<SEC-DOCUMENT>0001213900-21-056829.txt : 20211105
<SEC-HEADER>0001213900-21-056829.hdr.sgml : 20211105
<ACCEPTANCE-DATETIME>20211104184306
ACCESSION NUMBER:		0001213900-21-056829
CONFORMED SUBMISSION TYPE:	DEFA14A
PUBLIC DOCUMENT COUNT:		1
FILED AS OF DATE:		20211105
DATE AS OF CHANGE:		20211104

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Actinium Pharmaceuticals, Inc.
		CENTRAL INDEX KEY:			0001388320
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				880378336
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		DEFA14A
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-36374
		FILM NUMBER:		211381628

	BUSINESS ADDRESS:	
		STREET 1:		275 MADISON AVENUE, 7TH FLOOR
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10016
		BUSINESS PHONE:		646-677-3875

	MAIL ADDRESS:	
		STREET 1:		275 MADISON AVENUE, 7TH FLOOR
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10016

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	Cactus Ventures, Inc.
		DATE OF NAME CHANGE:	20070130
</SEC-HEADER>
<DOCUMENT>
<TYPE>DEFA14A
<SEQUENCE>1
<FILENAME>ea150014-defa14a_actinium.htm
<DESCRIPTION>DEFA14A
<TEXT>
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<P STYLE="font: 18pt Times New Roman, Times, Serif; margin: 0pt; text-align: center"><FONT STYLE="color: Black"><B>UNITED STATES</B></FONT></P>

<P STYLE="font: 18pt Times New Roman, Times, Serif; margin: 0pt; text-align: center"><FONT STYLE="color: Black"><B>SECURITIES AND EXCHANGE
COMMISSION</B></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-align: center"><FONT STYLE="color: Black"><B>WASHINGTON, D.C. 20549</B></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-align: center"><FONT STYLE="color: Black">&nbsp;</FONT></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-align: center"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<P STYLE="font: 18pt Times New Roman, Times, Serif; margin: 0pt; text-align: center"><FONT STYLE="color: Black"><B>SCHEDULE 14A INFORMATION</B></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-align: center"><FONT STYLE="color: Black"><B>Proxy Statement Pursuant
to Section 14(a) of the </B></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-align: center"><FONT STYLE="color: Black"><B>Securities Exchange
Act of 1934</B></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt"><FONT STYLE="color: Black">&nbsp;</FONT></P>

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    <TD STYLE="width: 145px"><FONT STYLE="color: Black">Filed by the Registrant</FONT></TD>
    <TD STYLE="width: 97px"><FONT STYLE="font-family: Times New Roman, Times, Serif; color: Black">&#9746;</FONT></TD>
    <TD STYLE="width: 241px"><FONT STYLE="color: Black">Filed by a Party other than the Registrant</FONT></TD>
    <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; color: Black">&#9744;</FONT></TD></TR>
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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt"><FONT STYLE="color: Black">Check the appropriate box:</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <TR STYLE="vertical-align: top">
    <TD STYLE="white-space: nowrap; width: 25px"><FONT STYLE="font-family: Times New Roman, Times, Serif; color: Black">&#9744;</FONT></TD>
    <TD STYLE="text-align: justify"><FONT STYLE="color: Black">Preliminary Proxy Statement</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="white-space: nowrap"><FONT STYLE="font-family: Times New Roman, Times, Serif; color: Black">&#9744;</FONT></TD>
    <TD STYLE="text-align: justify"><FONT STYLE="color: Black"><B>Confidential, For Use of the Commission Only (As Permitted by Rule
    14a-6(e)(2))</B></FONT></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="white-space: nowrap"><FONT STYLE="font-family: Times New Roman, Times, Serif; color: Black">&#9744;</FONT></TD>
    <TD STYLE="text-align: justify"><FONT STYLE="color: Black">Definitive Proxy Statement</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="white-space: nowrap"><FONT STYLE="font-family: Times New Roman, Times, Serif; color: Black">&#9746;</FONT></TD>
    <TD STYLE="text-align: justify"><FONT STYLE="color: Black">Definitive Additional Materials</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="white-space: nowrap"><FONT STYLE="font-family: Times New Roman, Times, Serif; color: Black">&#9744;</FONT></TD>
