are hereby amended to $2.10 per share. All references
to the prospectus supplement are hereby amended to refer to the prospectus supplement, as amended by this amendment. </P>
<P CLASS="Textflush" STYLE=
"mso-style-name: Text_flush; margin-top: 12.0pt; margin-right: 0in; margin-bottom: .0001pt; margin-left: 0in; line-height: 12.0pt; text-autospace: none; font-size: 10.0pt; font-family: TimesNewRomanPSStd-Regular; color: black;"> The
sections of the prospectus supplement entitled &ldquo;Summary of the Rights Offering&rdquo; and &ldquo;Dilution&rdquo; are hereby
replaced by the following new Summary of the Rights Offering and Dilution sections (which reflect the changes to the Subscription
Price of the Units, the exercise prices of the Warrants, and the redemption price thresholds of the Warrants). </P>
<P CLASS="Textflush" STYLE=
"mso-style-name: Text_flush; margin-top: 12.0pt; margin-right: 0in; margin-bottom: .0001pt; margin-left: 0in; line-height: 12.0pt; text-autospace: none; font-size: 10.0pt; font-family: TimesNewRomanPSStd-Regular; color: black;"> This
amendment should be read in conjunction with and is qualified by reference to the prospectus supplement, except to the extent
that the information provided by this amendment supersedes the information contained in the prospectus supplement. </P>
<P CLASS="LRH" STYLE=
"margin: 10px 0px 10px 0px !important; page-break-after: always; border-bottom: 1px solid; mso-style-name: LRH; margin-top: 10.0pt; margin-right: 0in; margin-bottom: 10.0pt; margin-left: 0in; text-align: center; text-autospace: none; font-size: 10.0pt; font-family: TimesNewRomanPSStd-Regular; color: black;">
S-1</P>
<P CLASS="H1" STYLE=
"margin-bottom: 10.0pt; mso-style-name: H1; margin-top: .25in; margin-right: 0in; margin-left: 0in; text-align: center; line-height: 14.0pt; page-break-after: avoid; text-autospace: none; font-size: 12.0pt; font-family: TimesNewRomanPSStd-Bold; color: black; font-weight: bold;">
<FONT CLASS="Bold" STYLE=
"mso-style-name: Bold; font-weight: bold;">Summary of the Rights
Offering</FONT></P>
<TABLE CLASS="MsoNormalTable" BORDER="0" CELLSPACING="0"
CELLPADDING="0" STYLE=
"margin-left: .4pt; border-collapse: collapse; border: 0px solid #000; border-width: 0px; margin: 0;">
<TR>
<TD WIDTH="176" VALIGN="top" STYLE=
"width: 132.0pt; padding: 0in 0in 0in 0in;">
<P CLASS="Texttablewrap" STYLE=
"line-height: normal; padding-bottom: 3px !important; mso-style-name: Texttable_wrap; margin-top: 0in; margin-right: 0in; margin-bottom: .0001pt; margin-left: 10.0pt; text-indent: -10.0pt; text-autospace: none; font-size: 10.0pt; font-family: TimesNewRomanPSStd-Regular; color: black;">
<FONT CLASS="Bold" STYLE=
"mso-style-name: Bold; font-weight: bold;"><FONT LANG=
"EN-GB">Securities to be Offered</FONT></FONT></P>
</TD>
<TD WIDTH="11" VALIGN="top" STYLE=
"width: 8.0pt; padding: 0in 0in 0in 0in;">
<P CLASS="NoParagraphStyle" STYLE=
'line-height: normal; mso-style-name: "\[No Paragraph Style\]"; margin: 0in; margin-bottom: .0001pt; text-autospace: none; font-size: 12.0pt; font-family: "MinionPro-Regular","serif"; color: black;'>
<FONT STYLE=
"font-family: TimesNewRomanPSStd-Regular; color: windowtext;">&nbsp;</FONT></P>
</TD>
<TD WIDTH="424" VALIGN="top" STYLE=
"width: 318.0pt; padding: 0in 0in 0in 0in;">
<P CLASS="Texttable" STYLE=
"line-height: normal; mso-style-name: Texttable; margin: 0in; margin-bottom: .0001pt; text-autospace: none; font-size: 10.0pt; font-family: TimesNewRomanPSStd-Regular; color: black;">
<FONT LANG="EN-GB">We are distributing to you, at no charge,
50,000,000 non-transferable Subscription Rights to purchase one
Unit for every share of our common stock or participating warrant
that you owned on the Record Date. Each Unit consists of one share
of Common Stock, 0.25 Series A Warrants and 0.75 Series B
Warrants.</FONT></P>
</TD>
</TR>
<TR>
<TD WIDTH="176" VALIGN="top" STYLE=
"width: 132.0pt; padding: 0in 0in 0in 0in;">
<P CLASS="NoParagraphStyle" STYLE=
'line-height: normal; mso-style-name: "\[No Paragraph Style\]"; margin: 0in; margin-bottom: .0001pt; text-autospace: none; font-size: 12.0pt; font-family: "MinionPro-Regular","serif"; color: black;'>
<FONT STYLE=
"font-family: TimesNewRomanPSStd-Regular; color: windowtext;">&nbsp;</FONT></P>
</TD>
<TD WIDTH="11" VALIGN="top" STYLE=
"width: 8.0pt; padding: 0in 0in 0in 0in;">
<P CLASS="NoParagraphStyle" STYLE=
'line-height: normal; mso-style-name: "\[No Paragraph Style\]"; margin: 0in; margin-bottom: .0001pt; text-autospace: none; font-size: 12.0pt; font-family: "MinionPro-Regular","serif"; color: black;'>
<FONT STYLE=
"font-family: TimesNewRomanPSStd-Regular; color: windowtext;">&nbsp;</FONT></P>
</TD>
<TD WIDTH="424" VALIGN="top" STYLE=
"width: 318.0pt; padding: 0in 0in 0in 0in;">
<P CLASS="NoParagraphStyle" STYLE=
'line-height: normal; mso-style-name: "\[No Paragraph Style\]"; margin: 0in; margin-bottom: .0001pt; text-autospace: none; font-size: 12.0pt; font-family: "MinionPro-Regular","serif"; color: black;'>
<FONT STYLE=
"font-family: TimesNewRomanPSStd-Regular; color: windowtext;">&nbsp;</FONT></P>
</TD>
</TR>
<TR>
<TD WIDTH="176" VALIGN="top" STYLE=
"width: 132.0pt; padding: 0in 0in 0in 0in;">
<P CLASS="Texttablewrap" STYLE=
"line-height: normal; padding-bottom: 3px !important; mso-style-name: Texttable_wrap; margin-top: 0in; margin-right: 0in; margin-bottom: .0001pt; margin-left: 10.0pt; text-indent: -10.0pt; text-autospace: none; font-size: 10.0pt; font-family: TimesNewRomanPSStd-Regular; color: black;">
<FONT CLASS="Bold" STYLE=
"mso-style-name: Bold; font-weight: bold;"><FONT LANG=
"EN-GB">Subscription Price</FONT></FONT></P>
</TD>
<TD WIDTH="11" VALIGN="top" STYLE=
"width: 8.0pt; padding: 0in 0in 0in 0in;">
<P CLASS="NoParagraphStyle" STYLE=
'line-height: normal; mso-style-name: "\[No Paragraph Style\]"; margin: 0in; margin-bottom: .0001pt; text-autospace: none; font-size: 12.0pt; font-family: "MinionPro-Regular","serif"; color: black;'>
<FONT STYLE=
"font-family: TimesNewRomanPSStd-Regular; color: windowtext;">&nbsp;</FONT></P>
</TD>
<TD WIDTH="424" VALIGN="top" STYLE=
"width: 318.0pt; padding: 0in 0in 0in 0in;">
<P CLASS="Texttable" STYLE=
"line-height: normal; mso-style-name: Texttable; margin: 0in; margin-bottom: .0001pt; text-autospace: none; font-size: 10.0pt; font-family: TimesNewRomanPSStd-Regular; color: black;">
$0.50 per Unit.</P>
</TD>
</TR>
<TR>
<TD WIDTH="176" VALIGN="top" STYLE=
"width: 132.0pt; padding: 0in 0in 0in 0in;">
<P CLASS="NoParagraphStyle" STYLE=
'line-height: normal; mso-style-name: "\[No Paragraph Style\]"; margin: 0in; margin-bottom: .0001pt; text-autospace: none; font-size: 12.0pt; font-family: "MinionPro-Regular","serif"; color: black;'>
<FONT STYLE=
"font-family: TimesNewRomanPSStd-Regular; color: windowtext;">&nbsp;</FONT></P>
</TD>
<TD WIDTH="11" VALIGN="top" STYLE=
"width: 8.0pt; padding: 0in 0in 0in 0in;">
<P CLASS="NoParagraphStyle" STYLE=
'line-height: normal; mso-style-name: "\[No Paragraph Style\]"; margin: 0in; margin-bottom: .0001pt; text-autospace: none; font-size: 12.0pt; font-family: "MinionPro-Regular","serif"; color: black;'>
<FONT STYLE=
"font-family: TimesNewRomanPSStd-Regular; color: windowtext;">&nbsp;</FONT></P>
</TD>
<TD WIDTH="424" VALIGN="top" STYLE=
"width: 318.0pt; padding: 0in 0in 0in 0in;">
<P CLASS="NoParagraphStyle" STYLE=
'line-height: normal; mso-style-name: "\[No Paragraph Style\]"; margin: 0in; margin-bottom: .0001pt; text-autospace: none; font-size: 12.0pt; font-family: "MinionPro-Regular","serif"; color: black;'>
<FONT STYLE=
"font-family: TimesNewRomanPSStd-Regular; color: windowtext;">&nbsp;</FONT></P>
</TD>
</TR>
<TR>
<TD WIDTH="176" VALIGN="top" STYLE=
"width: 132.0pt; padding: 0in 0in 0in 0in;">
<P CLASS="Texttablewrap" STYLE=
"line-height: normal; padding-bottom: 3px !important; mso-style-name: Texttable_wrap; margin-top: 0in; margin-right: 0in; margin-bottom: .0001pt; margin-left: 10.0pt; text-indent: -10.0pt; text-autospace: none; font-size: 10.0pt; font-family: TimesNewRomanPSStd-Regular; color: black;">
<FONT CLASS="Bold" STYLE=
"mso-style-name: Bold; font-weight: bold;"><FONT LANG=
"EN-GB">Warrants</FONT></FONT></P>
</TD>
<TD WIDTH="11" VALIGN="top" STYLE=
"width: 8.0pt; padding: 0in 0in 0in 0in;">
<P CLASS="NoParagraphStyle" STYLE=
'line-height: normal; mso-style-name: "\[No Paragraph Style\]"; margin: 0in; margin-bottom: .0001pt; text-autospace: none; font-size: 12.0pt; font-family: "MinionPro-Regular","serif"; color: black;'>
<FONT STYLE=
"font-family: TimesNewRomanPSStd-Regular; color: windowtext;">&nbsp;</FONT></P>
</TD>
<TD WIDTH="424" VALIGN="top" STYLE=
"width: 318.0pt; padding: 0in 0in 0in 0in;">
<P CLASS="Texttable" STYLE=
"line-height: normal; mso-style-name: Texttable; margin: 0in; margin-bottom: .0001pt; text-autospace: none; font-size: 10.0pt; font-family: TimesNewRomanPSStd-Regular; color: black;"> <FONT STYLE="letter-spacing: -0.05pt">Each
whole Series A Warrant entitles the holder to purchase one share of common stock at an exercise price of $0.60 per share from
the closing date through its expiration 12 months from the date of issuance. Each whole Series B Warrant entitles the holder to
purchase one share of common stock at an exercise price of $0.70 per share from the closing date through its expiration 30 months
from the date of issuance. The Warrants will be exercisable for cash, or, solely during any period when a registration statement
for the exercise of the Warrants is not in effect, on a cashless basis. We may redeem the Series A Warrants for $0.001 per warrant
if our common stock closes above $1.20 per share for ten consecutive trading days. We may redeem the Series B Warrants for $0.001
per warrant if our common stock closes above $2.10 per share for ten consecutive trading days.</FONT> </P>
</TD>
</TR>
<TR>
<TD WIDTH="176" VALIGN="top" STYLE=
"width: 132.0pt; padding: 0in 0in 0in 0in;">
<P CLASS="NoParagraphStyle" STYLE=
'line-height: normal; mso-style-name: "\[No Paragraph Style\]"; margin: 0in; margin-bottom: .0001pt; text-autospace: none; font-size: 12.0pt; font-family: "MinionPro-Regular","serif"; color: black;'>
<FONT STYLE=
"font-family: TimesNewRomanPSStd-Regular; color: windowtext;">&nbsp;</FONT></P>
</TD>
<TD WIDTH="11" VALIGN="top" STYLE=
"width: 8.0pt; padding: 0in 0in 0in 0in;">
<P CLASS="NoParagraphStyle" STYLE=
'line-height: normal; mso-style-name: "\[No Paragraph Style\]"; margin: 0in; margin-bottom: .0001pt; text-autospace: none; font-size: 12.0pt; font-family: "MinionPro-Regular","serif"; color: black;'>
<FONT STYLE=
"font-family: TimesNewRomanPSStd-Regular; color: windowtext;">&nbsp;</FONT></P>
</TD>
<TD WIDTH="424" VALIGN="top" STYLE=
"width: 318.0pt; padding: 0in 0in 0in 0in;">
<P CLASS="NoParagraphStyle" STYLE=
'line-height: normal; mso-style-name: "\[No Paragraph Style\]"; margin: 0in; margin-bottom: .0001pt; text-autospace: none; font-size: 12.0pt; font-family: "MinionPro-Regular","serif"; color: black;'>
<FONT STYLE=
"font-family: TimesNewRomanPSStd-Regular; color: windowtext;">&nbsp;</FONT></P>
</TD>
</TR>
<TR>
<TD WIDTH="176" VALIGN="top" STYLE=
"width: 132.0pt; padding: 0in 0in 0in 0in;">
<P CLASS="Texttablewrap" STYLE=
"line-height: normal; padding-bottom: 3px !important; mso-style-name: Texttable_wrap; margin-top: 0in; margin-right: 0in; margin-bottom: .0001pt; margin-left: 10.0pt; text-indent: -10.0pt; text-autospace: none; font-size: 10.0pt; font-family: TimesNewRomanPSStd-Regular; color: black;">
<FONT CLASS="Bold" STYLE=
"mso-style-name: Bold; font-weight: bold;"><FONT LANG=
"EN-GB">Record Date</FONT></FONT></P>
</TD>
<TD WIDTH="11" VALIGN="top" STYLE=
"width: 8.0pt; padding: 0in 0in 0in 0in;">
<P CLASS="NoParagraphStyle" STYLE=
'line-height: normal; mso-style-name: "\[No Paragraph Style\]"; margin: 0in; margin-bottom: .0001pt; text-autospace: none; font-size: 12.0pt; font-family: "MinionPro-Regular","serif"; color: black;'>
<FONT STYLE=
"font-family: TimesNewRomanPSStd-Regular; color: windowtext;">&nbsp;</FONT></P>
</TD>
<TD WIDTH="424" VALIGN="top" STYLE=
"width: 318.0pt; padding: 0in 0in 0in 0in;">
<P CLASS="Texttable" STYLE=
"line-height: normal; mso-style-name: Texttable; margin: 0in; margin-bottom: .0001pt; text-autospace: none; font-size: 10.0pt; font-family: TimesNewRomanPSStd-Regular; color: black;">
<FONT LANG="EN-GB">5:00 p.m., Eastern Time, February 14,
2018.</FONT></P>
</TD>
</TR>
<TR>
<TD WIDTH="176" VALIGN="top" STYLE=
"width: 132.0pt; padding: 0in 0in 0in 0in;">
<P CLASS="NoParagraphStyle" STYLE=
