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Income Taxes (Details) - Schedule of deferred tax assets and liabilities - USD ($) $ in Thousands | Dec. 31, 2021 | Dec. 31, 2020
--- | --- | ---
Deferred tax assets: |  |
Net operating losses carry forward | $ 36,405 | $ 33,955
Share-based compensation | 1,213 | 1,689
Research and development/orphan drug credits | 14,536 | 12,638
Intangibles | 10,426 | 7,873
Others | 19 | 19
Less: valuation allowance | (62,599) | (56,174)
Deferred tax assets, net |  |

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