    <TD STYLE="text-align: justify"><FONT STYLE="color: Black">Soliciting Material under &sect;240.14a-12</FONT></TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-align: center"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<P STYLE="font: 18pt Times New Roman, Times, Serif; margin: 0pt; text-align: center"><FONT STYLE="color: Black"><B>Actinium Pharmaceuticals,
Inc.</B></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-align: center"><FONT STYLE="color: Black"><B>(Name of Registrant
as Specified in Its Charter)</B></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-align: center"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-align: center"><FONT STYLE="color: Black"><B>N/A</B></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-align: center"><FONT STYLE="color: Black"><B>(Name of Person(s)
Filing Proxy Statement, if other than the Registrant)</B></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-align: center"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt"><FONT STYLE="color: Black">Payment of Filing Fee (Check the appropriate
box):</FONT></P>

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<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <TR STYLE="vertical-align: top">
    <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; color: Black">&#9746;</FONT></TD>
    <TD COLSPAN="2"><FONT STYLE="color: Black">No fee required</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="width: 25px"><FONT STYLE="color: Black">&nbsp;</FONT></TD>
    <TD STYLE="width: 25px"><FONT STYLE="color: Black">&nbsp;</FONT></TD>
    <TD STYLE="text-align: justify"><FONT STYLE="color: Black">&nbsp;</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; color: Black">&#9744;</FONT></TD>
    <TD COLSPAN="2"><FONT STYLE="color: Black">Fee computed on table below per Exchange Act Rules 14a-6(i)(1) and 0-11.</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD><FONT STYLE="color: Black">&nbsp;</FONT></TD>
    <TD><FONT STYLE="color: Black">&nbsp;</FONT></TD>
    <TD STYLE="text-align: justify"><FONT STYLE="color: Black">&nbsp;</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD><FONT STYLE="color: Black">&nbsp;</FONT></TD>
    <TD><FONT STYLE="color: Black">(1)</FONT></TD>
    <TD STYLE="text-align: justify"><FONT STYLE="color: Black">Title of each class of securities to which transaction applies:</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="border-bottom: black 1.5pt solid"><FONT STYLE="color: Black">&nbsp;</FONT></TD>
    <TD STYLE="border-bottom: black 1.5pt solid"><FONT STYLE="color: Black">&nbsp;</FONT></TD>
    <TD STYLE="border-bottom: black 1.5pt solid; text-align: justify"><FONT STYLE="color: Black">&nbsp;</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD><FONT STYLE="color: Black">&nbsp;</FONT></TD>
    <TD><FONT STYLE="color: Black">(2)</FONT></TD>
    <TD STYLE="text-align: justify"><FONT STYLE="color: Black">Aggregate number of securities to which transaction applies:</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="border-bottom: black 1.5pt solid"><FONT STYLE="color: Black">&nbsp;</FONT></TD>
    <TD STYLE="border-bottom: black 1.5pt solid"><FONT STYLE="color: Black">&nbsp;</FONT></TD>
    <TD STYLE="border-bottom: black 1.5pt solid; text-align: justify"><FONT STYLE="color: Black">&nbsp;</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD><FONT STYLE="color: Black">&nbsp;</FONT></TD>
    <TD><FONT STYLE="color: Black">(3)</FONT></TD>
    <TD STYLE="text-align: justify"><FONT STYLE="color: Black">Per unit price or other underlying value of transaction computed pursuant
    to Exchange Act Rule 0-11 (set forth the amount on which the filing fee is calculated and state how it was determined):</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="border-bottom: black 1.5pt solid"><FONT STYLE="color: Black">&nbsp;</FONT></TD>
    <TD STYLE="border-bottom: black 1.5pt solid"><FONT STYLE="color: Black">&nbsp;</FONT></TD>
    <TD STYLE="border-bottom: black 1.5pt solid; text-align: justify"><FONT STYLE="color: Black">&nbsp;</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD><FONT STYLE="color: Black">&nbsp;</FONT></TD>
    <TD><FONT STYLE="color: Black">(4)</FONT></TD>
    <TD STYLE="text-align: justify"><FONT STYLE="color: Black">Proposed maximum aggregate value of transaction:</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="border-bottom: black 1.5pt solid"><FONT STYLE="color: Black">&nbsp;</FONT></TD>
    <TD STYLE="border-bottom: black 1.5pt solid"><FONT STYLE="color: Black">&nbsp;</FONT></TD>