'line-height: normal; mso-style-name: "\[No Paragraph Style\]"; margin: 0in; margin-bottom: .0001pt; text-autospace: none; font-size: 12.0pt; font-family: "MinionPro-Regular","serif"; color: black;'>
<FONT STYLE=
"font-family: TimesNewRomanPSStd-Regular; color: windowtext;">&nbsp;</FONT></P>
</TD>
<TD WIDTH="11" VALIGN="top" STYLE=
"width: 8.0pt; padding: 0in 0in 0in 0in;">
<P CLASS="NoParagraphStyle" STYLE=
'line-height: normal; mso-style-name: "\[No Paragraph Style\]"; margin: 0in; margin-bottom: .0001pt; text-autospace: none; font-size: 12.0pt; font-family: "MinionPro-Regular","serif"; color: black;'>
<FONT STYLE=
"font-family: TimesNewRomanPSStd-Regular; color: windowtext;">&nbsp;</FONT></P>
</TD>
<TD WIDTH="424" VALIGN="top" STYLE=
"width: 318.0pt; padding: 0in 0in 0in 0in;">
<P CLASS="NoParagraphStyle" STYLE=
'line-height: normal; mso-style-name: "\[No Paragraph Style\]"; margin: 0in; margin-bottom: .0001pt; text-autospace: none; font-size: 12.0pt; font-family: "MinionPro-Regular","serif"; color: black;'>
<FONT STYLE=
"font-family: TimesNewRomanPSStd-Regular; color: windowtext;">&nbsp;</FONT></P>
</TD>
</TR>
<TR>
<TD WIDTH="176" VALIGN="top" STYLE=
"width: 132.0pt; padding: 0in 0in 0in 0in;">
<P CLASS="Texttablewrap" STYLE=
"line-height: normal; padding-bottom: 3px !important; mso-style-name: Texttable_wrap; margin-top: 0in; margin-right: 0in; margin-bottom: .0001pt; margin-left: 10.0pt; text-indent: -10.0pt; text-autospace: none; font-size: 10.0pt; font-family: TimesNewRomanPSStd-Regular; color: black;">
<FONT CLASS="Bold" STYLE=
"mso-style-name: Bold; font-weight: bold;"><FONT LANG="EN-GB">Basic
Subscription Rights</FONT></FONT></P>
</TD>
<TD WIDTH="11" VALIGN="top" STYLE=
"width: 8.0pt; padding: 0in 0in 0in 0in;">
<P CLASS="NoParagraphStyle" STYLE=
'line-height: normal; mso-style-name: "\[No Paragraph Style\]"; margin: 0in; margin-bottom: .0001pt; text-autospace: none; font-size: 12.0pt; font-family: "MinionPro-Regular","serif"; color: black;'>
<FONT STYLE=
"font-family: TimesNewRomanPSStd-Regular; color: windowtext;">&nbsp;</FONT></P>
</TD>
<TD WIDTH="424" VALIGN="top" STYLE=
"width: 318.0pt; padding: 0in 0in 0in 0in;">
<P CLASS="Texttable" STYLE=
"line-height: normal; mso-style-name: Texttable; margin: 0in; margin-bottom: .0001pt; text-autospace: none; font-size: 10.0pt; font-family: TimesNewRomanPSStd-Regular; color: black;">
<FONT LANG="EN-GB">Your Basic Subscription Right will entitle you
to purchase one Unit at the Subscription Price.</FONT></P>
</TD>
</TR>
<TR>
<TD WIDTH="176" VALIGN="top" STYLE=
"width: 132.0pt; padding: 0in 0in 0in 0in;">
<P CLASS="NoParagraphStyle" STYLE=
'line-height: normal; mso-style-name: "\[No Paragraph Style\]"; margin: 0in; margin-bottom: .0001pt; text-autospace: none; font-size: 12.0pt; font-family: "MinionPro-Regular","serif"; color: black;'>
<FONT STYLE=
"font-family: TimesNewRomanPSStd-Regular; color: windowtext;">&nbsp;</FONT></P>
</TD>
<TD WIDTH="11" VALIGN="top" STYLE=
"width: 8.0pt; padding: 0in 0in 0in 0in;">
<P CLASS="NoParagraphStyle" STYLE=
'line-height: normal; mso-style-name: "\[No Paragraph Style\]"; margin: 0in; margin-bottom: .0001pt; text-autospace: none; font-size: 12.0pt; font-family: "MinionPro-Regular","serif"; color: black;'>
<FONT STYLE=
"font-family: TimesNewRomanPSStd-Regular; color: windowtext;">&nbsp;</FONT></P>
</TD>
<TD WIDTH="424" VALIGN="top" STYLE=
"width: 318.0pt; padding: 0in 0in 0in 0in;">
<P CLASS="NoParagraphStyle" STYLE=
'line-height: normal; mso-style-name: "\[No Paragraph Style\]"; margin: 0in; margin-bottom: .0001pt; text-autospace: none; font-size: 12.0pt; font-family: "MinionPro-Regular","serif"; color: black;'>
<FONT STYLE=
"font-family: TimesNewRomanPSStd-Regular; color: windowtext;">&nbsp;</FONT></P>
</TD>
</TR>
<TR>
<TD WIDTH="176" VALIGN="top" STYLE=
"width: 132.0pt; padding: 0in 0in 0in 0in;">
<P CLASS="Texttablewrap" STYLE=
"line-height: normal; padding-bottom: 3px !important; mso-style-name: Texttable_wrap; margin-top: 0in; margin-right: 0in; margin-bottom: .0001pt; margin-left: 10.0pt; text-indent: -10.0pt; text-autospace: none; font-size: 10.0pt; font-family: TimesNewRomanPSStd-Regular; color: black;">
<FONT CLASS="Bold" STYLE=
"mso-style-name: Bold; font-weight: bold;"><FONT LANG=
"EN-GB">Over-Subscription Privilege</FONT></FONT></P>
</TD>
<TD WIDTH="11" VALIGN="top" STYLE=
"width: 8.0pt; padding: 0in 0in 0in 0in;">
<P CLASS="NoParagraphStyle" STYLE=
'line-height: normal; mso-style-name: "\[No Paragraph Style\]"; margin: 0in; margin-bottom: .0001pt; text-autospace: none; font-size: 12.0pt; font-family: "MinionPro-Regular","serif"; color: black;'>
<FONT STYLE=
"font-family: TimesNewRomanPSStd-Regular; color: windowtext;">&nbsp;</FONT></P>
</TD>
<TD WIDTH="424" VALIGN="top" STYLE=
"width: 318.0pt; padding: 0in 0in 0in 0in;">
<P CLASS="Texttable" STYLE=
"line-height: normal; mso-style-name: Texttable; margin: 0in; margin-bottom: .0001pt; text-autospace: none; font-size: 10.0pt; font-family: TimesNewRomanPSStd-Regular; color: black;">
<FONT LANG="EN-GB">If you exercise your Basic Subscription Rights
in full, you may also choose to purchase a portion of any Units
that are not purchased by our other stockholders or participating
warrant holders through the exercise of their Basic Subscription
Rights, subject to proration and stock ownership limitations
described elsewhere in this prospectus supplement.</FONT></P>
</TD>
</TR>
<TR>
<TD WIDTH="176" VALIGN="top" STYLE=
"width: 132.0pt; padding: 0in 0in 0in 0in;">
<P CLASS="NoParagraphStyle" STYLE=
'line-height: normal; mso-style-name: "\[No Paragraph Style\]"; margin: 0in; margin-bottom: .0001pt; text-autospace: none; font-size: 12.0pt; font-family: "MinionPro-Regular","serif"; color: black;'>
<FONT STYLE=
"font-family: TimesNewRomanPSStd-Regular; color: windowtext;">&nbsp;</FONT></P>
</TD>
<TD WIDTH="11" VALIGN="top" STYLE=
"width: 8.0pt; padding: 0in 0in 0in 0in;">
<P CLASS="NoParagraphStyle" STYLE=
'line-height: normal; mso-style-name: "\[No Paragraph Style\]"; margin: 0in; margin-bottom: .0001pt; text-autospace: none; font-size: 12.0pt; font-family: "MinionPro-Regular","serif"; color: black;'>
<FONT STYLE=
"font-family: TimesNewRomanPSStd-Regular; color: windowtext;">&nbsp;</FONT></P>
</TD>
<TD WIDTH="424" VALIGN="top" STYLE=
"width: 318.0pt; padding: 0in 0in 0in 0in;">
<P CLASS="NoParagraphStyle" STYLE=
'line-height: normal; mso-style-name: "\[No Paragraph Style\]"; margin: 0in; margin-bottom: .0001pt; text-autospace: none; font-size: 12.0pt; font-family: "MinionPro-Regular","serif"; color: black;'>
<FONT STYLE=
"font-family: TimesNewRomanPSStd-Regular; color: windowtext;">&nbsp;</FONT></P>
</TD>
</TR>
<TR>
<TD WIDTH="176" VALIGN="top" STYLE=
"width: 132.0pt; padding: 0in 0in 0in 0in;">
<P CLASS="Texttablewrap" STYLE=
"line-height: normal; padding-bottom: 3px !important; mso-style-name: Texttable_wrap; margin-top: 0in; margin-right: 0in; margin-bottom: .0001pt; margin-left: 10.0pt; text-indent: -10.0pt; text-autospace: none; font-size: 10.0pt; font-family: TimesNewRomanPSStd-Regular; color: black;">
<FONT CLASS="Bold" STYLE=
"mso-style-name: Bold; font-weight: bold;"><FONT LANG=
"EN-GB">Expiration date</FONT></FONT></P>
</TD>
<TD WIDTH="11" VALIGN="top" STYLE=
"width: 8.0pt; padding: 0in 0in 0in 0in;">
<P CLASS="NoParagraphStyle" STYLE=
'line-height: normal; mso-style-name: "\[No Paragraph Style\]"; margin: 0in; margin-bottom: .0001pt; text-autospace: none; font-size: 12.0pt; font-family: "MinionPro-Regular","serif"; color: black;'>
<FONT STYLE=
"font-family: TimesNewRomanPSStd-Regular; color: windowtext;">&nbsp;</FONT></P>
</TD>
<TD WIDTH="424" VALIGN="top" STYLE=
"width: 318.0pt; padding: 0in 0in 0in 0in;">
<P CLASS="Texttable" STYLE=
"line-height: normal; mso-style-name: Texttable; margin: 0in; margin-bottom: .0001pt; text-autospace: none; font-size: 10.0pt; font-family: TimesNewRomanPSStd-Regular; color: black;">
<FONT LANG="EN-GB">The Subscription Rights will expire at 5:00
p.m., Eastern Time, on March 2, 2018.</FONT></P>
</TD>
</TR>
<TR>
<TD WIDTH="176" VALIGN="top" STYLE=
"width: 132.0pt; padding: 0in 0in 0in 0in;">
<P CLASS="NoParagraphStyle" STYLE=
'line-height: normal; mso-style-name: "\[No Paragraph Style\]"; margin: 0in; margin-bottom: .0001pt; text-autospace: none; font-size: 12.0pt; font-family: "MinionPro-Regular","serif"; color: black;'>
<FONT STYLE=
"font-family: TimesNewRomanPSStd-Regular; color: windowtext;">&nbsp;</FONT></P>
</TD>
<TD WIDTH="11" VALIGN="top" STYLE=
"width: 8.0pt; padding: 0in 0in 0in 0in;">
<P CLASS="NoParagraphStyle" STYLE=
'line-height: normal; mso-style-name: "\[No Paragraph Style\]"; margin: 0in; margin-bottom: .0001pt; text-autospace: none; font-size: 12.0pt; font-family: "MinionPro-Regular","serif"; color: black;'>
<FONT STYLE=
"font-family: TimesNewRomanPSStd-Regular; color: windowtext;">&nbsp;</FONT></P>
</TD>
<TD WIDTH="424" VALIGN="top" STYLE=
"width: 318.0pt; padding: 0in 0in 0in 0in;">
<P CLASS="NoParagraphStyle" STYLE=
'line-height: normal; mso-style-name: "\[No Paragraph Style\]"; margin: 0in; margin-bottom: .0001pt; text-autospace: none; font-size: 12.0pt; font-family: "MinionPro-Regular","serif"; color: black;'>
<FONT STYLE=
"font-family: TimesNewRomanPSStd-Regular; color: windowtext;">&nbsp;</FONT></P>
</TD>
</TR>
<TR>
<TD WIDTH="176" VALIGN="top" STYLE=
"width: 132.0pt; padding: 0in 0in 0in 0in;">
<P CLASS="Texttablewrap" STYLE=
"line-height: normal; padding-bottom: 3px !important; mso-style-name: Texttable_wrap; margin-top: 0in; margin-right: 0in; margin-bottom: .0001pt; margin-left: 10.0pt; text-indent: -10.0pt; text-autospace: none; font-size: 10.0pt; font-family: TimesNewRomanPSStd-Regular; color: black;">
<FONT CLASS="Bold" STYLE=
"mso-style-name: Bold; font-weight: bold;"><FONT LANG=
"EN-GB">Procedure for Exercising Subscription
Rights</FONT></FONT></P>
</TD>
<TD WIDTH="11" VALIGN="top" STYLE=
"width: 8.0pt; padding: 0in 0in 0in 0in;">
<P CLASS="NoParagraphStyle" STYLE=
'line-height: normal; mso-style-name: "\[No Paragraph Style\]"; margin: 0in; margin-bottom: .0001pt; text-autospace: none; font-size: 12.0pt; font-family: "MinionPro-Regular","serif"; color: black;'>
<FONT STYLE=
"font-family: TimesNewRomanPSStd-Regular; color: windowtext;">&nbsp;</FONT></P>
</TD>
<TD WIDTH="424" VALIGN="top" STYLE=
"width: 318.0pt; padding: 0in 0in 0in 0in;">
<P CLASS="Texttable" STYLE=
"line-height: normal; mso-style-name: Texttable; margin: 0in; margin-bottom: .0001pt; text-autospace: none; font-size: 10.0pt; font-family: TimesNewRomanPSStd-Regular; color: black;">
<FONT LANG="EN-GB"><BR>
To exercise your Subscription Rights, you must take the following
steps: If you are a record holder of our common stock or
participating warrant holder, you must deliver payment and a
properly completed Rights Certificate to the Subscription Agent to
be received before 5:00 p.m., Eastern Time, on March 2, 2018. You
may deliver the documents and payments by first class mail or
courier service. If you use first class mail for this purpose, we
recommend using registered mail, properly insured, with return
receipt requested. If you are a beneficial owner of shares or
participating warrants that are registered in the name of a broker,
dealer, bank or other nominee, you should instruct your broker,
dealer, bank or other nominee to exercise your Subscription Rights
on your behalf. Please follow the instructions of your nominee, who
may require that you meet a deadline earlier than 5:00 p.m.,
Eastern Time, on March 2, 2018.</FONT></P>
</TD>
</TR>
</TABLE>
<P CLASS="RRH" STYLE=
"margin: 10px 0px 10px 0px !important; page-break-after: always; border-bottom: 1px solid; mso-style-name: RRH; margin-top: 10.0pt; margin-right: 0in; margin-bottom: 10.0pt; margin-left: 0in; text-align: center; text-autospace: none; font-size: 10.0pt; font-family: TimesNewRomanPSStd-Regular; color: black;">
S-2</P>
<TABLE CLASS="MsoNormalTable" BORDER="0" CELLSPACING="0"
CELLPADDING="0" STYLE=
"margin-left: .4pt; border-collapse: collapse; border: 0px solid #000; border-width: 0px; margin: 0;">
<TR>
<TD WIDTH="176" VALIGN="top" STYLE=
"width: 132.0pt; padding: 0in 0in 0in 0in;">
<P CLASS="NoParagraphStyle" STYLE=
'line-height: normal; mso-style-name: "\[No Paragraph Style\]"; margin: 0in; margin-bottom: .0001pt; text-autospace: none; font-size: 12.0pt; font-family: "MinionPro-Regular","serif"; color: black;'>
<FONT STYLE=
"font-family: TimesNewRomanPSStd-Regular; color: windowtext;">&nbsp;</FONT></P>
</TD>
<TD WIDTH="11" VALIGN="top" STYLE=
"width: 8.0pt; padding: 0in 0in 0in 0in;">
<P CLASS="NoParagraphStyle" STYLE=
