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Equity (Tables)
12 Months Ended
Dec. 31, 2018
Stock Options [Member]  
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]  
Summary of option and warrant activities

   Number of Options   Weighted
Average
Exercise
Price
   Weighted
Average
Remaining
Contractual
Term
(in years)
   Aggregate
Intrinsic
Value
 
Outstanding, January 1, 2016   3,971,583   $4.34    8.01    2,964,146 
Granted   2,225,000    1.92           
Cancelled   (266,485)   2.51           
Exercised   (23,212)   0.78           
Outstanding, December 31, 2016   5,906,886    3.52    7.90    51,704 
Granted   2,597,500    1.32           
Cancelled   (3,329,794)   2.85           
Outstanding, December 31, 2017   5,174,592    2.83    7.95    2,648 
Granted   3,577,159    0.69           
Cancelled   (1,515,650)   2.96           
Outstanding, December 31, 2018   7,236,101    1.74    7.97    6,400 
                     
Exercisable, December 31, 2018   3,021,818    2.88    6.55    - 
Warrant [Member]  
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]  
Summary of option and warrant activities

   Number of Units   Weighted
Average
Exercise
Price
   Weighted
Average
Remaining
Contractual
Term
(in years)
   Aggregate
Intrinsic
Value
 
Outstanding, January 1, 2016   9,018,470    3.73    2.93    10,199,230 
Granted   130,000    0.96           
Exercised   (183,718)   0.90           
Outstanding, December 31, 2016   8,964,752    3.72    1.95    1,445,786 
Granted   18,496,575    1.05           
Exercised   (9,364)   0.78           
Cancelled   (1,789,623)   2.22           
Outstanding, December 31, 2017   25,662,340    1.89    3.62    995,373 
Granted   30,360,466    0.67           
Exercised   (7,332)   0.66           
Cancelled   (194,598)   9.00           
Outstanding, December 31, 2018   55,820,876    1.20    2.04    569,038 
                     
Exercisable, December 31, 2018   55,613,377    1.19    2.03    566,676