    <TD STYLE="border-bottom: black 1.5pt solid; text-align: justify"><FONT STYLE="color: Black">&nbsp;</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD><FONT STYLE="color: Black">&nbsp;</FONT></TD>
    <TD><FONT STYLE="color: Black">(5)</FONT></TD>
    <TD STYLE="text-align: justify"><FONT STYLE="color: Black">Total fee paid:</FONT></TD></TR>
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    <TD STYLE="border-bottom: black 1.5pt solid"><FONT STYLE="color: Black">&nbsp;</FONT></TD>
    <TD STYLE="border-bottom: black 1.5pt solid"><FONT STYLE="color: Black">&nbsp;</FONT></TD>
    <TD STYLE="border-bottom: black 1.5pt solid; text-align: justify"><FONT STYLE="color: Black">&nbsp;</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; color: Black">&#9744;</FONT></TD>
    <TD COLSPAN="2" STYLE="text-align: justify"><FONT STYLE="color: Black">Fee paid previously with preliminary materials.</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD><FONT STYLE="color: Black">&nbsp;</FONT></TD>
    <TD><FONT STYLE="color: Black">&nbsp;</FONT></TD>
    <TD STYLE="text-align: justify"><FONT STYLE="color: Black">&nbsp;</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; color: Black">&#9744;</FONT></TD>
    <TD COLSPAN="2" STYLE="text-align: justify"><FONT STYLE="color: Black">Check box if any part of the fee is offset as provided by
    Exchange Act Rule 0-11(a)(2) and identify the filing for which the offsetting fee was paid previously. Identify the previous filing
    by registration statement number, or the form or schedule and the date of its filing.</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD><FONT STYLE="color: Black">&nbsp;</FONT></TD>
    <TD><FONT STYLE="color: Black">&nbsp;</FONT></TD>
    <TD STYLE="text-align: justify"><FONT STYLE="color: Black">&nbsp;</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD><FONT STYLE="color: Black">&nbsp;</FONT></TD>
    <TD><FONT STYLE="color: Black">(1)</FONT></TD>
    <TD STYLE="text-align: justify"><FONT STYLE="color: Black">Amount Previously Paid:</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="border-bottom: black 1.5pt solid"><FONT STYLE="color: Black">&nbsp;</FONT></TD>
    <TD STYLE="border-bottom: black 1.5pt solid"><FONT STYLE="color: Black">&nbsp;</FONT></TD>
    <TD STYLE="border-bottom: black 1.5pt solid; text-align: justify"><FONT STYLE="color: Black">&nbsp;</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD><FONT STYLE="color: Black">&nbsp;</FONT></TD>
    <TD><FONT STYLE="color: Black">(2)</FONT></TD>
    <TD STYLE="text-align: justify"><FONT STYLE="color: Black">Form, Schedule or Registration Statement No.:</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="border-bottom: black 1.5pt solid"><FONT STYLE="color: Black">&nbsp;</FONT></TD>
    <TD STYLE="border-bottom: black 1.5pt solid"><FONT STYLE="color: Black">&nbsp;</FONT></TD>
    <TD STYLE="border-bottom: black 1.5pt solid; text-align: justify"><FONT STYLE="color: Black">&nbsp;</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD><FONT STYLE="color: Black">&nbsp;</FONT></TD>
    <TD><FONT STYLE="color: Black">(3)</FONT></TD>
    <TD STYLE="text-align: justify"><FONT STYLE="color: Black">Filing Party:</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="border-bottom: black 1.5pt solid"><FONT STYLE="color: Black">&nbsp;</FONT></TD>
    <TD STYLE="border-bottom: black 1.5pt solid"><FONT STYLE="color: Black">&nbsp;</FONT></TD>
    <TD STYLE="border-bottom: black 1.5pt solid; text-align: justify"><FONT STYLE="color: Black">&nbsp;</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD><FONT STYLE="color: Black">&nbsp;</FONT></TD>
    <TD><FONT STYLE="color: Black">(4)</FONT></TD>
    <TD STYLE="text-align: justify"><FONT STYLE="color: Black">Date Filed:</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="border-bottom: black 1.5pt solid"><FONT STYLE="color: Black">&nbsp;</FONT></TD>
    <TD STYLE="border-bottom: black 1.5pt solid"><FONT STYLE="color: Black">&nbsp;</FONT></TD>
    <TD STYLE="border-bottom: black 1.5pt solid; text-align: justify"><FONT STYLE="color: Black">&nbsp;</FONT></TD></TR>
  </TABLE>
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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-align: center; background-color: white"><FONT STYLE="color: Black"><B>Actinium
Pharmaceuticals, Inc.</B><BR>
<B>Supplement to the Proxy Statement</B><BR>