'line-height: normal; mso-style-name: "\[No Paragraph Style\]"; margin: 0in; margin-bottom: .0001pt; text-autospace: none; font-size: 12.0pt; font-family: "MinionPro-Regular","serif"; color: black;'>
<FONT STYLE=
"font-family: TimesNewRomanPSStd-Regular; color: windowtext;">&nbsp;</FONT></P>
</TD>
<TD WIDTH="424" VALIGN="top" STYLE=
"width: 318.0pt; padding: 0in 0in 0in 0in;">
<P CLASS="Texttable" STYLE=
"line-height: normal; mso-style-name: Texttable; margin: 0in; margin-bottom: .0001pt; text-autospace: none; font-size: 10.0pt; font-family: TimesNewRomanPSStd-Regular; color: black;"> <FONT STYLE="letter-spacing: -0.1pt"><B>As
a result of the revisions to the pricing terms of the Rights Offering described in the amendment, dated February 26, 2018, to
this prospectus supplement, any holders of subscription rights who previously exercised their subscription rights at the original
subscription price of $0.70 per Unit, or who submit election forms referencing the original subscription price of $0.70 per Unit,
will be considered to have exercised their subscription rights at the revised Subscription Price of $0.50 per Unit and will receive
the appropriate number of shares of Common Stock, Series A Warrants and Series B Warrants as if such holder had subscribed at
the revised Subscription Price of $0.50 per Unit.</B></FONT> </P>
</TD>
</TR>
<TR>
<TD WIDTH="176" VALIGN="top" STYLE=
"width: 132.0pt; padding: 0in 0in 0in 0in;">
<P CLASS="NoParagraphStyle" STYLE=
'line-height: normal; mso-style-name: "\[No Paragraph Style\]"; margin: 0in; margin-bottom: .0001pt; text-autospace: none; font-size: 12.0pt; font-family: "MinionPro-Regular","serif"; color: black;'>
<FONT STYLE=
"font-family: TimesNewRomanPSStd-Regular; color: windowtext;">&nbsp;</FONT></P>
</TD>
<TD WIDTH="11" VALIGN="top" STYLE=
"width: 8.0pt; padding: 0in 0in 0in 0in;">
<P CLASS="NoParagraphStyle" STYLE=
'line-height: normal; mso-style-name: "\[No Paragraph Style\]"; margin: 0in; margin-bottom: .0001pt; text-autospace: none; font-size: 12.0pt; font-family: "MinionPro-Regular","serif"; color: black;'>
<FONT STYLE=
"font-family: TimesNewRomanPSStd-Regular; color: windowtext;">&nbsp;</FONT></P>
</TD>
<TD WIDTH="424" VALIGN="top" STYLE=
"width: 318.0pt; padding: 0in 0in 0in 0in;">
<P CLASS="NoParagraphStyle" STYLE=
'line-height: normal; mso-style-name: "\[No Paragraph Style\]"; margin: 0in; margin-bottom: .0001pt; text-autospace: none; font-size: 12.0pt; font-family: "MinionPro-Regular","serif"; color: black;'>
<FONT STYLE=
"font-family: TimesNewRomanPSStd-Regular; color: windowtext;">&nbsp;</FONT></P>
</TD>
</TR>
<TR>
<TD WIDTH="176" VALIGN="top" STYLE=
"width: 132.0pt; padding: 0in 0in 0in 0in;">
<P CLASS="Texttablewrap" STYLE=
"line-height: normal; padding-bottom: 3px !important; mso-style-name: Texttable_wrap; margin-top: 0in; margin-right: 0in; margin-bottom: .0001pt; margin-left: 10.0pt; text-indent: -10.0pt; text-autospace: none; font-size: 10.0pt; font-family: TimesNewRomanPSStd-Regular; color: black;">
<FONT CLASS="Bold" STYLE=
"mso-style-name: Bold; font-weight: bold;"><FONT LANG=
"EN-GB">Delivery of Shares and Warrant</FONT></FONT><FONT LANG=
"EN-GB">s</FONT></P>
</TD>
<TD WIDTH="11" VALIGN="top" STYLE=
"width: 8.0pt; padding: 0in 0in 0in 0in;">
<P CLASS="NoParagraphStyle" STYLE=
'line-height: normal; mso-style-name: "\[No Paragraph Style\]"; margin: 0in; margin-bottom: .0001pt; text-autospace: none; font-size: 12.0pt; font-family: "MinionPro-Regular","serif"; color: black;'>
<FONT STYLE=
"font-family: TimesNewRomanPSStd-Regular; color: windowtext;">&nbsp;</FONT></P>
</TD>
<TD WIDTH="424" VALIGN="top" STYLE=
"width: 318.0pt; padding: 0in 0in 0in 0in;">
<P CLASS="Texttable" STYLE=
"line-height: normal; mso-style-name: Texttable; margin: 0in; margin-bottom: .0001pt; text-autospace: none; font-size: 10.0pt; font-family: TimesNewRomanPSStd-Regular; color: black;">
<FONT LANG="EN-GB"><BR>
As soon as practicable after the expiration of the Rights Offering,
and within five business days thereof, we expect to close on
subscriptions and for the Subscription Agent to arrange for the
issuance of the shares of Common Stock, Series A Warrants and
Series B Warrants purchased pursuant to the Rights Offering. All
shares and Warrants that are purchased in the Rights Offering will
be issued in book-entry, or uncertificated form, meaning that you
will receive a direct registration, or DRS, account statement from
our transfer agent reflecting ownership of these securities if you
are a holder of record of shares or warrants. If you hold your
shares in the name of a bank, broker, dealer, or other nominee, DTC
will credit your account with your nominee with the securities you
purchased in the Rights Offering.</FONT></P>
</TD>
</TR>
<TR>
<TD WIDTH="176" VALIGN="top" STYLE=
"width: 132.0pt; padding: 0in 0in 0in 0in;">
<P CLASS="NoParagraphStyle" STYLE=
'line-height: normal; mso-style-name: "\[No Paragraph Style\]"; margin: 0in; margin-bottom: .0001pt; text-autospace: none; font-size: 12.0pt; font-family: "MinionPro-Regular","serif"; color: black;'>
<FONT STYLE=
"font-family: TimesNewRomanPSStd-Regular; color: windowtext;">&nbsp;</FONT></P>
</TD>
<TD WIDTH="11" VALIGN="top" STYLE=
"width: 8.0pt; padding: 0in 0in 0in 0in;">
<P CLASS="NoParagraphStyle" STYLE=
'line-height: normal; mso-style-name: "\[No Paragraph Style\]"; margin: 0in; margin-bottom: .0001pt; text-autospace: none; font-size: 12.0pt; font-family: "MinionPro-Regular","serif"; color: black;'>
<FONT STYLE=
"font-family: TimesNewRomanPSStd-Regular; color: windowtext;">&nbsp;</FONT></P>
</TD>
<TD WIDTH="424" VALIGN="top" STYLE=
"width: 318.0pt; padding: 0in 0in 0in 0in;">
<P CLASS="NoParagraphStyle" STYLE=
'line-height: normal; mso-style-name: "\[No Paragraph Style\]"; margin: 0in; margin-bottom: .0001pt; text-autospace: none; font-size: 12.0pt; font-family: "MinionPro-Regular","serif"; color: black;'>
<FONT STYLE=
"font-family: TimesNewRomanPSStd-Regular; color: windowtext;">&nbsp;</FONT></P>
</TD>
</TR>
<TR>
<TD WIDTH="176" VALIGN="top" STYLE=
"width: 132.0pt; padding: 0in 0in 0in 0in;">
<P CLASS="Texttablewrap" STYLE=
"line-height: normal; padding-bottom: 3px !important; mso-style-name: Texttable_wrap; margin-top: 0in; margin-right: 0in; margin-bottom: .0001pt; margin-left: 10.0pt; text-indent: -10.0pt; text-autospace: none; font-size: 10.0pt; font-family: TimesNewRomanPSStd-Regular; color: black;">
<FONT CLASS="Bold" STYLE=
"mso-style-name: Bold; font-weight: bold;"><FONT LANG=
"EN-GB">Non-transferability of Subscription
Rights</FONT></FONT></P>
</TD>
<TD WIDTH="11" VALIGN="top" STYLE=
"width: 8.0pt; padding: 0in 0in 0in 0in;">
<P CLASS="NoParagraphStyle" STYLE=
'line-height: normal; mso-style-name: "\[No Paragraph Style\]"; margin: 0in; margin-bottom: .0001pt; text-autospace: none; font-size: 12.0pt; font-family: "MinionPro-Regular","serif"; color: black;'>
<FONT STYLE=
"font-family: TimesNewRomanPSStd-Regular; color: windowtext;">&nbsp;</FONT></P>
</TD>
<TD WIDTH="424" VALIGN="top" STYLE=
"width: 318.0pt; padding: 0in 0in 0in 0in;">
<P CLASS="Texttable" STYLE=
"line-height: normal; mso-style-name: Texttable; margin: 0in; margin-bottom: .0001pt; text-autospace: none; font-size: 10.0pt; font-family: TimesNewRomanPSStd-Regular; color: black;">
<FONT LANG="EN-GB"><BR>
The Subscription Rights may not be sold, transferred, assigned or
given away to anyone. The Subscription Rights will not be listed
for trading on any stock exchange or market.</FONT></P>
</TD>
</TR>
<TR>
<TD WIDTH="176" VALIGN="top" STYLE=
"width: 132.0pt; padding: 0in 0in 0in 0in;">
<P CLASS="NoParagraphStyle" STYLE=
'line-height: normal; mso-style-name: "\[No Paragraph Style\]"; margin: 0in; margin-bottom: .0001pt; text-autospace: none; font-size: 12.0pt; font-family: "MinionPro-Regular","serif"; color: black;'>
<FONT STYLE=
"font-family: TimesNewRomanPSStd-Regular; color: windowtext;">&nbsp;</FONT></P>
</TD>
<TD WIDTH="11" VALIGN="top" STYLE=
"width: 8.0pt; padding: 0in 0in 0in 0in;">
<P CLASS="NoParagraphStyle" STYLE=
'line-height: normal; mso-style-name: "\[No Paragraph Style\]"; margin: 0in; margin-bottom: .0001pt; text-autospace: none; font-size: 12.0pt; font-family: "MinionPro-Regular","serif"; color: black;'>
<FONT STYLE=
"font-family: TimesNewRomanPSStd-Regular; color: windowtext;">&nbsp;</FONT></P>
</TD>
<TD WIDTH="424" VALIGN="top" STYLE=
"width: 318.0pt; padding: 0in 0in 0in 0in;">
<P CLASS="NoParagraphStyle" STYLE=
'line-height: normal; mso-style-name: "\[No Paragraph Style\]"; margin: 0in; margin-bottom: .0001pt; text-autospace: none; font-size: 12.0pt; font-family: "MinionPro-Regular","serif"; color: black;'>
<FONT STYLE=
"font-family: TimesNewRomanPSStd-Regular; color: windowtext;">&nbsp;</FONT></P>
</TD>
</TR>
<TR>
<TD WIDTH="176" VALIGN="top" STYLE=
"width: 132.0pt; padding: 0in 0in 0in 0in;">
<P CLASS="Texttablewrap" STYLE=
"line-height: normal; padding-bottom: 3px !important; mso-style-name: Texttable_wrap; margin-top: 0in; margin-right: 0in; margin-bottom: .0001pt; margin-left: 10.0pt; text-indent: -10.0pt; text-autospace: none; font-size: 10.0pt; font-family: TimesNewRomanPSStd-Regular; color: black;">
<FONT CLASS="Bold" STYLE=
"mso-style-name: Bold; font-weight: bold;"><FONT LANG=
"EN-GB">Transferability of Warrants</FONT></FONT></P>
</TD>
<TD WIDTH="11" VALIGN="top" STYLE=
"width: 8.0pt; padding: 0in 0in 0in 0in;">
<P CLASS="NoParagraphStyle" STYLE=
'line-height: normal; mso-style-name: "\[No Paragraph Style\]"; margin: 0in; margin-bottom: .0001pt; text-autospace: none; font-size: 12.0pt; font-family: "MinionPro-Regular","serif"; color: black;'>
<FONT STYLE=
"font-family: TimesNewRomanPSStd-Regular; color: windowtext;">&nbsp;</FONT></P>
</TD>
<TD WIDTH="424" VALIGN="top" STYLE=
"width: 318.0pt; padding: 0in 0in 0in 0in;">
<P CLASS="Texttable" STYLE=
"line-height: normal; mso-style-name: Texttable; margin: 0in; margin-bottom: .0001pt; text-autospace: none; font-size: 10.0pt; font-family: TimesNewRomanPSStd-Regular; color: black;">
<FONT LANG="EN-GB">The Series A Warrants and Series B Warrants will
be separately transferable following their issuance and through
their expiration 12 months and 30 months, respectively, from the
date of issuance.</FONT></P>
</TD>
</TR>
<TR>
<TD WIDTH="176" VALIGN="top" STYLE=
"width: 132.0pt; padding: 0in 0in 0in 0in;">
<P CLASS="NoParagraphStyle" STYLE=
'line-height: normal; mso-style-name: "\[No Paragraph Style\]"; margin: 0in; margin-bottom: .0001pt; text-autospace: none; font-size: 12.0pt; font-family: "MinionPro-Regular","serif"; color: black;'>
<FONT STYLE=
"font-family: TimesNewRomanPSStd-Regular; color: windowtext;">&nbsp;</FONT></P>
</TD>
<TD WIDTH="11" VALIGN="top" STYLE=
"width: 8.0pt; padding: 0in 0in 0in 0in;">
<P CLASS="NoParagraphStyle" STYLE=
'line-height: normal; mso-style-name: "\[No Paragraph Style\]"; margin: 0in; margin-bottom: .0001pt; text-autospace: none; font-size: 12.0pt; font-family: "MinionPro-Regular","serif"; color: black;'>
<FONT STYLE=
"font-family: TimesNewRomanPSStd-Regular; color: windowtext;">&nbsp;</FONT></P>
</TD>
<TD WIDTH="424" VALIGN="top" STYLE=
"width: 318.0pt; padding: 0in 0in 0in 0in;">
<P CLASS="NoParagraphStyle" STYLE=
'line-height: normal; mso-style-name: "\[No Paragraph Style\]"; margin: 0in; margin-bottom: .0001pt; text-autospace: none; font-size: 12.0pt; font-family: "MinionPro-Regular","serif"; color: black;'>
<FONT STYLE=
"font-family: TimesNewRomanPSStd-Regular; color: windowtext;">&nbsp;</FONT></P>
</TD>
</TR>
<TR>
<TD WIDTH="176" VALIGN="top" STYLE=
"width: 132.0pt; padding: 0in 0in 0in 0in;">
<P CLASS="Texttablewrap" STYLE=
"line-height: normal; padding-bottom: 3px !important; mso-style-name: Texttable_wrap; margin-top: 0in; margin-right: 0in; margin-bottom: .0001pt; margin-left: 10.0pt; text-indent: -10.0pt; text-autospace: none; font-size: 10.0pt; font-family: TimesNewRomanPSStd-Regular; color: black;">
<FONT CLASS="Bold" STYLE=
"mso-style-name: Bold; font-weight: bold;"><FONT LANG="EN-GB">No
board recommendation</FONT></FONT></P>
</TD>
<TD WIDTH="11" VALIGN="top" STYLE=
"width: 8.0pt; padding: 0in 0in 0in 0in;">
<P CLASS="NoParagraphStyle" STYLE=
'line-height: normal; mso-style-name: "\[No Paragraph Style\]"; margin: 0in; margin-bottom: .0001pt; text-autospace: none; font-size: 12.0pt; font-family: "MinionPro-Regular","serif"; color: black;'>
<FONT STYLE=
"font-family: TimesNewRomanPSStd-Regular; color: windowtext;">&nbsp;</FONT></P>
</TD>
<TD WIDTH="424" VALIGN="top" STYLE=
"width: 318.0pt; padding: 0in 0in 0in 0in;">
<P CLASS="Texttable" STYLE=
