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Description of Business and Summary of Significant Accounting Policies (Tables)
12 Months Ended
Dec. 31, 2018
Organization, Consolidation and Presentation of Financial Statements [Abstract]  
Schedule of antidilutive securities excluded from computation of diluted net loss per share

   December 31,
2018
   December 31,
2017
   December 31,
2016
 
Options   7,236,101    5,174,592    5,906,886 
Warrants   55,820,876    25,662,340    8,964,752 
Total   63,056,977    30,836,932    14,871,638 

Schedule of impacts to consolidated statements of cash flows

   Previously Reported   Adjustment   As Revised 
Net cash used in investing activities  $(380,946)  $356,207   $(24,739)

Summary of cash and cash equivalent and restricted cash

   December 31,
2018
   December 31,
2017
   December 31,
2016
 
Cash and cash equivalents  $13,673,308   $17,399,636   $20,519,294 
Restricted cash – current   40,075    -    34,733 
Restricted cash – long term   391,131    390,940    - 
Cash and cash equivalent and restricted cash  $14,104,514   $17,790,576   $20,554,027