<B>For the Annual Meeting of Stockholders</B><BR>
<B>To be Held on November&nbsp;9, 2021</B></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-align: center; background-color: white"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-align: center; background-color: white"><FONT STYLE="color: Black"><B>EXPLANATORY
NOTE</B></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-align: center; background-color: white"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-align: justify; background-color: white"><FONT STYLE="color: Black">On
October&nbsp;18, 2021, Actinium Pharmaceuticals, Inc. (&ldquo;Actinium&rdquo; or the &ldquo;Company&rdquo;) filed with the Securities
and Exchange Commission its definitive proxy statement (the &ldquo;Proxy Statement&rdquo;) for its annual meeting of stockholders to
be held on November&nbsp;9, 2021 at 9:30&nbsp;a.m. E.T. (the &ldquo;Annual Meeting&rdquo;).</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-align: justify; background-color: white"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; background-color: white">On November&nbsp;4, 2021,
the Board of Directors of the Company, or the Board, approved the reconstitution of the Corporate Governance Committee as the Nominating
and Corporate Governance Committee. In connection with the reconstitution, the Board adopted a new charter for the Nominating and Corporate
Governance Committee defining its purposes and responsibilities.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; background-color: white">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; background-color: white">The Company is voluntarily
supplementing the Proxy Statement with the information provided in this supplement to the Proxy Statement (this &ldquo;Supplement&rdquo;)
to describe the purposes and responsibilities of the new Nominating and Corporate Governance Committee.</P>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-align: justify; background-color: white"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-align: justify; background-color: white"><FONT STYLE="color: Black"><B>Any
proxies submitted by stockholders before the date of this Supplement will be voted as instructed on those proxies, unless a stockholder
changes his or her vote by submitting a later dated proxy. Stockholders should follow the instructions described in the Proxy Statement
regarding how to submit proxies or vote at the Annual Meeting.</B></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; background-color: white"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; background-color: white"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; background-color: white"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-align: center; background-color: white"><FONT STYLE="color: Black"><B>THIS
SUPPLEMENT SHOULD BE READ<BR>
IN CONJUNCTION WITH THE PROXY STATEMENT.</B></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-align: justify; background-color: white"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-align: justify; background-color: white"><FONT STYLE="color: Black"><I>This
supplemental information should be read in conjunction with the Proxy Statement, which should be read in its entirety. Section references
in the below disclosures are to sections in the Proxy Statement, and defined terms used but not defined herein have the meanings set
forth in the Proxy Statement. To the extent the following information differs from or conflicts with the information contained in the
Proxy Statement, the information set forth below shall be deemed to supersede the respective information in the Proxy Statement. Except
as described above, this Supplement to the Proxy Statement does not modify, amend, supplement or otherwise affect the Proxy Statement.</I></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-align: justify; background-color: white"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-align: justify; background-color: white"><FONT STYLE="color: Black"><B>Supplemental
Disclosure</B></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-align: justify; background-color: white"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-align: justify; background-color: white"><FONT STYLE="color: Black"><B><U>Proxy
Statement</U></B></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-align: justify; background-color: white"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-align: justify; background-color: white"><FONT STYLE="color: Black"><I>The