"line-height: normal; mso-style-name: Texttable; margin: 0in; margin-bottom: .0001pt; text-autospace: none; font-size: 10.0pt; font-family: TimesNewRomanPSStd-Regular; color: black;"> Our
board of directors is not making a recommendation regarding your exercise of the Subscription Rights. You are urged to make your
decision to invest based on your own assessment of our business and financial condition, our prospects for the future, the terms
of the Rights Offering, the information contained or incorporated by reference in this prospectus supplement and the accompanying
prospectus and other information relevant to your circumstances. Please see &ldquo;Risk Factors&rdquo; in the prospectus supplement
for a discussion of some of the risks involved in investing in our securities. </P>
</TD>
</TR>
</TABLE>
<P CLASS="LRH" STYLE=
"margin: 10px 0px 10px 0px !important; page-break-after: always; border-bottom: 1px solid; mso-style-name: LRH; margin-top: 10.0pt; margin-right: 0in; margin-bottom: 10.0pt; margin-left: 0in; text-align: center; text-autospace: none; font-size: 10.0pt; font-family: TimesNewRomanPSStd-Regular; color: black;">
S-3</P>
<TABLE CLASS="MsoNormalTable" BORDER="0" CELLSPACING="0"
CELLPADDING="0" WIDTH="611" STYLE=
"margin-left: .4pt; border-collapse: collapse; border: 0px solid #000; border-width: 0px; margin: 0;">
<TR>
<TD WIDTH="176" VALIGN="top" STYLE=
"width: 132.0pt; padding: 0in 0in 0in 0in;">
<P CLASS="Texttablewrap" STYLE=
"line-height: normal; padding-bottom: 3px !important; mso-style-name: Texttable_wrap; margin-top: 0in; margin-right: 0in; margin-bottom: .0001pt; margin-left: 10.0pt; text-indent: -10.0pt; text-autospace: none; font-size: 10.0pt; font-family: TimesNewRomanPSStd-Regular; color: black;">
<FONT CLASS="Bold" STYLE=
"mso-style-name: Bold; font-weight: bold;"><FONT LANG="EN-GB">No
Revocation</FONT></FONT></P>
</TD>
<TD WIDTH="11" VALIGN="top" STYLE=
"width: 8.0pt; padding: 0in 0in 0in 0in;">
<P CLASS="NoParagraphStyle" STYLE=
'line-height: normal; mso-style-name: "\[No Paragraph Style\]"; margin: 0in; margin-bottom: .0001pt; text-autospace: none; font-size: 12.0pt; font-family: "MinionPro-Regular","serif"; color: black;'>
<FONT STYLE=
"font-family: TimesNewRomanPSStd-Regular; color: windowtext;">&nbsp;</FONT></P>
</TD>
<TD WIDTH="424" VALIGN="top" STYLE=
"width: 318.0pt; padding: 0in 0in 0in 0in;">
<P CLASS="Texttable" STYLE=
"line-height: normal; mso-style-name: Texttable; margin: 0in; margin-bottom: .0001pt; text-autospace: none; font-size: 10.0pt; font-family: TimesNewRomanPSStd-Regular; color: black;">
<FONT LANG="EN-GB">All exercises of Subscription Rights are
irrevocable, even if you later learn of information that you
consider to be unfavorable to the exercise of your Subscription
Rights.</FONT></P>
</TD>
</TR>
<TR>
<TD WIDTH="176" VALIGN="top" STYLE=
"width: 132.0pt; padding: 0in 0in 0in 0in;">
<P CLASS="NoParagraphStyle" STYLE=
'line-height: normal; mso-style-name: "\[No Paragraph Style\]"; margin: 0in; margin-bottom: .0001pt; text-autospace: none; font-size: 12.0pt; font-family: "MinionPro-Regular","serif"; color: black;'>
<FONT STYLE=
"font-family: TimesNewRomanPSStd-Regular; color: windowtext;">&nbsp;</FONT></P>
</TD>
<TD WIDTH="11" VALIGN="top" STYLE=
"width: 8.0pt; padding: 0in 0in 0in 0in;">
<P CLASS="NoParagraphStyle" STYLE=
'line-height: normal; mso-style-name: "\[No Paragraph Style\]"; margin: 0in; margin-bottom: .0001pt; text-autospace: none; font-size: 12.0pt; font-family: "MinionPro-Regular","serif"; color: black;'>
<FONT STYLE=
"font-family: TimesNewRomanPSStd-Regular; color: windowtext;">&nbsp;</FONT></P>
</TD>
<TD WIDTH="424" VALIGN="top" STYLE=
"width: 318.0pt; padding: 0in 0in 0in 0in;">
<P CLASS="NoParagraphStyle" STYLE=
'line-height: normal; mso-style-name: "\[No Paragraph Style\]"; margin: 0in; margin-bottom: .0001pt; text-autospace: none; font-size: 12.0pt; font-family: "MinionPro-Regular","serif"; color: black;'>
<FONT STYLE=
"font-family: TimesNewRomanPSStd-Regular; color: windowtext;">&nbsp;</FONT></P>
</TD>
</TR>
<TR>
<TD WIDTH="176" VALIGN="top" STYLE=
"width: 132.0pt; padding: 0in 0in 0in 0in;"><P CLASS="Texttablewrap" STYLE=
"line-height: normal; padding-bottom: 3px !important; mso-style-name: Texttable_wrap; margin-top: 0in; margin-right: 0in; margin-bottom: .0001pt; margin-left: 10.0pt; text-indent: -10.0pt; text-autospace: none; font-size: 10.0pt; font-family: TimesNewRomanPSStd-Regular; color: black;"> <B>Use
of Proceeds</B> </P>
</TD>
<TD WIDTH="11" VALIGN="top" STYLE=
"width: 8.0pt; padding: 0in 0in 0in 0in;"><P CLASS="NoParagraphStyle" STYLE=
'line-height: normal; mso-style-name: "\[No Paragraph Style\]"; margin: 0in; margin-bottom: .0001pt; text-autospace: none; font-size: 12.0pt; font-family: "MinionPro-Regular","serif"; color: black;'> <FONT STYLE="font-family: TimesNewRomanPSStd-Regular; color: windowtext">&nbsp;</FONT> </P>
</TD>
<TD WIDTH="424" VALIGN="top" STYLE=
"width: 318.0pt; padding: 0in 0in 0in 0in;"><P CLASS="Texttable" STYLE=
"line-height: normal; mso-style-name: Texttable; margin: 0in; margin-bottom: .0001pt; text-autospace: none; font-size: 10.0pt; font-family: TimesNewRomanPSStd-Regular; color: black;"> <FONT STYLE="letter-spacing: -0.05pt">Assuming
that the Rights Offering is fully subscribed, after deducting fees and expenses and excluding any proceeds received upon exercise
of any Series A Warrants and Series B Warrants, we estimate the net proceeds of the Rights Offering will be approximately $23
million. We currently intend to use the net proceeds from the sale of securities offered by this prospectus supplement to complete
our ongoing pivotal, Phase 3 SIERRA trial for our lead product candidate Iomab-B, generate topline results and support the filing
of a BLA application with the U.S. Food and Drug Administration (FDA), all of which are anticipated to cost an aggregate of approximately
$12 to $15 million. We may elect to use any additional proceeds above $15 million to fund proof-of-concept of our planned Phase
2 Actimab-MDS trial from the CD33 Program, if appropriate, as we believe this can further support its partnering strategy for
the CD33 program. We will also use the proceeds to support our AWE Technology Platform, research and development and general working
capital needs. See &ldquo;Use of Proceeds&rdquo; in the prospectus supplement.</FONT> </P>
</TD>
</TR>
<TR>
<TD WIDTH="176" VALIGN="top" STYLE=
"width: 132.0pt; padding: 0in 0in 0in 0in;">
<P CLASS="NoParagraphStyle" STYLE=
'line-height: normal; mso-style-name: "\[No Paragraph Style\]"; margin: 0in; margin-bottom: .0001pt; text-autospace: none; font-size: 12.0pt; font-family: "MinionPro-Regular","serif"; color: black;'>
<FONT STYLE=
"font-family: TimesNewRomanPSStd-Regular; color: windowtext;">&nbsp;</FONT></P>
</TD>
<TD WIDTH="11" VALIGN="top" STYLE=
"width: 8.0pt; padding: 0in 0in 0in 0in;">
<P CLASS="NoParagraphStyle" STYLE=
'line-height: normal; mso-style-name: "\[No Paragraph Style\]"; margin: 0in; margin-bottom: .0001pt; text-autospace: none; font-size: 12.0pt; font-family: "MinionPro-Regular","serif"; color: black;'>
<FONT STYLE=
"font-family: TimesNewRomanPSStd-Regular; color: windowtext;">&nbsp;</FONT></P>
</TD>
<TD WIDTH="424" VALIGN="top" STYLE=
"width: 318.0pt; padding: 0in 0in 0in 0in;">
<P CLASS="NoParagraphStyle" STYLE=
'line-height: normal; mso-style-name: "\[No Paragraph Style\]"; margin: 0in; margin-bottom: .0001pt; text-autospace: none; font-size: 12.0pt; font-family: "MinionPro-Regular","serif"; color: black;'>
<FONT STYLE=
"font-family: TimesNewRomanPSStd-Regular; color: windowtext;">&nbsp;</FONT></P>
</TD>
</TR>
<TR>
<TD WIDTH="176" VALIGN="top" STYLE=
"width: 132.0pt; padding: 0in 0in 0in 0in;">
<P CLASS="Texttablewrap" STYLE=
"line-height: normal; padding-bottom: 3px !important; mso-style-name: Texttable_wrap; margin-top: 0in; margin-right: 0in; margin-bottom: .0001pt; margin-left: 10.0pt; text-indent: -10.0pt; text-autospace: none; font-size: 10.0pt; font-family: TimesNewRomanPSStd-Regular; color: black;">
<FONT CLASS="Bold" STYLE=
"mso-style-name: Bold; font-weight: bold;"><FONT LANG=
"EN-GB">Maximum Exercise of Subscription Rights</FONT></FONT></P>
</TD>
<TD WIDTH="11" VALIGN="top" STYLE=
"width: 8.0pt; padding: 0in 0in 0in 0in;">
<P CLASS="NoParagraphStyle" STYLE=
'line-height: normal; mso-style-name: "\[No Paragraph Style\]"; margin: 0in; margin-bottom: .0001pt; text-autospace: none; font-size: 12.0pt; font-family: "MinionPro-Regular","serif"; color: black;'>
<FONT STYLE=
"font-family: TimesNewRomanPSStd-Regular; color: windowtext;">&nbsp;</FONT></P>
</TD>
<TD WIDTH="424" VALIGN="top" STYLE=
"width: 318.0pt; padding: 0in 0in 0in 0in;">
<P CLASS="Texttable" STYLE=
"line-height: normal; mso-style-name: Texttable; margin: 0in; margin-bottom: .0001pt; text-autospace: none; font-size: 10.0pt; font-family: TimesNewRomanPSStd-Regular; color: black;"> <BR>
Unless we otherwise agree in writing, a person or entity, together with related persons or entities, may not exercise Subscription
Rights (including Over-Subscription Privileges) to purchase Units that, when aggregated with their existing ownership, would result
in such person or entity, together with any related persons or entities, owning in excess of 19.9% of our issued and outstanding
shares of common stock following the closing of the transactions contemplated by this Rights Offering. In addition, to the extent
that any participating warrant holder&rsquo;s right to participate in this Rights Offering would result in the holder exceeding
the beneficial ownership limitation set forth in the participating warrants, then the holder will not be entitled to participate
in this Rights Offering. See &ldquo;The Rights Offering &mdash; Limitation on the Purchase of Units&rdquo; in the prospectus supplement. </P>
</TD>
</TR>
<TR>
<TD WIDTH="176" VALIGN="top" STYLE=
"width: 132.0pt; padding: 0in 0in 0in 0in;">
<P CLASS="NoParagraphStyle" STYLE=
'line-height: normal; mso-style-name: "\[No Paragraph Style\]"; margin: 0in; margin-bottom: .0001pt; text-autospace: none; font-size: 12.0pt; font-family: "MinionPro-Regular","serif"; color: black;'>
<FONT STYLE=
"font-family: TimesNewRomanPSStd-Regular; color: windowtext;">&nbsp;</FONT></P>
</TD>
<TD WIDTH="11" VALIGN="top" STYLE=
"width: 8.0pt; padding: 0in 0in 0in 0in;">
<P CLASS="NoParagraphStyle" STYLE=
'line-height: normal; mso-style-name: "\[No Paragraph Style\]"; margin: 0in; margin-bottom: .0001pt; text-autospace: none; font-size: 12.0pt; font-family: "MinionPro-Regular","serif"; color: black;'>
<FONT STYLE=
"font-family: TimesNewRomanPSStd-Regular; color: windowtext;">&nbsp;</FONT></P>
</TD>
<TD WIDTH="424" VALIGN="top" STYLE=
"width: 318.0pt; padding: 0in 0in 0in 0in;">
<P CLASS="NoParagraphStyle" STYLE=
'line-height: normal; mso-style-name: "\[No Paragraph Style\]"; margin: 0in; margin-bottom: .0001pt; text-autospace: none; font-size: 12.0pt; font-family: "MinionPro-Regular","serif"; color: black;'>
<FONT STYLE=
"font-family: TimesNewRomanPSStd-Regular; color: windowtext;">&nbsp;</FONT></P>
</TD>
</TR>
<TR>
<TD WIDTH="176" VALIGN="top" STYLE=
"width: 132.0pt; padding: 0in 0in 0in 0in;"><P CLASS="Texttablewrap" STYLE=
"line-height: normal; padding-bottom: 3px !important; mso-style-name: Texttable_wrap; margin-top: 0in; margin-right: 0in; margin-bottom: .0001pt; margin-left: 10.0pt; text-indent: -10.0pt; text-autospace: none; font-size: 10.0pt; font-family: TimesNewRomanPSStd-Regular; color: black;"> <B>Material
U.S. Federal Income Tax Consequences</B> </P>
</TD>
<TD WIDTH="11" VALIGN="top" STYLE=
"width: 8.0pt; padding: 0in 0in 0in 0in;"><P CLASS="NoParagraphStyle" STYLE=
'line-height: normal; mso-style-name: "\[No Paragraph Style\]"; margin: 0in; margin-bottom: .0001pt; text-autospace: none; font-size: 12.0pt; font-family: "MinionPro-Regular","serif"; color: black;'> <FONT STYLE="font-family: TimesNewRomanPSStd-Regular; color: windowtext">&nbsp;</FONT> </P>
</TD>
<TD WIDTH="424" VALIGN="top" STYLE=
"width: 318.0pt; padding: 0in 0in 0in 0in;"><P CLASS="Texttable" STYLE=
"line-height: normal; mso-style-name: Texttable; margin: 0in; margin-bottom: .0001pt; text-autospace: none; font-size: 10.0pt; font-family: TimesNewRomanPSStd-Regular; color: black;"> <BR>
For U.S. federal income tax purposes, we do not believe you should recognize income or loss upon receipt or exercise of a Subscription
Right. You should consult your own tax advisor as to the tax consequences of the Rights Offering in light of your particular circumstances.
