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Equity (Tables)
12 Months Ended
Dec. 31, 2020
Stockholders' Equity Note [Abstract]  
Schedule of stock option activity
(in thousands, except for per-share amount)  Number of
Options
   Weighted
Average
Exercise
Price
   Weighted
Average
Remaining
Contractual
Term
(in years)
   Aggregate
Intrinsic
Value
 
Outstanding, January 1, 2019   241    52.20    7.97    6,400 
Granted   195    8.10           
Cancelled   (56)   14.40           
Outstanding, December 31, 2019   380    35.10    7.88    155 
Granted   458    9.99           
Cancelled   (23)   16.84           
Outstanding, December 31, 2020   815    21.53    8.51    120 
                     
Exercisable, December 31, 2020   254    45.98    6.74    41 
Schedule of pre-funded warrant activity
(in thousands, except for per-share amounts)  Number of Shares   Weighted
Average
Exercise
Price
   Aggregate
Intrinsic
Value
 
Outstanding, December 31, 2019   -   $-   $- 
Granted   3,459    0.003      
Exercised   (3,459)   0.003      
Outstanding, December 31, 2020   -   $-   $- 
Schedule of warrant activities
(in thousands, except for per-share amounts)   Number of
Warrants
    Weighted
Average
Exercise
Price
    Weighted
Average
Remaining
Contractual
Term
(in years)
    Aggregate
Intrinsic
Value
 
Outstanding, January 1, 2019     1,861       36.00       2.04       569  
Granted     1,430       15.00                  
Exercised     (85 )     17.70                  
Cancelled     (335 )     82.80                  
Outstanding, December 31, 2019     2,871       20.71       2.95       301  
Granted     -       -                  
Exercised     (2 )     15.00                  
Cancelled     (756 )     20.99                  
Outstanding, December 31, 2020     2,113       20.55       2.76       362  
                                 
Exercisable, December 31, 2020     2,111       20.56       2.76       362