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Income Taxes (Tables)

12 Months Ended

Dec. 31, 2022

Income Tax Disclosure [Abstract]

Schedule of deferred tax assets and liabilities

(in thousands)		2022				2021
Deferred tax assets:
Net operating losses carry forward		$	44,233			$	36,405
Share-based compensation			1,334				1,213
Research and development/orphan drug credits			17,247				14,536
Capitalized research and development expenses			13,210				10,426
Others			69				19
Less: valuation allowance			(76,093	)			(62,599	)
Deferred tax assets, net		$	-			$	-

Schedule of difference between income tax provision and U.S federal statutory rates

(in thousands)		December 31, 2022								December 31, 2021
Federal statutory income taxes		$	(6,943	)			(21.0	)%		$	(5,202	)			(21.0	)%
State income taxes			(4,863	)			(14.7	)%			(373	)			(1.5	)%
Deferred true-up			89				0.3	%			562				2.3	%
Research and development/orphan drug tax credit			(2,711	)			(8.2	)%			(1,898	)			(7.7	)%
Other			934				2.8	%			486				2.0	%
Change in valuation allowance			13,494				40.8	%			6,425				25.9	%
Provision for income tax		$	-				-			$	-				-

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- References

No definition available.

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- Definition

Tabular disclosure of the components of net deferred tax asset or liability recognized in an entity's statement of financial position, including the following: the total of all deferred tax liabilities, the total of all deferred tax assets, the total valuation allowance recognized for deferred tax assets.

+ References

Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 740
-SubTopic 10
-Section 50
-Paragraph 2
-URI https://asc.fasb.org/extlink&oid=121826272&loc=d3e32537-109319

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- Definition

Tabular disclosure of the reconciliation using percentage or dollar amounts of the reported amount of income tax expense attributable to continuing operations for the year to the amount of income tax expense that would result from applying domestic federal statutory tax rates to pretax income from continuing operations.

+ References

Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 740
-SubTopic 10
-Section 50
-Paragraph 12
-URI https://asc.fasb.org/extlink&oid=121826272&loc=d3e32687-109319

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