See &ldquo;Material U.S. Federal Income Tax Consequences&rdquo; in the prospectus supplement. </P>
</TD>
</TR>
<TR>
<TD WIDTH="176" VALIGN="top" STYLE=
"width: 132.0pt; padding: 0in 0in 0in 0in;">
<P CLASS="NoParagraphStyle" STYLE=
'line-height: normal; mso-style-name: "\[No Paragraph Style\]"; margin: 0in; margin-bottom: .0001pt; text-autospace: none; font-size: 12.0pt; font-family: "MinionPro-Regular","serif"; color: black;'>
<FONT STYLE=
"font-family: TimesNewRomanPSStd-Regular; color: windowtext;">&nbsp;</FONT></P>
</TD>
<TD WIDTH="11" VALIGN="top" STYLE=
"width: 8.0pt; padding: 0in 0in 0in 0in;">
<P CLASS="NoParagraphStyle" STYLE=
'line-height: normal; mso-style-name: "\[No Paragraph Style\]"; margin: 0in; margin-bottom: .0001pt; text-autospace: none; font-size: 12.0pt; font-family: "MinionPro-Regular","serif"; color: black;'>
<FONT STYLE=
"font-family: TimesNewRomanPSStd-Regular; color: windowtext;">&nbsp;</FONT></P>
</TD>
<TD WIDTH="424" VALIGN="top" STYLE=
"width: 318.0pt; padding: 0in 0in 0in 0in;">
<P CLASS="NoParagraphStyle" STYLE=
'line-height: normal; mso-style-name: "\[No Paragraph Style\]"; margin: 0in; margin-bottom: .0001pt; text-autospace: none; font-size: 12.0pt; font-family: "MinionPro-Regular","serif"; color: black;'>
<FONT STYLE=
"font-family: TimesNewRomanPSStd-Regular; color: windowtext;">&nbsp;</FONT></P>
</TD>
</TR>
<TR>
<TD WIDTH="176" VALIGN="top" STYLE=
"width: 132.0pt; padding: 0in 0in 0in 0in;">
<P CLASS="Texttablewrap" STYLE=
"line-height: normal; padding-bottom: 3px !important; mso-style-name: Texttable_wrap; margin-top: 0in; margin-right: 0in; margin-bottom: .0001pt; margin-left: 10.0pt; text-indent: -10.0pt; text-autospace: none; font-size: 10.0pt; font-family: TimesNewRomanPSStd-Regular; color: black;">
<FONT CLASS="Bold" STYLE=
"mso-style-name: Bold; font-weight: bold;"><FONT LANG=
"EN-GB">Extension and Termination</FONT></FONT></P>
</TD>
<TD WIDTH="11" VALIGN="top" STYLE=
"width: 8.0pt; padding: 0in 0in 0in 0in;">
<P CLASS="NoParagraphStyle" STYLE=
'line-height: normal; mso-style-name: "\[No Paragraph Style\]"; margin: 0in; margin-bottom: .0001pt; text-autospace: none; font-size: 12.0pt; font-family: "MinionPro-Regular","serif"; color: black;'>
<FONT STYLE=
"font-family: TimesNewRomanPSStd-Regular; color: windowtext;">&nbsp;</FONT></P>
</TD>
<TD WIDTH="424" VALIGN="top" STYLE=
"width: 318.0pt; padding: 0in 0in 0in 0in;">
<P CLASS="Texttable" STYLE=
"line-height: normal; mso-style-name: Texttable; margin: 0in; margin-bottom: .0001pt; text-autospace: none; font-size: 10.0pt; font-family: TimesNewRomanPSStd-Regular; color: black;">
<FONT LANG="EN-GB">Although we do not presently intend to do so, we
may extend the Rights Offering for additional time in our sole
discretion. Our board of directors may for any reason terminate the
Rights Offering at any time before the completion of the Rights
Offering.</FONT></P>
</TD>
</TR>
<TR>
<TD WIDTH="176" VALIGN="top" STYLE=
"width: 132.0pt; padding: 0in 0in 0in 0in;">
<P CLASS="NoParagraphStyle" STYLE=
'line-height: normal; mso-style-name: "\[No Paragraph Style\]"; margin: 0in; margin-bottom: .0001pt; text-autospace: none; font-size: 12.0pt; font-family: "MinionPro-Regular","serif"; color: black;'>
<FONT STYLE=
"font-family: TimesNewRomanPSStd-Regular; color: windowtext;">&nbsp;</FONT></P>
</TD>
<TD WIDTH="11" VALIGN="top" STYLE=
"width: 8.0pt; padding: 0in 0in 0in 0in;">
<P CLASS="NoParagraphStyle" STYLE=
'line-height: normal; mso-style-name: "\[No Paragraph Style\]"; margin: 0in; margin-bottom: .0001pt; text-autospace: none; font-size: 12.0pt; font-family: "MinionPro-Regular","serif"; color: black;'>
<FONT STYLE=
"font-family: TimesNewRomanPSStd-Regular; color: windowtext;">&nbsp;</FONT></P>
</TD>
<TD WIDTH="424" VALIGN="top" STYLE=
"width: 318.0pt; padding: 0in 0in 0in 0in;">
<P CLASS="NoParagraphStyle" STYLE=
'line-height: normal; mso-style-name: "\[No Paragraph Style\]"; margin: 0in; margin-bottom: .0001pt; text-autospace: none; font-size: 12.0pt; font-family: "MinionPro-Regular","serif"; color: black;'>
<FONT STYLE=
"font-family: TimesNewRomanPSStd-Regular; color: windowtext;">&nbsp;</FONT></P>
</TD>
</TR>
<TR>
<TD WIDTH="176" VALIGN="top" STYLE=
"width: 132.0pt; padding: 0in 0in 0in 0in;">
<P CLASS="Texttablewrap" STYLE=
"line-height: normal; padding-bottom: 3px !important; mso-style-name: Texttable_wrap; margin-top: 0in; margin-right: 0in; margin-bottom: .0001pt; margin-left: 10.0pt; text-indent: -10.0pt; text-autospace: none; font-size: 10.0pt; font-family: TimesNewRomanPSStd-Regular; color: black;">
<FONT CLASS="Bold" STYLE=
"mso-style-name: Bold; font-weight: bold;"><FONT LANG=
"EN-GB">Subscription Agent</FONT></FONT></P>
</TD>
<TD WIDTH="11" VALIGN="top" STYLE=
"width: 8.0pt; padding: 0in 0in 0in 0in;">
<P CLASS="NoParagraphStyle" STYLE=
'line-height: normal; mso-style-name: "\[No Paragraph Style\]"; margin: 0in; margin-bottom: .0001pt; text-autospace: none; font-size: 12.0pt; font-family: "MinionPro-Regular","serif"; color: black;'>
<FONT STYLE=
"font-family: TimesNewRomanPSStd-Regular; color: windowtext;">&nbsp;</FONT></P>
</TD>
<TD WIDTH="424" VALIGN="top" STYLE=
"width: 318.0pt; padding: 0in 0in 0in 0in;">
<P CLASS="Texttable" STYLE=
"line-height: normal; mso-style-name: Texttable; margin: 0in; margin-bottom: .0001pt; text-autospace: none; font-size: 10.0pt; font-family: TimesNewRomanPSStd-Regular; color: black;">
<FONT LANG="EN-GB">Broadridge Corporate Issuer Solutions,
Inc.</FONT></P>
</TD>
</TR>
<TR>
<TD WIDTH="176" VALIGN="top" STYLE=
"width: 132.0pt; padding: 0in 0in 0in 0in;">
<P CLASS="NoParagraphStyle" STYLE=
'line-height: normal; mso-style-name: "\[No Paragraph Style\]"; margin: 0in; margin-bottom: .0001pt; text-autospace: none; font-size: 12.0pt; font-family: "MinionPro-Regular","serif"; color: black;'>
<FONT STYLE=
"font-family: TimesNewRomanPSStd-Regular; color: windowtext;">&nbsp;</FONT></P>
</TD>
<TD WIDTH="11" VALIGN="top" STYLE=
"width: 8.0pt; padding: 0in 0in 0in 0in;">
<P CLASS="NoParagraphStyle" STYLE=
'line-height: normal; mso-style-name: "\[No Paragraph Style\]"; margin: 0in; margin-bottom: .0001pt; text-autospace: none; font-size: 12.0pt; font-family: "MinionPro-Regular","serif"; color: black;'>
<FONT STYLE=
"font-family: TimesNewRomanPSStd-Regular; color: windowtext;">&nbsp;</FONT></P>
</TD>
<TD WIDTH="424" VALIGN="top" STYLE=
"width: 318.0pt; padding: 0in 0in 0in 0in;">
<P CLASS="NoParagraphStyle" STYLE=
'line-height: normal; mso-style-name: "\[No Paragraph Style\]"; margin: 0in; margin-bottom: .0001pt; text-autospace: none; font-size: 12.0pt; font-family: "MinionPro-Regular","serif"; color: black;'>
<FONT STYLE=
"font-family: TimesNewRomanPSStd-Regular; color: windowtext;">&nbsp;</FONT></P>
</TD>
</TR>
<TR>
<TD WIDTH="176" VALIGN="top" STYLE=
"width: 132.0pt; padding: 0in 0in 0in 0in;">
<P CLASS="Texttablewrap" STYLE=
"line-height: normal; padding-bottom: 3px !important; mso-style-name: Texttable_wrap; margin-top: 0in; margin-right: 0in; margin-bottom: .0001pt; margin-left: 10.0pt; text-indent: -10.0pt; text-autospace: none; font-size: 10.0pt; font-family: TimesNewRomanPSStd-Regular; color: black;">
<FONT CLASS="Bold" STYLE=
"mso-style-name: Bold; font-weight: bold;"><FONT LANG=
"EN-GB">Questions</FONT></FONT></P>
</TD>
<TD WIDTH="11" VALIGN="top" STYLE=
"width: 8.0pt; padding: 0in 0in 0in 0in;">
<P CLASS="NoParagraphStyle" STYLE=
'line-height: normal; mso-style-name: "\[No Paragraph Style\]"; margin: 0in; margin-bottom: .0001pt; text-autospace: none; font-size: 12.0pt; font-family: "MinionPro-Regular","serif"; color: black;'>
<FONT STYLE=
"font-family: TimesNewRomanPSStd-Regular; color: windowtext;">&nbsp;</FONT></P>
</TD>
<TD WIDTH="424" VALIGN="top" STYLE=
"width: 318.0pt; padding: 0in 0in 0in 0in;">
<P CLASS="Texttable" STYLE=
"line-height: normal; mso-style-name: Texttable; margin: 0in; margin-bottom: .0001pt; text-autospace: none; font-size: 10.0pt; font-family: TimesNewRomanPSStd-Regular; color: black;">
<FONT LANG="EN-GB">If you have any questions about the Rights
Offering, please contact the Subscription and Information Agent,
Broadridge Corporate Issuer Solutions, Inc., at (855) 793-5068
(toll free).</FONT></P>
</TD>
</TR>
<TR>
<TD WIDTH="176" VALIGN="top" STYLE=
"width: 132.0pt; padding: 0in 0in 0in 0in;">
<P CLASS="NoParagraphStyle" STYLE=
'line-height: normal; mso-style-name: "\[No Paragraph Style\]"; margin: 0in; margin-bottom: .0001pt; text-autospace: none; font-size: 12.0pt; font-family: "MinionPro-Regular","serif"; color: black;'>
<FONT STYLE=
"font-family: TimesNewRomanPSStd-Regular; color: windowtext;">&nbsp;</FONT></P>
</TD>
<TD WIDTH="11" VALIGN="top" STYLE=
"width: 8.0pt; padding: 0in 0in 0in 0in;">
<P CLASS="NoParagraphStyle" STYLE=
'line-height: normal; mso-style-name: "\[No Paragraph Style\]"; margin: 0in; margin-bottom: .0001pt; text-autospace: none; font-size: 12.0pt; font-family: "MinionPro-Regular","serif"; color: black;'>
<FONT STYLE=
"font-family: TimesNewRomanPSStd-Regular; color: windowtext;">&nbsp;</FONT></P>
</TD>
<TD WIDTH="424" VALIGN="top" STYLE=
"width: 318.0pt; padding: 0in 0in 0in 0in;">
<P CLASS="NoParagraphStyle" STYLE=
'line-height: normal; mso-style-name: "\[No Paragraph Style\]"; margin: 0in; margin-bottom: .0001pt; text-autospace: none; font-size: 12.0pt; font-family: "MinionPro-Regular","serif"; color: black;'>
<FONT STYLE=
"font-family: TimesNewRomanPSStd-Regular; color: windowtext;">&nbsp;</FONT></P>
</TD>
</TR>
<TR>
<TD WIDTH="176" VALIGN="top" STYLE=
"width: 132.0pt; padding: 0in 0in 0in 0in;">
<P CLASS="Texttablewrap" STYLE=
"line-height: normal; padding-bottom: 3px !important; mso-style-name: Texttable_wrap; margin-top: 0in; margin-right: 0in; margin-bottom: .0001pt; margin-left: 10.0pt; text-indent: -10.0pt; text-autospace: none; font-size: 10.0pt; font-family: TimesNewRomanPSStd-Regular; color: black;">
<FONT CLASS="Bold" STYLE=
"mso-style-name: Bold; font-weight: bold;"><FONT LANG=
"EN-GB">Market for common stoc</FONT></FONT><FONT LANG=
"EN-GB">k</FONT></P>
</TD>
<TD WIDTH="11" VALIGN="top" STYLE=
"width: 8.0pt; padding: 0in 0in 0in 0in;">
<P CLASS="NoParagraphStyle" STYLE=
'line-height: normal; mso-style-name: "\[No Paragraph Style\]"; margin: 0in; margin-bottom: .0001pt; text-autospace: none; font-size: 12.0pt; font-family: "MinionPro-Regular","serif"; color: black;'>
<FONT STYLE=
"font-family: TimesNewRomanPSStd-Regular; color: windowtext;">&nbsp;</FONT></P>
</TD>
<TD WIDTH="424" VALIGN="top" STYLE=
"width: 318.0pt; padding: 0in 0in 0in 0in;">
<P CLASS="Texttable" STYLE=
"line-height: normal; mso-style-name: Texttable; margin: 0in; margin-bottom: .0001pt; text-autospace: none; font-size: 10.0pt; font-family: TimesNewRomanPSStd-Regular; color: black;">
<FONT LANG="EN-GB">Our common stock is listed on NYSE American
under the symbol &ldquo;ATNM.&rdquo;</FONT></P>
</TD>
</TR>
<TR>
<TD WIDTH="176" VALIGN="top" STYLE=
"width: 132.0pt; padding: 0in 0in 0in 0in;">
<P CLASS="NoParagraphStyle" STYLE=
'line-height: normal; mso-style-name: "\[No Paragraph Style\]"; margin: 0in; margin-bottom: .0001pt; text-autospace: none; font-size: 12.0pt; font-family: "MinionPro-Regular","serif"; color: black;'>
<FONT STYLE=