text under the heading &ldquo;Committees of the Board of Directors&rdquo; is amended and restated as follows (new text in bold and underline):
</I></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-align: justify; background-color: white"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-align: justify; background-color: white"><FONT STYLE="color: Black"><B>Committees
of the Board of Directors</B></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-align: justify; background-color: white"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-align: justify; background-color: white"><FONT STYLE="color: Black">Our
Board has formed three standing committees: Audit, Compensation and <B><U>Nominating and Corporate Governance</U></B>. Actions taken
by our committees are reported to the full Board. Each of our committees has a charter and each charter is posted on our website.</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-align: justify; background-color: white"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <TR>
    <TD STYLE="vertical-align: bottom; width: 34%; border-bottom: black 1.5pt solid; text-align: justify"><FONT STYLE="color: Black"><B>Audit
    Committee</B></FONT></TD>
    <TD STYLE="vertical-align: top; width: 1%; text-align: justify"><FONT STYLE="color: Black">&nbsp;</FONT></TD>
    <TD STYLE="vertical-align: bottom; width: 32%; border-bottom: black 1.5pt solid; text-align: justify"><FONT STYLE="color: Black"><B>Compensation
    Committee</B></FONT></TD>
    <TD STYLE="vertical-align: top; width: 1%; text-align: justify"><FONT STYLE="color: Black">&nbsp;</FONT></TD>
    <TD STYLE="vertical-align: bottom; width: 32%; border-bottom: black 1.5pt solid"><FONT STYLE="color: Black"><B><U>Nominating and
    Corporate Governance Committee</U></B></FONT></TD></TR>
  <TR STYLE="vertical-align: top; background-color: #CCEEFF">
    <TD STYLE="text-align: justify"><FONT STYLE="color: Black">Richard I. Steinhart*</FONT></TD>
    <TD STYLE="text-align: justify"><FONT STYLE="color: Black">&nbsp;</FONT></TD>
    <TD STYLE="text-align: justify"><FONT STYLE="color: Black">David Nicholson*</FONT></TD>
    <TD STYLE="text-align: justify"><FONT STYLE="color: Black">&nbsp;</FONT></TD>
    <TD STYLE="text-align: justify"><FONT STYLE="color: Black">Ajit S. Shetty*</FONT></TD></TR>
  <TR STYLE="vertical-align: top; background-color: white">
    <TD STYLE="text-align: justify"><FONT STYLE="color: Black">Jeffrey W. Chell</FONT></TD>
    <TD STYLE="text-align: justify"><FONT STYLE="color: Black">&nbsp;</FONT></TD>
    <TD STYLE="text-align: justify"><FONT STYLE="color: Black">Jeffrey W. Chell</FONT></TD>
    <TD STYLE="text-align: justify"><FONT STYLE="color: Black">&nbsp;</FONT></TD>
    <TD STYLE="text-align: justify"><FONT STYLE="color: Black">David Nicholson</FONT></TD></TR>
  <TR STYLE="vertical-align: top; background-color: #CCEEFF">
    <TD STYLE="text-align: justify"><FONT STYLE="color: Black">Ajit S. Shetty</FONT></TD>
    <TD STYLE="text-align: justify"><FONT STYLE="color: Black">&nbsp;</FONT></TD>
    <TD STYLE="text-align: justify"><FONT STYLE="color: Black">Ajit S. Shetty</FONT></TD>
    <TD STYLE="text-align: justify"><FONT STYLE="color: Black">&nbsp;</FONT></TD>
    <TD STYLE="text-align: justify"><FONT STYLE="color: Black">Richard I. Steinhart</FONT></TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-align: justify; background-color: white"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <TR STYLE="vertical-align: top">
    <TD STYLE="width: 5%; text-align: justify"><FONT STYLE="color: Black"><B>*</B></FONT></TD>
    <TD STYLE="width: 95%; text-align: justify"><FONT STYLE="color: Black">Indicates committee chair&nbsp;</FONT></TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-align: justify; background-color: white"><FONT STYLE="color: Black"></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-align: justify; background-color: white"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-align: justify; background-color: white"><FONT STYLE="color: Black"><I>The
text under the headings &ldquo;Corporate Governance Committee&rdquo; and &ldquo;Nominating Committee&rdquo; is amended and restated as
follows:</I></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-align: justify; background-color: white"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-align: justify; background-color: white"><FONT STYLE="color: Black"><B><I>Corporate
