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Income Taxes (Tables) | 12 Months Ended
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Dec. 31, 2021
Income Tax Disclosure [Abstract] |
Schedule of deferred tax assets and liabilities |
(in thousands) |  | 2021 |  |  | 2020 |
Deferred tax assets: |  |  |  |  |  |
Net operating losses carry forward |  | $ | 36,405 |  |  | $ | 33,955 |
Share-based compensation |  |  | 1,213 |  |  |  | 1,689 |
Research and development/orphan drug credits |  |  | 14,536 |  |  |  | 12,638 |
Intangibles |  |  | 10,426 |  |  |  | 7,873 |
Others |  |  | 19 |  |  |  | 19 |
Less: valuation allowance |  |  | (62,599 | ) |  |  | (56,174 | )
Deferred tax assets, net |  | $ | - |  |  | $ | - |
Schedule of difference between income tax provision and U.S federal statutory rates |
(in thousands) |  | December 31, 2021 |  |  | December 31, 2020 |
Federal statutory income taxes |  | $ | (5,202 | ) |  |  | (21.0 | )% |  | $ | (4,665 | ) |  |  | (21.0 | )%
State income taxes |  |  | (373 | ) |  |  | (1.5 | )% |  |  | 56 |  |  |  | 0.3 | %
Deferred true-up |  |  | 562 |  |  |  | 2.3 | % |  |  | (64 | ) |  |  | (0.3 | )%
Research and development/orphan drug tax credit |  |  | (1,898 | ) |  |  | (7.7 | )% |  |  | (1,766 | ) |  |  | (8.0 | )%
Other |  |  | 486 |  |  |  | 2.0 | % |  |  | 202 |  |  |  | 0.9 | %
Change in valuation allowance |  |  | 6,425 |  |  |  | 25.9 | % |  |  | 6,237 |  |  |  | 28.1 | %
Provision for income tax |  | $ | - |  |  |  | - |  |  | $ | - |  |  |  | - |

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- Definition Tabular disclosure of the components of net deferred tax asset or liability recognized in an entity's statement of financial position, including the following: the total of all deferred tax liabilities, the total of all deferred tax assets, the total valuation allowance recognized for deferred tax assets. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 740 -SubTopic 10 -Section 50 -Paragraph 2 -URI http://asc.fasb.org/extlink&oid=121826272&loc=d3e32537-109319 + Details
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- Definition Tabular disclosure of the reconciliation using percentage or dollar amounts of the reported amount of income tax expense attributable to continuing operations for the year to the amount of income tax expense that would result from applying domestic federal statutory tax rates to pretax income from continuing operations. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 740 -SubTopic 10 -Section 50 -Paragraph 12 -URI http://asc.fasb.org/extlink&oid=121826272&loc=d3e32687-109319 + Details
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