"font-family: TimesNewRomanPSStd-Regular; color: windowtext;">&nbsp;</FONT></P>
</TD>
<TD WIDTH="11" VALIGN="top" STYLE=
"width: 8.0pt; padding: 0in 0in 0in 0in;">
<P CLASS="NoParagraphStyle" STYLE=
'line-height: normal; mso-style-name: "\[No Paragraph Style\]"; margin: 0in; margin-bottom: .0001pt; text-autospace: none; font-size: 12.0pt; font-family: "MinionPro-Regular","serif"; color: black;'>
<FONT STYLE=
"font-family: TimesNewRomanPSStd-Regular; color: windowtext;">&nbsp;</FONT></P>
</TD>
<TD WIDTH="424" VALIGN="top" STYLE=
"width: 318.0pt; padding: 0in 0in 0in 0in;">
<P CLASS="NoParagraphStyle" STYLE=
'line-height: normal; mso-style-name: "\[No Paragraph Style\]"; margin: 0in; margin-bottom: .0001pt; text-autospace: none; font-size: 12.0pt; font-family: "MinionPro-Regular","serif"; color: black;'>
<FONT STYLE=
"font-family: TimesNewRomanPSStd-Regular; color: windowtext;">&nbsp;</FONT></P>
</TD>
</TR>
<TR>
<TD WIDTH="176" VALIGN="top" STYLE=
"width: 132.0pt; padding: 0in 0in 0in 0in;">
<P CLASS="Texttablewrap" STYLE=
"line-height: normal; padding-bottom: 3px !important; mso-style-name: Texttable_wrap; margin-top: 0in; margin-right: 0in; margin-bottom: .0001pt; margin-left: 10.0pt; text-indent: -10.0pt; text-autospace: none; font-size: 10.0pt; font-family: TimesNewRomanPSStd-Regular; color: black;">
<FONT CLASS="Bold" STYLE=
"mso-style-name: Bold; font-weight: bold;"><FONT LANG=
"EN-GB">Dealer-Manager</FONT></FONT></P>
</TD>
<TD WIDTH="11" VALIGN="top" STYLE=
"width: 8.0pt; padding: 0in 0in 0in 0in;">
<P CLASS="NoParagraphStyle" STYLE=
'line-height: normal; mso-style-name: "\[No Paragraph Style\]"; margin: 0in; margin-bottom: .0001pt; text-autospace: none; font-size: 12.0pt; font-family: "MinionPro-Regular","serif"; color: black;'>
<FONT STYLE=
"font-family: TimesNewRomanPSStd-Regular; color: windowtext;">&nbsp;</FONT></P>
</TD>
<TD WIDTH="424" VALIGN="top" STYLE=
"width: 318.0pt; padding: 0in 0in 0in 0in;">
<P CLASS="Texttable" STYLE=
"line-height: normal; mso-style-name: Texttable; margin: 0in; margin-bottom: .0001pt; text-autospace: none; font-size: 10.0pt; font-family: TimesNewRomanPSStd-Regular; color: black;">
Maxim Group LLC.</P>
</TD>
</TR>
</TABLE>
<P CLASS="RRH" STYLE=
"margin: 10px 0px 10px 0px !important; page-break-after: always; border-bottom: 1px solid; mso-style-name: RRH; margin-top: 10.0pt; margin-right: 0in; margin-bottom: 10.0pt; margin-left: 0in; text-align: center; text-autospace: none; font-size: 10.0pt; font-family: TimesNewRomanPSStd-Regular; color: black;">
S-4</P>
<P CLASS="H1" STYLE=
"mso-style-name: H1; margin-top: .25in; margin-right: 0in; margin-bottom: .0001pt; margin-left: 0in; text-align: center; line-height: 14.0pt; page-break-after: avoid; text-autospace: none; font-size: 12.0pt; font-family: TimesNewRomanPSStd-Bold; color: black; font-weight: bold;">
<FONT CLASS="Bold" STYLE=
"mso-style-name: Bold; font-weight: bold;">Dilution</FONT></P>
<P CLASS="Textflush" STYLE=
"mso-style-name: Text_flush; margin-top: 12.0pt; margin-right: 0in; margin-bottom: .0001pt; margin-left: 0in; line-height: 12.0pt; text-autospace: none; font-size: 10.0pt; font-family: TimesNewRomanPSStd-Regular; color: black;">
Purchasers of Units in the Rights Offering will experience an
immediate dilution of the net tangible book value per share of our
common stock. Our net tangible book value as of September 30, 2017
was approximately $18.2 million, or $0.23 per share of our common
stock based upon 80,025,639 shares of our common stock outstanding.
Net tangible book value per share is equal to our total tangible
assets less our total liabilities, divided by the number of shares
of our outstanding common stock.</P>
<P CLASS="Textflush" STYLE=
"mso-style-name: Text_flush; margin-top: 12.0pt; margin-right: 0in; margin-bottom: .0001pt; margin-left: 0in; line-height: 12.0pt; text-autospace: none; font-size: 10.0pt; font-family: TimesNewRomanPSStd-Regular; color: black;">
Dilution per share of common stock equals the difference between
the amount per share of common stock paid by purchasers of Units in
the Rights Offering (ascribing no value to the Warrants contained
in the Units) and the net tangible book value per share of our
common stock immediately after the Rights Offering.</P>
<P CLASS="Textflush" STYLE=
"margin-bottom: 10.0pt; mso-style-name: Text_flush; margin-top: 12.0pt; margin-right: 0in; margin-left: 0in; line-height: 12.0pt; text-autospace: none; font-size: 10.0pt; font-family: TimesNewRomanPSStd-Regular; color: black;">
Based on the sale by us in this Rights Offering of a maximum of
50,000,000 Units at the Subscription Price of $0.50 per Unit
(assuming no exercise of the Warrants), and after deducting
estimated offering expenses and dealer-manager fees and expenses
payable by us, our pro forma net tangible book value as of
September 30, 2017 would have been approximately $41.4 million, or
$0.32 per share. This represents an immediate increase in pro forma
net tangible book value to existing stockholders of $0.09 per share
and an immediate dilution to purchasers in the Rights Offering of
$(0.18) per share. The following table illustrates this per-share
dilution:</P>
<TABLE CLASS="MsoNormalTable" BORDER="0" CELLSPACING="0"
CELLPADDING="0" STYLE=
"margin-left: .4pt; border-collapse: collapse; border: 0px solid #000; border-width: 0px; margin: 0;">
<TR>
<TD WIDTH="424" VALIGN="bottom" STYLE=
"width: 318.0pt; background: #CCEEFF; padding: 0in 0in 0in 0in;">
<P CLASS="Tbody" STYLE=
"line-height: normal; padding-bottom: 3px !important; mso-style-name: Tbody; margin-top: 0in; margin-right: 0in; margin-bottom: .0001pt; margin-left: 10.0pt; text-indent: -10.0pt; text-autospace: none; font-size: 10.0pt; font-family: TimesNewRomanPSStd-Regular; color: black;">
Subscription Price</P>
</TD>
<TD WIDTH="11" VALIGN="bottom" STYLE=
"width: 8.0pt; background: #CCEEFF; padding: 0in 0in 0in 0in;">
<P CLASS="NoParagraphStyle" STYLE=
'line-height: normal; mso-style-name: "\[No Paragraph Style\]"; margin: 0in; margin-bottom: .0001pt; text-autospace: none; font-size: 12.0pt; font-family: "MinionPro-Regular","serif"; color: black;'>
<FONT STYLE=
"font-family: TimesNewRomanPSStd-Regular; color: windowtext;">&nbsp;</FONT></P>
</TD>
<TD WIDTH="8" VALIGN="bottom" STYLE=
"width: 6.0pt; background: #CCEEFF; padding: 0in 0in 0in 0in;">
<P CLASS="NoParagraphStyle" STYLE=
'line-height: normal; mso-style-name: "\[No Paragraph Style\]"; margin: 0in; margin-bottom: .0001pt; text-autospace: none; font-size: 12.0pt; font-family: "MinionPro-Regular","serif"; color: black;'>
<FONT STYLE=
"font-family: TimesNewRomanPSStd-Regular; color: windowtext;">&nbsp;</FONT></P>
</TD>
<TD WIDTH="80" VALIGN="bottom" STYLE=
"width: 60.0pt; background: #CCEEFF; padding: 0in 0in 0in 0in;">
<P CLASS="NoParagraphStyle" STYLE=
'line-height: normal; mso-style-name: "\[No Paragraph Style\]"; margin: 0in; margin-bottom: .0001pt; text-autospace: none; font-size: 12.0pt; font-family: "MinionPro-Regular","serif"; color: black;'>
<FONT STYLE=
"font-family: TimesNewRomanPSStd-Regular; color: windowtext;">&nbsp;</FONT></P>
</TD>
<TD WIDTH="11" VALIGN="bottom" STYLE=
"width: 8.0pt; background: #CCEEFF; padding: 0in 0in 0in 0in;">
<P CLASS="NoParagraphStyle" STYLE=
'line-height: normal; mso-style-name: "\[No Paragraph Style\]"; margin: 0in; margin-bottom: .0001pt; text-autospace: none; font-size: 12.0pt; font-family: "MinionPro-Regular","serif"; color: black;'>
<FONT STYLE=
"font-family: TimesNewRomanPSStd-Regular; color: windowtext;">&nbsp;</FONT></P>
</TD>
<TD WIDTH="8" VALIGN="bottom" STYLE=
"width: 6.0pt; background: #CCEEFF; padding: 0in 0in 0in 0in;">
<P CLASS="Tbodyrightalign" ALIGN="left" STYLE=
"margin-right: 0in; text-align: left; line-height: normal; padding-bottom: 3px !important; mso-style-name: Tbody_rightalign; margin-top: 0in; margin-bottom: .0001pt; margin-left: 0in; text-autospace: none; font-size: 10.0pt; font-family: TimesNewRomanPSStd-Regular; color: black;">
$</P>
</TD>
<TD WIDTH="72" VALIGN="bottom" STYLE=
"width: .75in; background: #CCEEFF; padding: 0in 0in 0in 0in;">
<P CLASS="Tbodyrightalign" STYLE=
"margin-right: 0in; line-height: normal; padding-bottom: 3px !important; mso-style-name: Tbody_rightalign; margin-top: 0in; margin-bottom: .0001pt; margin-left: 0in; text-align: right; text-autospace: none; font-size: 10.0pt; font-family: TimesNewRomanPSStd-Regular; color: black;">
0.50</P>
</TD>
<TD WIDTH="8" VALIGN="bottom" STYLE=
"width: 6.0pt; background: #CCEEFF; padding: 0in 0in 0in 0in;">
<P CLASS="NoParagraphStyle" STYLE=
'line-height: normal; mso-style-name: "\[No Paragraph Style\]"; margin: 0in; margin-bottom: .0001pt; text-autospace: none; font-size: 12.0pt; font-family: "MinionPro-Regular","serif"; color: black;'>
<FONT STYLE=
"font-family: TimesNewRomanPSStd-Regular; color: windowtext;">&nbsp;</FONT></P>
</TD>
</TR>
<TR>
<TD WIDTH="424" VALIGN="bottom" STYLE=
"width: 318.0pt; background: white; padding: 0in 0in 0in 0in;">
<P CLASS="Tbody" STYLE=
"line-height: normal; padding-bottom: 3px !important; mso-style-name: Tbody; margin-top: 0in; margin-right: 0in; margin-bottom: .0001pt; margin-left: 10.0pt; text-indent: -10.0pt; text-autospace: none; font-size: 10.0pt; font-family: TimesNewRomanPSStd-Regular; color: black;">
Offering price per share and related warrants contained in a
Unit</P>
</TD>
<TD WIDTH="11" VALIGN="bottom" STYLE=
"width: 8.0pt; background: white; padding: 0in 0in 0in 0in;">
<P CLASS="NoParagraphStyle" STYLE=
'line-height: normal; mso-style-name: "\[No Paragraph Style\]"; margin: 0in; margin-bottom: .0001pt; text-autospace: none; font-size: 12.0pt; font-family: "MinionPro-Regular","serif"; color: black;'>
<FONT STYLE=
"font-family: TimesNewRomanPSStd-Regular; color: windowtext;">&nbsp;</FONT></P>
</TD>
<TD WIDTH="8" VALIGN="bottom" STYLE=
"width: 6.0pt; background: white; padding: 0in 0in 0in 0in;">
<P CLASS="NoParagraphStyle" STYLE=
'line-height: normal; mso-style-name: "\[No Paragraph Style\]"; margin: 0in; margin-bottom: .0001pt; text-autospace: none; font-size: 12.0pt; font-family: "MinionPro-Regular","serif"; color: black;'>
<FONT STYLE=
"font-family: TimesNewRomanPSStd-Regular; color: windowtext;">&nbsp;</FONT></P>
</TD>
<TD WIDTH="80" VALIGN="bottom" STYLE=
"width: 60.0pt; background: white; padding: 0in 0in 0in 0in;">
<P CLASS="NoParagraphStyle" STYLE=
'line-height: normal; mso-style-name: "\[No Paragraph Style\]"; margin: 0in; margin-bottom: .0001pt; text-autospace: none; font-size: 12.0pt; font-family: "MinionPro-Regular","serif"; color: black;'>
<FONT STYLE=
"font-family: TimesNewRomanPSStd-Regular; color: windowtext;">&nbsp;</FONT></P>
</TD>
<TD WIDTH="11" VALIGN="bottom" STYLE=
"width: 8.0pt; background: white; padding: 0in 0in 0in 0in;">
<P CLASS="NoParagraphStyle" STYLE=
'line-height: normal; mso-style-name: "\[No Paragraph Style\]"; margin: 0in; margin-bottom: .0001pt; text-autospace: none; font-size: 12.0pt; font-family: "MinionPro-Regular","serif"; color: black;'>
<FONT STYLE=
"font-family: TimesNewRomanPSStd-Regular; color: windowtext;">&nbsp;</FONT></P>
</TD>
<TD WIDTH="8" VALIGN="bottom" STYLE=
"width: 6.0pt; background: white; padding: 0in 0in 0in 0in;">