Governance Committee</I></B></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-align: justify; background-color: white"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-align: justify; background-color: white"><FONT STYLE="color: Black">On
November&nbsp;4, 2021, the Corporate Governance Committee of the Board was reconstituted as the Nominating and Corporate Governance Committee.
For a description of the Nominating and Corporate Governance Committee, see the subsection titled &ldquo;&mdash;Nominating and Corporate
Governance Committee&rdquo; below. Prior to that date, the Corporate Governance Committee consisted of three directors and was responsible
for monitoring our corporate governance system. The Corporate Governance Committee met one time during 2020.</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-align: justify; background-color: white">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-align: justify; background-color: white"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-align: justify; background-color: white">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-align: justify; background-color: white"><FONT STYLE="color: Black"><B><I>Nominating
and Corporate Governance Committee</I></B></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-align: justify; background-color: white"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-align: justify"><FONT STYLE="color: Black"></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify">Our Nominating and Corporate Governance Committee
is composed of Ajit S. Shetty (Chairman), David Nicholson, and Richard I. Steinhart. Our Board has determined that each member of our
Nominating and Corporate Governance Committee qualifies as an &ldquo;independent&rdquo; member of the Board as defined by the rules and
regulations of the SEC and the NYSE American. The Nominating and Corporate Governance Committee was formed on November 4, 2021.</P>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-align: justify"><FONT STYLE="color: Black"></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-align: justify"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-align: justify"><FONT STYLE="color: Black">The Nominating and Corporate
Governance Committee is charged with the responsibility of reviewing our corporate governance policies and proposing potential director
nominees to the Board for consideration. Our Nominating and Corporate Governance Committee&rsquo;s primary responsibilities and obligations
are set forth in the Nominating and Corporate Governance Committee Charter, which is available on our website at www.actiniumpharma.com
in the &ldquo;Governance&rdquo; section found under the &ldquo;Investors&rdquo; tab, and include, among other things:</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-align: justify"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <TR STYLE="vertical-align: top">
    <TD STYLE="width: 24px; text-align: justify"><FONT STYLE="color: Black">&nbsp;</FONT></TD>
    <TD STYLE="width: 24px; text-align: justify"><FONT STYLE="color: Black">&#9679;</FONT></TD>
    <TD STYLE="text-align: justify"><FONT STYLE="color: Black">overseeing the administration of our Code of Business Ethics and Conduct
    and related policies;</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="text-align: justify"><FONT STYLE="color: Black">&nbsp;</FONT></TD>
    <TD STYLE="text-align: justify"><FONT STYLE="color: Black">&#9679;</FONT></TD>
    <TD STYLE="text-align: justify"><FONT STYLE="color: Black">leading the search for and recommending individuals qualified to become
    members of the Board, and selecting director nominees to be presented for election by the shareholders at each annual meeting;</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="text-align: justify"><FONT STYLE="color: Black">&nbsp;</FONT></TD>
    <TD STYLE="text-align: justify"><FONT STYLE="color: Black">&#9679;</FONT></TD>
    <TD STYLE="text-align: justify"><FONT STYLE="color: Black">ensuring, in cooperation with the Compensation Committee, that no agreements
    or arrangements are made with directors or relatives of directors for providing professional or consulting services to us or our
    affiliate or individual officer or one of their affiliated, without appropriate review and evaluation for conflicts of interest;</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="text-align: justify"><FONT STYLE="color: Black">&nbsp;</FONT></TD>
