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Income Taxes (Details) - Schedule of difference between income tax provision and U.S federal statutory rates - USD ($) $ in Thousands | 12 Months Ended
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Dec. 31, 2021 | Dec. 31, 2020
Schedule of difference between income tax provision and U.S federal statutory rates [Abstract] |  |
Federal statutory income taxes | $ (5,202) | $ (4,665)
Federal statutory income taxes, percentage | (21.00%) | (21.00%)
State income taxes | $ (373) | $ 56
State income taxes, percentage | (1.50%) | 0.30%
Deferred true-up | $ 562 | $ (64)
Deferred true-up, percentage | 2.30% | (0.30%)
Research and development/orphan drug tax credit | $ (1,898) | $ (1,766)
Research and development/orphan drug tax credit, percentage | (7.70%) | (8.00%)
Other | $ 486 | $ 202
Other, percentage | 2.00% | 0.90%
Change in valuation allowance | $ 6,425 | $ 6,237
Change in valuation allowance, percentage | 25.90% | 28.10%
Provision for income tax |  |
Provision for income tax, percentage |  |

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- Definition Percentage of the difference, between reported income tax expense (benefit) and the expected income tax expense (benefit) computed by applying the domestic federal statutory income tax rates to pretax income (loss) from continuing operations, that is attributable to tax exempt income, equity in earnings (loss) of an unconsolidated subsidiary, minority interest income (expense), tax holiday, disposition of a business, disposition of an asset, repatriation of foreign earnings, repatriation of foreign earnings jobs creation act of 2004, change in enacted tax rate, prior year income taxes, change in deferred tax asset valuation allowance, and other adjustments. + References No definition available. + Details
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- Definition Percentage of the difference between reported income tax expense (benefit) and expected income tax expense (benefit) computed by applying the domestic federal statutory income tax rates to pretax income (loss) from continuing operations attributable to research tax credit. + References Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef -Publisher FASB -Name Accounting Standards Codification -Topic 740 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SAB Topic 6.I.Fact.4) -URI http://asc.fasb.org/extlink&oid=122134291&loc=d3e330036-122817 Reference 2: http://www.xbrl.org/2009/role/commonPracticeRef -Publisher FASB -Name Accounting Standards Codification -Topic 740 -SubTopic 10 -Section 50 -Paragraph 12 -URI http://asc.fasb.org/extlink&oid=121826272&loc=d3e32687-109319 + Details
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