<P CLASS="Tbodyrightalign" ALIGN="left" STYLE=
"margin-right: 0in; text-align: left; line-height: normal; padding-bottom: 3px !important; mso-style-name: Tbody_rightalign; margin-top: 0in; margin-bottom: .0001pt; margin-left: 0in; text-autospace: none; font-size: 10.0pt; font-family: TimesNewRomanPSStd-Regular; color: black;">
$</P>
</TD>
<TD WIDTH="72" VALIGN="bottom" STYLE=
"width: .75in; background: white; padding: 0in 0in 0in 0in;">
<P CLASS="Tbodyrightalign" STYLE=
"margin-right: 0in; line-height: normal; padding-bottom: 3px !important; mso-style-name: Tbody_rightalign; margin-top: 0in; margin-bottom: .0001pt; margin-left: 0in; text-align: right; text-autospace: none; font-size: 10.0pt; font-family: TimesNewRomanPSStd-Regular; color: black;">
0.50</P>
</TD>
<TD WIDTH="8" VALIGN="bottom" STYLE=
"width: 6.0pt; background: white; padding: 0in 0in 0in 0in;">
<P CLASS="NoParagraphStyle" STYLE=
'line-height: normal; mso-style-name: "\[No Paragraph Style\]"; margin: 0in; margin-bottom: .0001pt; text-autospace: none; font-size: 12.0pt; font-family: "MinionPro-Regular","serif"; color: black;'>
<FONT STYLE=
"font-family: TimesNewRomanPSStd-Regular; color: windowtext;">&nbsp;</FONT></P>
</TD>
</TR>
<TR>
<TD WIDTH="424" VALIGN="bottom" STYLE=
"width: 318.0pt; background: #CCEEFF; padding: 0in 0in 0in 0in;">
<P CLASS="Tbody" STYLE=
"line-height: normal; padding-bottom: 3px !important; mso-style-name: Tbody; margin-top: 0in; margin-right: 0in; margin-bottom: .0001pt; margin-left: 10.0pt; text-indent: -10.0pt; text-autospace: none; font-size: 10.0pt; font-family: TimesNewRomanPSStd-Regular; color: black;">
<FONT LANG="EN-GB">Net tangible book value per share as of
September 30, 2017</FONT></P>
</TD>
<TD WIDTH="11" VALIGN="bottom" STYLE=
"width: 8.0pt; background: #CCEEFF; padding: 0in 0in 0in 0in;">
<P CLASS="NoParagraphStyle" STYLE=
'line-height: normal; mso-style-name: "\[No Paragraph Style\]"; margin: 0in; margin-bottom: .0001pt; text-autospace: none; font-size: 12.0pt; font-family: "MinionPro-Regular","serif"; color: black;'>
<FONT STYLE=
"font-family: TimesNewRomanPSStd-Regular; color: windowtext;">&nbsp;</FONT></P>
</TD>
<TD WIDTH="8" VALIGN="bottom" STYLE=
"width: 6.0pt; background: #CCEEFF; padding: 0in 0in 0in 0in;">
<P CLASS="Tbodyrightalign" ALIGN="left" STYLE=
"margin-right: 0in; text-align: left; line-height: normal; padding-bottom: 3px !important; mso-style-name: Tbody_rightalign; margin-top: 0in; margin-bottom: .0001pt; margin-left: 0in; text-autospace: none; font-size: 10.0pt; font-family: TimesNewRomanPSStd-Regular; color: black;">
$</P>
</TD>
<TD WIDTH="80" VALIGN="bottom" STYLE=
"width: 60.0pt; background: #CCEEFF; padding: 0in 0in 0in 0in;">
<P CLASS="Tbodyrightalign" STYLE=
"margin-right: 0in; line-height: normal; padding-bottom: 3px !important; mso-style-name: Tbody_rightalign; margin-top: 0in; margin-bottom: .0001pt; margin-left: 0in; text-align: right; text-autospace: none; font-size: 10.0pt; font-family: TimesNewRomanPSStd-Regular; color: black;">
0.23</P>
</TD>
<TD WIDTH="11" VALIGN="bottom" STYLE=
"width: 8.0pt; background: #CCEEFF; padding: 0in 0in 0in 0in;">
<P CLASS="NoParagraphStyle" STYLE=
'line-height: normal; mso-style-name: "\[No Paragraph Style\]"; margin: 0in; margin-bottom: .0001pt; text-autospace: none; font-size: 12.0pt; font-family: "MinionPro-Regular","serif"; color: black;'>
<FONT STYLE=
"font-family: TimesNewRomanPSStd-Regular; color: windowtext;">&nbsp;</FONT></P>
</TD>
<TD WIDTH="8" VALIGN="bottom" STYLE=
"width: 6.0pt; background: #CCEEFF; padding: 0in 0in 0in 0in;">
<P CLASS="NoParagraphStyle" STYLE=
'line-height: normal; mso-style-name: "\[No Paragraph Style\]"; margin: 0in; margin-bottom: .0001pt; text-autospace: none; font-size: 12.0pt; font-family: "MinionPro-Regular","serif"; color: black;'>
<FONT STYLE=
"font-family: TimesNewRomanPSStd-Regular; color: windowtext;">&nbsp;</FONT></P>
</TD>
<TD WIDTH="72" VALIGN="bottom" STYLE=
"width: .75in; background: #CCEEFF; padding: 0in 0in 0in 0in;">
<P CLASS="NoParagraphStyle" STYLE=
'line-height: normal; mso-style-name: "\[No Paragraph Style\]"; margin: 0in; margin-bottom: .0001pt; text-autospace: none; font-size: 12.0pt; font-family: "MinionPro-Regular","serif"; color: black;'>
<FONT STYLE=
"font-family: TimesNewRomanPSStd-Regular; color: windowtext;">&nbsp;</FONT></P>
</TD>
<TD WIDTH="8" VALIGN="bottom" STYLE=
"width: 6.0pt; background: #CCEEFF; padding: 0in 0in 0in 0in;">
<P CLASS="NoParagraphStyle" STYLE=
'line-height: normal; mso-style-name: "\[No Paragraph Style\]"; margin: 0in; margin-bottom: .0001pt; text-autospace: none; font-size: 12.0pt; font-family: "MinionPro-Regular","serif"; color: black;'>
<FONT STYLE=
"font-family: TimesNewRomanPSStd-Regular; color: windowtext;">&nbsp;</FONT></P>
</TD>
</TR>
<TR>
<TD WIDTH="424" VALIGN="bottom" STYLE=
"width: 318.0pt; background: white; padding: 0in 0in 0in 0in;">
<P CLASS="Tbody" STYLE=
"line-height: normal; padding-bottom: 3px !important; mso-style-name: Tbody; margin-top: 0in; margin-right: 0in; margin-bottom: .0001pt; margin-left: 10.0pt; text-indent: -10.0pt; text-autospace: none; font-size: 10.0pt; font-family: TimesNewRomanPSStd-Regular; color: black;">
<FONT LANG="EN-GB">Increase in net tangible book value per share
attributable to Rights Offering</FONT></P>
</TD>
<TD WIDTH="11" VALIGN="bottom" STYLE=
"width: 8.0pt; background: white; padding: 0in 0in 0in 0in;">
<P CLASS="NoParagraphStyle" STYLE=
'line-height: normal; mso-style-name: "\[No Paragraph Style\]"; margin: 0in; margin-bottom: .0001pt; text-autospace: none; font-size: 12.0pt; font-family: "MinionPro-Regular","serif"; color: black;'>
<FONT STYLE=
"font-family: TimesNewRomanPSStd-Regular; color: windowtext;">&nbsp;</FONT></P>
</TD>
<TD WIDTH="8" VALIGN="bottom" STYLE=
"width: 6.0pt; background: white; padding: 0in 0in 0in 0in;">
<P CLASS="Tbodyrightalign" ALIGN="left" STYLE=
"margin-right: 0in; text-align: left; line-height: normal; padding-bottom: 3px !important; mso-style-name: Tbody_rightalign; margin-top: 0in; margin-bottom: .0001pt; margin-left: 0in; text-autospace: none; font-size: 10.0pt; font-family: TimesNewRomanPSStd-Regular; color: black;">
$</P>
</TD>
<TD WIDTH="80" VALIGN="bottom" STYLE=
"width: 60.0pt; background: white; padding: 0in 0in 0in 0in;">
<P CLASS="Tbodyrightalign" STYLE=
"margin-right: 0in; line-height: normal; padding-bottom: 3px !important; mso-style-name: Tbody_rightalign; margin-top: 0in; margin-bottom: .0001pt; margin-left: 0in; text-align: right; text-autospace: none; font-size: 10.0pt; font-family: TimesNewRomanPSStd-Regular; color: black;">
0.09</P>
</TD>
<TD WIDTH="11" VALIGN="bottom" STYLE=
"width: 8.0pt; background: white; padding: 0in 0in 0in 0in;">
<P CLASS="NoParagraphStyle" STYLE=
'line-height: normal; mso-style-name: "\[No Paragraph Style\]"; margin: 0in; margin-bottom: .0001pt; text-autospace: none; font-size: 12.0pt; font-family: "MinionPro-Regular","serif"; color: black;'>
<FONT STYLE=
"font-family: TimesNewRomanPSStd-Regular; color: windowtext;">&nbsp;</FONT></P>
</TD>
<TD WIDTH="8" VALIGN="bottom" STYLE=
"width: 6.0pt; background: white; padding: 0in 0in 0in 0in;">
<P CLASS="NoParagraphStyle" STYLE=
'line-height: normal; mso-style-name: "\[No Paragraph Style\]"; margin: 0in; margin-bottom: .0001pt; text-autospace: none; font-size: 12.0pt; font-family: "MinionPro-Regular","serif"; color: black;'>
<FONT STYLE=
"font-family: TimesNewRomanPSStd-Regular; color: windowtext;">&nbsp;</FONT></P>
</TD>
<TD WIDTH="72" VALIGN="bottom" STYLE=
"width: .75in; background: white; padding: 0in 0in 0in 0in;">
<P CLASS="NoParagraphStyle" STYLE=
'line-height: normal; mso-style-name: "\[No Paragraph Style\]"; margin: 0in; margin-bottom: .0001pt; text-autospace: none; font-size: 12.0pt; font-family: "MinionPro-Regular","serif"; color: black;'>
<FONT STYLE=
"font-family: TimesNewRomanPSStd-Regular; color: windowtext;">&nbsp;</FONT></P>
</TD>
<TD WIDTH="8" VALIGN="bottom" STYLE=
"width: 6.0pt; background: white; padding: 0in 0in 0in 0in;">
<P CLASS="NoParagraphStyle" STYLE=
'line-height: normal; mso-style-name: "\[No Paragraph Style\]"; margin: 0in; margin-bottom: .0001pt; text-autospace: none; font-size: 12.0pt; font-family: "MinionPro-Regular","serif"; color: black;'>
<FONT STYLE=
"font-family: TimesNewRomanPSStd-Regular; color: windowtext;">&nbsp;</FONT></P>
</TD>
</TR>
<TR>
<TD WIDTH="424" VALIGN="bottom" STYLE=
"width: 318.0pt; background: #CCEEFF; padding: 0in 0in 0in 0in;">
<P CLASS="Tbody" STYLE=
"line-height: normal; padding-bottom: 3px !important; mso-style-name: Tbody; margin-top: 0in; margin-right: 0in; margin-bottom: .0001pt; margin-left: 10.0pt; text-indent: -10.0pt; text-autospace: none; font-size: 10.0pt; font-family: TimesNewRomanPSStd-Regular; color: black;">
<FONT LANG="EN-GB">Pro forma net tangible book value per share as
of September 30, 2017, after giving effect to Rights
Offering</FONT></P>
</TD>
<TD WIDTH="11" VALIGN="bottom" STYLE=
"width: 8.0pt; background: #CCEEFF; padding: 0in 0in 0in 0in;">
<P CLASS="NoParagraphStyle" STYLE=
'line-height: normal; mso-style-name: "\[No Paragraph Style\]"; margin: 0in; margin-bottom: .0001pt; text-autospace: none; font-size: 12.0pt; font-family: "MinionPro-Regular","serif"; color: black;'>
<FONT STYLE=
"font-family: TimesNewRomanPSStd-Regular; color: windowtext;">&nbsp;</FONT></P>
</TD>
<TD WIDTH="8" VALIGN="bottom" STYLE=
"width: 6.0pt; background: #CCEEFF; padding: 0in 0in 0in 0in;">
<P CLASS="NoParagraphStyle" STYLE=
'line-height: normal; mso-style-name: "\[No Paragraph Style\]"; margin: 0in; margin-bottom: .0001pt; text-autospace: none; font-size: 12.0pt; font-family: "MinionPro-Regular","serif"; color: black;'>
<FONT STYLE=
"font-family: TimesNewRomanPSStd-Regular; color: windowtext;">&nbsp;</FONT></P>
</TD>
<TD WIDTH="80" VALIGN="bottom" STYLE=
"width: 60.0pt; background: #CCEEFF; padding: 0in 0in 0in 0in;">
<P CLASS="NoParagraphStyle" STYLE=
'line-height: normal; mso-style-name: "\[No Paragraph Style\]"; margin: 0in; margin-bottom: .0001pt; text-autospace: none; font-size: 12.0pt; font-family: "MinionPro-Regular","serif"; color: black;'>
<FONT STYLE=
"font-family: TimesNewRomanPSStd-Regular; color: windowtext;">&nbsp;</FONT></P>
</TD>
<TD WIDTH="11" VALIGN="bottom" STYLE=
"width: 8.0pt; background: #CCEEFF; padding: 0in 0in 0in 0in;">
<P CLASS="NoParagraphStyle" STYLE=
'line-height: normal; mso-style-name: "\[No Paragraph Style\]"; margin: 0in; margin-bottom: .0001pt; text-autospace: none; font-size: 12.0pt; font-family: "MinionPro-Regular","serif"; color: black;'>
<FONT STYLE=
"font-family: TimesNewRomanPSStd-Regular; color: windowtext;">&nbsp;</FONT></P>
</TD>
<TD WIDTH="8" VALIGN="bottom" STYLE=
"width: 6.0pt; border: none; border-bottom: solid windowtext 1.0pt; background: #CCEEFF; padding: 0in 0in 0in 0in;">
<P CLASS="Tbodyrule1" ALIGN="left" STYLE=
"margin-right: 0in; text-align: left; line-height: normal; border: none; padding-bottom: 3px !important; mso-style-name: Tbody_rule1; margin-top: 0in; margin-bottom: .0001pt; margin-left: 0in; text-autospace: none; padding: 0in; font-size: 10.0pt; font-family: TimesNewRomanPSStd-Regular; color: black;">
$</P>
</TD>
<TD WIDTH="72" VALIGN="bottom" STYLE=