    <TD STYLE="text-align: justify"><FONT STYLE="color: Black">&#9679;</FONT></TD>
    <TD STYLE="text-align: justify"><FONT STYLE="color: Black">ensuring that Board members do not serve on more than six other for-profit
    public company boards that have a class of securities registered under the Exchange Act in addition to the Board;</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="text-align: justify"><FONT STYLE="color: Black">&nbsp;</FONT></TD>
    <TD STYLE="text-align: justify"><FONT STYLE="color: Black">&#9679;</FONT></TD>
    <TD STYLE="text-align: justify"><FONT STYLE="color: Black"></FONT>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt">reviewing the Board&rsquo;s committee structure and to recommend
to the Board for its approval directors to serve as members of each committee as well as recommendations for committee chairs;</P>
<FONT STYLE="color: Black"></FONT></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="text-align: justify"><FONT STYLE="color: Black">&nbsp;</FONT></TD>
    <TD STYLE="text-align: justify"><FONT STYLE="color: Black">&#9679;</FONT></TD>
    <TD STYLE="text-align: justify"><FONT STYLE="color: Black">reviewing recommendations received from shareholders for persons to be
    considered for nomination to the Board;</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="text-align: justify"><FONT STYLE="color: Black">&nbsp;</FONT></TD>
    <TD STYLE="text-align: justify"><FONT STYLE="color: Black">&#9679;</FONT></TD>
    <TD STYLE="text-align: justify"><FONT STYLE="color: Black">monitoring compliance with our corporate governance guidelines;</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="text-align: justify"><FONT STYLE="color: Black">&nbsp;</FONT></TD>
    <TD STYLE="text-align: justify"><FONT STYLE="color: Black">&#9679;</FONT></TD>
    <TD STYLE="text-align: justify"><FONT STYLE="color: Black">developing and implementing an annual self-evaluation of the Board, both
    individually and as a Board, and of its committees;</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="text-align: justify"><FONT STYLE="color: Black">&nbsp;</FONT></TD>
    <TD STYLE="text-align: justify"><FONT STYLE="color: Black">&#9679;</FONT></TD>
    <TD STYLE="text-align: justify"><FONT STYLE="color: Black">reviewing and recommending changes to procedures whereby shareholders
    may communicate with the Board;</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="text-align: justify"><FONT STYLE="color: Black">&nbsp;</FONT></TD>
    <TD STYLE="text-align: justify"><FONT STYLE="color: Black">&#9679;</FONT></TD>
    <TD STYLE="text-align: justify"><FONT STYLE="color: Black"></FONT>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt">assessing the independence of directors annually and report to the
Board; and</P>
<FONT STYLE="color: Black"></FONT></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="text-align: justify"><FONT STYLE="color: Black">&nbsp;</FONT></TD>
    <TD STYLE="text-align: justify"><FONT STYLE="color: Black">&#9679;</FONT></TD>
    <TD STYLE="text-align: justify"><FONT STYLE="color: Black"></FONT>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt">recommending to the Board for its approval, the leadership structure
of the Board, including whether the Board should have an executive or non-executive Chairman, whether the roles of Chairman and Chief
Executive Officer should be combined, and whether a Lead Director of the Board should be appointed; provided that such structure shall
be subject to the bylaws of the Company then in effect.</P>
<FONT STYLE="color: Black"></FONT></TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-align: justify"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-align: justify; background-color: white"><FONT STYLE="color: Black">Our
Nominating and Corporate Governance Committee considers all qualified candidates identified by members of the Board, by senior management
and by stockholders. The committee follows the same process and uses the same criteria for evaluating candidates proposed by stockholders,
members of the Board and members of senior management. When evaluating a candidate to serve on our Board, the members of our Nominating
and Corporate Governance Committee consider items such as experience in the biotechnology sector, experience with public companies, executive
managerial experience, operations and commercial experience, fundraising experience and contacts in the investment banking industry,
personal and skill set compatibility with current Board members, industry reputation, knowledge of our company generally, and independence.</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-align: justify; background-color: white"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-align: justify; background-color: white"><FONT STYLE="color: Black"></FONT></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-align: justify; background-color: white"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-align: justify; background-color: white"><FONT STYLE="color: Black">Our
Amended and Restated Bylaws, as amended (the &ldquo;Bylaws&rdquo;) contains provisions that address the process by which a stockholder
may nominate an individual to stand for election to the Board at our annual meetings. To recommend a nominee for election to the Board,
a stockholder must submit his or her recommendation to our Secretary at our corporate offices at 275 Madison Avenue, 7th Floor, New York,
New York 10016. Such nomination must satisfy the notice, information and consent requirements set forth in our Bylaws and must be received
by us prior to the date set forth under &ldquo;Submission of Future Stockholder Proposals&rdquo; below. A stockholder&rsquo;s recommendation
must be accompanied by the information with respect to stockholder nominees as specified in our Bylaws, including among other things,
the name, age, address and occupation of the recommended person, the proposing stockholder&rsquo;s name and address, the ownership interests
of the proposing stockholder and any beneficial owner on whose behalf the nomination is being made (including the number of shares beneficially
owned, any hedging, derivative, short or other economic interests and any rights to vote any shares) and any material monetary or other
relationships between the recommended person and the proposing stockholder and/or the beneficial owners, if any, on whose behalf the
nomination is being made.</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-align: justify; background-color: white"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-align: justify; background-color: white"><FONT STYLE="color: Black">Our
approach toward Board diversity takes into consideration the overall composition and diversity of the Board and areas of expertise that
director nominees may be able to offer, including business experience, knowledge, abilities, customer relationships and appropriate perspectives
on environmental, social and governance matters. Generally, we strive to assemble and maintain a Board that brings to us a variety of
perspectives and skills derived from business and professional experience as we may deem are in our and our stockholders&rsquo; best
interests. In doing so, we also consider candidates with appropriate non-business backgrounds.</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-align: justify; background-color: white"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-align: justify; background-color: white"><FONT STYLE="color: Black"><I>In
the section titled &ldquo;Background of Executive Officers and Directors,&rdquo; all references to the Corporate Governance Committee
should be taken to mean the Nominating and Corporate Governance Committee.</I></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-align: justify; background-color: white"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-align: center; background-color: white"><FONT STYLE="text-transform: uppercase; color: Black"><B>IMPORTANT
NOTICE REGARDING THE AVAILABILITY OF PROXY MATERIALS</B><BR>
<B>FOR THE ANNUAL MEETING TO BE HELD ON November 9, 2021:</B></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-align: justify; background-color: white"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt"><FONT STYLE="color: Black">This supplement, the Proxy Statement, the
proxy card and the Company&rsquo;s 2020 Annual Report are available at www.viewproxy.com/actiniumpharma/2021. Additionally, you can find
a copy of the Company&rsquo;s Annual Report on Form 10-K on the website of the SEC at www.sec.gov.</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-align: justify; background-color: white"><FONT STYLE="color: Black">&nbsp;</FONT></P>

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