"width: .75in; border: none; border-bottom: solid windowtext 1.0pt; background: #CCEEFF; padding: 0in 0in 0in 0in;">
<P CLASS="Tbodyrule1" STYLE=
"margin-right: 0in; line-height: normal; border: none; padding-bottom: 3px !important; mso-style-name: Tbody_rule1; margin-top: 0in; margin-bottom: .0001pt; margin-left: 0in; text-align: right; text-autospace: none; padding: 0in; font-size: 10.0pt; font-family: TimesNewRomanPSStd-Regular; color: black;">
0.32</P>
</TD>
<TD WIDTH="8" VALIGN="bottom" STYLE=
"width: 6.0pt; background: #CCEEFF; padding: 0in 0in 0in 0in;">
<P CLASS="NoParagraphStyle" STYLE=
'line-height: normal; mso-style-name: "\[No Paragraph Style\]"; margin: 0in; margin-bottom: .0001pt; text-autospace: none; font-size: 12.0pt; font-family: "MinionPro-Regular","serif"; color: black;'>
<FONT STYLE=
"font-family: TimesNewRomanPSStd-Regular; color: windowtext;">&nbsp;</FONT></P>
</TD>
</TR>
<TR>
<TD WIDTH="424" VALIGN="bottom" STYLE=
"width: 318.0pt; background: white; padding: 0in 0in 0in 0in;">
<P CLASS="Tbody" STYLE=
"line-height: normal; padding-bottom: 3px !important; mso-style-name: Tbody; margin-top: 0in; margin-right: 0in; margin-bottom: .0001pt; margin-left: 10.0pt; text-indent: -10.0pt; text-autospace: none; font-size: 10.0pt; font-family: TimesNewRomanPSStd-Regular; color: black;">
<FONT LANG="EN-GB">Dilution in net tangible book value per share to
purchasers in the Rights Offering</FONT></P>
</TD>
<TD WIDTH="11" VALIGN="bottom" STYLE=
"width: 8.0pt; background: white; padding: 0in 0in 0in 0in;">
<P CLASS="NoParagraphStyle" STYLE=
'line-height: normal; mso-style-name: "\[No Paragraph Style\]"; margin: 0in; margin-bottom: .0001pt; text-autospace: none; font-size: 12.0pt; font-family: "MinionPro-Regular","serif"; color: black;'>
<FONT STYLE=
"font-family: TimesNewRomanPSStd-Regular; color: windowtext;">&nbsp;</FONT></P>
</TD>
<TD WIDTH="8" VALIGN="bottom" STYLE=
"width: 6.0pt; background: white; padding: 0in 0in 0in 0in;">
<P CLASS="NoParagraphStyle" STYLE=
'line-height: normal; mso-style-name: "\[No Paragraph Style\]"; margin: 0in; margin-bottom: .0001pt; text-autospace: none; font-size: 12.0pt; font-family: "MinionPro-Regular","serif"; color: black;'>
<FONT STYLE=
"font-family: TimesNewRomanPSStd-Regular; color: windowtext;">&nbsp;</FONT></P>
</TD>
<TD WIDTH="80" VALIGN="bottom" STYLE=
"width: 60.0pt; background: white; padding: 0in 0in 0in 0in;">
<P CLASS="NoParagraphStyle" STYLE=
'line-height: normal; mso-style-name: "\[No Paragraph Style\]"; margin: 0in; margin-bottom: .0001pt; text-autospace: none; font-size: 12.0pt; font-family: "MinionPro-Regular","serif"; color: black;'>
<FONT STYLE=
"font-family: TimesNewRomanPSStd-Regular; color: windowtext;">&nbsp;</FONT></P>
</TD>
<TD WIDTH="11" VALIGN="bottom" STYLE=
"width: 8.0pt; background: white; padding: 0in 0in 0in 0in;">
<P CLASS="NoParagraphStyle" STYLE=
'line-height: normal; mso-style-name: "\[No Paragraph Style\]"; margin: 0in; margin-bottom: .0001pt; text-autospace: none; font-size: 12.0pt; font-family: "MinionPro-Regular","serif"; color: black;'>
<FONT STYLE=
"font-family: TimesNewRomanPSStd-Regular; color: windowtext;">&nbsp;</FONT></P>
</TD>
<TD WIDTH="8" VALIGN="bottom" STYLE=
"width: 6.0pt; border: none; background: white; padding: 0in 0in 0in 0in;">
<P CLASS="Tbodybracket" ALIGN="left" STYLE=
"text-align: left; line-height: normal; padding-bottom: 3px !important; mso-style-name: Tbody_bracket; margin: 0in; margin-bottom: .0001pt; text-autospace: none; font-size: 10.0pt; font-family: TimesNewRomanPSStd-Regular; color: black;">
$</P>
</TD>
<TD WIDTH="72" VALIGN="bottom" STYLE=
"width: .75in; border: none; background: white; padding: 0in 0in 0in 0in;">
<P CLASS="Tbodybracket" STYLE=
"line-height: normal; padding-bottom: 3px !important; mso-style-name: Tbody_bracket; margin: 0in; margin-bottom: .0001pt; text-align: right; text-autospace: none; font-size: 10.0pt; font-family: TimesNewRomanPSStd-Regular; color: black;">
(0.18</P>
</TD>
<TD WIDTH="8" VALIGN="bottom" STYLE=
"width: 6.0pt; background: white; padding: 0in 0in 0in 0in;">
<P CLASS="Tbodybracket" ALIGN="left" STYLE=
"text-align: left; line-height: normal; padding-bottom: 3px !important; mso-style-name: Tbody_bracket; margin: 0in; margin-bottom: .0001pt; text-autospace: none; font-size: 10.0pt; font-family: TimesNewRomanPSStd-Regular; color: black;">
)</P>
</TD>
</TR>
</TABLE>
<P CLASS="Textflush" STYLE=
"margin-top: 10.0pt; mso-style-name: Text_flush; margin-right: 0in; margin-bottom: .0001pt; margin-left: 0in; line-height: 12.0pt; text-autospace: none; font-size: 10.0pt; font-family: TimesNewRomanPSStd-Regular; color: black;">
The number of shares of our common stock that will be outstanding
immediately after the offering is based on 80,025,639 shares
outstanding as of September 30, 2017, and excludes:</P>
<P CLASS="BLm" STYLE=
"mso-style-name: BL_m; margin-top: 6.0pt; margin-right: 0in; margin-bottom: .0001pt; margin-left: .25in; text-indent: -9.5pt; line-height: 12.0pt; text-autospace: none; font-size: 10.0pt; font-family: TimesNewRomanPSStd-Regular; color: black;">
<FONT CLASS="bullet" STYLE=
"mso-style-name: bullet;">&bull;</FONT><FONT CLASS="bullet" STYLE=
"mso-style-name: bullet;"><FONT STYLE=
"font-size: 8.5pt;">&nbsp;&nbsp;</FONT></FONT> 6,156,361 shares of
common stock issuable upon the exercise of stock options
outstanding as of September 30, 2017 under our equity incentive
plans, with a weighted average exercise price of $2.62 per
share;</P>
<P CLASS="BLm" STYLE=
"mso-style-name: BL_m; margin-top: 6.0pt; margin-right: 0in; margin-bottom: .0001pt; margin-left: .25in; text-indent: -9.5pt; line-height: 12.0pt; text-autospace: none; font-size: 10.0pt; font-family: TimesNewRomanPSStd-Regular; color: black;">
<FONT CLASS="bullet" STYLE=
"mso-style-name: bullet;">&bull;</FONT><FONT CLASS="bullet" STYLE=
"mso-style-name: bullet;"><FONT STYLE=
"font-size: 8.5pt;">&nbsp;&nbsp;</FONT></FONT> 6,991,975 shares of
common stock available for future grants under our equity incentive
plans as of September 30, 2017;</P>
<P CLASS="BLm" STYLE=
"mso-style-name: BL_m; margin-top: 6.0pt; margin-right: 0in; margin-bottom: .0001pt; margin-left: .25in; text-indent: -9.5pt; line-height: 12.0pt; text-autospace: none; font-size: 10.0pt; font-family: TimesNewRomanPSStd-Regular; color: black;">
<FONT CLASS="bullet" STYLE=
"mso-style-name: bullet;">&bull;</FONT><FONT CLASS="bullet" STYLE=
"mso-style-name: bullet;"><FONT STYLE=
"font-size: 8.5pt;">&nbsp;&nbsp;</FONT></FONT> 222,908 shares of
restricted stock reserved for issuance as of September 30, 2017;
and</P>
<P CLASS="BLm" STYLE=
"mso-style-name: BL_m; margin-top: 6.0pt; margin-right: 0in; margin-bottom: .0001pt; margin-left: .25in; text-indent: -9.5pt; line-height: 12.0pt; text-autospace: none; font-size: 10.0pt; font-family: TimesNewRomanPSStd-Regular; color: black;">
<FONT CLASS="bullet" STYLE=
"mso-style-name: bullet;">&bull;</FONT><FONT CLASS="bullet" STYLE=
"mso-style-name: bullet;"><FONT STYLE=
"font-size: 8.5pt;">&nbsp;&nbsp;</FONT></FONT> 27,220,388 shares of
common stock issuable upon the exercise of warrants outstanding as
of September 30, 2017, with a weighted average exercise price of
$1.92 per share.</P>
<P CLASS="LRH" STYLE=
"margin: 10px 0px 10px 0px !important; page-break-after: always; border-bottom: 1px solid; mso-style-name: LRH; margin-top: 10.0pt; margin-right: 0in; margin-bottom: 10.0pt; margin-left: 0in; text-align: center; text-autospace: none; font-size: 10.0pt; font-family: TimesNewRomanPSStd-Regular; color: black;">
S-5</P>
<DIV STYLE=
"border: none; border-top: double windowtext 6.0pt; padding: 31.0pt 0in 0in 0in;">
<P CLASS="Textflush" ALIGN="center" STYLE=
"text-align: center; border: none; padding: 0in; mso-style-name: Text_flush; margin-top: 12.0pt; margin-right: 0in; margin-bottom: .0001pt; margin-left: 0in; line-height: 12.0pt; text-autospace: none; font-size: 10.0pt; font-family: TimesNewRomanPSStd-Regular; color: black;">
<FONT STYLE="font-size: 12.0pt;">Subscription Rights to Purchase Up
to 50,000,000 Units</FONT></P>
</DIV>
<P CLASS="H1" STYLE=
"margin-top: 1.5in; mso-style-name: H1; margin-right: 0in; margin-bottom: .0001pt; margin-left: 0in; text-align: center; line-height: 14.0pt; page-break-after: avoid; text-autospace: none; font-size: 12.0pt; font-family: TimesNewRomanPSStd-Bold; color: black; font-weight: bold;">
<FONT CLASS="Bold" STYLE=
"mso-style-name: Bold; font-weight: bold;">____________________</FONT></P>
<P CLASS="H1" STYLE=
"margin-top: 6.0pt; mso-style-name: H1; margin-right: 0in; margin-bottom: .0001pt; margin-left: 0in; text-align: center; line-height: 14.0pt; page-break-after: avoid; text-autospace: none; font-size: 12.0pt; font-family: TimesNewRomanPSStd-Bold; color: black; font-weight: bold;"> <B>Amendment
No. 1 to</B> </P>
<P CLASS="H1" STYLE=
"margin-top: 6.0pt; mso-style-name: H1; margin-right: 0in; margin-bottom: .0001pt; margin-left: 0in; text-align: center; line-height: 14.0pt; page-break-after: avoid; text-autospace: none; font-size: 12.0pt; font-family: TimesNewRomanPSStd-Bold; color: black; font-weight: bold;"> <B>Prospectus
Supplement</B> </P>
<P CLASS="H1" STYLE=
"margin-top: 0in; mso-style-name: H1; margin-right: 0in; margin-bottom: .0001pt; margin-left: 0in; text-align: center; line-height: 14.0pt; page-break-after: avoid; text-autospace: none; font-size: 12.0pt; font-family: TimesNewRomanPSStd-Bold; color: black; font-weight: bold;">
<FONT CLASS="Bold" STYLE=
"mso-style-name: Bold; font-weight: bold;">____________________</FONT></P>
<P CLASS="Textflush" ALIGN="center" STYLE=
"margin-top: 1.5in; text-align: center; mso-style-name: Text_flush; margin-right: 0in; margin-bottom: .0001pt; margin-left: 0in; line-height: 12.0pt; text-autospace: none; font-size: 10.0pt; font-family: TimesNewRomanPSStd-Regular; color: black;">
<FONT CLASS="italic0" STYLE=
"mso-style-name: italic; font-style: italic;">Dealer-Manager</FONT></P>
<P CLASS="H1" STYLE=
"margin-top: 12.0pt; mso-style-name: H1; margin-right: 0in; margin-bottom: .0001pt; margin-left: 0in; text-align: center; line-height: 14.0pt; page-break-after: avoid; text-autospace: none; font-size: 12.0pt; font-family: TimesNewRomanPSStd-Bold; color: black; font-weight: bold;"> <FONT STYLE="font-size: 16pt"><B>Maxim
Group LLC</B></FONT> </P>
<DIV STYLE=
"border: none; border-bottom: double windowtext 6.0pt; padding: 0in 0in 30.0pt 0in;">
<P CLASS="Textflush" ALIGN="center" STYLE=
"margin-top: 48.0pt; text-align: center; border: none; padding: 0in; mso-style-name: Text_flush; margin-right: 0in; margin-bottom: .0001pt; margin-left: 0in; line-height: 12.0pt; text-autospace: none; font-size: 10.0pt; font-family: TimesNewRomanPSStd-Regular; color: black;">
February 26, 2018</P>
</DIV>
<P CLASS="RRH" STYLE=
"margin: 0in; margin-bottom: .0001pt; border-bottom: 1px solid; mso-style-name: RRH; margin-top: 10.0pt; margin-right: 0in; margin-left: 0in; text-align: center; text-autospace: none; font-size: 10.0pt; font-family: TimesNewRomanPSStd-Regular; color: black;">
&nbsp;</P>
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end
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
